Analysis on medication rule of traditional Chinese medicine treating chemotherapy-induced diarrhea based on traditional Chinese medicine(TCM) inheritance computing platform system

Objective:To dig deeper into the traditional Chinese medicine treatment rules of chemotherapy-induced diarrhea with traditional Chinese medicine(TCM)inheritance computing platform system.Methods:Taking“traditional Chinese medicine”,“chemotherapy”and“diarrhea”as the theme words,comprehensive search of the database of CNKI,Wanfang and VIP from its inception to November 2020 was conduct-ed.The formulas of external treatment of traditional Chinese medicine for chemotherapy-induced diarrhea were included and the association rule,clustering and factor analysis were carried out.Results:A total of 145 papers,57 prescriptions meeting the inclusion criteria were collected,among which high-frequency drugs including Baizhu(Atractylodis macrocephalae rhizoma),Fuling(Poria),Dangshen(Codonopsisradix),Huanglian(Coptidis rhizoma),Zhigancao(Glycyrrhizae radix et rhizoma praeparata cum melle)were the most commonly used.The confidence level was set as 0.7 and the support level was set as 10,12 core compatibility groups were obtained,and 6 categories were cluster analyzed.Conclusion:The principle of external treatment of chemotherapy-induced diarrhea is mainly“restore deficiency and benefiting qi”,“benefiting water infiltration and dampness”,“clearing heat”and“inducing astringency”.Prescription combination and new prescription combination based on traditional Chinese medicine(TCM)inheritance computing platform system can be used as reference for clinicians and applied in primary hospitals.

Contemporary Inheritance of the Legend of ZHANG Zhongjing's Practicing Medicine in the Clinic

From the perspective of narratology, this paper explores the contemporary inheritance of the medical legacy of Zhang Zhongjing's practice medicine in the clinic. Its inheritance mode includes: the enrichment of language and characters and the narratio of romance, the spatial reductive narratio of cultural landscape, the body expressive narratio of ritual behavior. This makes the legend more concerned with the real society, enhances the regional cultural image, develops the local economy, and confidences to the practices role of carrying forward the response and mission of practicing medicine to save people. Compared with the previous academic circle, which previous focus on the textual research of the dispute over its historical authentication, or focus on the retrospective study of its historical origin, this paper is based on the research perspective of historical inheritance, which is constructive to the living inheritance and protection of legends.

Analysis on the compatibility rules and mechanism of formulae treatment for COVID-2019 based on the TCM inheritance assistance system and network pharmacology

Background:On December 8,2019,Wuhan City,Hubei Province,a new type of coronavirus disease 2019(COVID-2019)was firstly discovered,and COVID-2019 spread rapidly in China.The number of confirmed cases in various provinces and cities rose sharply in China.In clinical treatment,Chinese medicine treatment showed significant efficacy.Since the outbreak,the National Health Commission(NHS)of China has issued seven editions of the“Pneumonitis Diagnosis and Treatment Program for COVID-2019”,at the same time,most provincial health boards and the Chinese Medicine Administration had also released information on the prevention and control scheme of COVID-2019 by Chinese medicine.The purpose of this study is to explore the compatibility rules of the main drugs in the prescription and the potential mechanism on COVID-2019 pneumonia,in order to provide reference for clinical research and new drug development of COVID-2019.Methods:This article uses the TCM inheritance assistance system and network pharmacology BATMAN-TCM online analysis system to collect and summarize the national“Pneumonitis Diagnosis and Treatment Program for COVID-2019(trial version sixth)”and formulae for adult treatment from the TCM prevention program of 23 provinces and cities.Results:We found that the most formulae for the treatment of COVID-2019 were modified on the basis of Maxing Shigan decoction and the top 5 high-frequencyn drugs are Xingren(Armeniacae semen amarum),Mahuang(Ephedrae herba),Gancao(Glycyrrhizae radix et rhizoma),Shigao(Gypsum fibrosum),and Haungqin(Radix scutellariae).High frequency traditional Chinese medicines are mainly used for relieving the symptoms,clearing away heat,eliminating dampness,resolving phlegm,relieving cough and asthma,promoting water and dampness,and tonifying deficiency.Warm medicine and bitter medicine are the most frequently used drugs in four Qi attribute and five flavor attribute,respectively.Most of drugs are belong to lung,stomach and spleen channel.Mahuang(Ephedrae herba),Xingren(Armeniacae semen amarum),Gancao(Glycyrrhizae radix et rhizoma),Shigao(Gypsum fibrosum),Cangzhu(Atractylodis rhizama)and Huoxiang(Pogostemonis herba)are the core drugs for treating COVID-2019.The TTD disease enrichment,target and signal transduction pathways of the six drugs showed that pneumonia and asthma were most closely related to COVID-2019.And the inflammatory reaction-related pathways may be the main pathways through which these drugs function.Conclusions:The modified Maxing Shigan decoction is the main prescription for the treatment of COVID-2019.The Xingren(Armeniacae semen amarum),Gancao(Glycyrrhizae radix et rhizoma),Shigao(Gypsum fibrosum),Cangzhu(Atractylodis rhizama)and Huoxiang(Pogostemonis herba)have certain theoretical and experimental basis for the treatment of COVID-2019 through network pharmacology analysis,but further experiments are needed to verify the effects.

