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(α,γ)-Anti-Multi-Fuzzy Subgroups and Some of Its Properties
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作者 Memet Sahin Vakkas Uluçay +2 位作者 S.A.Edalatpanah Fayza Abdel Aziz Elsebaee Hamiden Abd El-Wahed Khalifa 《Computers, Materials & Continua》 SCIE EI 2023年第2期3221-3229,共9页
Recently,fuzzy multi-sets have come to the forefront of scientists’interest and have been used in algebraic structures such asmulti-groups,multirings,anti-fuzzy multigroup and(α,γ)-anti-fuzzy subgroups.In this pape... Recently,fuzzy multi-sets have come to the forefront of scientists’interest and have been used in algebraic structures such asmulti-groups,multirings,anti-fuzzy multigroup and(α,γ)-anti-fuzzy subgroups.In this paper,we first summarize the knowledge about the algebraic structure of fuzzy multi-sets such as(α,γ)-anti-multi-fuzzy subgroups.In a way,the notion of anti-fuzzy multigroup is an application of anti-fuzzy multi sets to the theory of group.The concept of anti-fuzzy multigroup is a complement of an algebraic structure of a fuzzy multi set that generalizes both the theories of classical group and fuzzy group.The aim of this paper is to highlight the connection between fuzzy multi-sets and algebraic structures from an anti-fuzzification point of view.Therefore,in this paper,we define(α,γ)-antimulti-fuzzy subgroups,(α,γ)-anti-multi-fuzzy normal subgroups,(α,γ)-antimulti-fuzzy homomorphism on(α,γ)-anti-multi-fuzzy subgroups and these been explicated some algebraic structures.Then,we introduce the concept(α,γ)-anti-multi-fuzzy subgroups and(α,γ)-anti-multi-fuzzy normal subgroups and of their properties.This new concept of homomorphism as a bridge among set theory,fuzzy set theory,anti-fuzzy multi sets theory and group theory and also shows the effect of anti-fuzzy multi sets on a group structure.Certain results that discuss the(α,γ)cuts of anti-fuzzy multigroup are explored. 展开更多
关键词 Fuzzy set anti-fuzzy multi set anti-fuzzy multi subgroup anti-fuzzy multi normal subgroup
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The Structure of Step Fuzzy Subgroups
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作者 李建新 胡刚 《广东工业大学学报》 CAS 1997年第2期5-12,共8页
定义了模糊阶梯型子群,并研究了阶梯型模糊子群与经典群之间的关系.
关键词 群论 模糊子群 T模 阶梯模糊子群
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On the Equal-height Elements of the Fuzzy Subgroups
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作者 张诚一 胡丽萍 党平安 《Chinese Quarterly Journal of Mathematics》 CSCD 2001年第2期82-85,共4页
The properties of the equal height elements of the fuzzy subroups and the classification of groups by its fuzzy subgroups are discussed.
关键词 GROUP fuzzy subgroup EQUIVALENCE equal height element
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“Finite Groups with Quasinormal Subgroups of Prince Power Order”一文的一点注记
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作者 朱静萍 《南昌大学学报(理科版)》 CAS 北大核心 2004年第4期336-337,355,共3页
用F (G)代替F(G),将文"FiniteGroupswithQuasinormalSubgroupsofPrimePowerOrder,ActaMathHun gar89(4),2000,321-326"一文中的主要定理的可解性的假设去除,从而推广了该文的结论。
关键词 有限群 Fitting-子群F(G) 广义Fitting-子群F(G) 拟正规子群
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ON F-z-SUPPLEMENTED SUBGROUPS OF FINITE GROUPS 被引量:5
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作者 郭文彬 唐娜 李保军 《Acta Mathematica Scientia》 SCIE CSCD 2011年第1期22-28,共7页
A subgroup H of a group G is called F-z-supplemented in G if there exists a subgroup K of G, such that G = HK and H∩K≤ Z∞F(G), where Z∞F(G) is the F-hypercenter of G. We obtain some results about the F-z-suppl... A subgroup H of a group G is called F-z-supplemented in G if there exists a subgroup K of G, such that G = HK and H∩K≤ Z∞F(G), where Z∞F(G) is the F-hypercenter of G. We obtain some results about the F-z-supplemented subgroups and use them to determine the structure of some groups. 展开更多
关键词 Finite groups local formations F-z-supplemented subgroups supersoluble groups p-nilpotent groups
