Dyslipidemia the major cause of atherosclerosis are suggested to act synergistically with non-lipid risk factors to increase atherogenesis.Low-density lipoprotein cholesterol(LDL-C) is the main therapeutic target in t...Dyslipidemia the major cause of atherosclerosis are suggested to act synergistically with non-lipid risk factors to increase atherogenesis.Low-density lipoprotein cholesterol(LDL-C) is the main therapeutic target in the prevention of CVD.Increased triglycerides(TG) and decreased high-density lipoprotein(LDL-C) are considered to be a major risk factor for the development of insulin resistant and metabolic syndrome.Although the TG/ HDL-C ratio has been used in recent studies as a clinical indicator for insulin resistance,results were inconsistent. The TG/HDL-C ratio is also widely used to assess the lipid atherogenesis.How ever the utility of this rate for predicting coronary heart disease(CHD) risk is not clear.We encountered myocardial infarct patients with normal serum lipid concentration so this study was undertaken to evaluate the usefulness of these lipid ratios in predicting CHD risk in normolipidemic AMI patients and to compare the results with healthy subjects.The aim of the present study was to evaluate serum TC/HDL-C,TG/HDL-C and LDL-C/HDL-C in myocardial infarct subjects with normal lipid profile.To study this,lipid profile was determined in 165 normolipidemic acute myocardial infarction patients and 165 age/sex-matched controls.Total cholesterol,triglycerides,and HDL-cholesterol were analyzed enzymatically using kits obtained from Randox Laboratories Limited,Crumlin,UK. Plasma LDL-cholesterol was determined from the values of total cholesterol and HDL- cholesterol using the friedwalds formula.The values were expressed as means±standard deviation(SD) and data from patients and controls was compared using students t-test.The results and conclusion of the study were:Total cholesterol, TC:HDL-C ratio,triglycerides,LDL-cholesterol,LDL:HDL-C ratio were higher in MI patients(p【0. 001).HDL-C concentration was significantly lower in MI patients than controls(p【0.001).Higher ratio of TC/HDL-C,TG/HDL-C and LDL-C/HDL-C was observed in AMI patients compared to controls.展开更多
目的研究冠心病患者三酰甘油(triglyceride,TG)及高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)水平表达与预后的相关性。方法选取本院2019年4月至2020年4月的86例冠心病患者作为研究对象,设为研究组,根据不同预后情况...目的研究冠心病患者三酰甘油(triglyceride,TG)及高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)水平表达与预后的相关性。方法选取本院2019年4月至2020年4月的86例冠心病患者作为研究对象,设为研究组,根据不同预后情况将其分为A组(死亡组,20例)与B组(存活组,66例);另选取本院同时期行常规体检的86例健康者作为对照研究对象,设为对照组,所有受试者均行TG及HDL-C水平检测,对比研究组与对照组以及A组与B组的检测结果,分析TG及HDL-C水平与冠心病患者病死率的相关性。结果研究组的TG及HDL-C水平均低于对照组,P<0.05;研究组86例患者中死亡20例,病死率为23.26%,A组的TG及HDL-C水平均低于B组,P<0.05;Pearson相关性分析结果显示,TG及HDL-C水平与冠心病患者病死率呈明显的负相关性。结论冠心病患者的TG及HDL-C水平呈低表达状态,且其水平表达与患者预后之间存在明显的负相关。展开更多
甘油三酯（TG）／高密度脂蛋白（HDL）比率升高已被描述为胰岛素抵抗和心血管事件的预测因子，作者评价是否TG／HDL比率〉=3.5与根据心导管检查的冠心病有关联，对连续到Montefiore医学中心急症科就诊的不稳定性心绞痛且不知有冠心病历...甘油三酯（TG）／高密度脂蛋白（HDL）比率升高已被描述为胰岛素抵抗和心血管事件的预测因子，作者评价是否TG／HDL比率〉=3.5与根据心导管检查的冠心病有关联，对连续到Montefiore医学中心急症科就诊的不稳定性心绞痛且不知有冠心病历史而作了心导管检查的156例成人患者，进行了回顾性研究，可得到100例患者在入院前6个月内的TG和HDL资料，并作了冠心病积分，经多变量分析，TG／HDL比率〉=3．5与冠心病相关联（odds ratio 2．87；95％ CI，1．03—7．96；P=0．04）．展开更多
目的探讨分析不同年龄阶段抗苗勒氏管激素(anti-mullerian hormone,AMH)与三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)、低密度脂蛋白(low density lipoprotein,LDL)等心血管风险因子相关...目的探讨分析不同年龄阶段抗苗勒氏管激素(anti-mullerian hormone,AMH)与三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)、低密度脂蛋白(low density lipoprotein,LDL)等心血管风险因子相关性。方法将我院2018年12月—2019年12月门诊计划生育专科体检的100例育龄期女性作为研究对象,将其分为25~35岁女性作为A组,将36~45岁女性作为B组,对其血清抗苗勒氏管激素进行测定,分析与其TG、HDL-C、LDL-C等心血管风险评估指标之间的相关性。结果A组女性抗苗勒氏管激素水平与血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、血清总胆固醇(TC)之间正线相关性(P<0.05),与高密度脂蛋白胆固醇(HDL-C)之间无明显相关性(P>0.05)。B组女性的抗苗勒氏管激素水平与TG、HDL-C、LDL-C、TC等风险因子之间并无明显相关性(P>0.05)。结论针对各年龄阶段育龄期女性血清抗苗勒氏管激素水平测定,对早期心血管疾病发生及评估具有一定的临床参考价值。展开更多
