Tunnel-type anchorages(TTAs)installed in human gathering areas are characterized by a shallow burial depth,and in many instances,they utilize soft rock as the bearing stratum.However,the stability control measures and...Tunnel-type anchorages(TTAs)installed in human gathering areas are characterized by a shallow burial depth,and in many instances,they utilize soft rock as the bearing stratum.However,the stability control measures and the principle of shallow TTAs in soft rock have not been fully studied.Hence,a structure suitable for improving the stability of shallow TTAs in soft rock strata,named the anti-pull tie(APT),was added to the floor of the back face.Physical tests and numerical models were established to study the influence of the APT on the load transfer of TTAs,the mechanical response of the surrounding rock,the stress distribution of the interface,and the failure model.The mechanical characteristics of APTs were also studied.The results show that the ultimate bearing capacity of TTAs with an APT is increased by approximately 11.8%,as compared to the TTAs without an APT.Also,the bearing capacity of TTAs increases approximately linearly with increasing height,width,length,and quantity of APTs,and decreases approximately linearly with increasing distance from the back face and slope angle of the tie slope.The normal squeezing between the tie slope and the surrounding rock increases the shear resistance of the interface and expands the range of the surrounding rock participating in bearing sharing.Both tension and compression zones exist in the APT during loading.The tension zone extends from the tie toe to the tie bottom along the tie slope.The range of the tie body tension zone constantly expands to the deep part of the APT with an increasing load.The peak tensile stress value is located at the tie toe.The distribution of compressive stress in the tie body is the largest at the tie top,followed by the tie slope,and then the tie bottom.展开更多
This research aimed to explore the influence of Src homology-2 containing protein tyrosine phosphatase(SHP-2)on the functions of tyrosine kinase receptors with immunoglobulin and EGF homology domains 2(Tie2)-expressin...This research aimed to explore the influence of Src homology-2 containing protein tyrosine phosphatase(SHP-2)on the functions of tyrosine kinase receptors with immunoglobulin and EGF homology domains 2(Tie2)-expressing monocyte/macrophages(TEMs)and the influence of the angiopoietin(Ang)/Tie2-phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)(Ang/Tie2-PI3K/Akt/mTOR)signaling pathway on the tumor microvascular remodeling in an immunosuppressive microenvironment.In vivo,SHP-2-deficient mice were used to construct colorectal cancer(CRC)liver metastasis models.SHP-2-deficient mice had significantly more metastatic cancer and inhibited nodules on the liver surface than wild-type mice,and the high-level expression of p-Tie2 was found in the liver tissue of the macrophages’specific SHP-2-deficient mice(SHP-2MACKO)+planted tumor mice.Compared with the SHP-2 wild type mice(SHP-2WT)+planted tumor group,the SHP-2MAC-KO+planted tumor group experienced increased expression of p-Tie2,p-PI3K,p-Akt,p-mTOR,vascular endothelial growth factor(VEGF),cyclooxygenase-2(COX-2),matrix metalloproteinase 2(MMP2),and MMP9 in the liver tissue.TEMs selected by in vitro experiments were co-cultured with remodeling endothelial cells and tumor cells as carriers.It was found that when Angpt1/2 was used for stimulation,the SHP-2MAC-KO+Angpt1/2 group displayed evident increases in the expression of the Ang/Tie2-PI3K/Akt/mTOR pathway.The number of cells passing through the lower chamber and the basement membrane and the number of blood vessels formed by cells compared with the SHP-2WT+Angpt1/2 group,while these indexes were subjected to no changes under the simultaneous stimulation of Angpt1/2+Neamine.To sum up,the conditional knockout of SHP-2 can activate the Ang/Tie2-PI3K/Akt/mTOR pathway in TEMs,thereby strengthening tumor micro angiogenesis in the microenvironment and facilitating CRC liver metastasis.展开更多