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A Comparative Study on the Effect of BCG-PSN and Thymopeptides on T-lymphocyte Subsets of Normal and Immunosuppressed Mice 被引量:12
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作者 邓云华 陈映玲 +2 位作者 陈兴平 李永喜 周礼义 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2003年第4期339-343,347,共6页
To compare the effects of polysaccharide nucleic acid fraction of bacillus calmette guerin (BCG PSN) and thymopeptides on T lymphocytes of normal and immunosuppressed mice, CD4 + and CD8 + T lymphocyte subsets of... To compare the effects of polysaccharide nucleic acid fraction of bacillus calmette guerin (BCG PSN) and thymopeptides on T lymphocytes of normal and immunosuppressed mice, CD4 + and CD8 + T lymphocyte subsets of single nucleic cell in thymus, spleen and peripheral blood were detected successively by flow cytometry after application of BCG PSN and thymopeptides. Meanwhile, CD4 +/CD8 + ratio was also calculated. The results showed that both BCG PSN and thymopeptides could decrease the proportion of CD4 + CD8 + T lymphocyte subsets in the thymus, at the same time increase CD4 + T lymphocyte, CD8 +T lymphocyte proportion in the three tissues. The fluctuation in amplitude was greater in thymopeptides group than that in BCG PSN group. It is concluded that acting location of thymopeptides is in thymus, its stimulating action is stronger than that of BCG PSN, while BCG PSN not only accelerates the differentiation in thymus, but also has some direct stimulation to peripheral CD4 +T lymphocytes, and can maintain CD4 +/CD8 + ratio within normal range. So, BCG PSN is safer. 展开更多
关键词 polysaccharide nucleic acid fraction of bacillus calmette guerin thymopeptides t-lymphocyte CD4 +/CD8 + ratio CD4 + t-lymphocyte CD8 + t-lymphocyte
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Distribution of natural killer cells and T-lymphocyte subsets in peripheral blood,gallbladder cancer and surrounding tissue 被引量:12
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作者 Liu, Gang Ren, Hong +1 位作者 Sun, Xue-Jun Shi, Jing-Sen 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2007年第1期81-86,共6页
BACKGROUND: The patient with malignant tumor always show immunologic function drawback and ingravescent with tumor development, especially in the aspect of cell-mediated immunity. This study was undertaken to define t... BACKGROUND: The patient with malignant tumor always show immunologic function drawback and ingravescent with tumor development, especially in the aspect of cell-mediated immunity. This study was undertaken to define the relationship between the immune function of local cells and cancer development by investigating the distribution of natural killer (NK) cells and T-lymphocyte subsets in peripheral blood, the cancer tissue and the tissue surrounding gallbladder carcinoma. METHODS: The numbers of CD4(+) and CD8(+) T-lymphocytes and NK cells were measured by flow cytometry in samples taken from gallbladder cancer tissue, the surrounding tissues and peripheral blood of 38 patients, and compared with the numbers in the peripheral blood and gallbladder tissue of 30 patients with cholecystitis as controls. RESULTS: The numbers of CD4(+) and CD8(+) T-cells and NK cells in gallbladder cancer tissues were significantly higher than those in the surrounding tissue and gallbladder with gallstone. However, the ratio of CD4(+)/CD8(+) was lower in the cancer tissue than that in the surrounding tissue and tissue from gallbladders with gallstones. The distribution of CD4(+) and CD8(+) T-cells and NK cells in mucous membrane of cholecystitis gallbladder and that in the tissue surrounding gallbladder cancer were significantly different. CONCLUSIONS: Disproportionate and imbalanced distribution of NK cells and subsets of T-lymphocytes occurs in the mucous membrane proper of gallbladder cancer and surrounding tissue. Although gallbladder cancer tissue has higher expressions of CD4(+), CD8(+) and NK cells, the immune function is low or in an inhibited state. In gallbladder cancer immunization therapy, local cellular immunological function should be enhanced and the protective barrier improved. 展开更多