Mechanism analysis of Traditional Chinese Medicine in treatment of Diabetic Nephropathy based on network pharmacology and Traditional Chinese Medicine inheritance support system

Diabetic nephropathy is one of the most serious complications of diabetes mellitus. In the early stage, edema and proteinuria are the main clinical manifestations. In the later stage, glomerulosclerosis and interstitial fibrosis will occur. And the prognosis is poor. Nowadays, traditional Chinese medicine has a remarkable curative effect in the treatment of diabetic nephropathy. There are more and more studies on the treatment of diabetic nephropathy with traditional Chinese medicine, but most of them focus on the syndromes of diabetic nephropathy, which are short of in-depth research and summary on the mechanism of Chinese herbal prescriptions. In this paper, the traditional Chinese medicine inheritance support system and network pharmacology BATMAN-TCM software were used to collect and analyze the relevant literature. It was found that the core compatibility of Shanzhuyu, Fuling and Shuyu in the treatment of diabetic nephropathy is closely related to the signal transduction pathway and target of diabetic nephropathy, and has a positive effect on the improvement of clinical symptoms such as proteinuria, glycometabolism disorder, edema, etc. This paper explores the core compatibility of Shanzhuyu, Fuling and Shuyu on diabetic nephropathy, in order to provide reference for clinical treatment.

Analysis of professor Wang Yongyan's experience in treating hemorrhagic diseases based on traditional Chinese medicine inheritance support system

Based on the data analysis platform provided by TCMISS(V2.5),this paper analyzes the rule of prescribing drugs used by Professor Yongyan Wang for the treatment of apoplexy and deepens the understanding of his academic research on syndrome differentiation and treatment.Professor Wang’s medical records were summarized and sorted into the"Chinese Medicine inheritance Assistance system".Through the functions of"frequency statistics","drug use mode","rule analysis"and so on,the characteristics of professor Yongyan Wang's prescription for treating apoplexy were statistically analyzed.It is helpful to understand and inherit Professor Wang's academic thoughts by analyzing the data of professor Wang's medical records of apoplexy.

The application of new media technology in the inheritance and innovation of traditional Chinese medicine culture

In the context of the new era,the use of new media technologies has enabled TCM culture to spread in a completely new way,and has achieved significant results on some new media platforms,which deserves our in-depth analysis.The first part of this article discusses the use of new social media to spread TCM culture to a larger extent.The second part discusses the propaganda effect of new media broadcasting platform on TCM documentaries.The third part discusses the role of new media mobile platform in TCM education and diagnosis.The fourth part discusses the role of new media sales platform in promoting health care products of TCM.The fifth part discusses the problems of traditional Chinese medicine culture in the dissemination of new media in the hope of providing new ideas for the development of Chinese medicine.

