[目的]探讨Omega-3必需脂肪酸饮食干预用于治疗干眼症病人的干预效果。[方法]通过检索PubMed,Embase,Cochrane Central Register of Controlled Trials,CINAHL和中国期刊全文数据库(CNKI)、万方数据库等资源,收集Omega-3必需脂肪酸饮食...[目的]探讨Omega-3必需脂肪酸饮食干预用于治疗干眼症病人的干预效果。[方法]通过检索PubMed,Embase,Cochrane Central Register of Controlled Trials,CINAHL和中国期刊全文数据库(CNKI)、万方数据库等资源,收集Omega-3必需脂肪酸饮食干预对于干眼症病人疗效的随机对照试验,并进行文献质量评价和数据提取,结局指标包括泪膜破裂时间(TBUT)、Schirmer试验、眼表疾病指数(OSDI)。[结果]共纳入7篇文献,文献证据质量大多为中等。Meta分析结果显示,Omega-3必需脂肪酸的饮食干预可以有效改善干眼症病人TBUT和Schirmer的试验结果,差异有统计学意义(P<0.05)。此外,Omega-3必需脂肪酸的饮食干预具有改善OSDI的趋势,但是差异并无统计学意义(P=0.06)。[结论]Omega-3必需脂肪酸饮食干预可以让干眼症病人获益。但是未来研究中仍然要克服相应的方法学缺陷。展开更多
Background : The objective of this study was to validate an animal model for dry eye during and after the administration of 1% ophthalmic atropine sulfate(OAS) in New Zealand white(NZW) rabbits.Methods : OAS(1%) was a...Background : The objective of this study was to validate an animal model for dry eye during and after the administration of 1% ophthalmic atropine sulfate(OAS) in New Zealand white(NZW) rabbits.Methods : OAS(1%) was applied three times per day to 30 eyes of 15 healthy NZW rabbits. Sacrifice, enucleation, and lacrimal gland removal took place on days 15, 21,and 30(OAS group). A second group(n = 5) was used as control. Clinical evaluations took place on days 3, 10, 15, 18, 21, 24 and 30. The primary endpoints were:Schirmer I test, tear break-up time(TBUT), and corneal fluorescein staining. As secondary endpoints, clinical changes including intraocular pressure, and histopathology were evaluated.Results : While OAS was administered, the Schirmer I test showed a statistically significant reduction for OAS group versus control( p < 0.001), and versus basal production( p < 0.001). TBUT showed statistically significant differences between groups(days 3 and 10;p = 0.001) and versus basal values(day 3;p < 0.001). Fluorescein staining showed a statistically significant difference(day 3;p = 0.001). The most frequent clinical finding was conjunctival hyperemia(76.9% OAS vs. 20% control). For histopathology, all OAS subjects presented some degree of inflammation(86.7% minimal;13.3% mild) whereas the control presented only 30% minimal inflammation. Goblet cell density showed no difference.Conclusions : The effectiveness of the OAS dry eye model in NZW rabbits as reported in previous studies was confirmed, provided that the application of the drug is maintained throughout the intervention;it is not a viable model after OAS administration is suspended.展开更多
Dry eye is a multifactorial,progressive,and chronic disease of the tears and ocular surface.The disease is multi-factorial and has intermittent symptoms.Discomfort,visual disturbance,tear film instability with potenti...Dry eye is a multifactorial,progressive,and chronic disease of the tears and ocular surface.The disease is multi-factorial and has intermittent symptoms.Discomfort,visual disturbance,tear film instability with potential damage to the ocular surface,and increased tear film osmolarity are known associates.Dry eye is a common clinical problem for eye-care providers worldwide and there is a large number of clinical investigative techniques for the evaluation of dry eye.Despite this,however,there is no globally accepted guideline for dry eye diagnosis and none of the available tests may hold the title of the‘gold standard’.The majority of the techniques involved in the diagnosis of the disease,particularly for its early stages,has a large degree of subjectivity.The purpose of this article is to review existing dry eye investigative techniques and to present a new objective dry eye screening technique based on optical coherence tomography.展开更多
文摘[目的]探讨Omega-3必需脂肪酸饮食干预用于治疗干眼症病人的干预效果。[方法]通过检索PubMed,Embase,Cochrane Central Register of Controlled Trials,CINAHL和中国期刊全文数据库(CNKI)、万方数据库等资源,收集Omega-3必需脂肪酸饮食干预对于干眼症病人疗效的随机对照试验,并进行文献质量评价和数据提取,结局指标包括泪膜破裂时间(TBUT)、Schirmer试验、眼表疾病指数(OSDI)。[结果]共纳入7篇文献,文献证据质量大多为中等。Meta分析结果显示,Omega-3必需脂肪酸的饮食干预可以有效改善干眼症病人TBUT和Schirmer的试验结果,差异有统计学意义(P<0.05)。此外,Omega-3必需脂肪酸的饮食干预具有改善OSDI的趋势,但是差异并无统计学意义(P=0.06)。[结论]Omega-3必需脂肪酸饮食干预可以让干眼症病人获益。但是未来研究中仍然要克服相应的方法学缺陷。
基金sponsored by Laboratorios Sophia,SA de CV(Zapopan,Jalisco,Mexico)。
文摘Background : The objective of this study was to validate an animal model for dry eye during and after the administration of 1% ophthalmic atropine sulfate(OAS) in New Zealand white(NZW) rabbits.Methods : OAS(1%) was applied three times per day to 30 eyes of 15 healthy NZW rabbits. Sacrifice, enucleation, and lacrimal gland removal took place on days 15, 21,and 30(OAS group). A second group(n = 5) was used as control. Clinical evaluations took place on days 3, 10, 15, 18, 21, 24 and 30. The primary endpoints were:Schirmer I test, tear break-up time(TBUT), and corneal fluorescein staining. As secondary endpoints, clinical changes including intraocular pressure, and histopathology were evaluated.Results : While OAS was administered, the Schirmer I test showed a statistically significant reduction for OAS group versus control( p < 0.001), and versus basal production( p < 0.001). TBUT showed statistically significant differences between groups(days 3 and 10;p = 0.001) and versus basal values(day 3;p < 0.001). Fluorescein staining showed a statistically significant difference(day 3;p = 0.001). The most frequent clinical finding was conjunctival hyperemia(76.9% OAS vs. 20% control). For histopathology, all OAS subjects presented some degree of inflammation(86.7% minimal;13.3% mild) whereas the control presented only 30% minimal inflammation. Goblet cell density showed no difference.Conclusions : The effectiveness of the OAS dry eye model in NZW rabbits as reported in previous studies was confirmed, provided that the application of the drug is maintained throughout the intervention;it is not a viable model after OAS administration is suspended.
文摘Dry eye is a multifactorial,progressive,and chronic disease of the tears and ocular surface.The disease is multi-factorial and has intermittent symptoms.Discomfort,visual disturbance,tear film instability with potential damage to the ocular surface,and increased tear film osmolarity are known associates.Dry eye is a common clinical problem for eye-care providers worldwide and there is a large number of clinical investigative techniques for the evaluation of dry eye.Despite this,however,there is no globally accepted guideline for dry eye diagnosis and none of the available tests may hold the title of the‘gold standard’.The majority of the techniques involved in the diagnosis of the disease,particularly for its early stages,has a large degree of subjectivity.The purpose of this article is to review existing dry eye investigative techniques and to present a new objective dry eye screening technique based on optical coherence tomography.
