Objective:To investigate the clinical diagnostic significance of peripheral blood T-cell test(T-spot test)for tuberculosis(TB)infection combined with erythrocyte sedimentation rate(ESR)in pulmonary TB.Methods:41 patie...Objective:To investigate the clinical diagnostic significance of peripheral blood T-cell test(T-spot test)for tuberculosis(TB)infection combined with erythrocyte sedimentation rate(ESR)in pulmonary TB.Methods:41 patients with a clinical diagnosis of TB during hospitalization from January 2020 to April 2023 in our hospital were selected as the experimental group,and 45 patients without TB(bronchopneumonia patients)were selected as the control group.The diagnostic specificity,sensitivity,and accuracy of the T-spot TB test,ESR test,and the combined test of the two were calculated respectively.Results:The sensitivity,specificity,and accuracy of the T-spot TB test combined with ESR for the diagnosis of TB in the experimental group were significantly higher than the individual results of the T-spot TB test and ESR test alone(P<0.05).Conclusion:The T-spot TB test combined with the ESR test for TB diagnosis has greater clinical value than carrying out the tests individually.展开更多
目的:探讨结节性红斑(Erythema nodosum,EN)复发的有关因素。方法:将2016年1月—2022年6月在赣南医科大学第一附属医院诊断为EN的患者分为复发组(26例)和未复发组(59例),对其临床资料进行回顾性对比分析。采用χ^(2)检验及t检验比较2组...目的:探讨结节性红斑(Erythema nodosum,EN)复发的有关因素。方法:将2016年1月—2022年6月在赣南医科大学第一附属医院诊断为EN的患者分为复发组(26例)和未复发组(59例),对其临床资料进行回顾性对比分析。采用χ^(2)检验及t检验比较2组临床特征及实验室检验指标,并对其进行多因素Logistic回归分析;比较EN患者结核菌素纯蛋白衍生物(Purified protein derivative of tuberculin,PPD)试验与结核感染T细胞斑点试验(T cell spot test of tuberculosis infection,T-SPOT.TB)的结果。结果:EN的复发与发病部位(χ^(2)=8.137,P=0.004)、C反应蛋白(χ^(2)=5.412,P=0.020)、中性粒细胞数目(χ^(2)=8.485,P=0.014)有关;多因素Logistic回归分析显示,发病部位(OR=5.394,95%CI=1.744~16.689)、C反应蛋白偏高(OR=3.383,95%CI=1.006~11.375)为EN复发的独立危险因素(P<0.05);T-SPOT.TB结果阳性时抗结核治疗的复发率(10%)比PPD试验结果阳性的复发率(81.4%)低(P<0.05)。结论:EN的复发与发病部位、C反应蛋白、中性粒细胞数目有关;影响EN复发的独立危险因素为发病部位、C反应蛋白;T-SPOT.TB与PPD试验联合应用有助于发现EN患者的结核感染,2项结果阳性时抗结核治疗的EN复发率较低。展开更多
文摘Objective:To investigate the clinical diagnostic significance of peripheral blood T-cell test(T-spot test)for tuberculosis(TB)infection combined with erythrocyte sedimentation rate(ESR)in pulmonary TB.Methods:41 patients with a clinical diagnosis of TB during hospitalization from January 2020 to April 2023 in our hospital were selected as the experimental group,and 45 patients without TB(bronchopneumonia patients)were selected as the control group.The diagnostic specificity,sensitivity,and accuracy of the T-spot TB test,ESR test,and the combined test of the two were calculated respectively.Results:The sensitivity,specificity,and accuracy of the T-spot TB test combined with ESR for the diagnosis of TB in the experimental group were significantly higher than the individual results of the T-spot TB test and ESR test alone(P<0.05).Conclusion:The T-spot TB test combined with the ESR test for TB diagnosis has greater clinical value than carrying out the tests individually.
文摘目的:探讨结节性红斑(Erythema nodosum,EN)复发的有关因素。方法:将2016年1月—2022年6月在赣南医科大学第一附属医院诊断为EN的患者分为复发组(26例)和未复发组(59例),对其临床资料进行回顾性对比分析。采用χ^(2)检验及t检验比较2组临床特征及实验室检验指标,并对其进行多因素Logistic回归分析;比较EN患者结核菌素纯蛋白衍生物(Purified protein derivative of tuberculin,PPD)试验与结核感染T细胞斑点试验(T cell spot test of tuberculosis infection,T-SPOT.TB)的结果。结果:EN的复发与发病部位(χ^(2)=8.137,P=0.004)、C反应蛋白(χ^(2)=5.412,P=0.020)、中性粒细胞数目(χ^(2)=8.485,P=0.014)有关;多因素Logistic回归分析显示,发病部位(OR=5.394,95%CI=1.744~16.689)、C反应蛋白偏高(OR=3.383,95%CI=1.006~11.375)为EN复发的独立危险因素(P<0.05);T-SPOT.TB结果阳性时抗结核治疗的复发率(10%)比PPD试验结果阳性的复发率(81.4%)低(P<0.05)。结论:EN的复发与发病部位、C反应蛋白、中性粒细胞数目有关;影响EN复发的独立危险因素为发病部位、C反应蛋白;T-SPOT.TB与PPD试验联合应用有助于发现EN患者的结核感染,2项结果阳性时抗结核治疗的EN复发率较低。