关键词 gallbladder cancer t-lymphocyte subset natural killer cell
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FINITE GROUPS WHOSE MINIMAL SUBGROUPS ARE WEAKLY H-SUBGROUPS 被引量:2
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作者 M.M.Al-Mosa Al-Shomrani M.Ramadan A.A.Heliel 《Acta Mathematica Scientia》 SCIE CSCD 2012年第6期2295-2301,共7页
Let G be a finite group. A subgroup H of G is called an H-subgroup in G if NG(H)∩ H^g ≤ H for all g C G. A subgroup H of G is called a weakly H-subgroup in G if there exists a normal subgroup K of G such that G = ... Let G be a finite group. A subgroup H of G is called an H-subgroup in G if NG(H)∩ H^g ≤ H for all g C G. A subgroup H of G is called a weakly H-subgroup in G if there exists a normal subgroup K of G such that G = HK and H N K is an H-subgroup in G. In this paper, we investigate the structure of the finite group G under the assumption that every subgroup of G of prime order or of order 4 is a weakly H-subgroup in G. Our results improve and generalize several recent results in the literature. 展开更多
关键词 c-normal subgroup H-subgroup p-nilpotent group supersolvable group generalized Fitting subgroupi saturated formation
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SOME SUBGROUPS OF THE EXTENDED HECKE GROUPS H^-(λq) 被引量:1
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作者 ReeepSahin OsmanBizim 《Acta Mathematica Scientia》 SCIE CSCD 2003年第4期497-502,共6页
The authors consider the extended Hecke groups H(γq) generated by T(z) = -1 / z, S(z) = -1(z +γq) and R(z) = 1 / z with A, = 2 cos(π/q) for q≥3 an integer. In this paper, the even subgroup He(γq), the second comm... The authors consider the extended Hecke groups H(γq) generated by T(z) = -1 / z, S(z) = -1(z +γq) and R(z) = 1 / z with A, = 2 cos(π/q) for q≥3 an integer. In this paper, the even subgroup He(γq), the second commutator subgroup H''(γq) and the principal congruence subgroups Hp(λq) of the extended Hecke groups .H(γq) are studied. Also, relations between them are given. 展开更多
关键词 Extended Hecke group even subgroup commutator subgroup principal congruence subgroup
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Hypertonic saline resuscitation maintains a more balanced profile of T-lymphocyte subpopulations in a rat model of hemorrhagic shock 被引量:11
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作者 LU Yuan-qiang CAI Xiu-jun +2 位作者 GU Lin-hui MU Han-zhou HUANG Wei-dong 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2007年第1期70-75,共6页
Objective: To investigate the potential and early effect of hypertonic saline resuscitation on T-lymphocyte sub- populations in rats with hemorrhagic shock. Methods: A model of rat with severe hemorrhagic shock was es... Objective: To investigate the potential and early effect of hypertonic saline resuscitation on T-lymphocyte sub- populations in rats with hemorrhagic shock. Methods: A model of rat with severe hemorrhagic shock was established in 18 Sprague-Dawley (SD) rats. The rats were randomly divided into Sham group, HTS group (hypertonic saline resuscitation group) and NS group (normal saline resuscitation group). Each group contained 6 rats. The CD4+ and CD8+ subpopulations of T-lymphocytes in peripheral blood were detected respectively before shock and after resuscitation by double antibody labelling and flow cytometry. Results: In the early stage after hemorrhagic shock, fluid resuscitation and emergency treatment, the CD4+ lymphocytes of peripheral blood in HTS and NS groups markedly increased. Small volume resuscitation with HTS also induced peripheral CD8+ lymphocytes to a certain extent, whereas NS resuscitation showed no effect in this respect. Consequently, compared with Sham and HTS groups, CD4+/CD8+ ratio of peripheral blood in NS group was obviously increased, and showed statistically differences. Conclusion: In this model of rat with severe hemorrhagic shock, small volume resuscitation with HTS is more effective than NS in reducing immunologic disorders and promoting a more balanced profile of T-lymphocyte subpopula- tions regulating network. 展开更多
