Effects of Heat Clearing and Stasis Resolving Method on PTS,Inflammatory Factors and T-lymphocyte Subsets in Peripheral Blood of URM Patients with Suppressed Internal Heat

[Objectives]To explore the effects of heat clearing and stasis resolving method on prethrombotic state,inflammatory factors and T-lymphocyte subsets in peripheral blood of unexplained recurrent miscarriage(URM)patients with suppressed internal heat.[Methods]Thirty cases of URM patients with suppressed internal heat and 30 normal women were collected,and characteristics of changes in peripheral serum D-dimer(D-D),fibrin degradation product(FDP),fibrinogen(FIB),IL-6,IL-10 and TNF-α,CD,CD,CD,CD,CDlevels were detected.URM patients were treated with traditional Chinese medicine for clearing heat and resolving blood stasis for 3 menstrual cycles,and the changes of indicators before and after treatment were observed.[Results]Compared with normal women,the peripheral serum levels of D-D,IL-6,TNF-αand CDin URM patients with suppressed internal heat were increased(P<0.05),while the IL-10 lymphocyte level was significantly decreased(P<0.05);compared with that before treatment,the contents of D-D,IL-6,TNF-αand CDdecreased after 3 menstrual cycles(P<0.05),while the contents of IL-10 and CDT lymphocytes increased significantly(P<0.05).[Conclusions]The heat clearing heat and stasis resolving method can effectively improve the prethrombotic state of URM,and the action mechanism may be related to the regulation of immune and peripheral blood inflammatory factors.

Effects of Intraoperative Administration of Dexmedetomidine on the Percentage of T-Lymphocyte Subsets and Natural Killer Cells in Patients with Colorectal Cancer

Study Objective: To observe the effect of dexmedetomidine (DEX) on T-lymphocyte subsets and natural killer (NK) cells in the peripheral blood of perioperative patients with colorectal cancer. Design: A random double-blind control clinical study. Setting: A university hospital. Patients: Forty patients with colorectal cancer, ASA I-П. Interventions: All patients were randomly divided into a DEX group (n = 20) and a control group (n = 20). Before induction of anesthesia, epidural catheters were placed in the L1-L2 or T12-L1 intervertebral spaces. The DEX group received 1 μg/kg of DEX (200 μg/50 ml) intravenously for 15 min prior to the surgery, which was then infused at a rate of 0.5 μg/kg/h until 30 min before the end of the surgery. The control group received an intravenous infusion of saline (50 ml) instead of DEX during the same periods as the DEX group. All patients received routine anesthesia and postoperative analgesia. Measurements: Blood samples from all patients were collected at the following time points: before anesthesia (T0), 24 h after surgery (T1), 48 h after surgery (T2) and 72 h after surgery (T3). Changes in T-lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) and NK cells were determined by flow cytometry. Main Results: Compared with the control group, the percentages of CD3+ and CD4+ cells and the CD4+/CD8+ ratio in the DEX group increased significantly from T1 to T3

Endothelial function and T-lymphocyte subsets in patients with overlap syndrome of chronic obstructive pulmonary disease and obstructive sleep apnea