国医大师熊继柏治疗失眠的方药规律分析

目的对国医大师熊继柏教授治疗失眠的病案进行数据挖掘,分析熊继柏教授诊治失眠的用方、用药经验。方法基于中医传承辅助平台软件(V3.5),归纳和分析熊继柏教授在湖南中医药大学第一附属医院治疗失眠患者的门诊病历数据,利用该平台软件的关联规则、复杂系统熵聚类等统计方法进行数据挖掘和分析,总结药物的性味、归经、应用频次、药对组合及合方,对“证-症-方”“证-症-药”“证-方-药”进行关联,结合熊继柏教授对失眠病因病机、治则治法的认识,明确核心用药,探索其对失眠的诊治规律及遣方用药心得。结果通过总结分析,共纳入病历276份,处方中用药频次较多的有酸枣仁、龙齿、茯神、甘草,重在补虚安神;黄连、陈皮、竹茹、半夏、珍珠母、远志,重在清热化痰安神。用药性味偏甘、苦、辛,归经多为心、脾经。并归纳出虚证治疗常用合方为酸枣仁汤、枕中丹和甘麦大枣汤;因痰所致失眠治疗的主方为温胆汤及温胆汤类方(枣仁温胆汤、黄连温胆汤及十味温胆汤)。结论国医大师熊继柏治疗失眠以“补脾化痰清热,养血补肝宁心”为治疗原则,以温胆汤为基础进行加减化裁。

文化与医学视域下对当代中医情志学说研究的思考

中医学根植于中国传统文化。儒、释、道三家思想为中国传统文化的基石和精髓,是中医情志学说形成和发展的文化和思想根源。中医情志学说的“形神一体观”“以心神为主导的五脏藏神论”“人格体质论”等核心理论及其中医情志病防治的“天人合一”“形神合一”“意象思维”等理念蕴含着丰富的文化内涵,是不同于现代心理学、精神病学的独特理论体系。该文通过剖析中医情志学说的文化内涵,在文化与医学视域下,探讨当代中医情志学说的继承与创新,认为当代情志学说的研究应着重于以下几个领域:不同人格体质的情志病发病及防治的流行病学和生物学基础研究;不同人格体质情志病的证候规范化判别模式研究;跨文化的情志学说研究;当代社会文化对情志病发病影响的研究;加强具有本土文化特色的情志病防治研究。在文化和医学视域下研究中医情志学说,不仅有助于继承和发扬其特色和优势,构建具有中国本土特色的精神心理理论和实践体系,且在当前医学全球化的背景下,通过理论和技术的交流,实现其理论创新与实践应用。

中医药治疗反流性食管炎用药规律

目的利用数据挖掘和中医传承辅助平台(V 2.5)探求中医药治疗反流性食管炎(RE)用药规律。方法在中国知网搜索中医药治疗RE方剂建立数据库,利用数据挖掘及中医传承辅助平台进行频数统计、关联规则、聚类分析、四气五味、功效归经及药量分析。结果共搜集到1406篇文献,获得306个有效方剂,涉及163味中药,高频药物(频数>35次)有29种,前5位分别是半夏、甘草、黄连、柴胡、白芍;关联规则置信度>90%有88组药物,聚类分析中距离集合为21时分为6类;中药四气以温、寒、平为主,五味以辛、苦、甘为主,归经以脾、胃、肺、肝为主,功效以补虚药、理气药、清热药、化痰止咳平喘药为主;药物用量均为常规用量。结论利用数据挖掘及中医传承辅助平台分析中医药治疗RE组方规律,有助于指导中医临床治疗RE。

推进中医院肺病学科建设的实践与思考

近几十年来,中医肺病学科建设在取得极大进展的同时,也面临诸多难点问题,距形成一门规范、系统、可持续发展的学科体系仍任重而道远。笔者所在团队从事中医肺病医、教、研工作已六十余年,为中医肺病学科建设做出许多积极探索。本文从传承守正、强调疗效、科研创新、衷中参西、医教协同、医德医风建设六个方面探讨中医肺病学科的建设发展思路。

