对THIO的模糊评价

对企业技术评价核心,是确定企业在同行业的技术水平,分析本企业与先进企业的差距。本文以技术四要素——设备(T)、人力(H)、信息(I)、组织(O)为中心,探讨影响技术水平的因素,建立了符合实际的“技术模糊评价模型”。并用此模型对南部一供电公司的技术水平进行确定,指出优势和不足,依据评价结果为公司日后的发展提出建议和策略。

Synthesis, Crystal Structure and Thermal Properties of N,N′-Bis(5,5-dimethyl-2-phospha-2-thio-1,3-dioxan-2-yl) Ethylene Diamine

The title compound N,N＇-bis（5,5-dimethyl-2-phospha-2-thio-1,3-dioxan-2-yl） ethylene diamine （DPTDEDA, C12H26N2O4P2S2） was synthesized by the reaction of neopentyl glycol, phosphorus thio-chloride and 1,2-ethylenediamine, and characterized by elemental analysis, IR and ^1H NMR spectra. Its crystal structure was determined by single-crystal X-ray diffraction analysis and the thermal property was analyzed by TG analysis. The crystal structure belongs to monoclinic, space group P21/c, with a = 14.557（16）, b = 11.299（12）, c = 12.163（13）A,β = 98.707（19）^o, Dc = 1.305 g/cm^3, Z = 4, γ = 0.71073A,μ（MoKa） = 0.447 mm^-1, Mr = 388.41, V = 1977（4）A3, F（000） = 824, S = 1.107, the final R = 0.0478 and wR = 0.0810 for 1738 observed reflections （I 〉 2σ（I））. X-ray analysis reveals that the crystal structure is centrosymmetrically distributed through 1,2-ethylenediamine to join two distorted six-membered rings. The weak N-H…S interactions are observed and link the molecules into sheets. TG analysis shows that the title compound has good thermal stability and char-forming capability, which are required for an excellent intumescent fire retardant.

Stereoselective Syntheses of Some β-D-1-Thioglycopyranosides and Bis(β-D-glycopyranosyl) Sulfides by Phase Transition Catalysis

The present paper covers the stereoselective syntheses of four 1 thiogalactopyranosides 1—4 and three thio disaccharides 5—7 through the PTC methods and their structures confirmed by means of elementary analysis, IR and NMR spectral data.

N-Substituted benzoxazolyl ureas and thioureas in Biginelli reaction promoted by trifluoromethane sulfonic acid:An efficient and convenient synthesis of substituted benzoxazolyl 3,4-dihydropyrimidine(1H)-(thio)-ones

An efficient synthesis of 3,4-dihydropyrimidine 2 （1H）-ones and thiones （3,4-DHPMs） core was prepared by one-pot threecomponent Biginelli condensation and which was catalyzed by trifluoromethane sulfonic acid. The classical BigneUi reaction has been extended by the use of N-substituted benzoxazolyl semicarbazides and thiosemicarbazides and this method has the advantage of excellent yields and short reaction times. ？2009 M. Saranga Pard. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

Studies on Chiral Thiophosphoric Acids and Their Derivatives 15.The Asymmetric Cyclizations of L-prolinol with (Thio)phosphoro(-no)dichlorides

The cyclizations of L-(+)-prolinol 1 derived from L-proline with (thio)phosphoro(-no)dichlorides 2 give 1,2,3-azaphosphaoxabicyclo[3.3.0] 3 consisting of unequal amounts of diastereoisomers, eight pairs of which have been successfully separated by silica gel column chromatography or recrystallization.

Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment

AIM: To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth (SIBO) in patients with inactive Crohn’s disease (CD).

Al-Se双元置换的基于LGPS的thio-LISICON的制备与性能表征

通过机械球磨制备的非晶态前驱体经烧结晶化,成功制备出具有高导电相的thio-LISICONⅡ结构的Li10Ge1-xAlxP2S12-2xSe3x/2(x=0,0.2,0.4,0.6,0.8)的多元体系固体电解质。Li10Ge P2S12经过Al-Se双掺杂在掺量为x=0.2时,离子电导率达到2.35 m S/cm,比Li10Ge P2S12提高了31%。与此同时,掺杂也提高了体系的化学稳定性。通过循环伏安曲线测得Li10Ge0.8Al0.2P2S11.6Se0.3具有良好的电化学稳定性,其电化学稳定窗口达8 V。