Background:The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is termed overlap syndrome (OS).COPD and OSA both have increased risks of developing cardiovascular diseases.This study aimed to explore if patients with OS exhibited a higher prevalence of cardiovascular complications,and if patients with OS exhibited vascular endothelial dysfunction and abnormalities in the cellular immune function of T lymphocytes.Methods:Totally 25 patients with stable COPD (COPD group),25 patients with OSA (OSA group),25 patients with OS (OS group),and 20 healthy adults (control group) were enrolled between January 2017 and December 2017 from the Respiratory Department of Tianjin Medical University General Hospital.The clinical characteristics of the four groups were collected and the expression levels of soluble vascular cell adhesion molecule-1 (sVCAM-1),tumor necrosis factor-α(TNF-α),and T-lymphocyte subsets were detected.One-way analysis of variance,x^2 test and Pearson correlation were used to manage the data.Results:The prevalence of hypertension and coronary heart disease was significantly higher in the OS group than in the control,OSA,and COPD groups (x^2 =20.69,P < 0.05 and x^2 =11.03,P < 0.05,respectively).The levels of sVCAM-1 and TNF-α were significantly higher in the OS group than in other groups (F =127.40,P < 0.05 and F =846.77,P < 0.05,respectively).The percentage of CD4+ lymphocytes and CD4+/CD8+ were both significantly lower in the OS group than in any other group (F =25.40,P < 0.05 and F =75.08,P < 0.05,respectively).There were significantly negative correlations in the levels of sVCAM-1 and TNF-α with CD4^+/CD8^+ lymphocytes (r =-0.77,P < 0.05 and r =-0.83,P < 0.05,respectively).Conclusions:The prevalence of hypertension and coronary heart disease was higher in patients with OS than in patients with either OSA or COPD alone.Patients with OS exhibited more severe vascular endothelial injury,stronger inflammatory response,and lower cellular immune function.

The relationship between serum interleukins and T-lymphocyte subsets in patients with severe acute respiratory syndrome

Objectives To observe the changes of serum interleukins (IL), T lymphocyte subsets, and white blood cell (WBC) count in patients with severe acute respiratory syndrome (SARS), and to investigate the relationship between injured immune function, immune response and disturbed immune adjustment in SARS patients Methods The levels of serum IL 2, IL 10, IL 12 and T lymphocyte subset counts were measured in 35 clinically diagnosed SARS patients by using enzyme linked immunosorbant assay (ELISA) The relationship between the measured results and WBC count was further analyzed Results The level of serum IL was increased to a great extent in the 35 SARS patients, and the levels of serum IL 2, IL 10 and IL 12 were 242 53 (92 69) pg/ml, 77 43 (63 37) pg/ml and 65 94 (43 21) pg/ml, respectively The level of serum IL 2 increased markedly ( P <0 01) The peripheral blood CD 3 +, CD 4 + and CD 8 + counts were lower than normal in 23 patients (67 7%), 26 patients (74 3%) and 15 patients (42 9%), respectively The peripheral blood WBC counts were lower than 4 0×10 9/L in 10 patients, and their CD 3 +, CD 4 + and CD 8 + counts were 583 90 (315 58)×10 6/L, 272 00 (94 13)×10 6/L and 209 00 (72 21)×10 6/L, respectively The peripheral blood WBC counts were (4 0-10 0)×10 9/L in 20 patients, and their CD 3 +, CD 4 + and CD 8 + counts were 700 00 (502 96)×10 6/L, 347 00 (247 58)×10 6/L and 322 05 (228 47)×10 6/L, respectively The peripheral blood WBC counts were higher than 10 0×10 9/L in 5 patients, and their CD 3 +, CD 4 + and CD 8 + counts were 1466 00 (630 86)×10 6/L, 783 00 (311 14)×10 6/L and 640 00 (294 40)×10 6/L, respectively The decreased CD 3 +, CD 4 + and CD 8 + counts were consistent with the decreased WBC counts The level of IL in SARS patients was significantly higher than that in patients with chronic hepatitis B ( P <0 01) Conclusions The level of serum IL is closely related to cell immunity in SARS patients The level of serum IL is increased evidently while CD 3 +, CD 4 + and CD 8 + counts decrease Both serum IL and CD are associated with injury of immune function, and thus they could be regarded as a monitoring index for judging the condition of SARS patients and prescribing immune

Machine learning-enhanced Monte Carlo and subset simulations for advanced risk assessment in transportation infrastructure

