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INSURE技术联合T-piece治疗新生儿呼吸窘迫综合征的临床有效性
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作者 丰晔瑛 王铁岩 《世界复合医学(中英文)》 2024年第8期21-24,共4页
目的探讨新生儿呼吸窘迫综合征(respiratory distress syndrome,RDS)采用INSURE技术+Tpiece方法完成治疗的有效性。方法回顾性选取2023年1—12月齐齐哈尔医学院附属第二医院收治的50例RDS患儿的临床资料,根据不同的治疗方法分为对照组(2... 目的探讨新生儿呼吸窘迫综合征(respiratory distress syndrome,RDS)采用INSURE技术+Tpiece方法完成治疗的有效性。方法回顾性选取2023年1—12月齐齐哈尔医学院附属第二医院收治的50例RDS患儿的临床资料,根据不同的治疗方法分为对照组(25例,复苏囊+INSURE技术)、研究组(25例,INSURE技术+T-piece方法)。比较两组血氧饱和度最低值、平均吸氧浓度、鼻塞持续气道正压通气应用时间、心率、并发症发生率。结果研究组血氧饱和度最低值为(90.79±3.59)%,高于对照组的(81.33±2.85)%,差异有统计学意义(t=10.319,P<0.05)。研究组平均吸氧浓度、鼻塞持续气道正压通气应用时间、心率优于对照组,差异有统计学意义(P均<0.05)。两组并发症总发生率比较,差异无统计学意义(P>0.05)。结论临床对RDS患儿在治疗期间,将INSURE技术以及T-piece方法进行充分结合,可有效改善患儿的氧合及血气指标,促进病情康复。 展开更多
关键词 INSURE技术 t-piece治疗 新生儿呼吸窘迫综合征 治疗效果
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Dynamic characteristics of coal specimens with varying static preloading levels under low-frequency disturbance load
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作者 WEN Xiao-ze FENG Guo-rui +5 位作者 GUO Jun YU Lu-yang QIAN Rui-peng ZHANG Jie ZHANG Peng-fei FENG Wen-ming 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2644-2657,共14页
The mechanical properties of residual coal pillars under the influence of upward mining disturbances significantly affect the safety of residual mining activities on working faces.This study conducted low-frequency di... The mechanical properties of residual coal pillars under the influence of upward mining disturbances significantly affect the safety of residual mining activities on working faces.This study conducted low-frequency disturbance dynamic uniaxial compression tests on coal specimens using a self-developed dynamic-static load coupling electro-hydraulic servo system,and studied the strength evolutions,surface deformations,acoustic emission(AE)characteristic parameters,and the failure modes of coal specimens with different static preloading levels were studied.The disturbance damage is positively correlated with the coal specimen static preload level.Specifically,the cumulative AE count rates of the initial accelerated damage stage for the coal specimens with static preloading level of 60%and 70%of the uniaxial compressive strength(UCS)were 2.66 and 3.19 times that of the 50%UCS specimens,respectively.Macroscopically,this behaviour manifested as a decrease in the compressive strength,and the mean strengths of the disturbance-damaged coal specimens with 60%and 70%of UCS static preloading decreased by 8.53%and 9.32%,respectively,compared to those of the specimens under pure static loading.The crack sources,such as the primary fissures,strongly control the dynamic response of the coal specimen.The difference between the dynamic responses of the coal specimens and that of dense rocks is significant. 展开更多
关键词 low-frequency disturbance dynamic response coal specimens static preloading level
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Energy-dispersive X-ray Spectroscopy for the Quantitative Analysis of Pyrite Thin Specimens
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作者 LUO Tingting GUO Yi +4 位作者 DENG Zhao LIU Xiaoqing SUN Zhenya QI Yanyuan YANG Meijun 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2023年第6期1304-1310,共7页
To explore ways to improve the accuracy of quantitative analysis of samples in the micrometer to nanometer range of magnitudes,we adopted analytical transmission electron microscopy(AEM/EDS)for qualitative and quantit... To explore ways to improve the accuracy of quantitative analysis of samples in the micrometer to nanometer range of magnitudes,we adopted analytical transmission electron microscopy(AEM/EDS)for qualitative and quantitative analysis of pyrite materials.Additionally,the k factor of pyrite is calculated experimentally.To develop an appropriate non-standard quantitative analysis model for pyrite materials,the experimentally calculated k factor is compared with that estimated from the non-standard quantitative analytical model of the instrument software.The experimental findings demonstrate that the EDS attached to a TEM can be employed for precise quantitative analysis of micro-and nanoscale regions of pyrite materials.Furthermore,it serves as a reference for improving the results of the EDS quantitative analysis of other sulfides. 展开更多
关键词 analytical transmission electron microscopy(AEM) energy dispersive X-ray spectroscopy(EDS) PYRITE thin specimen quantitative analysis
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Bird specimen number linked with species trait and climate niche breadth
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作者 Xiaoyu Duan Xiongwei Huang +4 位作者 Jingya Zhang Shuo Lv Gang Song Yanping Wang Gang Feng 《Avian Research》 SCIE CSCD 2024年第1期108-115,共8页