基于数据挖掘分析胡欣主任中医维持治疗乳腺癌的用药规律

目的:总结胡欣主任中医维持治疗乳腺癌的用药规律。方法:收集并筛选2019年1月―2021年12月胡欣主任中医维持治疗乳腺癌患者的门诊处方102首,录入中医传承计算平台系统(V3.0),运用频数统计、关联规则等方法进行统计和分析。结果:(1)药物频次分析:102首处方共涉及中药133味。用药频次≥40的药物有18味,使用频次居前10位的药物依次是山药、槲寄生、夏枯草、党参、浙贝母、山慈菇、薏苡仁、红景天、甘草、茯苓。(2)药物性味归经:平性药物使用频数最多,达724次,占比42.12%;五味以甘、苦为主,占比分别为45.12%和30.76%;归经多归肺、脾二经,其次为胃、肝、心、肾经。(3)组方规律分析:药物组合67个,包含中药13味,组合频次从高到低依次是山药和槲寄生、山药和薏苡仁、山药和山慈菇、山药和夏枯草、夏枯草和浙贝母等;30条药物关联规则,关联度较高的组合分别为薏苡仁、红景天-山药;槲寄生、薏苡仁-山药;夏枯草、薏苡仁-山药;竹茹-山药;浙贝母、薏苡仁-山药等。结论:胡欣主任中医维持治疗乳腺癌强调其“本虚标实”的病机,临床采用“补脾养胃益肺以固护其本,清热化痰散结以兼顾其标”的治疗思路,对临床上中药维持治疗乳腺癌具有参考意义。

基于数据挖掘探讨张炳厚治疗糖尿病肾病用药规律

目的 采用数据挖掘方法分析张炳厚教授治疗糖尿病肾病的用药经验,并筛选核心药对药组。方法 选择2014年1月-2021年12月首都医科大学附属北京中医医院门诊张炳厚教授治疗糖尿病肾病处方,采用中医传承辅助平台2.5、SPSS Modeler 18及SPSS Statistics 21软件进行关联规则、聚类分析、因子分析,总结药物用药频次、性味归经、药对组合。结果 共纳入处方161首,涉及中药188味,总频次为2 220,频次较高的中药为熟地黄、龟甲、黄芪、生地黄等,药物药性以寒、温为主,药味以甘、苦为主,归经多归肾经、肝经、脾经,共得到药对关联规则14条,药物常用组合27对,聚类分析根据谱系图提取组合10个,因子分析提取公因子14个。结论 张炳厚教授治疗糖尿病肾病以培补真阴、清利湿热为主要治法,同时注重益肾固精、育阴涵阳、活血化瘀等,体现其治疗糖尿病肾病独特的学术思想。

我国现代中医药传承创新发展影响因素研究

目的:探讨中医药传承创新发展的关键影响因素及其逻辑关系,为现代中医药事业发展提供参考。方法:综合文献研究成果和专家访谈梳理影响现代中医药传承创新发展的因素,运用解释结构模型分析影响因素之间的关系,进行层级划分。结果:构建了包含10个要素、3个层级的递阶结构模型;模型以宏观环境3个因素为基础条件的宏观层影响因素,以组织系统5个因素为组织建设的中观层影响因素,以现代技术创新等为技术创新的微观层影响因素。结论:政策的制度化、中医药组织的社会化、社会的技术化3个关键影响因素形成了层次网络关系;用树形结构描述,宏观政策制度化是网络的根节点,组织社会化是网络的枝干分叉点,社会的技术化是叶节点。