The maintenance of safety and dependability in rail and road embankments is of utmost importance in order to facilitate the smooth operation of transportation networks.This study introduces a comprehensive methodology for soil slope stability evaluation,employing Monte Carlo Simulation(MCS)and Subset Simulation(SS)with the"UPSS 3.0 Add-in"in MS-Excel.Focused on an 11.693-meter embankment with a soil slope(inclination ratio of 2H:1V),the investigation considers earthquake coefficients(kh)and pore water pressure ratios(ru)following Indian zoning requirements.The chance of slope failure showed a considerable increase as the Coefficient of Variation(COV),seismic coefficients(kh),and pore water pressure ratios(ru)experienced an escalation.The SS approach showed exceptional efficacy in calculating odds of failure that are notably low.Within computational modeling,the study optimized the worst-case scenario using ANFIS-GA,ANFIS-GWO,ANFIS-PSO,and ANFIS-BBO models.The ANFIS-PSO model exhibits exceptional accuracy(training R2=0.9011,RMSE=0.0549;testing R2=0.8968,RMSE=0.0615),emerging as the most promising.This study highlights the significance of conducting thorough risk assessments and offers practical insights into evaluating and improving the stability of soil slopes in transportation infrastructure.These findings contribute to the enhancement of safety and reliability in real-world situations.

Clinical characteristics and T-lymphocyte subsets in 48 acquired immune deficiency syndrome patients with cytomegalovirus infections

Objective To investigate the clinical features and Tlymphocytes subsets in patients with acquired immunedeficiency syndrome ( AIDS ) and cytomegalovirus(CMV) infection. Methods A total of 48 hospitalizedpatients with human immunodeficiency virus (HIV)-1 /AIDS and CMV infections were recruited at Peking UnionMedical College Hospital from Jan 2010 to Aug 2017.Their clinical features and immune function were retrospectivelyanalyzed. Patients with only HIV/AIDS inprevious study were recruited as controls. Results All 48patients were at C3 stage, including 36 men and12 women. Five of them were younger than 30 years old,33 cases within 31 - 50 years old,and 10 cases olderthan 50 years old.

Regulatory Effect of Langchuang Serial Recipes on T-Lymphocyte Subsets Th and Tc in Patients with Systemic Lupus Erythematosus

学习清除 Fei 的原则的目的(象养育 yin 和 moisening Fei 一样的肺) ，冷却的血，和 detoxification (abbr。作为 CCD-NM ) 在调整外部 T 淋巴细胞子集 Th 和 Tc 房间的层次为与全身性红斑狼疮(SLE ) 在病人降低感染的发生探索它的机制。没有复杂感染的六十个 SLE 病人被分到治疗组和控制的方法组织， 30 在每个组。当治疗组用西方的药的一样的节目被对待时，控制组独自与西方的药被对待，但是另外与任何一个 Langchuang No.1 管理了( 狼疮I 号)或 2 ( 狼疮I 我号)，连续一致中国配方，在进行期或在静止期在病人分别地适用。为两个组的治疗的全部的时间是 1 年。进一步，一个健康控制组与 20 个健康题目一起被建立。Th1， Th2，和在外部血的 Tc1 和 Tc2 房间的表达式被检测并且在健康控制与那些相比组织。结果(1 ) 作为与健康控制相比组织，在 SLE 病人的 Th1/Th2 和 Tc1/Tc2 的比率，是否与感染复杂，显著地更低(P【0.05 或 P【0.01 ) 。(2 ) 在有复杂并发症和与感染不复杂的那些的病人之间的比较证明二比率和 Th1 表情更低， Tc2 比在后者(所有 P【0.05 ) 的那些在前者是更高的。(3 ) Th1/Th2 和 Tc1/Tc2 的比率在治疗组和控制组(P【0.05 和 P【0.01 ) 的病人增加了术后疗法，但是在治疗组的变化是更重要的(P【0.05 ) 。CCD-NM 的原则能在 SLE 病人向平衡调整 Th 和 Tc 子集的结论，它可能是为减轻复杂感染的行动的机制之一。

SFSDA:Secure and Flexible Subset Data Aggregation with Fault Tolerance for Smart Grid