Biological specimens are fundamental for taxonomy and flora/fauna research.More importantly,they also play crucial roles in recording environmental impacts on morphology and behavior,which is vital for biodiversity re... Biological specimens are fundamental for taxonomy and flora/fauna research.More importantly,they also play crucial roles in recording environmental impacts on morphology and behavior,which is vital for biodiversity research and conservation.However,there are few systematic studies on the patterns and drivers of bird specimen number at regional scales.This study is the first attempt to examine the relationships between bird specimen number and species traits as well as climate niche breadth in China,aiming to answer two questions:1)how do species’temperature niche breadth and precipitation niche breadth influence specimen number?2)which trait is most associated with bird specimen number?The associations between bird specimen number and explanatory variables were examined using ordinary least squares,generalized linear models,phylogenetic generalized linear mixed models,and multiple comparisons.The results showed that Muscicapidae was the family with the highest specimen number,and Passeriformes was the order with the highest specimen number.Bird specimen number significantly increased with larger temperature niche breadth and precipitation niche breadth.Specimen number was also positively associated with geographic range size,habitat specificity,hunting vulnerability and clutch size,but negatively associated with body size.These findings suggest that future bird specimen collection should pay more attention to birds with limited ecological niches,large body sizes,and small clutch sizes.This research enhances the use of bird specimen data to study and preserve biodiversity. 展开更多
关键词 Biodiversity conservation Biological specimens Bird traits Scientific collection specimen number Temperature and precipitation
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Species’ geographical range, environmental range and traits lead to specimen collection preference of dominant plant species of grasslands in Northern China
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作者 Jingya Zhang Cui Xiao +5 位作者 Xiaoyu Duan Xin Gao Hao Zeng Rong'an Dong Gang Feng Keping Ma 《Plant Diversity》 SCIE CAS CSCD 2024年第3期353-361,共9页
Many different factors,such as species traits,socio-economic factors,geographical and environmental factors,can lead to specimen collection preference.This study aims to determine whether grassland specimen collection... Many different factors,such as species traits,socio-economic factors,geographical and environmental factors,can lead to specimen collection preference.This study aims to determine whether grassland specimen collection in China is preferred by species traits(i.e.,plant height,flowering and fruiting period),environmental range(i.e.,the temperature and precipitation range)and geographical range(i.e.,distribution range and altitudinal range).Ordinary least squares models and phylogenetic generalized linear mixed models were used to analyze the relationships between specimen number and the explanatory variables.Random Forest models were then used to find the most parsimonious multivariate model.The results showed that interannual variation in specimen number between 1900 and 2020 was considerable.Specimen number of these species in southeast China was notably lower than that in northwest China.Environmental range and geographical range of species had significant positive correlations with specimen number.In addition,there were relatively weak but significant associations between specimen number and species trait(i.e.,plant height and flowering and fruiting period).Random Forest models indicated that distribution range was the most important variable,followed by flowering and fruiting period,and altitudinal range.These findings suggest that future floristic surveys should pay more attention to species with small geographical range,narrow environmental range,short plant height,and short flowering and fruiting period.The correction of specimen collection preference will also make the results of species distribution model,species evolution and other works based on specimen data more accurate. 展开更多
关键词 Biological specimen Collection preference Dominant plant species Environmental range Geographical range Species traits
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Direct Pointwise Comparison of FE Predictions to StereoDIC Measurements:Developments and Validation Using Double Edge-Notched Tensile Specimen
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作者 Troy Myers Michael A.Sutton +2 位作者 Hubert Schreier Alistair Tofts Sreehari Rajan Kattil 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第8期1263-1298,共36页
