Exploring the therapeutic potential of Qi Teng Mai Ning recipe in ischemic stroke and vascular cognitive impairment

Background:This study aims to explore the therapeutic effects of the Qi Teng Mai Ning recipe on ischemic stroke and vascular cognitive impairment through its potential to modulate cellular autophagy,with a focus on identifying its active ingredients and their target proteins.Methods:The study began with the identification of active ingredients in the Qi Teng Mai Ning recipe.It proceeded to screen the gene expression omnibus database for ischemic stroke and vascular cognitive impairment-associated differentially expressed mRNAs and to identify cellular autophagy-related proteins via the Human Autophagy Database.These proteins were annotated with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functions and subjected to molecular docking with the recipe’s core active ingredients.In vitro cell experiments were conducted on hypoxic HT22 cells,involving CCK8 assay,lentiviral transfection to silence autophagy related 9B(ATG9B),immunofluorescence staining,and qPCR validation to investigate the effects of the recipe on autophagy.Results:The analysis identified 104 active ingredients targeting 408 proteins and forming a complex ingredient-target network.Intersecting 55 ischemic stroke-related and 909 vascular cognitive impairment-related differentially expressed mRNAs revealed 14 co-expressed mRNAs.Molecular docking showed quercetin,kaempferol,myrcene,and conferone as key ingredients targeting autophagy-related proteins.Cellular experiments indicated that the recipe significantly enhanced cell viability under hypoxic conditions,reduced apoptosis,and modulated the expression of autophagy-related factors,thereby decreasing apoptosis rates in HT22 cells.Conclusion:The Qi Teng Mai Ning recipe offers protective effects against ischemic stroke and vascular cognitive impairment by modulating autophagy-related proteins.Its efficacy highlights the potential of traditional Chinese medicine in treating these conditions,though further research is needed to fully understand its mechanisms and clinical applications.

基于大型波流水槽的FL-TENG水动力试验研究

本研究以莲花状摩擦纳米发电装置(FL-TENG)为研究对象。利用大型波流水槽构建FL-TENG模型试验,得到FL-TENG在不同工况下的发电性能和水动力性能。分析FL-TENG的电流和电压等效值以及横摇和缆力幅值随波浪波高、周期、流速以及装置负重等工程变量的变化规律;并从船舶动力学和FL-TENG结构原理的角度出发,分析和讨论呈现该变化规律的原因;最后通过分析不同工况变量的情况下,FL-TENG的发电性能随横摇幅值的变化规律,得到FL-TENG发电性能和横摇幅值的关系。

TENG在可穿戴人体健康状态监测中的应用和研究进展

本文将深入阐述摩擦纳米发电机(TENG)的基本工作原理、不同的运行模式以及结构制备与性能优化的方法;重点归纳和分析TENG在智能可穿戴医疗设备及脉诊监测两大方面的应用实践,其中,智能可穿戴医疗涵盖了人体康复、植入式技术等领域,而脉诊监测则主要涉及脉搏、心跳及呼吸等关键生理指标的监测。本文分析了各种基于TENG的可穿戴医疗器件在能量收集和自供电传感方面的应用,并展望TENG在智能可穿戴医疗设备领域的应用前景。

基于TENG 的人体运动监测及其在跌倒检测中的应用

随着物联网技术的广泛应用,传统电源在使用时存在频繁更换或充电等问题,限制了可穿戴设备的发展。利用聚四氟乙烯(PTFE)和铝(Al)箔制备了接触-分离式摩擦纳米发电机(TENG),通过人体布设完成人体运动能量的采集,根据输出电信号的变化对人体运动姿态进行监测。此外,还设计了基于TENG的自供电跌倒检测系统,采用TENG进行人体能量收集,利用基于LTC3588芯片的能量管理电路实现电压转换,加速度传感器实现人体运动数据采集,最后通过串口传输至计算机显示。实测结果表明,该TENG的开路电压和短路电流分别为48 V和2.6μA,其结果验证了TENG具有输出电压高、电流低的特性。TENG作为自驱动传感器用于人体运动监测,在行走状态下输出电压最大值为63 V,在跑步状态下为116 V,在跳跃状态下达到130 V,根据输出特性可以准确判断人体当前运动状态。此外,对TENG的能量管理电路进行仿真和测试,结果表明其能够实现3.3 V稳压输出,可满足利用加速度传感器设计的跌倒检测系统的供电需求。