Smart grid(SG)brings convenience to users while facing great chal-lenges in protecting personal private data.Data aggregation plays a key role in protecting personal privacy by aggregating all personal data into a single value,preventing the leakage of personal data while ensuring its availability.Recently,a flexible subset data aggregation(FSDA)scheme based on the Pail-lier homomorphic encryption was first proposed by Zhang et al.Their scheme can dynamically adjust the size of each subset and obtain the aggregated data in the corresponding subset.In this paper,firstly,an efficient attack with both theorems proving and experimentative verification is launched.We find that in a specific scenario where the encrypted data constructed by a smart meter(SM)exceeds the size of one Paillier ciphertext,the malicious fog node(FN)may use the received ciphertext to obtain the reading of the SM.Secondly,to avoid the possibility of privacy disclosure under certain circumstances,additional hash functions are added to the individual encryption process.In addition,fault tolerance is very important to aggregation schemes in practical scenarios.In most of the current schemes,once some SMs failed,then they will not work.As far as we know,there is no multi-subset aggregation scheme both supports flexible subset data aggregation and fault tolerance.Finally,we construct the first secure flexible subset data aggregation(SFSDA)scheme with fault tolerance by combining the fault tolerance method with the flexible multi-subset aggregation,where FN enables the control server(CS)to finally decrypt the aggregated ciphertext by recovering equivalent ciphertexts when some SMs fail to submit their ciphertexts.Experiments show that our SFSDA scheme keeps the efficiency in implementing a flexible multi-subset aggregation function,and only has a small delay in implementing fault-tolerant data aggregation.

Association of T lymphocyte subset counts with the clinical features of colorectal cancer

Background:Colorectal cancer(CRC)is a common gastrointestinal malignancy.The T lymphocyte subsets are important in the develop-ment,invasion and metastasis of tumors,including CRC.Nevertheless,limited research has explored the relationship between T cell subpopu-lations and the clinical characteristics of CRC.This study compared the T lymphocyte subsets in patients with CRC and healthy individuals,and assessed the relationship between these values and clinical characteristics.Methods:Peripheral blood was collected from 100 patients with CRC and 54 healthy individuals.The numbers of CD3^(+)T,CD4^(+)T,and CD8^(+)T lymphocytes,NK cells,and the CD4^(+)T/CD8^(+)T ratio in peripheral blood were measured using flow cytometry,and were compared between CRC patients and healthy individuals.Spearman's correlation analysis was performed to investigate the relationship between the T lymphocyte subsets in patients diagnosed with CRC and the levels of carcinoembryonic antigen(CEA)and thymidine kinase 1(TK1).Receiver operating characteristic(ROC)curves were utilized to evaluate the potential utility of the T lymphocyte counts in predicting lymph node metastasis,vas-cular infiltration,and high Ki-67 expression.Results:The CRC patients had lower counts of CD3^(+)T,CD4^(+)T,and CD8^(+)T lymphocytes compared to the healthy population(P<0.05).However,no significant differences were observed in the CD4^(+)/CD8^(+)ratio or NK cells(P>0.05).Notably,the CD3^(+)T,CD4^(+)T,and CD8^(+)T lym-phocyte counts were higher in patients with stageⅠ-Ⅱdisease,no lymph node metastasis,no vascular invasion,and low Ki-67 expression than in those with stageⅢ,lymph node metastasis,vascular invasion,and high Ki-67 expression(P<0.05).There was a negative association be-tween the CD3^(+)T,CD4^(+)T,and CD8^(+)T lymphocyte counts and CEA and TK1 levels in patients with CRC.The ROC curves demonstrated that CD3^(+)T,CD4^(+)T,and CD8^(+)T lymphocyte counts had significant predictive value for lymph node metastasis,vascular infiltration,and high Ki-67 expression.Conclusions:The peripheral blood CD3^(+)T,CD4^(+)T,and CD8^(+)T lymphocyte counts are related to the clinical traits of patients with CRC and can predict the prognosis of the disease.

