热辅助磁头(Thermal Assisted Magnetic Recording,简称TAMR)技术是通过激光瞬间加热磁记录介质,使其局部温度升高,矫顽力迅速下降到写磁头磁场可写范围完成写入动作后,磁记录介质温度快速冷却到原来高矫顽力状态从而实现信息保持。本文...热辅助磁头(Thermal Assisted Magnetic Recording,简称TAMR)技术是通过激光瞬间加热磁记录介质,使其局部温度升高,矫顽力迅速下降到写磁头磁场可写范围完成写入动作后,磁记录介质温度快速冷却到原来高矫顽力状态从而实现信息保持。本文从TAMR的基本原理出发,介绍了TAMR当前的研发状况和生产TAMR的相关设备,相关技术以及所存在的问题,为进一步加快TAMR量产上市提供技术参考。展开更多
The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor cells.The pro-death effect of Nur77 can be regulated by its interaction with Bcl-2,resulting in conversion of Bcl-2 from a s...The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor cells.The pro-death effect of Nur77 can be regulated by its interaction with Bcl-2,resulting in conversion of Bcl-2 from a survival to killer.As Bcl-2 is overexpressed in various cancers preventing them from apoptosis and promoting their resistance to chemotherapy,targeting the apoptotic pathway of Nur77/Bcl-2 may lead to new cancer therapeutics.Here,we report our identification of XS561 as a novel Nur77 ligand that induces apoptosis of tumor cells by activating the Nur77/Bcl-2 pathway.In vitro and animal studies revealed an apoptotic effect of XS561 in a range of tumor cell lines including MDA-MB-231 triple-negative breast cancer(TNBC)and MCF-7/LCC2 tamoxifen-resistant breast cancer(TAMR)in a Nur77-dependent manner.Mechanistic studies showed XS561 potently induced the translocation of Nur77 from the nucleus to mitochondria,resulting in mitochondria-related apoptosis.Interestingly,XS561-induced accumulation of Nur77 at mitochondria was associated with XS561 induction of Nur77 phase separation and the formation of Nur77/Bcl-2 condensates.Together,our studies identify XS561 as a new activator of the Nur77/Bcl-2 apoptotic pathway and reveal a role of phase separation in mediating the apoptotic effect of Nur77 at mitochondria.展开更多
文摘热辅助磁头(Thermal Assisted Magnetic Recording,简称TAMR)技术是通过激光瞬间加热磁记录介质,使其局部温度升高,矫顽力迅速下降到写磁头磁场可写范围完成写入动作后,磁记录介质温度快速冷却到原来高矫顽力状态从而实现信息保持。本文从TAMR的基本原理出发,介绍了TAMR当前的研发状况和生产TAMR的相关设备,相关技术以及所存在的问题,为进一步加快TAMR量产上市提供技术参考。
基金partially supported by grants from the The National Natural Science Foundation of China,China(81672749 and 22207093)Xiamen Bureau of Science&Technology,Xiamen city,China(3502Z20193004 and 3502Z20150007,China)+1 种基金Youth Innovation Fund from Xiamen City,Fujian Province,China.(3502Z20206033)the Fujian Provincial Key Laboratory of Innovative Drug Target Research,Fujian Province,China(FJYW-2022KF01,China)。
文摘The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor cells.The pro-death effect of Nur77 can be regulated by its interaction with Bcl-2,resulting in conversion of Bcl-2 from a survival to killer.As Bcl-2 is overexpressed in various cancers preventing them from apoptosis and promoting their resistance to chemotherapy,targeting the apoptotic pathway of Nur77/Bcl-2 may lead to new cancer therapeutics.Here,we report our identification of XS561 as a novel Nur77 ligand that induces apoptosis of tumor cells by activating the Nur77/Bcl-2 pathway.In vitro and animal studies revealed an apoptotic effect of XS561 in a range of tumor cell lines including MDA-MB-231 triple-negative breast cancer(TNBC)and MCF-7/LCC2 tamoxifen-resistant breast cancer(TAMR)in a Nur77-dependent manner.Mechanistic studies showed XS561 potently induced the translocation of Nur77 from the nucleus to mitochondria,resulting in mitochondria-related apoptosis.Interestingly,XS561-induced accumulation of Nur77 at mitochondria was associated with XS561 induction of Nur77 phase separation and the formation of Nur77/Bcl-2 condensates.Together,our studies identify XS561 as a new activator of the Nur77/Bcl-2 apoptotic pathway and reveal a role of phase separation in mediating the apoptotic effect of Nur77 at mitochondria.