化学液相沉积制备氧化铝薄膜及在TENG中的应用

采用化学液相沉积(CLD)法在氧化铟锡(ITO)导电玻璃和硅基板表面制备了大面积的氧化铝(Al2O3)薄膜,并以非腐蚀的方式在硅片表面使用CLD法直接生长图案化Al2O3薄膜。Al2O3薄膜的表面均匀、连续,生长2 h后膜厚度约为20~30 nm。薄膜的电绝缘性能良好,平均击穿场强达到1.74 MV/cm,可以用作半导体器件的绝缘层。进一步将CLD法制备的Al2O3薄膜用作摩擦电纳米发电机(TENG)中的电子阻挡层,其开路电压和短路电流约为120 V和5μA,分别是不含Al2O3 TENG的1.6倍和2倍。该薄膜不受摩擦层磨损的影响,可以有效地改善TENG性能。结果表明,CLD法可作为一种在室温下、低成本、无毒且简便的新方法,用于半导体器件中绝缘或钝化薄膜的制备。

Preparation of Polyporus Albicans Teng Sulfate andIts Anti-coagulation Activity

More studies have indicated that polysaccharide sulfate has anti-coagulant activity.Now,heparin is the most popular anticoagulant used in clinic,however,its side effects have also caused highly concern.It is still under intensive investigations to synthesize effective safe polysaccharide sulfate as heparin substitute.We extracted water-soluble polysaccharide from fermented mycelium of edible polyporus albicans（Imaz.） teng,and got the water-soluble polyporus albicans teng sulfate（PATS） by modifying the water-solubility polyose with the method of chlorosulfonic acid-pyridine.The anti-coagulant assay of PATS in vitro towards normal human plasma indicates its remarkable anticoagulant activity,while the dose could be as low as 5 mg/L for anticoagulation.The anti-coagulant effect was equivalent to that of heparin about 150 U when the concentration of PATS was 10 mg/L.The study on anti-coagulation mechanism suggests that PATS got involved in the intrinsic pathway.The anti-coagulation activity of PATS was due to the inhibition of the coagulation factors IIa and Xa activities mediated by antithrombin Ⅲ（ATIII）.The anti-coagulation mechanism of PATS is absolutely identical to that of heparin.In conclusion,we suggest that PATS has the similar anti-coagulation characteristic to heparin,but with a better anti-coagulation effect.Meanwhile,derived from edible fungus-polysaccharide,PATS has more bio-safety advantage.Therefore,PATS has promising future to be developed and used as an ideal substitute for heparin in clinic.

Effect of Zhuang Yi Liu Fang Teng Fang on the Expression of TNF-αand NF-κB in Chronic Pelvic Inflammatory Disease(CPID)Model Rats

Objecrive:To investigate the expression of TNF-αand NF-κB in the uterus of chronic pelvic inflammatory disease(CPID)model rats.Methods:40 female rats that adaptive fed for 5 days were randomly divided into normal group,model group,high dose group,medium dose group and low dosegroup.In addition to the normal group:the rats in each group were made chronic pelvic inflammatory model by mechanical injuuy combined with implantation of bacteria.The rats in each group were administrated by gavage for 20days.After the last administration,the level of TNF-αand NF-κB in serum was measured by ELASA method.Results:(1)after the establishment of the model,the uterus of the chronic pelvic inflammatory model rats showed the pathological damage of chroic infilammation;the levels of lNF-αand NF-κB inserum were higher than those in the normal group,the difference was statistically significant(P<0.05).(2)After the drug intervention,the uterine tissue morphology of the rats in the Zhuang Yi Liu Fang Teng Fang Group was basically restored to normal,with only a small amount of inflammatory cell infiltration and other pathological changes;compared with the rats in the model group,the TNF-αin serum of the rats in each treatment group was lower,the difference was statistically significant(P<0.05).The expression of NF-κB in serum of each treatment group was lower fthan that of the model group(P<0.05).Conclusion:Zhuang Yi Liu Teng Fang can efectively improve the endometrial histomorphology of CPID model rats,and regulate the levels of TNF-αand NF-κB in the uterus of chronic pelvic inflammatory model rats.