黄芪对甲状腺功能正常的桥本甲状腺炎患者外周血T淋巴细胞亚群表达的影响

目的·探讨黄芪对甲状腺功能正常的桥本甲状腺炎患者T淋巴细胞亚群及细胞因子表达的影响。方法·选择2020年1月—12月在上海市第六人民医院金山分院接受治疗且资料完整的甲状腺功能正常的桥本甲状腺炎患者120例,采用随机数字表将患者为干预组及对照组,每组各60例。对照组治疗方案为碘适宜状态饮食,干预组在对照组治疗方案基础上联合黄芪药液口服(150 mL/次,2次/d)治疗。连续治疗6个月,比较2组治疗前后外周血清T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)),细胞因子[包括白细胞介素2(interleukin-2,IL-2)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、IL-6、IL-10],超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP),红细胞沉降率(erythrocyte sedimentation rate,ESR),以及甲状腺功能及自身抗体、肝肾功能等指标的变化。观察黄芪治疗期间不良反应。应用多因素线性回归分析甲状腺过氧化物酶抗体(thyroid peroxidase antibody,TPOAb)变化幅度的影响因素。结果·最终纳入118例患者,每组各59例。治疗6个月后,干预组CD4^(+)T细胞比例,CD4^(+)/CD8^(+)比值,IL-2、TNF-α、IL-6、IL-10、hs-CRP、ESR、TPOAb和甲状腺球蛋白抗体(thyroglobulin antibody,TGAb)水平均较治疗前及其同期对照组显著改善,差异均有统计学意义(均P<0.05)。对照组治疗后上述指标与治疗前比较,差异均无统计学意义(P>0.05)。治疗后干预组未见严重不良反应。多因素线性回归分析结果显示,应用黄芪、CD4^(+)T细胞、CD4^(+)/CD8^(+)比值升高幅度及hs-CRP下降幅度均是TPOAb下降幅度的独立影响因素(β=−0.393,P=0.029;β=−0.513,P=0.010;β=−0.351,P=0.035;β=0.434,P=0.023)。结论·黄芪可改善甲状腺功能正常的桥本甲状腺炎患者CD4^(+)T细胞、IL-2、TNF-α、IL-6、IL-10水平及CD4^(+)/CD8^(+)比值,且安全性佳。

不同剂量异烟肼治疗肺结核的临床效果及对患者肺功能和T淋巴细胞亚群的影响

目的 探讨不同剂量异烟肼治疗肺结核的临床效果及对患者肺功能、T淋巴细胞亚群的影响。方法 选取2020年6月至2022年6月河北省胸科医院收治的肺结核患者90例为研究对象,按照随机数字表法分为对照组和观察组,各45例。对照组在常规抗结核药物基础上予0.3 g/d异烟肼治疗,观察组在常规抗结核药物基础上予0.5 g/d异烟肼治疗,2组疗程均为6个月。比较2组临床疗效,评估患者肺功能及T淋巴细胞亚群变化情况。结果 观察组总有效率高于对照组(P<0.05)。治疗后,2组最大呼气流量、第1秒用力呼气容积均高于治疗前,且观察组均高于对照组[(7.8±1.4)L/s比(6.3±1.2)L/s、(1.48±0.28)L比(1.15±0.23)L](均P<0.05)。治疗后,2组血清CD+3、CD+4、CD+4/CD+8比值均高于治疗前,且观察组均高于对照组,CD+8均低于治疗前,且观察组低于对照组(均P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论 不同剂量异烟肼治疗肺结核的临床效果不同,增加异烟肼剂量至0.5 g/d能够提升疗效,促进肺结核患者肺功能改善,提高免疫功能,且安全性较好。

雷帕霉素在移植物抗宿主病防治中作用的研究进展

移植物抗宿主病(GVHD)降低异基因造血干细胞移植后患者的疗效和生活质量,特别是激素耐药的GVHD,探索新的防治策略至关重要。雷帕霉素通过抑制mTOR信号通路,在急、慢性GVHD的预防和治疗中均显示出一定的临床优势。另外,雷帕霉素可以调节T细胞、B细胞、树突细胞、骨髓来源的抑制细胞等细胞亚群,阐明了其有效防控GVHD的机制。本文就mTOR抑制剂雷帕霉素防治GVHD的最新研究进展作一综述,同时就如何优化使用雷帕霉素提出新的思考。