To compare finite element analysis(FEA)predictions and stereovision digital image correlation(StereoDIC)strain measurements at the same spatial positions throughout a region of interest,a field comparison procedure is... To compare finite element analysis(FEA)predictions and stereovision digital image correlation(StereoDIC)strain measurements at the same spatial positions throughout a region of interest,a field comparison procedure is developed.The procedure includes(a)conversion of the finite element data into a triangular mesh,(b)selection of a common coordinate system,(c)determination of the rigid body transformation to place both measurements and FEA data in the same system and(d)interpolation of the FEA nodal information to the same spatial locations as the StereoDIC measurements using barycentric coordinates.For an aluminum Al-6061 double edge notched tensile specimen,FEA results are obtained using both the von Mises isotropic yield criterion and Hill’s quadratic anisotropic yield criterion,with the unknown Hill model parameters determined using full-field specimen strain measurements for the nominally plane stress specimen.Using Hill’s quadratic anisotropic yield criterion,the point-by-point comparison of experimentally based full-field strains and stresses to finite element predictions are shown to be in excellent agreement,confirming the effectiveness of the field comparison process. 展开更多
关键词 StereoDIC spatial co-registration data transformation finite element simulations point-wise comparison of measurements and FEA predictions double edge notch specimen model validation
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Perioperative outcomes of transvaginal specimen extraction laparoscopic total gastrectomy and conventional laparoscopicassisted total gastrectomy
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作者 Zhi-Cao Zhang Wen-Sheng Wang +5 位作者 Jiang-Hong Chen Yuan-Hang Ma Qi-Fa Luo Yun-Bo Li Yang Yang Dan Ma 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第6期1527-1536,共10页
BACKGROUND Natural orifice specimen extraction surgery(NOSES)has emerged as a promising alternative compared to conventional laparoscopic-assisted total gastrectomy(LATG)for treating gastric cancer(GC).However,evidenc... BACKGROUND Natural orifice specimen extraction surgery(NOSES)has emerged as a promising alternative compared to conventional laparoscopic-assisted total gastrectomy(LATG)for treating gastric cancer(GC).However,evidence regarding the efficacy and safety of NOSES for GC surgery is limited.This study aimed to compare the safety and feasibility,in addition to postoperative complications of NOSES and LATG.METHODS Dual circular staplers were used in Roux-en-Y digestive tract reconstruction for transvaginal specimen extraction LATG,and its outcomes were compared with LATG in a cohort of 51 GC patients with tumor size≤5 cm.The study was conducted from May 2018 to September 2020,and patients were categorized into the NOSES group(n=22)and LATG group(n=29).Perioperative parameters were compared and analyzed,including patient and tumor characteristics,postoperative outcomes,and anastomosis-related complications,postoperative hospital stay,the length of abdominal incision,difference in tumor type,postoperative complications,and postoperative survival.RESULTS Postoperative exhaust time,operation duration,mean postoperative hospital stay,length of abdominal incision,number of specific staplers used,and Brief Illness Perception Questionnaire score were significant in both groups(P<0.01).In the NOSES group,the postoperative time to first flatus,mean postoperative hospital stay,and length of abdominal incision were significantly shorter than those in the LATG group.Patients in the NOSES group had faster postoperative recovery,and achieved abdominal minimally invasive incision that met aesthetic requirements.There were no significant differences in gender,age,tumor type,postoperative complications,and postoperative survival between the two groups.CONCLUSION The application of dual circular staplers in Roux-en-Y digestive tract reconstruction combined with NOSES gastrectomy is safe and convenient.This approach offers better short-term outcomes compared to LATG,while long-term survival rates are comparable to those of conventional laparoscopic surgery. 展开更多
关键词 Gastric cancer Circular stapler Natural orifice specimen extraction surgery Laparoscopic-assisted total gastrectomy
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Wireless Preamplifier for the Specimen Current Mode Detector in a SEM
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作者 Valentin G. Dyukov 《Optics and Photonics Journal》 2024年第2期23-28,共6页
Using a scanning electron microscope (SEM) in the back-scattered electron (BSE) mode the composition of multi-element specimens may be determined based on the strong dependence of emission coefficient η on the averag... Using a scanning electron microscope (SEM) in the back-scattered electron (BSE) mode the composition of multi-element specimens may be determined based on the strong dependence of emission coefficient η on the average atomic number of elements Z. The output video signal of the usual BSE detectors is produced from their sensors, and the larger proportion of high-energy electrons with modified spectrum is added. Since η = is/ip (is and ip currents of specimen and probe), better accuracy must be achieved by direct measurements those currents on the specimen surface. Here, an experimental model of a current detector for a presented specimen is described. The cage is mounted on the carousel of the moving specimen stage. The input of the preamplifier is connected to the specimen holder in the form of a disk, the diameter of which is 12 mm. When the probe along its surface scanned, the input potential begins to pulsate with a negative polarity. The output of this preamplifier is connected to a small light-emitting diode, which creates intensity-modulated radiation in the chamber. Thus created the light video signal will be picked up by the photomultiplier of the E-T detector. The modes of true SE and BSE are set by applying tens bias volts of various polarities to the specimens or the cage itself. 展开更多
