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TF3-H4对CD4^+CD25^+调节性T细胞和CD4^+CD25^-效应性T细胞早期活化的影响 被引量:10
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作者 李晓娟 胡义平 +2 位作者 刘燕 姜志宏 刘叔文 《中国药理学通报》 CAS CSCD 北大核心 2012年第3期371-374,共4页
目的观察1',2',3',7'-四氢茶黄素-3,3'-双没食子酸酯(TF3-H4)对CD4+CD25+调节性T细胞和CD4+CD25-效应性T细胞早期活化的影响,分析TF3-H4对两群功能相反的CD4+T细胞的作用。方法免疫磁珠分离BALB/c小鼠脾脏CD4+CD25... 目的观察1',2',3',7'-四氢茶黄素-3,3'-双没食子酸酯(TF3-H4)对CD4+CD25+调节性T细胞和CD4+CD25-效应性T细胞早期活化的影响,分析TF3-H4对两群功能相反的CD4+T细胞的作用。方法免疫磁珠分离BALB/c小鼠脾脏CD4+CD25+调节性T细胞和CD4+CD25-效应性T细胞,加入ConA或PDB,和TF3-H4共同孵育12 h后收集细胞,流式细胞仪分析细胞表面早期活化标志CD69的表达。结果在ConA和PDB的作用下,两群细胞早期活化标志CD69的表达均升高。TF3-H4(20 mg.L-1)不能抑制PKC激动剂PDB激活的CD4+CD25-效应性T细胞CD69的表达,却能抑制ConA激活的CD4+CD25-效应性T细胞CD69表达;同时,TF3-H4也能明显抑制ConA激活的CD4+CD25+调节性T细胞的CD69表达。结论茶黄素衍生物TF3-H4可能经由TCR活化途径的上游抑制CD4+CD25-效应性T细胞活化;TF3-H4对CD4+CD25+调节性T细胞和CD4+CD25-效应性T细胞早期活化的抑制作用,可能是该类化合物发挥抗炎、抗肿瘤作用的机制之一。 展开更多
关键词 CD4+CD25+调节性T细胞 TF3-H4 CD69 免疫活化 茶黄素 CD4+CD25-效应性T细胞
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200例健康老人甲状腺功能分析
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作者 王旭光 丛培玲 王爱平 《济宁医学院学报》 1994年第4期39-40,共2页
本文应用甲状腺机能体外新战略诊断程序,对200例健康老人的促甲状腺激素(hTSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)进行检测,发现其甲状腺功能随年龄增长而逐渐降低,提示老年人存在着甲状腺机能减... 本文应用甲状腺机能体外新战略诊断程序,对200例健康老人的促甲状腺激素(hTSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)进行检测,发现其甲状腺功能随年龄增长而逐渐降低,提示老年人存在着甲状腺机能减退的潜在危险性。 展开更多
关键词 甲状腺功能 FT3 TF4 老年人 促甲状腺 激素
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基于测试内容视域下法语专业四级考试阅读理解效度的历时研究——以2011—2017年为例 被引量:3
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作者 卢晓帆 《外语测试与教学》 2018年第1期48-55,共8页
本研究以2011—2017年法语专业四级考试(TFS4)阅读理解真题为样本,从语篇输入角度进行内容效度分析。结果表明,2011—2017年TFS4阅读理解命题总体上具有较高的内容效度,但在语篇长度、文章布局、体裁多样性等方面有待进一步完善。本文... 本研究以2011—2017年法语专业四级考试(TFS4)阅读理解真题为样本,从语篇输入角度进行内容效度分析。结果表明,2011—2017年TFS4阅读理解命题总体上具有较高的内容效度,但在语篇长度、文章布局、体裁多样性等方面有待进一步完善。本文最后对TFS4阅读理解命题提出了一些建议。 展开更多
关键词 法语专业四级考试 阅读理解 内容效度
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法语专业四级考试动词的适当形式填空内容效度历时研究(2010-2017)
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作者 温煜东 《考试研究》 2021年第5期10-15,共6页
以2010年至2017年全国高等学校法语专业四级考试(TFS4)动词的适当形式填空真题为样本,从文章长度、文章难度、考点分布、考点层次和动词变位难度等五个维度进行内容效度分析。结果表明,2010年至2017年TFS4动词的适当形式填空试题总体上... 以2010年至2017年全国高等学校法语专业四级考试(TFS4)动词的适当形式填空真题为样本,从文章长度、文章难度、考点分布、考点层次和动词变位难度等五个维度进行内容效度分析。结果表明,2010年至2017年TFS4动词的适当形式填空试题总体上具有较高的内容效度,但可适当增加句子总数和对个别时态、语式的考查。 展开更多
关键词 法语专业四级考试 动词的适当形式填空 内容效度
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浅析TF21-4系列智能保护装置的电能计量功能
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作者 邓嵘 姜金德 《广西电力》 2005年第5期29-29,34,共2页
进行了与标准电能计量装置的比对试验,得出TF21-4系列智能保护装置的电能计量装置的精确度,具体分析了TF21-4系列智能保护装置在电能计量上的优缺点。
关键词 TF21-4 智能保护 电能计量
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Treatment of acne vulgaris with auricular acupoint pricking-bloodletting plus auricular point sticking therapy: a randomized controlled study 被引量:6
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作者 Song Ya-jing Fan Xi-sheng +11 位作者 Li Meng-yun Zhang Jie Geng Jing-ran Liang Xiao Zhang Jun-cha Zhang Xiao-qi Zhou Shu-bo Wang Nan Zhang Jia-xu Song Xiao-dan She Yan-fen Zhang Fu-qing 《Journal of Acupuncture and Tuina Science》 CSCD 2019年第3期196-202,共7页