老年初治肺结核中医证型与细胞因子及免疫表达的相关性分析

目的 观察老年初治肺结核患者血清中细胞因子及TB淋巴细胞亚群的表达水平,探究中医证型与细胞因子、TB淋巴细胞表达之间的关系。方法 纳入2016年5月至2021年12月解放军总医院第八医学中心结核医学部收治的初治老年肺结核病患者322例作为研究对象,根据辨证分型分为肺阴亏虚组78例、阴虚火旺组83例、气阴两虚组79例、阴阳两虚组82例。采用酶联免疫吸附试验检测血清中γ干扰素(IFN-γ)、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、IL-5、IL-2、IL-6、IL-8、IL-17、IL-4、IL-10等细胞因子的表达水平,流式细胞仪测定TB淋巴细胞亚群中CD3^(+)、CD4^(+)、CD8^(+)、B细胞、NK细胞的绝对数及CD4^(+)/CD8^(+)T细胞比值,并将测定结果进行统计学分析。结果 四组肺结核患者IL-β、IL-5、IL-2、IL-17、IL-4、IL-10水平差异无统计学意义(P>0.05)。气阴两虚组IFN-γ水平显著高于其他三组(P<0.05);阴阳两虚组TNF-α水平显著高于其他三组(P<0.05);阴阳两虚组、气阴两虚组、阴虚火旺组、肺阴亏虚组的IL-6水平依次降低(P<0.05);阴阳两虚组IL-8水平显著高于其他三组,气阴两虚组高于肺阴亏虚组、阴虚火旺组(P<0.05)。CD3^(+)、CD4^(+)、CD8^(+)、B细胞、NK细胞绝对数在阴阳两虚组、气阴两虚组、阴虚火旺组、肺阴亏虚组依次降低,差异均有统计学意义(P<0.05)。阴阳两虚组CD4^(+)/CD8^(+)T细胞比值显著高于其他三组,肺阴亏虚组、阴虚火旺组、气阴两虚组组间比较差异无统计学意义(P>0.05)。结论 不同证型的老年肺结核病患者细胞因子及免疫细胞表达存在差异性,可作为中医辨证论治的客观参考标准之一,为临床辨证治疗提供一定参考。

贝伐珠单抗联合雷替曲塞或卡培他滨治疗晚期结直肠癌疗效比较

目的比较贝伐珠单抗联合雷替曲塞或卡培他滨治疗晚期结直肠癌的临床疗效。方法选取沧州市中心医院2021年2月至2022年8月收治的晚期结直肠癌患者110例,按随机数字表法分为贝伐珠单抗+卡培他滨组(简称贝+卡组)和贝伐珠单抗+雷替曲塞组(简称贝+雷组),各55例。两组患者均予贝伐珠单抗注射液静脉滴注,贝+卡组患者加用卡培他滨片口服,贝+雷组患者加用注射用雷替曲塞静脉滴注(另外建立一组静脉滴注通路)。两组均以3周为1个疗程,共治疗6个疗程,并随访6个月。结果治疗后,贝+卡组患者总生存期(OS)和无进展生存期(PFS)分别为(12.26±2.94)个月和(6.17±1.74)个月,与贝+雷组的(12.57±2.15)个月和(6.62±1.80)个月相当(P>0.05)。贝+雷组的客观缓解率和疾病控制率分别为34.55%和65.45%,与贝+卡组的32.73%和61.82%相当(P>0.05)。治疗后,两组患者的血管内皮生长因子、碱性成纤维细胞生长因子、血小板源性生长因子及T淋巴细胞亚群(CD_(3)^(+),CD_(4)^(+),CD_(8)^(+))水平均显著改善(P<0.05),且贝+雷组改善幅度均显著大于贝+卡组(P<0.05)。贝+雷组Ⅰ-Ⅱ级、Ⅲ-Ⅳ级手足综合征及腹泻,Ⅰ-Ⅱ级恶心呕吐及周围神经毒性的发生率均显著低于贝+卡组(P<0.05)。结论贝伐珠单抗联合雷替曲塞或卡培他滨治疗晚期结直肠癌的疗效相近,但前一组合在改善血清血管生长因子及T淋巴细胞亚群水平方面更具优势。