关键词 Scanning Electron Microscopy Backscattered Electron Imaging Wireless specimen Current Preamplifier Universal (SE/BSE) Dyukov Detector
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Application Effect of Feedforward Control in Outpatient Blood Specimen Management
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作者 Meiying Lu 《Journal of Clinical and Nursing Research》 2024年第6期177-183,共7页
Objective:To analyze the application effect of feedforward control in outpatient blood specimen management.Methods:1,200 patients who had their venous blood collected in outpatient phlebotomy room of our hospital'... Objective:To analyze the application effect of feedforward control in outpatient blood specimen management.Methods:1,200 patients who had their venous blood collected in outpatient phlebotomy room of our hospital's outpatient clinic from January 2021 to April 2021 were selected as study subjects and divided into 600 cases in the control group and 600 cases in the observation group.The two groups of patients were compared in terms of their satisfaction with the staff,the efficiency of the nurses and the quality of nursing care,turnaround time before specimen analysis,the rejection rate of the blood specimens,and the time of result reporting.Results:After the implementation of feedforward control,patients'satisfaction with staff,nurses work efficiency and quality of care,turnaround time before specimen analysis,specimen rejection rate,and result reporting time in the observation group were significantly higher than those in the control group(P<0.05).Conclusion:The application of feedforward control in the management of outpatient blood specimens has significant effect,which effectively improves patients'satisfaction,enhances the efficiency of nurses and the quality of nursing care,shortens the turnaround time of specimens before analysis and the reporting time of results,and reduces the rejection rate of specimens. 展开更多
关键词 Feedforward control Venous blood specimen Nursing management Application effect
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Stability of SARS Coronavirus in Human Specimens and Environment and Its Sensitivity to Heating and UV Irradiation 被引量:32
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作者 SHU-MING DUAN, XIN-SHENG ZHAO, RUI-FU WEN, JING-JING HUANG, GUO-HUA PI, SU-XIANG ZHANG, JUN HAN, SHENG-LI BI, LI RUAN, XIAO-PING DONGAND SARS RESEARCH TEAMInstitute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention,Ying-Xin Rd. 100, Beijing 100052, China 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2003年第3期246-255,共10页
Objective The causal agent for SARS is considered as a novel coronavirus that has never been described both in human and animals previously. The stability of SARS coronavirus in human specimens and in environments was... Objective The causal agent for SARS is considered as a novel coronavirus that has never been described both in human and animals previously. The stability of SARS coronavirus in human specimens and in environments was studied. Methods Using a SARS coronavirus strain CoV-P9, which was isolated from pharyngeal swab of a probable SARS case in Beijing, its stability in mimic human specimens and in mimic environment including surfaces of commonly used materials or in household conditions, as well as its resistances to temperature and UV irradiation were analyzed. A total of 106 TCID50 viruses were placed in each tested condition, and changes of the viral infectivity in samples after treatments were measured by evaluating cytopathic effect (CPE) in cell line Vero-E6 at 48 h after infectionn. Results The results showed that SARS coronavirus in the testing condition could survive in serum, 1:20 diluted sputum and feces for at least 96 h, whereas it could remain alive in urine for at least 72 h with a low level of infectivity. The survival abilities on the surfaces of eight different materials and in water were quite comparable, revealing reduction of infectivity after 72 to 96 h exposure. Viruses stayed stable at 4℃, at room temperature (20℃) and at 37℃ for at least 2 h without remarkable change in the infectious ability in cells, but were converted to be non-infectious after 90-, 60- and 30-min exposure at 56℃, at 67℃ and at 75℃, respectively. Irradiation of UV for 60 min on the virus in culture medium resulted in the destruction of viral infectivity at an undetectable level. Conclusion The survival ability of SARS coronavirus in human specimens and in environments seems to be relatively strong. Heating and UV irradiation can efficiently eliminate the viral infectivity. 展开更多