The Mountain People——Ethnic Teng

The Teng people are an ethnic group who live in the boundary area of Tibet.For various reasons,the survey of ethnic minorities in China.conducted in the 1950s,excluded the Teng people. Nevertheless,the products,the lifestyle and even the culture of the Teng people are unique amongst ethnic Tibetan.Moinpa, and Lhopa.They are,therefore,named as the"Teng people".

High-efficiency preparation of multifunctional conjugated electrospun graphene doped PVDF/CF yarns for energy harvesting and human movement monitoring in TENG textile

Portable power is an effective solution to realize self-powered sensors for wearable devices,promoting future sustainable development.Membrane-based triboelectric nanogenerators(M-TENGs)have emerged as a promising technology for harvesting biomechanical energy from human motion owing to their advantages,such as simple structure,lightweight design,and efficient energy conversion.However,the poor durability,low adaptability,and un-washability of two-dimensional membrane materials have largely hindered their application in wearable electronics.In this study,we propose a sheath-core polyvinylidene fluoride(PVDF)/graphene(G)-carbon fiber(CF)yarn fabricated via conjugate electrospinning,comprising a commercial CF core and an electrospun graphene-doped PVDF sheath,which improves the fatigue resistance of electrospun nanofiber films under prolonged friction and keeps a high degree of freedom.The resulting electronic textile,woven with the large-scale electrospun PVDF/G-CF yarn,demonstrates a remarkable power density of 25.5 mW·m^(-2).The tight distribution of PVDF/G nanofibers on the textile surface ensures excellent softness,washability,and durability.Furthermore,the electrospun PVDF/G-CF textile exhibits significant potential in pressure sensing,self-powered operation,and motion detection,making it highly suitable for wearable electronics applications.

Solid-liquid contact TENG using a melting near-field direct writing PCL nano-fiber structure

Recently,the triboelectric nanogenerator(TENG)has been widely studied for the development of flexible and wearable electronics.Among the various methods for TENG modification,melting nearfield direct writing is a new method to fabricate solid-liquid TENG.Here,the electrospun PCL was introduced with traditional polymers to fabricate the compound solid triboelectric layer,and water,dimethicone and GaIn were chosen as the liquid triboelectric layers.In this paper,the solid substrate effect,temperature gradient effect,and the liquid substrate effect were compared in terms of TENGs.A free-standing model of TENG is employed in this paper,and the charge generated by the PCL-PI composite solid triboelectrical solid layer is more than 10 times higher than the pristine one,showing the high charge generating ability to melt near-field direct written microfibers.Furthermore,detailed investigation will be discussed how we can get a high the out-circuit voltage and short-circuit current.

用于人体运动姿态监测基于IL@PDMS复合膜的摩擦电纳米发电机

摩擦电纳米发电机(TENG)在自供电可穿戴领域得到了广泛关注,通过材料修饰及制备工艺优化可实现对人体运动姿态的监测。研制了一种可用于人体运动姿态监测的TENG。一方面基于聚二甲基硅氧烷(PDMS)引入高介电性离子液体(IL),制备了IL@PDMS复合膜作为摩擦层,有效提高了摩擦电输出性能;另一方面,基于光刻微电子机械系统(MEMS)工艺及模板转移技术对IL@PDMS复合膜表面进行金字塔微结构修饰,实现摩擦效应的增强。与纯PDMS膜相比,IL的引入可使摩擦电输出电流及输出电压分别提高近4倍和6倍;另外,表面微结构的修饰也使得输出电流及输出电压分别提升近1.5倍和0.7倍。此外,当工作10 000个周期后,摩擦电输出性能仍保持不变。实验表明,当将IL@PDMS-TENG贴附在手指上时,实现了对人体运动姿态的有效监测。该研究为可穿戴人体运动传感器提供了新的技术路径及应用前景。

旋转结构摩擦纳米发电机的材料、结构及应用研究进展

综述了近年来旋转结构摩擦纳米发电机(R-TENG)在能量收集和传感领域的研究进展,介绍了不同结构R-TENG的基本工作原理、性能调控以及应用。详细分析了导电刷式结构、接触-分离式结构、独立层式结构以及恒流式结构的R-TENG,总结了各种结构R-TENG将振动、旋转、波浪、风和热源等能量高效转化为电能的方法和规律,比较了它们各自的结构设计、外部激励和电力输出。重点介绍了独立层结构中较为关键的减磨结构、悬浮结构以及模式切换。研究表明R-TENG具有将环境中的机械能转化为电能的应用潜力。最后,指出了R-TENG未能进行产业化的主要原因,同时展望了R-TENG在自供能传感、分布式能源等领域的未来发展方向。