Objective: To observe the clinical efficacy of auricular point pricking-bloodletting plus auricular point sticking therapy for acne vulgaris. Methods: A total of 66 patients with acne vulgaris were randomized into an ... Objective: To observe the clinical efficacy of auricular point pricking-bloodletting plus auricular point sticking therapy for acne vulgaris. Methods: A total of 66 patients with acne vulgaris were randomized into an observation group and a control group by the random number table, with 33 cases in each group. The observation group was treated with auricular point pricking-bloodletting plus auricular point sticking therapy, and the control group was treated only with auricular point sticking therapy. The treatments of both groups were performed twice a week, 4 weeks as a course of treatment, for 3 courses in total. The scores of skin lesions and dermatology life quality index (DLQI) scores were recorded before and after treatment to assess the clinical efficacy. Results: During the trial, there were 3 cases of drop-out both in the observation group and the control group. After 3 courses of treatment, the total effective rate of the observation group was 96.7%, while that of the control group was 76.7%. The difference between the two groups was statistically significant (P<0.05). The intra-group comparison showed that the scores of skin lesion and DLQI were both decreased with the increase of treatment times, that was, the scores were lower than those at the previous time point (allP<0.05). After 1, 2, and 3 courses of treatment, the scores of skin lesion and DLQI of both groups were statistically different from those of the same group before treatment (allP<0.05). At every time point during the treatment, the scores of skin lesion and DLQI of the observation group were lower than those of the control group, and the differences between the two groups were statistically significant (all P<0.05). Conclusion: Auricular point pricking-bloodletting plus auricular point sticking has a better curative effect than auricular point sticking therapy alone in the treatment of acne vulgaris, and has a time-effect correlation. 展开更多
关键词 Acupoint Therapy Auricular Point Sticking Bloodletting Therapy Otopoint Cheek (LO5) Point Erjian (EX-HN 6) Otopoint Lung (CO14) Otopoint Shenmen (TF4) ACNE
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Clinical study on auricular point sticking plus Western medicine for moderate gastric cancer pain 被引量:4
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作者 Chen Li-xia Yan Feng 《Journal of Acupuncture and Tuina Science》 CSCD 2020年第4期276-280,共5页
Objective:To explore the clinical efficacy and mechanism of auricular point sticking plus Western medicine for moderate gastric cancer pain.Methods:A total of 80 patients were selected and divided into an observation ... Objective:To explore the clinical efficacy and mechanism of auricular point sticking plus Western medicine for moderate gastric cancer pain.Methods:A total of 80 patients were selected and divided into an observation group and a control group according to the random number table method,with 40 cases in each group.Patients in the control group received Western medicine treatment,while patients in the observation group received additional auricular point sticking.Both groups were treated for 2 weeks.Numeric rating scale(NRS)and Karnofsky performance status(KPS)were adopted before and after treatment.The total time and times of flare-up pain in 24 h were recorded.The cyclooxygenase-2(COX-2)and tumor necrosis factor-α(TNF-α)levels were detected.The clinical efficacy of both groups was evaluated after treatment.