关键词 Severe acute respiratory syndrome CORONAVIRUS STABILITY ENVIRONMENT specimen
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Unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis 被引量:10
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作者 Mehmet Yilmaz Sami Akbulut +4 位作者 Koray Kutluturk Nurhan Sahin Ebru Arabaci Cengiz Ara Sezai Yilmaz 《World Journal of Gastroenterology》 SCIE CAS 2013年第25期4015-4022,共8页
AIM: To investigate the prevalence and implications of unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis. METHODS: The demographic and histopathological data ... AIM: To investigate the prevalence and implications of unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis. METHODS: The demographic and histopathological data of 1621 patients (≥ 16 years-old) who underwent appendectomy to treat an initial diagnosis of acute appendicitis between January 1999 and November 2011 were retrospectively assessed. Microscopic findings were used to classify the patients under six categories: appendix vermiformis, phlegmonous appendicitis, gan- grenous appendicitis, perforated appendicitis, supurative appendicitis, and unusual histopathologic findings. The demographic and clinicopathologic characteristics of patients with unusual histopathologic findings were evaluated in detail, and re-analysis of archived resected appendix specimens was carried out. RESULTS: A total of 912 males and 709 females, from16 to 94 years old, were included in the study and comprised 789 cases of suppurative appendicitis, 370 cases of appendix vermiformis, 243 cases of perforated gangrenous appendicitis, 53 cases of flegmaneous appendicitis, 32 cases of gangrenous appendicitis, and 134 (8.3%) cases of unusual histopathological findings. The unusual histopathological findings included fibrous obliteration (n = 62), enterobius vermicularis (n = 31), eosinophilic infiltration (n = 10), mucinous cystadenoma (n = 8), carcinoid tumor (n = 6), granulomatous inflammation (n = 5), adenocarcinoma (n = 4; one of them mucinous), and mucocele (n = 3), adenomatous polyp (n = 1), taenia sup (n = 1), ascaris lumbricoides (n = 1), appendiceal diverticula (n = 1), and B cell non-hodgkin lymphoma (n = 1). None of the 11 patients with subsequent diagnosis of tumor were suspected of cancer prior to the appendectomy. CONCLUSION: Even when the macroscopic appearance of appendectomy specimens is normal, histopathological assessment will allow early diagnosis of many unusual diseases. 展开更多
关键词 APPENDICITIS APPENDECTOMY specimens Histopathology UNUSUAL FINDINGS APPENDICEAL malignancy
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An Improved Barcoded Oligonucleotide Primers-based Next-generation Sequencing Approach for Direct Identification of Viral Pathogens in Clinical Specimens 被引量:7
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作者 WANG Churl Hua NIE Kai +6 位作者 ZHANG Yi WANG Ji ZHOU Shuai Feng LI Xin Na ZHOU Hang Yu QI Shun Xiang MA Xue Jun 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2017年第1期22-34,共13页
Objective To provide a feasible and cost-effective next-generation sequencing (NGS) method for accurate identification of viral pathogens in clinical specimens, because enormous limitations impede the clinical use o... Objective To provide a feasible and cost-effective next-generation sequencing (NGS) method for accurate identification of viral pathogens in clinical specimens, because enormous limitations impede the clinical use of common NGS, such as high cost, complicated procedures, tremendous data analysis, and high background noise in clinical samples. Methods Viruses from cell culture materials or clinical specimens were identified following an improved NGS procedure: reduction of background noise by sample preprocessing, viral enrichment by barcoded oligonucleotide (random hexamer or non-ribosomal hexanucleotide) primer-based amplification, fragmentation-free library construction and sequencing of one-tube mixtures, as well as rapid data analysis using an in-house pipeline. Results NGS data demonstrated that both barcoded primer sets were useful to simultaneously capture multiple viral pathogens in cell culture materials or clinical specimens and verified that hexanucleotide primers captured as many viral sequences as hexamers did. Moreover, direct testing of clinical specimens using this improved hexanucleotide primer-based NGS approach provided further detailed genotypes of enteroviruses causing hand, foot, and mouth disease (HFMD) and identified other potential viruses or differentiated misdiagnosis events. Conclusion The improved barcoded oligonucleotide primer-based NGS approach is simplified, time saving, cost effective, and appropriate for direct identification of viral pathogens in clinical practice. 展开更多
关键词 NGS Barcoded oligonucleotide primers Virus identification Clinical specimen