关键词 Hemorrhagic shock RESUSCITATION Sodium chloride solution Hypertonic saline t-lymphocyte subpopulations Flow cytometry
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Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B 被引量:30
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作者 Jing You Hutcha Sriplung +6 位作者 Alan Geater Virasakdi Chongsuvivatwong Lin Zhuang Hong-Ying Chen Lan Yu Bao-Zhang Tang Jun-Hua Huang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第7期1112-1119,共8页
AIM: To investigate peripheral T-lymphocyte sub-population profile and its correlation with hepatitis B virus (HBV) replication in patients with chronic hepatitis B (CHB).METHODS: Distribution of T-lymphocyte subpopul... AIM: To investigate peripheral T-lymphocyte sub-population profile and its correlation with hepatitis B virus (HBV) replication in patients with chronic hepatitis B (CHB).METHODS: Distribution of T-lymphocyte subpopulations in peripheral blood was measured by flow cytometry in 206 CHB patients. HBV markers were detected with ELISA. Serum HBV DNA load was assessed with quantitative real-time polymerase chain reaction (PCR). The relationship between HBV replication and variation in peripheral T-cell subsets was analyzed.RESULTS: CHB patients had significantly decreased CD3+ and CD4+ cells and CD4+/CD8+ ratio, and increased CD8+ cells compared with uninfected controls (55.44 ± 12.39 vs 71.07 ± 4.76, 30.92 ± 7.48 vs 38.94 ± 3.39, 1.01 ± 0.49 vs 1.67 ± 0.33, and 34.39 ± 9.22 vs 24.02 ± 4.35; P < 0.001, respectively). Univariate analysis showed a similar pattern of these parameters was significantly associated with high viral load, presence of serum hepatitis B e antigen (HBeAg) expression, liver disease severity, history of maternal HBV infection, and young age at HBV infection, all with P < 0.01. There was a significant linear relationship between viral load and these parameters of T-lymphocyte subpopulations (linear trend test P < 0.001). There was a negative correlation between the levels of CD3+ and CD4+ cells and CD4+/CD8+ ratio and serum level of viral load in CHB patients (r = -0.68, -0.65 and -0.75, all P < 0.0001), and a positive correlation between CD8+ cells and viral load (r = 0.70, P < 0.0001). There was a significant decreasing trend in CD3+ and CD4+ cells and CD4+/CD8+ ratio with increasing severity of hepatocyte damage and decreasing age at HBV infection (linear trend test P < 0.01). In multiple regression (after adjustment for age at HBV infection, maternal HBV infection status and hepatocyte damage severity) log copies of HBV DNA maintained a highly significant predictive coefficient on T-lymphocyte subpopulations, and was the strongest predictor of variation in CD3+, CD4+, CD8+ cells and CD4+/CD8+ ratio. However, the effect of HBeAg was not significant.CONCLUSION: T-lymphocyte failure was signifi-cantly associated with viral replication level. The substantial linear dose-response relationship and strong independent predictive effect of viral load on T-lymphocyte subpopulations suggests the possibility of a causal relationship between them, and indicates the importance of viral load in the pathogenesis of T cell hyporesponsiveness in these patients. 展开更多
关键词 Hepatitis B virus Chronic hepatitis B virus infection Hepatitis B virus DNA t-lymphocyte subpopulation Immune function
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Some Generalized Normal Subgroups and p-nilpotency of Finite Groups 被引量:1
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作者 ZHONG Guo LIN Shi-Xun +1 位作者 CHEN Qi-le QIN Li-hua 《Chinese Quarterly Journal of Mathematics》 2018年第1期17-24,共8页
In this paper, the influence of s-semipermutable, c~#-normal, subnormally embedded and ss-quasinormal subgroups on the p-nilpotency of finite groups is investigated and some recent results are generalized.