冲击式波浪能摩擦纳米发电机的设计与半物理实验

提出并设计了一种基于冲击式空气透平的波浪能摩擦纳米发电机,将其应用于振荡水柱波浪能转换装置中,能够将低频的海洋波浪能高效转换为电能。详细阐述了该发电机的结构与工作原理,搭建了两个实验平台,分别进行了电极参数优化实验和电学输出性能实验。实验结果表明,利用聚四氟乙烯作为电极的介电材料,其电学输出性能最优,聚四氟乙烯的厚度越大,电学性能输出越好。当发电机电极角度逐渐减小时,短路电流呈上升趋势。设计并制造了冲击式波浪能摩擦纳米发电机,进行了单风向半物理仿真实验。研究了不同风速下的电学输出性能,并进行了电容充电实验。通过电路设计驱动点亮了33盏LED。验证了冲击式波浪能摩擦纳米发电机的可靠性以及对小型传感器供能的潜力。

基于摩擦纳米发电机的输电线路振动能量收集装置

在电力物联网蓬勃发展的当下,如何持续且长时间地供能成为了数以万计的传感器所要面临的技术难题。摩擦纳米发电机(triboelectric nanogenerator,TENG)作为新崛起的高效供能技术,在传感器的自供电领域有着非常广阔的应用前景。文中基于摩擦电工作原理,利用多层弹性体结构的垂直接触分离TENG,设计出一种面向输电线路微风振动的多层弹性体TENG能量采集装置。通过振动能量采集器输出性能测试平台模拟输电线路微风振动状态,对不同频率和振幅下能量采集器的基本电气特性进行测试,结合电能管理策略,构建面向输电线路微风振动的振动能量采集自供电系统,实现宽频带振动能量的高效采集与转换,完成对商用传感器的供能。最后,通过输电线路振动缩比模型验证文中所设计振动能量采集装置的有效性与可行性。文中设计的振动能量采集自供电系统能够有效地将输电线路宽频振动能量转换为电能,具有结构简易、经济性好的特点,解决了电力物联网传感器不能持久绿色供电的问题。

雨滴能量收集型摩擦纳米发电机的研究进展

简单阐述了摩擦纳米发电机(TENG)的工作原理及4种基本工作模式。总结了雨滴能量收集型TENG在基于垂直接触-分离结构、单电极结构、独立层结构3种工作模式及多种基本工作模式集成的结构优化及应用。介绍了开发出的其他结构类型的TENG及通过表面处理、结构优化等方式对雨滴能量收集效率的增强。此外,对其他类型如太阳能、风能等清洁能源收集装置与雨滴能量收集型TENG集成为互补的混合能源装置进行了介绍和分析。最后,对目前TENG在雨滴能量收集方面存在的问题和不足进行总结,并展望了未来的挑战和发展方向。

摩擦纳米发电机在收集蓝色能源上的应用与研究

为了减少碳排放,保护生态环境,人们对海洋资源的开发和研究愈发深入,可再生能源收集技术是该领域研究的重点。其中,摩擦纳米发电机是利用接触电气化现象的最有前途的机械能收集器之一,其具有可利用的机械能资源丰富、材料可得性和可选性广、器件结构相对简单、加工成本低等诸多优势。最近10年,世界各地研究人员在这一领域的研究取得了巨大进展。本文综述了近年来应用于摩擦纳米发电机(TENG)上的各种新型摩擦电材料,介绍了摩擦电材料的选取规则,并总结了对摩擦电材料进行物理表面修饰、化学表面修饰和其他相关改性方式,最后归纳了用于收集蓝色能源的摩擦纳米发电机装置的仿生结构的设计研究进展,并对未来的应用和发展方向进行了展望。

