Objective: The objective is to assess the relationship of Log (TG)/HDL-c as surrogate estimate of atherogenic dyslipidemia with urinary albumin excretion rate and cardiovascular risk among black patients with type 2 d...Objective: The objective is to assess the relationship of Log (TG)/HDL-c as surrogate estimate of atherogenic dyslipidemia with urinary albumin excretion rate and cardiovascular risk among black patients with type 2 diabetes. Patients and methods: A post-hoc analysis of data from 181 type 2 diabetes patients enrolled in a cross-sectional study of urinary albumin excretion rate seen at a tertiary healthcare. Microalbuminuria and macroalbuminuria were defined as ACR 30 - 299.9 mg/g and ACR ≥ 300 mg/g, respectively. Quartiles of Log (TG)/HDL-c were used as surrogate estimates of atherogenic dyslipidemia. Cardiovascular risk was assessed using WHO chart for estimation of CV risk in low and middle income countries. Comparisons across Log (TG)/HDL-c quartiles were performed using one way ANOVA and Chi square for trend as appropriate. P < 0.05 defined the level of statistical significance. Results: A high prevalence (69%) of atherogenic dyslipidemia (AD) was observed in the present case series of Black Africans with type 2 diabetes. Average total cholesterol levels showed significant (p = 0.010) trends towards lower values across quartiles of Log (TG)/ HDL-c. No significant trends were observed for average UAER and cardiovascular risk across quartiles of Log (TG)/HDL-c. Conclusion: Log (TG)/HDL-c as a surrogate estimate of atherogenic failed to predict cardiovascular risk in the present case series of black patients with type 2 diabetes.展开更多
Dyslipidemia the major cause of atherosclerosis are suggested to act synergistically with non-lipid risk factors to increase atherogenesis.Low-density lipoprotein cholesterol(LDL-C) is the main therapeutic target in t...Dyslipidemia the major cause of atherosclerosis are suggested to act synergistically with non-lipid risk factors to increase atherogenesis.Low-density lipoprotein cholesterol(LDL-C) is the main therapeutic target in the prevention of CVD.Increased triglycerides(TG) and decreased high-density lipoprotein(LDL-C) are considered to be a major risk factor for the development of insulin resistant and metabolic syndrome.Although the TG/ HDL-C ratio has been used in recent studies as a clinical indicator for insulin resistance,results were inconsistent. The TG/HDL-C ratio is also widely used to assess the lipid atherogenesis.How ever the utility of this rate for predicting coronary heart disease(CHD) risk is not clear.We encountered myocardial infarct patients with normal serum lipid concentration so this study was undertaken to evaluate the usefulness of these lipid ratios in predicting CHD risk in normolipidemic AMI patients and to compare the results with healthy subjects.The aim of the present study was to evaluate serum TC/HDL-C,TG/HDL-C and LDL-C/HDL-C in myocardial infarct subjects with normal lipid profile.To study this,lipid profile was determined in 165 normolipidemic acute myocardial infarction patients and 165 age/sex-matched controls.Total cholesterol,triglycerides,and HDL-cholesterol were analyzed enzymatically using kits obtained from Randox Laboratories Limited,Crumlin,UK. Plasma LDL-cholesterol was determined from the values of total cholesterol and HDL- cholesterol using the friedwalds formula.The values were expressed as means±standard deviation(SD) and data from patients and controls was compared using students t-test.The results and conclusion of the study were:Total cholesterol, TC:HDL-C ratio,triglycerides,LDL-cholesterol,LDL:HDL-C ratio were higher in MI patients(p【0. 001).HDL-C concentration was significantly lower in MI patients than controls(p【0.001).Higher ratio of TC/HDL-C,TG/HDL-C and LDL-C/HDL-C was observed in AMI patients compared to controls.展开更多
目的研究冠心病患者三酰甘油(triglyceride,TG)及高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)水平表达与预后的相关性。方法选取本院2019年4月至2020年4月的86例冠心病患者作为研究对象,设为研究组,根据不同预后情况...目的研究冠心病患者三酰甘油(triglyceride,TG)及高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)水平表达与预后的相关性。方法选取本院2019年4月至2020年4月的86例冠心病患者作为研究对象,设为研究组,根据不同预后情况将其分为A组(死亡组,20例)与B组(存活组,66例);另选取本院同时期行常规体检的86例健康者作为对照研究对象,设为对照组,所有受试者均行TG及HDL-C水平检测,对比研究组与对照组以及A组与B组的检测结果,分析TG及HDL-C水平与冠心病患者病死率的相关性。结果研究组的TG及HDL-C水平均低于对照组,P<0.05;研究组86例患者中死亡20例,病死率为23.26%,A组的TG及HDL-C水平均低于B组,P<0.05;Pearson相关性分析结果显示,TG及HDL-C水平与冠心病患者病死率呈明显的负相关性。结论冠心病患者的TG及HDL-C水平呈低表达状态,且其水平表达与患者预后之间存在明显的负相关。展开更多