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Development of a reverse-transcription loop-mediated isothermal amplification assay to detect avian influenza viruses in clinical specimens 被引量:3
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作者 SHI Lin YU Xue-wu +7 位作者 YAO Wei YU Ben-liang HE Li-kun GAO Yuan ZHANG Yun-xian TIAN Guo-bin PING Ji-hui WANG Xiu-rong 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2019年第7期1428-1435,共8页
In recent years,the avian influenza has brought not only serious economic loss to the poultry industry in China but also a serious threat to human health because of the avian influenza virus(AIV) gene recombination an... In recent years,the avian influenza has brought not only serious economic loss to the poultry industry in China but also a serious threat to human health because of the avian influenza virus(AIV) gene recombination and reassortment.Until now,traditional RT-PCR,fluorescence RT-PCR and virus isolation identification have been developed and utilized to detect AIV,but these methods require high-level instruments and experimental conditions,not suitable for the rapid detection in field and farms.In order to develop a rapid,sensitive and practical method to detect and identify AIV subtypes,4 specific primers to the conserved region of AIV M gene were designed and a loop-mediated isothermal amplification(RT-LAMP) method was established.Using this method,the M gene of H1–H16 subtypes of AIV were amplified in 30 min with a water bath and all 16 H subtypes of AIV were able to be visually identified in presence of fluorescein,without cross reaction with other susceptible avian viruses.In addition,the detection limit of the common H1,H5,H7,and H9 AIV subtypes with the RT-LAMP method was 0.1 PFU(plaque-forming unit),which was 10 times more sensitive than that using the routine RT-PCR.Further comparative tests found that the positivity rate of RT-LAMP on detecting clinical samples was 4.18%(14/335) comparing with 3.58%(12/335) from real-time RT-PCR.All these results suggested that the RT-LAMP method can specifically detect and identify AIV with high sensitivity and can be considered as a fast,convenient and practical method for the clinic test and epidemiological investigation of AIV. 展开更多
关键词 AVIAN INFLUENZA virus(AIV) RT-LAMP diagnostic method clinical specimens
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Histopathological characteristics of needle core biopsy and surgical specimens from patients with solitary hepatocellular carcinoma or intrahepatic cholangiocarcinoma 被引量:3
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作者 Ju-Shan Wu Ji-Liang Feng +3 位作者 Rui-Dong Zhu San-Guang Liu Da-Wei Zhao Ning Li 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2019年第5期404-415,共12页
BACKGROUND Pathological manifestations of hepatic tumours are often associated with prognosis. Although surgical specimens(SS) can provide more information,currently, pre-treatment needle core biopsy(NCB) is increasin... BACKGROUND Pathological manifestations of hepatic tumours are often associated with prognosis. Although surgical specimens(SS) can provide more information,currently, pre-treatment needle core biopsy(NCB) is increasingly showing important value in understanding the nature of liver tumors and even in diagnosis and treatment decisions. However, the concordance of the clinicopathological characteristics and immunohistochemical(IHC) staining between NCB and SS from patients with hepatic tumours were less concerned.AIM To introduce a more accurate method for interpreting the IHC staining results in order to improve the diagnostic value of hepatic malignancy in NCB samples.METHOD A total of 208 patients who underwent both preoperative NCB and surgical resection for hepatocellular carcinoma(HCC) or intrahepatic cholangiocarcinomaRESULTS Morphologically, the presence of compact tumour nests or a cord-like structure in NCB was considered the primary cause of misdiagnosis of HCC from ICC. The kappa statistic showed a moderate agreement in histomorphology(k = 0.504) and histological grade(k = 0.488) between NCB and SS of the tumours. A 4-tier(+++,++, +, and-) scoring scheme that emphasized the focal neoplastic cell immunoreactivity of tumour cells revealed perfect concordance of CK19, GPC3 and HepPar1 between NCB and SS(k = 0.717; k = 0.768; k = 0.633). Furthermore,with the aid of a binary classification derived from the 4-tier score, a high concordance was achieved in interpreting the IHC staining of the three markers between NCB and final SS(k = 0.931; k = 0.907; k = 0.803), increasing the accuracy of NCB diagnosis C(k = 0.987; area under the curve = 0.997, 95%CI: 0.990-1.000; P< 0.001).CONCLUSION These findings imply that reasonable interpretation of IHC results in NCB is vital for improving the accuracy of tumour diagnosis. The simplified binary classification provides an easy and applicable approach. 展开更多
关键词 HISTOPATHOLOGICAL Needle core biopsy SURGICAL specimens SOLITARY hepatocellular carcinoma INTRAHEPATIC CHOLANGIOCARCINOMA
