A new isocoumarin,tenuissimasatin（1）,was isolated from metabolites of the endophytic fungus Alternaria tenuissima（Nees ＆ T.Nees：Fr.） Wiltshire,which was isolated from the bark of Erythrophleum fordii Oliver,toge...A new isocoumarin,tenuissimasatin（1）,was isolated from metabolites of the endophytic fungus Alternaria tenuissima（Nees ＆ T.Nees：Fr.） Wiltshire,which was isolated from the bark of Erythrophleum fordii Oliver,together with 11 known compounds（2- 12）.The structure and absolute configuration of 1 was determined by means of NMR and CD analysis.Compound 3 shows selective cytotoxic activity on human colon cancer cell HCT-8（IC_（50） = 1.78μmol/L） by MTT test in vitro.Other compounds show no such activities（IC_（50）〉10μmol/L）.展开更多
运用冷冻切片、显微观察及显微照相的方法,对阴香[Cinnamomum burmanni(Nees et T.Nees)Blume]的茎结构进行了解剖研究。结果表明,阴香茎由周皮、皮层、韧皮部、木质部以及髓部5部分组成。茎横切面生长轮不明显,韧皮纤维发达,散孔材,管...运用冷冻切片、显微观察及显微照相的方法,对阴香[Cinnamomum burmanni(Nees et T.Nees)Blume]的茎结构进行了解剖研究。结果表明,阴香茎由周皮、皮层、韧皮部、木质部以及髓部5部分组成。茎横切面生长轮不明显,韧皮纤维发达,散孔材,管孔排列方式多为径向复管孔或孔团,管孔壁薄,平均厚度为4.04μm±0.58μm,平均弦向直径为7.64μm±2.57μm,导管平均数为(432.30±134.21)个/mm2。角质层厚薄不均,平均厚度为21.91μm±20.36μm。木射线为异形单列和异形I型。展开更多
Panax japonicus, which in the Tujia dialect is known as "Baisan Qi" and "Zhujieshen", is a classic "qi" drug of Tujia ethnomedicine and it has unique effects on disease caused by "qi...Panax japonicus, which in the Tujia dialect is known as "Baisan Qi" and "Zhujieshen", is a classic "qi" drug of Tujia ethnomedicine and it has unique effects on disease caused by "qi" stagnation and blood stasis.This paper serves as the basis of further scientific research and development of Panax japonicus. The pharmacology effects of molecular pharmacology were discussed and summarized. P. japonicus plays an important role on several diseases, such as rheumatic arthritis, cancer, cardiovascular agents, and this review provides new insights into P. japonicus as promising agents to substitute ginseng and notoginseng.展开更多
A high-order Navier-Stokes solver based on the flux reconstruction(FR)or the correction procedure via reconstruction(CPR)formulation is employed to perform a direct numerical simulation(DNS)and large eddy simulations(...A high-order Navier-Stokes solver based on the flux reconstruction(FR)or the correction procedure via reconstruction(CPR)formulation is employed to perform a direct numerical simulation(DNS)and large eddy simulations(LES)of a well-known benchmark problem–transitional flow over the low-pressure T106C turbine cascade.Hp-refinement studies are carried out to assess the resolution requirement.A 4th order(p3)simulation on the fine mesh is performed with a DNS resolution to establish a"converged"solution,including the mean pressure and skin-friction distributions,and the power spectral density in the wake.Then LES on the coarse and fine meshes with lower order schemes are conducted to assess the mesh and order dependence of the solution.In particular,we study the error in the transition location,the mean skin-friction distribution,and the mean lift and drag coefficients.These h-and p-refinement studies provide a much-needed guideline in h-and p-resolutions to achieve a certain level of accuracy for industrial LES applications.展开更多
基金Financial support from the National Science and Technology Project of China(No2009ZX09311-004)the Natural Science Foundation of China(No201072234)
文摘A new isocoumarin,tenuissimasatin（1）,was isolated from metabolites of the endophytic fungus Alternaria tenuissima（Nees ＆ T.Nees：Fr.） Wiltshire,which was isolated from the bark of Erythrophleum fordii Oliver,together with 11 known compounds（2- 12）.The structure and absolute configuration of 1 was determined by means of NMR and CD analysis.Compound 3 shows selective cytotoxic activity on human colon cancer cell HCT-8（IC_（50） = 1.78μmol/L） by MTT test in vitro.Other compounds show no such activities（IC_（50）〉10μmol/L）.
文摘运用冷冻切片、显微观察及显微照相的方法,对阴香[Cinnamomum burmanni(Nees et T.Nees)Blume]的茎结构进行了解剖研究。结果表明,阴香茎由周皮、皮层、韧皮部、木质部以及髓部5部分组成。茎横切面生长轮不明显,韧皮纤维发达,散孔材,管孔排列方式多为径向复管孔或孔团,管孔壁薄,平均厚度为4.04μm±0.58μm,平均弦向直径为7.64μm±2.57μm,导管平均数为(432.30±134.21)个/mm2。角质层厚薄不均,平均厚度为21.91μm±20.36μm。木射线为异形单列和异形I型。
基金financially supported by Natural Science Foundation of Hunan Province (No. 2017JJ5041, 2018JJ2293)the National Key R&D Program of China (No. 2018YFC1707900)+1 种基金National Natural Science Foundation of China (No. 81703819, 81874369, 81803708, 81673579 and 81374062)Key Research and Development Programs of Hunan Science and Technology Department (No. 2018SK2113, 2018SK2119, 2018WK2081)。
文摘Panax japonicus, which in the Tujia dialect is known as "Baisan Qi" and "Zhujieshen", is a classic "qi" drug of Tujia ethnomedicine and it has unique effects on disease caused by "qi" stagnation and blood stasis.This paper serves as the basis of further scientific research and development of Panax japonicus. The pharmacology effects of molecular pharmacology were discussed and summarized. P. japonicus plays an important role on several diseases, such as rheumatic arthritis, cancer, cardiovascular agents, and this review provides new insights into P. japonicus as promising agents to substitute ginseng and notoginseng.
基金AFOSR grant(FA9550-16-1-0128)US Army Research Office grant(W911NF-15-1-0505).
文摘A high-order Navier-Stokes solver based on the flux reconstruction(FR)or the correction procedure via reconstruction(CPR)formulation is employed to perform a direct numerical simulation(DNS)and large eddy simulations(LES)of a well-known benchmark problem–transitional flow over the low-pressure T106C turbine cascade.Hp-refinement studies are carried out to assess the resolution requirement.A 4th order(p3)simulation on the fine mesh is performed with a DNS resolution to establish a"converged"solution,including the mean pressure and skin-friction distributions,and the power spectral density in the wake.Then LES on the coarse and fine meshes with lower order schemes are conducted to assess the mesh and order dependence of the solution.In particular,we study the error in the transition location,the mean skin-friction distribution,and the mean lift and drag coefficients.These h-and p-refinement studies provide a much-needed guideline in h-and p-resolutions to achieve a certain level of accuracy for industrial LES applications.
