骨组织是晚期肿瘤远处转移最常见部位之一。而骨转移的发生大多将导致灾难性的并发症,严重影响癌症患者的生存质量。生长停滞特异性蛋白6(Gas6)与TAM家族受体相互作用起到调节细胞增殖、迁移、分化、黏附和凋亡。G a s6/T A M信号通路...骨组织是晚期肿瘤远处转移最常见部位之一。而骨转移的发生大多将导致灾难性的并发症,严重影响癌症患者的生存质量。生长停滞特异性蛋白6(Gas6)与TAM家族受体相互作用起到调节细胞增殖、迁移、分化、黏附和凋亡。G a s6/T A M信号通路调节细胞的增殖、迁移、分化、黏附和凋亡,目前研究发现其在肺癌、前列腺癌、乳腺癌等癌症的发展中发挥着关键性的作用,并且与癌症的转移密切相关。因此,深入探讨G a s6/T A M在肿瘤骨转移过程中发挥的作用及靶向Gas6、TAM治疗的研究进展,对明确肿瘤骨转移的机制和寻找抗肿瘤骨转移的潜在靶点具有重要的意义。展开更多
The TAM family of receptors is preferentially expressed by professional and non-professional phagocytes,including macrophages,dendritic cells and natural killer cells in the immune system,osteoclasts in bone,Sertoli c...The TAM family of receptors is preferentially expressed by professional and non-professional phagocytes,including macrophages,dendritic cells and natural killer cells in the immune system,osteoclasts in bone,Sertoli cells in testis,and retinal pigmental epithelium cells in the retina.Mutations in the Mertk single gene or in different combinations of the double or triple gene mutations in the same cell cause complete or partial impairment in phagocytosis of their preys;and as a result,either the normal apoptotic cells cannot be efficiently removed or the tissue neighbor cells die by apoptosis.This scenario of TAM regulation represents a widely adapted model system used by phagocytes in all different tissues.The present review will summarize current known functional roles of TAM receptors and their ligands,Gas 6 and protein S,in the regulation of phagocytosis.展开更多
文摘骨组织是晚期肿瘤远处转移最常见部位之一。而骨转移的发生大多将导致灾难性的并发症,严重影响癌症患者的生存质量。生长停滞特异性蛋白6(Gas6)与TAM家族受体相互作用起到调节细胞增殖、迁移、分化、黏附和凋亡。G a s6/T A M信号通路调节细胞的增殖、迁移、分化、黏附和凋亡,目前研究发现其在肺癌、前列腺癌、乳腺癌等癌症的发展中发挥着关键性的作用,并且与癌症的转移密切相关。因此,深入探讨G a s6/T A M在肿瘤骨转移过程中发挥的作用及靶向Gas6、TAM治疗的研究进展,对明确肿瘤骨转移的机制和寻找抗肿瘤骨转移的潜在靶点具有重要的意义。
基金This study was partially supported by NIH EY018830,RR017702,and RR018733Research to Prevent Blindnessand the National Natural Science Foundation of China(Grant Nos.30400229,30670643 and 30870788).
文摘The TAM family of receptors is preferentially expressed by professional and non-professional phagocytes,including macrophages,dendritic cells and natural killer cells in the immune system,osteoclasts in bone,Sertoli cells in testis,and retinal pigmental epithelium cells in the retina.Mutations in the Mertk single gene or in different combinations of the double or triple gene mutations in the same cell cause complete or partial impairment in phagocytosis of their preys;and as a result,either the normal apoptotic cells cannot be efficiently removed or the tissue neighbor cells die by apoptosis.This scenario of TAM regulation represents a widely adapted model system used by phagocytes in all different tissues.The present review will summarize current known functional roles of TAM receptors and their ligands,Gas 6 and protein S,in the regulation of phagocytosis.