Syntheses, Characterization and Antitumour Activities of Rare Earth Metal Complexes with 2-(((4,6-dimethyl)-2-Pyrimidinyl)thio)-Acetic Acid

Eight rare earth metal （ Ⅲ ） complexes with 2- （ （（4,6-dimethyl）-2-pyrimidinyl） thio）-acetic acid, LnL3· n H2O [HL = 2-（（（4,6-dimethyl）-2-pyrimidinyl）thio）-acetic acid; Ln = La, Ce, Pr, Nd, Sm Eu, Gd, Tb; n = 4 or 5], were prepared and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR and ^1H- NMR. The results reveal that carboxyl group of the hgand coordinates with rare earth ions in bidentate mode after deprotonated. The water molecules exist as crystal water in the complexes. The anti-tumour activities of HL and some complexes were tested by both the MTT and SRB methods. The results show that the suppression ratios of some complexes against the tested tumour cells （HL-60 human leukemia cell lines, BGC-823 human gastric carcinoma cell lines, hela human cervix adenocarcinoma cell lines and Bel-7402 human hepatic carcinoma cell lines） are superior to HL.

Thiostrepton介导FOXM1下调对非小细胞肺癌细胞生长及其AG1478药物敏感性的影响

目的:探讨硫链丝菌素(thiostrepton,TST)对肺癌细胞A549增殖及其对AG1478药物敏感性的影响。方法:CCK-8法检测TST、AG1478单药及两药联用后A549细胞的增殖抑制率;Western blot检测不同浓度TST对A549细胞中FOXM1的表达影响;利用RNAi技术沉默A549细胞中FOXM1基因,RT-PCR及Westernblot检测转染效率;集落形成实验检测转染前后细胞集落形成能力的改变。结果:TST明显抑制A549细胞增殖并提高其对AG1478的药物敏感性。TST呈剂量依赖性抑制FOXM1、c-myc、CyclinB1及Bcl-2表达;与对照组相比,FOXM1 siRNA转染组的FOXM1 mRNA及蛋白表达均下降,其下游c-myc、Bcl-2的表达下降,Cleaved-PARP的表达明显上调;转染组集落数为(32.0±3.0)个,明显低于空白组及阴性对照组(NC)[集落数分别为(146.0±4.6)个、(128.7±5.7)个],P<0.05。转染组及NC组细胞集落形成抑制率分别为78.08%、11.87%,转染后细胞的集落形成能力明显降低(P<0.05);AG1478单药组的IC50值是TST与AG1478联用组的5.96倍,P<0.05。结论:TST可能通过下调FOXM1的表达抑制A549细胞的增殖、诱导其凋亡,并增加其对AG1478的药物敏感性。

Synthesis and Biological Activities of 2,4-Dichlorophenoxyacetyl(thio)urea and S-(+)-3-Methyl-2-(4-chlorophenyl)butyramide Derivatives

2,4-Dichlorophenoxyacetyl（thio）urea and S-（＋）-3-methyl-2-（4-chlorophenyl）butyramides were synthesized via acylation,aminolysis,esterification and addition reactions,and the partial new compounds have desirable bioactive activity.

Theoretical Investigation on Structures and Second-order Nonlinear Optical Properties of (Thiophene) Manganese Tricarbonyl Cations

The structures of several recently reported organometallic NLO chromophores, (thio-phene) manganese tricarbonyl cations, were fully optimized at the DFT non-local (GGA) level. The calculated results show that the fragments 2-SC4H3CH=CHC6H4-R in these organometallic chromophores are not planar with dihedral angles of 42.2~59.8 between two aromatic rings, which are different from those of uncoordinated counterparts. Based on the DFT geometry opti-mization, the second-order nonlinear optical polarizabilities were calculated by using RPA method. The calculated results indicate that incorporation of +3Mn(CO) unit with thiophene leads to a sub-stantial increase in the second-order polarizability (b).

Synthesis and Crystal Structure of 2,3-Diethoxycarbonyl-4-phenyl-5-morpholinyl Thiophene

The title compound 2, 3-diethoxycarbonyl-4-phenyl-5-morpholinylthiophene (C20H23NO5S, Mr=389. 47) was obtained by the reaction of a-thiobenzoylth-ioformmorpholine with diethyl acetylene dicarboxylate - The crystal is prismatic, spacegroup P1 ( 2), with unit cell constants 2337 observed reflections . X-ray analysis reveals that interatomic dis-tances for C(1 ) -C(2) and C(3) -C (4) are 1. 393 (4), 1. 370 (4) , respectively,which show that they are C=C double bond. The atoms of C(1 ), C(2), C(3), C(4)and S form a thiophene ring. The dihedral ang1es between thiophene ring and C(5) -C(6) -C(7) -C(8) plane, phenyl ring are 31. 42 and 43. 78, respectively. The mor-pholine ring adopts chair conformation.