文摘Dyslipidemia the major cause of atherosclerosis are suggested to act synergistically with non-lipid risk factors to increase atherogenesis.Low-density lipoprotein cholesterol(LDL-C) is the main therapeutic target in the prevention of CVD.Increased triglycerides(TG) and decreased high-density lipoprotein(LDL-C) are considered to be a major risk factor for the development of insulin resistant and metabolic syndrome.Although the TG/ HDL-C ratio has been used in recent studies as a clinical indicator for insulin resistance,results were inconsistent. The TG/HDL-C ratio is also widely used to assess the lipid atherogenesis.How ever the utility of this rate for predicting coronary heart disease(CHD) risk is not clear.We encountered myocardial infarct patients with normal serum lipid concentration so this study was undertaken to evaluate the usefulness of these lipid ratios in predicting CHD risk in normolipidemic AMI patients and to compare the results with healthy subjects.The aim of the present study was to evaluate serum TC/HDL-C,TG/HDL-C and LDL-C/HDL-C in myocardial infarct subjects with normal lipid profile.To study this,lipid profile was determined in 165 normolipidemic acute myocardial infarction patients and 165 age/sex-matched controls.Total cholesterol,triglycerides,and HDL-cholesterol were analyzed enzymatically using kits obtained from Randox Laboratories Limited,Crumlin,UK. Plasma LDL-cholesterol was determined from the values of total cholesterol and HDL- cholesterol using the friedwalds formula.The values were expressed as means±standard deviation(SD) and data from patients and controls was compared using students t-test.The results and conclusion of the study were:Total cholesterol, TC:HDL-C ratio,triglycerides,LDL-cholesterol,LDL:HDL-C ratio were higher in MI patients(p【0. 001).HDL-C concentration was significantly lower in MI patients than controls(p【0.001).Higher ratio of TC/HDL-C,TG/HDL-C and LDL-C/HDL-C was observed in AMI patients compared to controls.
文摘目的研究冠心病患者三酰甘油(triglyceride,TG)及高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)水平表达与预后的相关性。方法选取本院2019年4月至2020年4月的86例冠心病患者作为研究对象,设为研究组,根据不同预后情况将其分为A组(死亡组,20例)与B组(存活组,66例);另选取本院同时期行常规体检的86例健康者作为对照研究对象,设为对照组,所有受试者均行TG及HDL-C水平检测,对比研究组与对照组以及A组与B组的检测结果,分析TG及HDL-C水平与冠心病患者病死率的相关性。结果研究组的TG及HDL-C水平均低于对照组,P<0.05;研究组86例患者中死亡20例,病死率为23.26%,A组的TG及HDL-C水平均低于B组,P<0.05;Pearson相关性分析结果显示,TG及HDL-C水平与冠心病患者病死率呈明显的负相关性。结论冠心病患者的TG及HDL-C水平呈低表达状态,且其水平表达与患者预后之间存在明显的负相关。
文摘甘油三酯（TG）／高密度脂蛋白（HDL）比率升高已被描述为胰岛素抵抗和心血管事件的预测因子，作者评价是否TG／HDL比率〉=3.5与根据心导管检查的冠心病有关联，对连续到Montefiore医学中心急症科就诊的不稳定性心绞痛且不知有冠心病历史而作了心导管检查的156例成人患者，进行了回顾性研究，可得到100例患者在入院前6个月内的TG和HDL资料，并作了冠心病积分，经多变量分析，TG／HDL比率〉=3．5与冠心病相关联（odds ratio 2．87；95％ CI，1．03—7．96；P=0．04）．
文摘目的探讨分析不同年龄阶段抗苗勒氏管激素(anti-mullerian hormone,AMH)与三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)、低密度脂蛋白(low density lipoprotein,LDL)等心血管风险因子相关性。方法将我院2018年12月—2019年12月门诊计划生育专科体检的100例育龄期女性作为研究对象,将其分为25~35岁女性作为A组,将36~45岁女性作为B组,对其血清抗苗勒氏管激素进行测定,分析与其TG、HDL-C、LDL-C等心血管风险评估指标之间的相关性。结果A组女性抗苗勒氏管激素水平与血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、血清总胆固醇(TC)之间正线相关性(P<0.05),与高密度脂蛋白胆固醇(HDL-C)之间无明显相关性(P>0.05)。B组女性的抗苗勒氏管激素水平与TG、HDL-C、LDL-C、TC等风险因子之间并无明显相关性(P>0.05)。结论针对各年龄阶段育龄期女性血清抗苗勒氏管激素水平测定,对早期心血管疾病发生及评估具有一定的临床参考价值。