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Cracks coalescence mechanism and cracks propagation paths in rock-like specimens containing pre-existing random cracks under compression 被引量:18
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作者 Hadi Haeri Kourosh Shahriar +1 位作者 Mohammad Fatehi Marji Parviz Moarefvand 《Journal of Central South University》 SCIE EI CAS 2014年第6期2404-2414,共11页
The mechanism of cracks propagation and cracks coalescence due to compressive loading of the brittle substances containing pre-existing cracks (flaws) was modeled experimentally using specially made rock-like specim... The mechanism of cracks propagation and cracks coalescence due to compressive loading of the brittle substances containing pre-existing cracks (flaws) was modeled experimentally using specially made rock-like specimens from Portland Pozzolana Cement (PPC). The breakage process of the specimens was studied by inserting single and double flaws with different inclination angles at the center and applying uniaxial compressive stress at both ends of the specimen. The first crack was oriented at 50&#176; from the horizontal direction and kept constant throughout the analysis while the orientation of the second crack was changed. It is experimentally observed that the wing cracks are produced at the first stage of loading and start their propagation toward the direction of uniaxial compressive loading. The secondary cracks may also be produced in form of quasi-coplanar and/or oblique cracks in a stable manner. The secondary cracks may eventually continue their propagation in the direction of maximum principle stress. These experimental works were also simulated numerically by a modified higher order displacement discontinuity method and the cracks propagation and cracks coalescence were studied based on Mode I and Mode II stress intensity factors (SIFs). It is concluded that the wing cracks initiation stresses for the specimens change from 11.3 to 14.1 MPain the case of numerical simulations and from 7.3 to 13.8 MPa in the case of experimental works. It is observed that cracks coalescence stresses change from 21.8 to 25.3 MPa and from 19.5 to 21.8 MPa in the numerical and experimental analyses, respectively. Comparing some of the numerical and experimental results with those recently cited in the literature validates the results obtained by the proposed study. Finally, a numerical simulation was accomplished to study the effect of confining pressure on the crack propagation process, showing that the SIFs increase and the crack initiation angles change in this case. 展开更多
关键词 crack propagation crack coalescence rock-like specimen numerical simulation experiment
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Fracture analyses of different pre-holed concrete specimens under compression 被引量:5
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作者 Hadi Haeri Alireza Khaloo Mohammad Fatehi Marji 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2015年第6期855-870,共16页
Crack propagation processes in specially prepared concrete discs and rectangular specimens containing a single cylindrical hole or multiple holes of varying diameters have been studied both experimentally and numerica... Crack propagation processes in specially prepared concrete discs and rectangular specimens containing a single cylindrical hole or multiple holes of varying diameters have been studied both experimentally and numerically. In this research, the cracks coalescence paths in Brazilian disc and rectangular specimens made from rock-like material containing multi-holes are investigated. These concrete specimens are specially prepared from an appropriate mixture of Portland Pozzolana Cement (PPC), fine sands, and water. The pre-holed Brazilian discs and rectangular specimens are experimentally tested under compression. The breakage load in the ring type disc specimens containing an axial hole with varying diameters is measured and the distribution of the induced lateral stress is obtained. The mechanism of cracks propagation in the wall of the ring type specimens is also stud- ied. In the case of multi-hole Brazilian disc and rectangular specimens, the cracks propagation and cracks coalescence are also investigated. These experiments are numerically modeled by a modified higher order displacement discontinuity method. It has been shown that the corresponding experimental and numerical results are in good agreement with each other. The results presented in this research vali date the accuracy and applicability of these crack analyses procedures. 展开更多
关键词 Concrete rings Pre-holed Brazilian disc ·Rectangular specimens Crack analyses Coalescence ·Induced lateral stress
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Catalog of insect type specimens preserved at the Kunming Institute of Zoology,Chinese Academy of Science with corrections of some specimens 被引量:2
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作者 Kai-Qin LI Yun-Zhen WANG +1 位作者 Da-Zhi DONG Li-Kun ZHANG 《Zoological Research》 CAS CSCD 2015年第5期263-284,共22页