关键词 s-semipermutable subgroups c#-normal subgroups subnormally embedded subgroups ss-quasinormal subgroups p-nilpotency
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Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to chronic hepatitis B 被引量:5
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作者 AmirHoushangMohammadAlizadeh FarahnazFallahian +2 位作者 SeyedMohsenMousavi MehrdadHajilooi MithraRanjbar 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第4期630-635,共6页
AIM: To assess the three polymorphJsm regions within cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene, a C/T base exchange in the promoter region-318 (CTLA-4 -318C/T), an A/G substitution in the exon 1 position 49 ... AIM: To assess the three polymorphJsm regions within cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene, a C/T base exchange in the promoter region-318 (CTLA-4 -318C/T), an A/G substitution in the exon 1 position 49 (CTLA-4 49A/G), a T/C substitution in 1172 (CTLA-4 -1172T/C) in patients with chronic hepatitis B. METHODS: Fifty-one patients with chronic hepatitis B virus infection and 150 healthy subjects were recruited sequentially as they presented to the hepatic clinic. Classification of chronic hepatitis B virus (HBV)-infected patients was as asymptomatic carrier state (26 patients) and chronic hepatitis B (25 patients). Genomic DNA was isolated from anti-coagulated peripheral blood Bully coat using Miller's salting-out method. The presence of the CTLA-4 gene polymorphisms was determined using polymerase chain reaction amplification refractory mutation system (ARMS). RESULTS: We observed a significant association between -318 genotypes frequency (T+C-, T+C+, T-C+) and susceptibility to chronic hepatitis B (P=0.012, OR=0.49, 95%CI: 0.206-1.162). However, we did not observe a significant association for +49 genotype frequency (T+C+, T+C- T-C+) and -1172 genotype frequency (C+T+, T+C- C+T-) and state of disease. CONCLUSION: Our results suggest that CTLA-4 gene polymorphisms may partially be involved in the susceptibility to chronic hepatitis B. 展开更多
关键词 Cytotoxic t-lymphocyte antigen 4 Chronic hepatitis B Gene polymorphism
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Hepatitis B virus DNA is more powerful than HBeAg in predicting peripheral T-lymphocyte subpopulations in chronic HBV-infected individuals with normal liver function tests 被引量:11
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作者 Jing You Hutcha Sriplung +5 位作者 Alan Geater Virasakdi Chongsuvivatwong Lin Zhuang Hong-Ying Chen Jun-Hua Huang Bao-Zhang Tang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第23期3710-3718,共9页
AIM:To investigate the peripheral T-lymphocyte subpopulation profile,and its correlations with hepatitis B virus(HBV) replication level in chronic HBV-infected(CHI) individuals with normal liver function tests(LFTs) .... AIM:To investigate the peripheral T-lymphocyte subpopulation profile,and its correlations with hepatitis B virus(HBV) replication level in chronic HBV-infected(CHI) individuals with normal liver function tests(LFTs) . METHODS:Frequencies of T-lymphocyte subpopu-lations in peripheral blood were measured by flow cytometry in 216 CHI individuals. HBV markers were detected with ELISA. Serum HBV DNA load was assessed with quantitative real-time PCR. Information of age at HBV infection,and maternal HBV infection status was collected. ANOVA linear trend test and linear regression were used in statistical analysis. RESULTS:CHI individuals had significantly decreased relative frequencies of CD3+,CD4+ subpopulationsand CD4+/CD8+ ratio,and increased CD8+ subset percentage compared with uninfected individuals(all P < 0.001) . There was a significant linear relationship between the load of HBV DNA and the parameters of T-lymphocyte subpopulations(ANOVA linear trend test P < 0.01) . The parameters were also significantly worse among individuals whose mothers were known to be HBV carriers,and those having gained infection before the age of 8 years. In multiple regressions,after adjustment for age at HBV infection and status of maternal HBV infection,log copies of HBV DNA maintained its highly significant predictive coefficient on T-lymphocyte subpopulations,whereas the effect of HBeAg was not significant. CONCLUSION:HBV DNA correlates with modification in the relative T-lymphocyte subpopulation frequencies. High viral load is more powerful than HBeAg in predicting the impaired balance of T-cell subsets. 展开更多
关键词 Hepatitis B virus Chronic hepatitis B virus infection Hepatitis B virus DNA t-lymphocyte subpopulation Immune function