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05);after treatment,NRS scores of both groups were significantly lower than those before treatment(both P<0.05),and the score of the observation group was lower than that of the control group(P<0.05);KPS scores of both groups were significantly higher than those before treatment(both P<0.05),and the score of the observation group was higher than that of the control group(P<0.05).After treatment,the total time and flare-up times of pain during 24 h of both groups were significantly reduced(all P<0.05),and those of the observation group were significantly less than those of the control group(both P<0.05).After treatment,the COX-2 and TNF-αlevels of both groups were significantly reduced(all P<0.05),and were lower in the observation group than in the control group(all P<0.05).Conclusion:The clinical efficacy of auricular point sticking plus Western medicine for moderate gastric cancer pain is valid.This combined treatment can alleviate cancer pain and improve patients'quality of life,which may be related to its ability to reduce COX-2 and TNF-αlevels. 展开更多
关键词 Acupoint Therapy Auricular Point Sticking Otopoint Spleen(CO13) Otopoint Stomach(CO4) Otopoint Shenmen(TF4) Pain Measurement Stomach Neoplasms Cancer Pain
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Auricular point sticking for relieving pain in arteriovenous fistula puncture 被引量:1
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作者 Liu Guang-min Lin Ri-yang +1 位作者 Lu Xiao-yan Huang Chun-xiang 《Journal of Acupuncture and Tuina Science》 CSCD 2019年第6期427-431,共5页
Objective:To observe the clinical efficacy of auricular point sticking at different points to relieve the pain in arteriovenous fistula puncture.Methods:A total of 42 patients with arteriovenous fistula were randomize... Objective:To observe the clinical efficacy of auricular point sticking at different points to relieve the pain in arteriovenous fistula puncture.Methods:A total of 42 patients with arteriovenous fistula were randomized into a Shenmen(TF4)group and an Elbow(SF3)group by the random number table method,with 21 cases in each group.After enrolled into different groups,before the dialysis,patients were given auricular point sticking with Wang Bu Liu Xing(Semen Vaccariae)seeds at Shenmen(TF4)and Elbow(SF3),respectively.Patients were asked to press the seeds themselves for 2 min each time,four times a day,and an additional 5-15 min before the arteriovenous fistula puncture.Intensive pressing was offered duri ng the pun cture,15・20 presses for each time,and the plasters were cha nged every 2-3 d.The nu merical rati ng scale(NRS)was used to score the pain level one week before and after auricular point sticking.The NRS score was then compared and analyzed.Results:The intra-group comparison showed that the changes of NRS score in both groups were statistically sigrdficant after auricular point sticking(both P<0.05).After the treatment,there was no sigrdficant differenee in NRS score between the two groups(P>0.05).Conclusion:Auricular point sticking at Shenmen(TF4)or Elbow(SF3)can effectively relieve the pain of arteriovenous fistula puncture,and these two points have equivale nt an algesic effect. 展开更多
关键词 Auricular Point Sticking Otopoint Elbow(SF3) Otopoint Shenmen(TF4) Arteriovenous Fistula Pain Measurement HEMODIALYSIS
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