T细胞亚群与应用免疫检查点抑制剂的肿瘤患者产生不良反应的相关性分析

目的观察临床不同癌种患者在接受肿瘤细胞免疫检查点抑制剂治疗前后外周血中T淋巴细胞亚群的变化,探索其与不良反应发生相关性。方法回顾性收集2021年8月~2022年12月于辽宁中医药大学附属医院住院接受ICIs治疗的60例肿瘤患者的临床资料,对比接受ICI治疗前后的CD3^(+)、CD4^(+)、CD8^(+)计数及CD4^(+)/CD8^(+)的变化,分析T细胞亚群变化的影响因素。结果接受ICI治疗后CD3^(+)、CD4^(+)计数较前升高、CD4^(+)/CD8^(+)较前升高,差异具有统计学意义(P<0.05);虽CD8^(+)较前降低,但差异无统计学意义(P>0.05)。结果显示使用中药时间越长,CD4^(+)/CD8^(+)更趋近于正常范围0.7~2.78,同时不良反应出现的几率越低,irAEs分级越低。结论细胞病理免疫分析的T淋巴细胞结果或可作为临床指导预防免疫相关不良反应的指标之一,治疗过程中联合应用中药可显著降低临床不良反应。

经导管动脉化疗栓塞术联合微波消融治疗原发性肝细胞癌患者疗效观察

目的观察经导管动脉化疗栓塞术(TACE)联合微波消融治疗原发性肝细胞癌(HCC)对患者血清肿瘤标志物、T淋巴细胞亚群的影响。方法收集2018年10月—2021年12月哈尔滨医科大学附属肿瘤医院介入科收治的原发性HCC患者104例临床资料,随机分为TACE组52例(TACE治疗)、联合组52例(TACE+微波消融治疗),评估术后1个月疗效,比较治疗前后2组患者肝功能指标、血清肿瘤标志物、T淋巴细胞亚群,统计患者并发症发生率。结果联合组总有效率为86.5%,高于TACE组的69.2%(χ^(2)/P=4.522/0.033);治疗后1个月联合组AST、ALT水平低于TACE组(t=10.473、8.602,P均<0.001);AFP水平低于TACE组(t=11.724,P<0.001);CD4^(+)、CD4^(+)/CD8^(+)高于TACE组,CD8^(+)低于TACE组(t=3.913、5.460、5.586,P均<0.001);2组并发症发生率比较差异无统计学意义(P>0.05)。结论原发性HCC患者接受TACE联合微波消融治疗可显著下调其血清肿瘤标志物水平,改善肝功能及免疫功能,提升整体疗效。

基于VPNRS-RF的飞机液压系统故障诊断模型

针对飞机液压系统故障诊断特征值冗余难以精准获取和准确率不高的问题,提出一种基于变精度邻域粗糙集(Variable Precision Neighborhood Rough Set,VPNRS)和随机森林(Random Forest,RF)相结合的特征选择算法,并以此为基础建立飞机液压系统故障诊断模型。VPNRS-RF算法主要是利用随机森林算法分别对变精度邻域和模糊熵粗糙集约简后的特征进行重要度排序,再次筛选后确定最优特征子集,使用最优特征子集对在线贯序极限学习机(OSELM)分类模型进行训练,从而提高故障信息获取准确率。最后以飞机起落架收放系统为例进行仿真研究,验证了VPNRS-RFOSELM模型的优越性。

中西医对扁桃体肥大发病免疫调节作用的认识以及研究意义

扁桃体肥大(TH)是儿童及青少年中较为常见的疾病,由咽扁桃体不正常肿大导致。TH可引发上呼吸道阻塞,造成呼吸窘迫、吞咽困难。TH发病机制比较复杂,文章通过相关文献整理,以T细胞亚群间平衡状态和调节性T细胞进行分析,对研究TH等自身免疫性疾病的免疫发病机制、疾病的进展具有重要的理论和实践意义,为下一步研究TH患者T细胞亚群及调节性T细胞的变化情况提供支持。