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Fully Secure Identity-based Broadcast Encryption in the Subgroups 被引量:1
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作者 张乐友 胡予濮 吴青 《China Communications》 SCIE CSCD 2011年第2期152-158,共7页
In this paper,we show how to use the dual techniques in the subgroups to give a secure identity-based broadcast encryption(IBBE) scheme with constant-size ciphertexts. Our scheme achieves the full security(adaptive se... In this paper,we show how to use the dual techniques in the subgroups to give a secure identity-based broadcast encryption(IBBE) scheme with constant-size ciphertexts. Our scheme achieves the full security(adaptive security) under three static(i.e. non q-based) assumptions. It is worth noting that only recently Waters gives a short ciphertext broadcast encryption system that is even adaptively secure under the simple assumptions. One feature of our methodology is that it is relatively simple to leverage our techniques to get adaptive security. 展开更多
关键词 identity-based broadcast encryption dual system encryption full security static assumption subgroup provable security
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Effects of Intraoperative Administration of Dexmedetomidine on the Percentage of T-Lymphocyte Subsets and Natural Killer Cells in Patients with Colorectal Cancer 被引量:5
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作者 Tonghang Zhao Zhong Liu +1 位作者 Ailan Yu Zongwang Zhang 《Open Journal of Anesthesiology》 2013年第2期104-108,共5页
Study Objective: To observe the effect of dexmedetomidine (DEX) on T-lymphocyte subsets and natural killer (NK) cells in the peripheral blood of perioperative patients with colorectal cancer. Design: A random double-b... Study Objective: To observe the effect of dexmedetomidine (DEX) on T-lymphocyte subsets and natural killer (NK) cells in the peripheral blood of perioperative patients with colorectal cancer. Design: A random double-blind control clinical study. Setting: A university hospital. Patients: Forty patients with colorectal cancer, ASA I-П. Interventions: All patients were randomly divided into a DEX group (n = 20) and a control group (n = 20). Before induction of anesthesia, epidural catheters were placed in the L1-L2 or T12-L1 intervertebral spaces. The DEX group received 1 μg/kg of DEX (200 μg/50 ml) intravenously for 15 min prior to the surgery, which was then infused at a rate of 0.5 μg/kg/h until 30 min before the end of the surgery. The control group received an intravenous infusion of saline (50 ml) instead of DEX during the same periods as the DEX group. All patients received routine anesthesia and postoperative analgesia. Measurements: Blood samples from all patients were collected at the following time points: before anesthesia (T0), 24 h after surgery (T1), 48 h after surgery (T2) and 72 h after surgery (T3). Changes in T-lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) and NK cells were determined by flow cytometry. Main Results: Compared with the control group, the percentages of CD3+ and CD4+ cells and the CD4+/CD8+ ratio in the DEX group increased significantly from T1 to T3 展开更多
关键词 DEXMEDETOMIDINE t-lymphocyte SUBSETS Natural KILLER Cell Colorectal Cancer Surgery
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On s*-Completions of Maximal Subgroups of Finite Groups 被引量:1
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作者 高辉 高胜哲 尹丽 《Chinese Quarterly Journal of Mathematics》 2015年第3期381-388,共8页
Given a maximal subgroup M of a group G, a θ*-completion C of M is called an s*-completion if either C = G or there exists a subgroup D of G which is not a θ*-completion of M such that D contains C as a maximal subg... Given a maximal subgroup M of a group G, a θ*-completion C of M is called an s*-completion if either C = G or there exists a subgroup D of G which is not a θ*-completion of M such that D contains C as a maximal subgroup. In this paper, we obtain several results on s*-completions which imply G to be solvable or supersolvable. 展开更多
关键词 MAXIMAL subgroups θ*-completions s*-completions SOLVABLE GROUPS super-solvable GROUPS
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No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples 被引量:3
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作者 Lili Magyari Bernadett Faragó +7 位作者 Judit Bene Katalin Horvatovich Lilla Lakner Márta Varga Mária Figler Beáta Gasztonyi Gyula Mózsik Béla Melegh 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第15期2205-2208,共4页
