The immunological responsiveness of the T-cell immunodificient NC nude mice tumor models was reconstructed by thymic transplantation of the semidominance NC mice. After immune reconstruction(IR) the tumor continued to...The immunological responsiveness of the T-cell immunodificient NC nude mice tumor models was reconstructed by thymic transplantation of the semidominance NC mice. After immune reconstruction(IR) the tumor continued to grow until 2 to 3 weeks, then the volume of the tumor reduced gradually and disappeared at the 9th week in both H901 and SW1116 solid tumor nodules was found by light microscopic study(IM), after IR. tumor cells gradually replaced by lymphocytes and fibroblasts, shrinked till only isolated cell groups, then totally disappeared. The whole processes like that the tumor cells were nibbled. It was found that the main tumor cell death related with a specific feature of apoptosis, which had typical dense chromatin distributed along the inner surface of the nuclear membrane by transmission electron microscopic study(TEM). The IR model could be useful for further mechanical research of immune system.展开更多
The efficacy of Radix Astragali membranaceus ( AM) oral liquor combined with routine thera-py and routine therapy alone on T-lymphocyte subsets of peripheral blood in viral myocarditis patients havebeen studied compar...The efficacy of Radix Astragali membranaceus ( AM) oral liquor combined with routine thera-py and routine therapy alone on T-lymphocyte subsets of peripheral blood in viral myocarditis patients havebeen studied comparatively. The results showed that the T-lymphocyte subsets profile and OKT4/OKT8 ratioof peripheral blood were significantly lower in viral myocarditis patients than that in healthy control ( P <0. 05, 0. 01 ) . Routine therapy combined with AM could singificantly enhance OKT3 , OKT4 and OKT4/OKT8ratio in the above-mentioned patients ( P< 0 . 05 , 0. 01 ) . The possible pharmacodynamic mechanism of com-bining routine therapy with AM in improving cell immunity in viral myocarditis patients was discussed.展开更多
文摘The immunological responsiveness of the T-cell immunodificient NC nude mice tumor models was reconstructed by thymic transplantation of the semidominance NC mice. After immune reconstruction(IR) the tumor continued to grow until 2 to 3 weeks, then the volume of the tumor reduced gradually and disappeared at the 9th week in both H901 and SW1116 solid tumor nodules was found by light microscopic study(IM), after IR. tumor cells gradually replaced by lymphocytes and fibroblasts, shrinked till only isolated cell groups, then totally disappeared. The whole processes like that the tumor cells were nibbled. It was found that the main tumor cell death related with a specific feature of apoptosis, which had typical dense chromatin distributed along the inner surface of the nuclear membrane by transmission electron microscopic study(TEM). The IR model could be useful for further mechanical research of immune system.
文摘The efficacy of Radix Astragali membranaceus ( AM) oral liquor combined with routine thera-py and routine therapy alone on T-lymphocyte subsets of peripheral blood in viral myocarditis patients havebeen studied comparatively. The results showed that the T-lymphocyte subsets profile and OKT4/OKT8 ratioof peripheral blood were significantly lower in viral myocarditis patients than that in healthy control ( P <0. 05, 0. 01 ) . Routine therapy combined with AM could singificantly enhance OKT3 , OKT4 and OKT4/OKT8ratio in the above-mentioned patients ( P< 0 . 05 , 0. 01 ) . The possible pharmacodynamic mechanism of com-bining routine therapy with AM in improving cell immunity in viral myocarditis patients was discussed.