文摘Objective: The objective is to assess the relationship of Log (TG)/HDL-c as surrogate estimate of atherogenic dyslipidemia with urinary albumin excretion rate and cardiovascular risk among black patients with type 2 diabetes. Patients and methods: A post-hoc analysis of data from 181 type 2 diabetes patients enrolled in a cross-sectional study of urinary albumin excretion rate seen at a tertiary healthcare. Microalbuminuria and macroalbuminuria were defined as ACR 30 - 299.9 mg/g and ACR ≥ 300 mg/g, respectively. Quartiles of Log (TG)/HDL-c were used as surrogate estimates of atherogenic dyslipidemia. Cardiovascular risk was assessed using WHO chart for estimation of CV risk in low and middle income countries. Comparisons across Log (TG)/HDL-c quartiles were performed using one way ANOVA and Chi square for trend as appropriate. P < 0.05 defined the level of statistical significance. Results: A high prevalence (69%) of atherogenic dyslipidemia (AD) was observed in the present case series of Black Africans with type 2 diabetes. Average total cholesterol levels showed significant (p = 0.010) trends towards lower values across quartiles of Log (TG)/ HDL-c. No significant trends were observed for average UAER and cardiovascular risk across quartiles of Log (TG)/HDL-c. Conclusion: Log (TG)/HDL-c as a surrogate estimate of atherogenic failed to predict cardiovascular risk in the present case series of black patients with type 2 diabetes.
文摘Dyslipidemia the major cause of atherosclerosis are suggested to act synergistically with non-lipid risk factors to increase atherogenesis.Low-density lipoprotein cholesterol(LDL-C) is the main therapeutic target in the prevention of CVD.Increased triglycerides(TG) and decreased high-density lipoprotein(LDL-C) are considered to be a major risk factor for the development of insulin resistant and metabolic syndrome.Although the TG/ HDL-C ratio has been used in recent studies as a clinical indicator for insulin resistance,results were inconsistent. The TG/HDL-C ratio is also widely used to assess the lipid atherogenesis.How ever the utility of this rate for predicting coronary heart disease(CHD) risk is not clear.We encountered myocardial infarct patients with normal serum lipid concentration so this study was undertaken to evaluate the usefulness of these lipid ratios in predicting CHD risk in normolipidemic AMI patients and to compare the results with healthy subjects.The aim of the present study was to evaluate serum TC/HDL-C,TG/HDL-C and LDL-C/HDL-C in myocardial infarct subjects with normal lipid profile.To study this,lipid profile was determined in 165 normolipidemic acute myocardial infarction patients and 165 age/sex-matched controls.Total cholesterol,triglycerides,and HDL-cholesterol were analyzed enzymatically using kits obtained from Randox Laboratories Limited,Crumlin,UK. Plasma LDL-cholesterol was determined from the values of total cholesterol and HDL- cholesterol using the friedwalds formula.The values were expressed as means±standard deviation(SD) and data from patients and controls was compared using students t-test.The results and conclusion of the study were:Total cholesterol, TC:HDL-C ratio,triglycerides,LDL-cholesterol,LDL:HDL-C ratio were higher in MI patients(p【0. 001).HDL-C concentration was significantly lower in MI patients than controls(p【0.001).Higher ratio of TC/HDL-C,TG/HDL-C and LDL-C/HDL-C was observed in AMI patients compared to controls.
文摘目的研究冠心病患者三酰甘油(triglyceride,TG)及高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)水平表达与预后的相关性。方法选取本院2019年4月至2020年4月的86例冠心病患者作为研究对象,设为研究组,根据不同预后情况将其分为A组(死亡组,20例)与B组(存活组,66例);另选取本院同时期行常规体检的86例健康者作为对照研究对象,设为对照组,所有受试者均行TG及HDL-C水平检测,对比研究组与对照组以及A组与B组的检测结果,分析TG及HDL-C水平与冠心病患者病死率的相关性。结果研究组的TG及HDL-C水平均低于对照组,P<0.05;研究组86例患者中死亡20例,病死率为23.26%,A组的TG及HDL-C水平均低于B组,P<0.05;Pearson相关性分析结果显示,TG及HDL-C水平与冠心病患者病死率呈明显的负相关性。结论冠心病患者的TG及HDL-C水平呈低表达状态,且其水平表达与患者预后之间存在明显的负相关。