Dietary supplementation with 2-hydroxy-4-methyl(thio)butanoic acid and DL-methionine improves productive performance,egg quality and redox status of commercial laying ducks

This experiment aimed to study the effects of supplemental methionine sources,2-hydroxy-4 methyl(thio)butanoic acid(HMTBa)and DL-Methionine(DL-Met),on productive performance,egg quality,and redox status of laying ducks.A total of 792 healthy 25-wk-old Longyan laying ducks with similar body weights were randomly allotted to 11 treatment groups.Each treatment group had 6 replicates of 12 ducks.The trial lasted for 16 wk.Ducks were fed a basal deficient diet(Met:0.24%;Met+Cys:0.51%)or supplemented with DL-Met or HMTBa at 0.05%,0.12%,0.19%,0.26%,and 0.33%of diet,respectively.Compared with the basal diet,supplementation with either DL-Met or HMTBa increased the average egg weight,egg mass,and decreased feed to egg ratio during the whole trial period(P<0.05).Albumen weight and its ratio to total egg weight were increased,but yolk and shell ratio,albumen height,Haugh unit and shell breaking strength were decreased(P<0.05).Dietary DL-Met or HMTBa supplementation increased taurine,methionine,leucine,tryptophan and arginine content,and decreased serine and lysine content in plasma(P<0.05).The redox status of laying ducks was improved by enhancing the glutathione peroxidase and catalase activities,glutathione content and its ratio relative to glutathione(oxidized)content and decreasing malondialdehyde content and increasing mRNA expression of superoxide dismutase-1,glutathione peroxidase-1,hemeoxygenase-1 and nuclear factor-like 2 in liver and ileum with the supplementation of DL-Met or HMTBa(P<0.05).Liver health status measured by average area proportion lipid droplet was improved with supplementation of DL-Met or HMTBa(P<0.05).Villus height and villus height to crypt depth ratio in the ileum and the ileal gene expression of tight junction protein and occludin were increased with DL-Met or HMTBa supplementation(P<0.05).Taken together,these results suggested that the efficacy of dietary supplementation of HMTBa was similar to DL-Met,and it ranged from 98%to 100%for productive performance and egg albumen ratio in laying ducks(25 to 41 wk).

Circular Polymers from Ring-Opening Polymerization of Five-Membered(Thio)lactones and Derivatives

The short lifespan of most commercial plastics as disposables and the failure to adequately address the end-of-life issues of synthetic polymers have led to outrageous global plastic pollution and resource depletion.To solve the problem,one of the most effective strategies is to develop circular polymers and thus establish a new circular material economy.Polymers from ring-opening polymerization of five-membered(thio)lactones contribute greatly to this field due to their excellent material performance and recyclability.The emerging topic emphasizes on the monomer design strategies based on five-membered(thio)lactones,and compares the thermal and mechanical properties and depolymerizability of the resulting polymers with different structures.

The synthesis of mono-6-thio-β-cyclodextrin capped CdTe QDs and its interaction with neutral red

This paper presents a novel method for the synthesis of CdTe quantum dots (QDs) capped with β-cyclodextrin in aqueous solution using both TGA and mono-6-thio-β-CD as stabilizers.The interaction between mono-6-thio-β-CD-CdTe QDs and neutral red (NR) was studied with fluorescence,UV-absorption and the resonance Rayleigh scattering spectrum.When its concentration was over 7.5 × 10-6 mol/L,the neutral red began to aggregate on the surface of the mono-6-thio-β-CD-CdTe QDs,which resulted in the mono-6-thio-β-CD-CdTe QDs particle size increasing,the sharply quenched fluorescence,and the marked increase of RRS intensity.