中医眼科古籍中内障眼病方剂遣方用药规律研究

目的:分析中医眼科古籍中治疗内障眼病方剂的遣方用药规律。方法:从7部历代主要中医眼科古籍中筛选出治疗内障眼病的方剂并建立数据库,导入中医传承计算平台(V3.0),运用频次统计分析、四气五味分布统计、基于关联规则的组方规律分析及聚类分析等数据挖掘方法,探索古籍中治疗内障眼病的组方用药规律和辨治经验。结果:共收集322首方剂,涉及用药187味,总使用频次2867次,频率≥40次的单味药有22味,药类以补虚药、清热药、解表药为主,药味多甘味,其次为苦味、辛味,归经主要为肝经,四气统计以寒性药最多,温性药次之,统计出核心药物组合48组,聚类分析得到核心处方7个。结论:本研究充分挖掘了主要中医眼科古籍中治疗内障眼病的遣方用药规律,对今后的临床用药具有参考价值。

中药炮制传承创新与饮片产业高质量发展现状及展望

中药饮片是在中医药理论指导下,根据中医临床辨证论治及制剂的需要,对中药材进行加工炮制后制成的药品。中药炮制是我国医药领域最具自主知识产权的制药技术,中药饮片的“生熟异治”是中药有别于天然药物的重要标志,中药饮片产业高质量发展是促进中医药传承创新的关键要素。当前国家相关科技政策及法规的发布,逐渐引导中药产业朝着传承创新与智能制造方向的转型发展。但中药饮片产业仍面临诸多挑战,例如中药炮制传承创新发展不足,饮片企业“小而全”的生产模式及较为分散的竞争格局,导致产业生产过程的规范化、标准化、智能化发展不足;饮片的质量控制缺乏整体性及特征性的质量标准,等级划分标准的科学性仍有待商榷等。针对上述问题,本文提出通过挖掘中药特色炮制技术及品种,探究传统中药炮制理论科学内涵,促进中药炮制的传承创新;加强饮片产地加工过程控制,提升生产过程质量控制水平,推进中药饮片行业集约化、规模化、智能化发展;解析饮片质量评价关键识别技术,积极探索饮片质量等级评价标准,构建体现中药饮片特色的质量评价体系;利用现代物联网技术建立饮片溯源体系。通过以中药饮片为主体,以促进中药传承创新发展为导向,实现饮片产业高质量发展。

基于数据挖掘探究黄青教授治疗黄褐斑的用药规律及经验

目的:利用数据挖掘方法分析和总结黄青教授治疗黄褐斑的用药经验和学术思想。方法:筛选整理2022年6月-2022年10月黄青教授门诊治疗黄褐斑首诊处方74首,统一录入中医传承辅助平台(V2.5)进行相关数据分析。结果:使用频率最高的药物依次为生地、川芎、续断、桑寄生、当归、合欢皮、赤芍、炒白术、白芍、茯苓等。使用频次最高的是温性药物,寒性及平性药物次之;药物五味以甘、苦、辛味最多。用药归经频次由高到低依次为肝、心、脾、肾经等;关联规则分析共得到36对常用药物组合和10个潜在新处方。结论:通过中医传承辅助平台对处方进行分析,整理出中医药治疗黄褐斑常用药对和潜在新处方,总结归纳出三补三消的黄褐斑治疗方法,三补即调补冲任、益气健脾、养心安神,三消即疏肝理气、活血化瘀、祛湿化痰。

基于专利分析的成都中药企业技术创新研究

目的 通过分析成都中药高新技术企业专利情况,了解成都中药企业技术创新现状,为四川中医药的传承创新发展提供参考。方法 基于Innography专利检索分析数据库,对成都中药高新技术企业的发明与实用新型专利进行检索、筛选、统计与分析,并从专利类型、CPC分布、专利强度、竞争态势等角度进行深入解读。结果 成都中药高新技术企业专利以一般强度专利为主,占比79.67%;国外布局专利份额较小,主要以化学成分为新颖突破口;发明专利占比52.57%,CPC主分类号集中在A部(A61K36、A61K31、A61K9)、G部(G01N30)及C部;实用新型专利占比47.43%,CPC主分类号集中在B部、A部(A61J3)及F部;排名前10位的热点中药材中仅黄芪、川芎、丹参为川产道地药材。结论 成都中药企业发明专利创新领域涵盖方剂、中药质量控制、中成药、中药提取物、中药化学成分等,实用新型专利主要围绕中药饮片进行创新;成都中药企业对川产道地药材的创新开发不足。