AIM: The goal of the current work was to analyse the prevalence of the +49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene (CTLA4) in Hungarian patients with Crohn's disease (CD) and ulcerative colitis ... AIM: The goal of the current work was to analyse the prevalence of the +49A/G variant of the cytotoxic T-lymphocyte antigen 4 gene (CTLA4) in Hungarian patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: A total of 130 unrelated subjects with CD and 150 with UC, and 170 matched controls were genotyped for the single nucleotide polymorphism (SNP). The genotypes were determined by using PCR/RFLP test. RESULTS: The G allele frequency and the prevalence of the GG genotype were 38.1% and 12.3% in the CD group, 40.6% and 18.6% in the UC patients, and 37.4% and 15.9% in the control group, respectively. CONCLUSION: The results of the current study show that carriage of the +49G SNP in heterozygous or in homozygous form does not confer risk either for CD or for UC in the Hungarian population. 展开更多
关键词 Cytotoxic t-lymphocyte antigen 4 Crohn's disease Ulcerative colitis Inflammatory bowel disease
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Effect of cytotoxic T-lymphocyte antigen-4,TNF-alpha polymorphisms on osteosarcoma: evidences from a meta-analysis 被引量:3
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作者 Jianwei Liu Junli Wang +1 位作者 Weiping Jiang Yujin Tang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第6期671-678,共8页
Objective: Previous studies have investigated the role of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and tumor necrosis factor-alpha (TNF-a) in carcinogenesis of osteosarcoma, but their results were inconsistent. ... Objective: Previous studies have investigated the role of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and tumor necrosis factor-alpha (TNF-a) in carcinogenesis of osteosarcoma, but their results were inconsistent. We aimed to clarify the associations between CTLA-4, TNF-a polymorphism and osteosarcoma risk by using meta-analysis. Methods: We searched relevant studies without language restriction in PubMed, EMbase, Cochrane Library, Google Scholar databases, Chinese National Knowledge Infrastructure (CNKI) and conference literature in humans published prior to March 2013. The strengths of the associations between genetic variants and osteosarcoma risk were estimated by odds ratio (OR) with 95% confidence interval (95% CI). Results: A total of seven studies with 1,198 osteosarcoma patients and 1,493 controls were selected. Four studies were eligible for CTLA-4 (1,003 osteosarcoma and 1,162 controls), and three studies for TNF-a (195 osteosarcoma and 331 controls). Pooled results showed that rs231775 polymorphism of CTLA-4 was associated with osteosarcoma risk (GG vs. AA: OR=1.63, 95% CI=1.24-2.13; GG + GA vs. AA: OR=1.56, 95% CI=1.21-2.01; AA + GA vs. GG: OR=0.83, 95% CI=0.71-0.97; G vs. A: OR=1.21, 95% CI=1.08-1.36). No significant heterogeneity was observed across the studies. No significant associations were found between rs5742909 polymorphism of CTLA-4 or rs1800629 polymorphism of TNF-a and osteosarcoma risk. Conclusions: These results suggest that the rs231775 polymorphism of CTLA-4 may play an important role in carcinogenesis of osteosarcoma. 展开更多
关键词 Cytotoxic t-lymphocyte antigen-4 (CTLA-4) tumor necrosis factor-alpha (TNF-a) OSTEOSARCOMA genetic polymorphism
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An Investigation on the Parabolic Subgroups of the General Linear Groups by Using GAP 被引量:1
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作者 Saad A Bedaiwi LI Shang-zhi 《Chinese Quarterly Journal of Mathematics》 CSCD 2004年第3期221-231,共11页
A typical example for the algebraic groups is the general linear groups G=GL(n,F), we have studied the structure of such groups and paid special attention to its important substructures, namely the Parabolic subgroups... A typical example for the algebraic groups is the general linear groups G=GL(n,F), we have studied the structure of such groups and paid special attention to its important substructures, namely the Parabolic subgroups. For a given G we computed all the Parabolic subgroups and determined their number, depending on the fact that any finite group has a composition series and the composition factors of a composition series are simple groups which are completely classified, we report here some investigations on the computed Parabolic subgroups. This has been done with the utility of GAP. 展开更多
关键词 general linear group parabolic subgroup GAP
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