纺织品摩擦纳米发电机的研究进展

阐述了纺织品摩擦纳米发电机(T-TENG)在智能可穿戴领域的优势。重点介绍了纺织品摩擦纳米发电机的四种工作模式,包含垂直接触-分离模式、单电极模式、水平滑动模式和独立摩擦层模式。分析了不同组成结构对电输出性能的影响,对国内外研究中涂覆、纺纱(加捻、编织和静电纺丝)、针织、机织、非织造等制备方法对纺织品摩擦纳米发电机电输出性能的影响进行了全面评估。总结了纺织品摩擦纳米发电机在改善电子纺织品的能量转换、存储寿命和拉伸性能等方面取得的重要进展。由于纤维/织物的可穿戴设备仍面临着材料和制造技术的限制,导致目前主要依靠实验室制造,材料和制造工艺仍未大规模商业化。最后指出了开发先进的摩擦材料和制造方法以及发展思路。展望了纺织品摩擦纳米发电机的未来发展方向。

响应面优化法制备“腾药”乳膏及其镇痛作用研究

目的:将“腾药”熥剂制备为“腾药”乳膏,并对比研究“腾药”熥剂和“腾药”乳膏的镇痛作用,为“腾药”熥剂的开发利用提供参考。方法:通过单因素筛选和Box-Behnken响应面法,筛选出“腾药”乳膏基质的最佳处方工艺,以乳膏的外观均匀性、离心稳定性、涂布延展性、耐寒稳定性、耐热稳定性5个方面作为评价指标对制备的“腾药”乳膏进行综合评价;运用醋酸扭体法、甲醛致痛模型、热板法对比研究“腾药”熥剂和“腾药”乳膏的镇痛作用。结果:最佳“腾药”乳膏处方为载药量0.29 g,硬脂酸用量0.91 g,单硬脂酸甘油酯用量0.50 g。“腾药”乳膏与“腾药”熥剂在醋酸扭体法中疼痛抑制率分别为28.77%、28.74%;甲醛致痛模型实验中“腾药”乳膏第I相、第Ⅱ相小鼠平均累计舔足时间分别为28.83 s、36.00 s;“腾药”熥剂第I相、第Ⅱ相小鼠平均累计舔足时间分别为30.17 s、38.25 s;热板法实验中“腾药”乳膏痛阈提高百分率为90.54%,“腾药”熥剂痛阈提高百分率为69.87%。结论:“腾药”乳膏制备工艺可行,其镇痛效果与“腾药”熥剂相当。

基于摩擦纳米发电机的乒乓球落点轨迹与速度识别的研究

随着科技的迅速发展,通过智能传感设备辅助运动成为科学研究的重要发展方向。为了更方便地收集运动员乒乓球训练的数据,对其进行针对性训练,提出了一种基于单电极式摩擦纳米发电机(TENG)的自驱动信息采集装置。该装置由乒乓球拍及表面摩擦层电极层组成,选用聚二甲基硅氧烷(PDMS)作为摩擦层制备材料,碳油作为电极层制备材料。同时设计了一种覆盖整个乒乓球拍面的阵列结构,通过收集乒乓球和球拍撞击产生的电信号来获取乒乓球落点和球速等信息,可以在LabVIEW上位机实时显示。经测试其输出电压在乒乓球球速为15 m/s的速度下可达11.2 V,在60 s内为100 nF的电容器充电到12 V,可以作为微型电子设备的电源,为LED灯和计时器供电。

Advances in Triboelectric Nanogenerators for Blue Energy Harvesting and Marine Environmental Monitoring

Blue energy,which includes rainfall,tidal current,wave,and water-flow energy,is a promising renewable resource,although its exploitation is limited by current technologies and thus remains low.This form of energy is mainly harvested by electromagnetic generators(EMGs),which generate electricity via Lorenz force-driven electron flows.Triboelectric nano genera tors(TENGs)and TENG networks exhibit superiority over EMGs in low-frequency and high-entropy energy harvesting as a new approach for blue energy harvesting.A TENG produces electrical outputs by adopting the mechanism of Maxwell’s displacement current.To date,a series of research efforts have been made to optimize the structure and performance of TENGs for effective blue energy harvesting and marine environmental applications.Despite the great progress that has been achieved in the use of TENGs in this context so far,continuous exploration is required in energy conversion,device durability,power management,and environmental applications.This review reports on advances in TENGs for blue energy harvesting and marine environmental monitoring.It introduces the theoretical foundations of TENGs and discusses advanced TENG prototypes for blue energy harvesting,including TENG structures that function in freestanding and contact-separation modes.Performance enhancement strategies for TENGs intended for blue energy harvesting are also summarized.Finally,marine environmental applications of TENGs based on blue energy harvesting are discussed.