荧光猝灭法研究NADH、Thio-NAD^+与3α-HSD的相互作用

采用荧光猝灭法研究了两种辅酶,还原型烟酰胺嘌呤二核苷酸(NADH)、氧化型硫代烟酰胺腺嘌呤二核苷酸(Thio-NAD+)与3α-羟类固醇脱氢酶(3α-HSD)的相互作用。研究结果表明,NADH和Thio-NAD+的加入均能使3α-HSD的内源性荧光发生猝灭,其猝灭机制均属于生成复合物的静态猝灭;25℃下NADH、Thio-NAD+与3α-HSD的结合常数分别为7.38×104、1.23×104L.mol-1;37℃下NADH、Thio-NAD+与3α-HSD的结合常数分别为4.69×104、9.74×103L.mol-1;NADH与3α-HSD的结合作用力为氢键和范德华力,Thio-NAD+与3α-HSD的结合作用力主要为静电引力和疏水作用力;NADH和Thio-NAD+均能使3α-HSD构象发生变化,导致色氨酸残基所处环境极性增大。

Arsenobetaine and thio-arsenic species in marine macroalgae and herbivorous animals: Accumulated through trophic transfer or produced in situ?

Arsenobetaine（AB） and thio-arsenoribosides were measured in common macroalgae species（8 phaeophyta, 4 rhodophyta and 2 chlorphyta）, along the Australian south east coast line. As well, arsenic species profiles were measured for two common marine herbivores, the sea urchin Centrostephanus rodgersii and the fish Odax cyanomelas that graze on these macroalgae to understand if trophic transfer of these species would account for their presence in marine herbivores. AB was found in seven of the fourteen macroalgae species investigated but does not contributed significantly to any of the macroalgae arsenic content（0.01-1.2 μg/g）. AB was found in only two of the brown macroalgae and all the red and green macroalgae（with the exception of Corallina officinalis）. Thio-arsenic species were found sporadically, but not in high concentrations in any of the macroalgae investigated.AB present in macroalgae is likely to be associated with epiphytic organisms while thio-arsenoribosides are likely to be produced by decaying parts of damaged macroalgae.A laboratory feeding experiment in which the herbivorous gastropod, Austrocochlea constricta, was fed macroalgae containing thio-arsenoribosides for a 24 hr period every three days showed that these are readily accumulated over a short period. Thio-arsenoribosides in herbivores are therefore probably obtained through trophic transfer. Some AB is also obtained through trophic transfer; however, the presence of trimethylated arsonioribosides,a hypothesized precursor of AB formation in herbivores, suggests that some AB is produced within herbivores from the transformation of arsenoribosides accumulated from their diet.

Synthesis of ribonucleoside analogues containing thio-substituted 1,3,4-triazole as heterocyclic base

New ribonucleoside analogues containing thio-substituted 1,3,4-triazole as heterocyclic base have been synthesized via condensation of the central intermediate 1 with various acids, esters, amides, and anhydrides in anhydrous solvent followed by deprotection.

Enhanced separation of Pd(Ⅱ)and Pt(Ⅳ)from hydrochloric acid aqueous solution using 2-((2-methoxyethyl)thio)-1H-benzimidazole

Separation of palladium(Pd)and platinum(Pt)by solvent extraction is difficult because of their extremely similar physicochemical properties.Development of new extractants with a high extraction efficiency and excellent separation selectivity is the primary focus for enhancing the separation of Pd and Pt by solvent extraction.In this study,a new extractant,2-((2-methoxyethyl)thio)-1 H-benzimidazole(MOBI),which contains N,S,and O atoms,was synthesized and used to separate Pd(Ⅱ)and Pt(Ⅳ)from a hydrochloric acid aqueous solution.The experimental results revealed that Pd(Ⅱ)and Pt(Ⅳ)were effectively separated under the optimal conditions:MOB I concentration of 0.005 mol·L^(-1),HCl concentration of0.2 mol·L^(-1),organic/aqueous(O/A)phase ratio of 1.0,and contact time of 15 min.The separation coefficient between Pd(Ⅱ)and Pt(Ⅳ)was 1246.40,which indicates that MOBI has a higher selectivity for Pd(Ⅱ)than Pt(Ⅳ).In addition,the mechanism of coordination between Pd(Ⅱ)and MOBI was demonstrated through the slope method,Fourier transform infrared spectroscopy(FTIR),hydrogen-1 nuclear magnetic resonance spectroscopy(^(1)H NMR),and carbon-13 nuclear magnetic resonance spectroscopy(^(13)C NMR).The results revealed that MOBI could coordinate with Pd(Ⅱ)via the N atom in the benzimidazole ring of MOBI molecules to form[Pd(MOBI)_(2)Cl_(2)](O).