This article presents a list of insect types preserved in Kunming Natural History Museum of Zoology (KNHMZ). As of March, 2015, 3412 type specimens belonging to 266 species/subspecies of 37 families in 9 orders (Od... This article presents a list of insect types preserved in Kunming Natural History Museum of Zoology (KNHMZ). As of March, 2015, 3412 type specimens belonging to 266 species/subspecies of 37 families in 9 orders (Odonata, Isoptera, Mantodea, Orthoptera, Hemiptera, Coleoptera, Diptera, Hymenoptera and Lepidoptera) are included. Information corrections of some specimens are provided in this article. 展开更多
关键词 CATALOG INSECTS Type specimens Information correction KIZ
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Using p53-immunostained large specimens to determine the distal intramural spread margin of rectal cancer 被引量:10
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作者 Zhi-Zhong Pan De-Sen Wan Chang-Qing Zhang Jian-Yong Shao Li-Ren Li Gong Chen Zhi-Wei Zhou Fu-Long Wang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第10期1626-1629,共4页
AIM: To determine the distal intramural spread (DIS) margin of rectal cancer.METHODS: Sixty-one p53-positive specimens of rectal cancer were used. After conventional hematoxylin and eosin (H&E) staining, the DI... AIM: To determine the distal intramural spread (DIS) margin of rectal cancer.METHODS: Sixty-one p53-positive specimens of rectal cancer were used. After conventional hematoxylin and eosin (H&E) staining, the DIS margin of rectal cancer in large specimens was examined by immunohistochemistry. The patients were divided into A, B, C, and D groups. After a long-term follow-up, the survival curves of the four groups were estimated using the life table. RESULTS: Fifty-one of the sixty-one cases (83.6%) had DIS. The extent of DIS ranged 0.11-3.5 cm; meanwhile the.mean of DIS measured by H&E staining was 0.13 cm. The significant difference was found between the means (t=5.622, P〈0.0001). Only 1 of 51 patients had DIS greater than 3 cm. The DIS was less than 1.0 cm in most rectal cancer patients. The long-term results indicated that the survival rate of the patients whose DIS was greater than 1.0 cm was lower than that of the patients whose DIS was less than 0.5 cm. CONCLUSION: Rectal cancer patients with DIS greater than 1.0 cm have poor prognosis. 展开更多
关键词 Rectal cancer Distal intramural spread P53 IMMUNOHISTOCHEMISTRY Large specimen
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Catalogue of the Type Specimens of Amphibians and Reptiles in the Herpetological Museum of Chengdu Institute of Biology, Chinese Academy of Sciences: I. Rhacophoridae(Anura, Amphibia) 被引量:2
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作者 Jiatang LI Yueying CHEN +2 位作者 Shengquan LI Ke LV Yuezhao WANG 《Asian Herpetological Research》 SCIE 2011年第3期129-141,共13页
In order to facilitate herpetological research for all the herpetologists both in and outside of China, we will report all the type specimens of amphibia and reptilia deposited in the Herpetological Museum of Chengdu ... In order to facilitate herpetological research for all the herpetologists both in and outside of China, we will report all the type specimens of amphibia and reptilia deposited in the Herpetological Museum of Chengdu Institute of Biology(CIB), Chinese Academy of Sciences in series. This report focuses on the family Rhacophoridae of Anura in Amphibia, including 13 species. The contents of the report include synonym lists and generic transfer of type species, measurements of type specimens, particularly for those with no previously published measurement data, and chromosomal data for each species. 展开更多
关键词 CATALOGUE Rhacophoridae taxonomy type specimen
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Catalogue of the Type Specimens of Amphibians and Reptiles in the Herpetological Museum of the Chengdu Institute of Biology,Chinese Academy of Sciences:Ⅱ.Hynobiidae (Amphibia,Urodela) 被引量:2
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作者 Jianli XIONG Yueying CHEN Xiaomao ZENG 《Asian Herpetological Research》 SCIE 2012年第4期327-333,共7页
In order to facilitate herpetological research for herpetologists in and outside of China,we will report all the type specimens of Amphibia and Reptilia deposited in the Herpetological Museum of the Chengdu Institute ... In order to facilitate herpetological research for herpetologists in and outside of China,we will report all the type specimens of Amphibia and Reptilia deposited in the Herpetological Museum of the Chengdu Institute of Biology(CIB),Chinese Academy of Sciences(CAS) in series. This report focuses on the type specimens of the family Hynobiidae of Urodela in Amphibia,which comprises seven species. Each entry provides the genus name,species name,information of the original description,the catalog number of holotype,sex,type locality,information of allotype(if any) and paratype,number and distribution of deposited specimens,and comments where they are appropriate. 展开更多
关键词 type specimen CATALOGUE hynobiid salamander MUSEUM
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