基于中医传承辅助平台及网络药理学分析中药治疗慢性胃炎的核心药物与作用机制

目的借助中医传承辅助平台整理中医药治疗慢性胃炎的用药规律,结合网络药理学分析中医药治疗慢性胃炎的作用机制。方法检索2010年1月至2024年6月与中医药治疗慢性胃炎有关的临床文献1214篇,应用中医传承辅助平台2.5软件对文献数据进行统计分析、关联分析,归纳中医药治疗慢性胃炎的潜在有效药物组合及用药特点,对核心药物组合用于慢性胃炎的主要有效成分、信号通路及作用靶点加以分析。结果共检索出有效处方28手,处方中涵盖中药116味,应用频次前20位以补气药、理气药、利水渗湿类药物为主,支持度≥10、置信度≥0.6的中药核心组合为甘草-党参-香附;甘草-党参-香附组合中涉及20个有效成分、35个核心靶点,7个信号通路,核心成分为槲皮素、山柰酚、黄芩素、7-甲氧基-2-甲基异黄酮等。结论中医药治疗慢性胃炎以补中益气类、疏肝理气、利水渗湿类中药为主,中药核心药物组合“甘草-党参-香附”可能利用炎症反应、细胞对非生物刺激的响应及细胞凋亡相关通路等多种信号通路参与慢性胃炎的治疗进程。

基于数据挖掘探析中医药治疗支气管扩张咯血的组方用药规律

目的 通过中医传承辅助平台探析中医药治疗支气管扩张咯血的用药特点和组方规律。方法 收集中国知网、万方数据库、维普中文期刊中运用中医药方剂治疗支气管扩张咯血的文献,筛选处方并建立数据库,运用中医传承辅助平台中关联规则分析、熵聚类算法等进行分析。结果 共计纳入处方121篇,其中用药频次排名前5位的药物分别为黄芩、甘草、生地黄、白及、桑白皮;出现频率最高的药对为黄芩-桑白皮;得到3味药核心组合54个、4味药核心组合11个,并演化出新处方16首。结论 中医药治疗支气管扩张咯血以清热、泻火、化痰、祛瘀、止血为主,兼以健脾、泻肝、养阴润肺,以扶正祛邪、标本兼顾为配伍特点。挖掘的新处方为临床治疗提供了参考。

基于数据挖掘探讨中医治疗鼻衄用药规律

目的 基于中医传承辅助平台2.5软件挖掘中医治疗鼻衄(鼻出血)的用药规律,探讨新方组合。方法 检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)建库至2022年12月1日中医治疗鼻衄的相关文献,录入中医传承辅助平台并建立处方数据库,运用频次统计、关联规则和复杂网络等方法分析处方药物使用频率、常用药对、组合规则,并探索新方。结果 筛选出有效方剂221首,涉及中药265味,其中使用频次≥20的常用中药33味,前3位分别为生地黄、黄芩、炙甘草。药性以寒、温为主,药味以苦、甘为主,归经主入肝经、肺经、心经、脾经、胃经。常用药物组合46个,核心组合36个,发现新方16首。生地黄为治疗鼻衄的核心药物,生地黄-黄芩、生地黄-当归、生地黄-黄芩-炙甘草、生地黄-牡丹皮-黄芩为常用药物组合。结论 中医治疗鼻衄秉清热凉血止血大法,佐以化瘀补血、补气摄血、滋阴降火,重视脏腑辨证精准治衄,并多用蜂蜜、炙甘草等甘味药取缓急、补中添益之功用,部分药物如黄芩、大蓟、栀子等用炒焦、炒炭以加强止血效力。