BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen...BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these patients.METHODS Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation cohort.Differences between the training and validation groups were analyzed.The training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram model.RESULTS The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,respectively.Enterostomy(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was constructed.CONCLUSION Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon cancer.The nomogram model exhibited good agreement and accuracy.展开更多
The^6 Li(n,t)~4 He reaction was measured as the first experiment involving neutron-induced charged particle emission reactions at the CSNS(China Spallation Neutron Source)Back-n white neutron source.The differential c...The^6 Li(n,t)~4 He reaction was measured as the first experiment involving neutron-induced charged particle emission reactions at the CSNS(China Spallation Neutron Source)Back-n white neutron source.The differential cross-sections of the^6 Li(n,t)~4 He reaction at 15 detection angles ranging from 19.2°to 160.8°are obtained from 1.0 eV to 3.0 MeV at 80 neutron energy points;for 50 energy points below 0.1 MeV they are reported for the first time.The results indicate that the anisotropy of the emitted tritium is noticeable above E_n=100 eV.The angle-integrated cross-sections are also obtained.The present differential cross-sections agree in general with the previous evaluations,but there are some differences in the details.More importantly,the present results indicate that the cross-sections of the^6 Li(n,t)~4 He reaction might be overestimated by most evaluations in the 0.5-3.0 MeV region,although they are recommended as standards below 1.0 MeV.展开更多
基金Supported by Health Science and Technology Project of Tianjin Health Commission,No.ZC20190Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-005ATianjin Medical University Clinical Research Fund,No.22ZYYLCCG04.
文摘BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these patients.METHODS Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation cohort.Differences between the training and validation groups were analyzed.The training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram model.RESULTS The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,respectively.Enterostomy(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was constructed.CONCLUSION Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon cancer.The nomogram model exhibited good agreement and accuracy.
基金Supported by National Key R&D Program of China(2016YFA0401604)National Natural Science Foundation of China(11775006)Science and Technology on Nuclear Data Laboratory and China Nuclear Data Center
文摘The^6 Li(n,t)~4 He reaction was measured as the first experiment involving neutron-induced charged particle emission reactions at the CSNS(China Spallation Neutron Source)Back-n white neutron source.The differential cross-sections of the^6 Li(n,t)~4 He reaction at 15 detection angles ranging from 19.2°to 160.8°are obtained from 1.0 eV to 3.0 MeV at 80 neutron energy points;for 50 energy points below 0.1 MeV they are reported for the first time.The results indicate that the anisotropy of the emitted tritium is noticeable above E_n=100 eV.The angle-integrated cross-sections are also obtained.The present differential cross-sections agree in general with the previous evaluations,but there are some differences in the details.More importantly,the present results indicate that the cross-sections of the^6 Li(n,t)~4 He reaction might be overestimated by most evaluations in the 0.5-3.0 MeV region,although they are recommended as standards below 1.0 MeV.