Cutaneomucosal venous malformations(VMCMs)can manifest as sporadic or familial forms,following an autosomal dominant inheritance pattern.This report highlights the case of a 5-year-old girl presenting with a substanti...Cutaneomucosal venous malformations(VMCMs)can manifest as sporadic or familial forms,following an autosomal dominant inheritance pattern.This report highlights the case of a 5-year-old girl presenting with a substantial congenital VMCM attributed to a TIE2 mutation,who underwent percutaneous sclerotherapy followed by surgery.The clinical,three-dimensional computed tomographic angiography(3D-CTA),as well as pathological and genetic findings concerning a patient with an extensive VMCM in the left pro-axillary region,are elucidated.The genetic analysis in this patient verified a missense mutation(c.2545T>C)in TIE2,confirming familial VMCMs.The combined strategy integrating percutaneous sclerotherapy and surgical excision is the most efficacious approach for managing large VMCMs and can successfully attain therapeutic goals.展开更多
“The Jakarta-Bandung High-Speed Railway(HSR)is a crucial achievement in practical cooperation between China and Indonesia,”said Paulus Rudolf Yuniarto,a researcher at the Indonesia National Research and Innovation A...“The Jakarta-Bandung High-Speed Railway(HSR)is a crucial achievement in practical cooperation between China and Indonesia,”said Paulus Rudolf Yuniarto,a researcher at the Indonesia National Research and Innovation Agency.展开更多
基金the financial support provided by the National Natural Science Foundation of China(Grant No.42302332)the Special Funding of Chongqing Postdoctoral Research Project(Grant No.2022CQBSHTB2061,2022CQBSHTB1010)+3 种基金the Chongqing Postdoctoral Science Foundation(Grant No.CSTB2022NSCQ-BHX0738,CSTB2023NSCQBHX0223)the China Postdoctoral Science Foundation(Grant No.2023M730432)the Natural Science Foundation of Chongqing(Grant No.CSTB2023NSCQMSX0913,cstc2021jcyj-msxm X0869)the Postdoctoral Science Foundation of Chongqing Jiaotong University(Grant No.F1220105,22JDKJC-A008)。
文摘Tunnel-type anchorages(TTAs)installed in human gathering areas are characterized by a shallow burial depth,and in many instances,they utilize soft rock as the bearing stratum.However,the stability control measures and the principle of shallow TTAs in soft rock have not been fully studied.Hence,a structure suitable for improving the stability of shallow TTAs in soft rock strata,named the anti-pull tie(APT),was added to the floor of the back face.Physical tests and numerical models were established to study the influence of the APT on the load transfer of TTAs,the mechanical response of the surrounding rock,the stress distribution of the interface,and the failure model.The mechanical characteristics of APTs were also studied.The results show that the ultimate bearing capacity of TTAs with an APT is increased by approximately 11.8%,as compared to the TTAs without an APT.Also,the bearing capacity of TTAs increases approximately linearly with increasing height,width,length,and quantity of APTs,and decreases approximately linearly with increasing distance from the back face and slope angle of the tie slope.The normal squeezing between the tie slope and the surrounding rock increases the shear resistance of the interface and expands the range of the surrounding rock participating in bearing sharing.Both tension and compression zones exist in the APT during loading.The tension zone extends from the tie toe to the tie bottom along the tie slope.The range of the tie body tension zone constantly expands to the deep part of the APT with an increasing load.The peak tensile stress value is located at the tie toe.The distribution of compressive stress in the tie body is the largest at the tie top,followed by the tie slope,and then the tie bottom.
基金Natural Science Foundation Project of Hebei Province(H2022405033).
文摘This research aimed to explore the influence of Src homology-2 containing protein tyrosine phosphatase(SHP-2)on the functions of tyrosine kinase receptors with immunoglobulin and EGF homology domains 2(Tie2)-expressing monocyte/macrophages(TEMs)and the influence of the angiopoietin(Ang)/Tie2-phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)(Ang/Tie2-PI3K/Akt/mTOR)signaling pathway on the tumor microvascular remodeling in an immunosuppressive microenvironment.In vivo,SHP-2-deficient mice were used to construct colorectal cancer(CRC)liver metastasis models.SHP-2-deficient mice had significantly more metastatic cancer and inhibited nodules on the liver surface than wild-type mice,and the high-level expression of p-Tie2 was found in the liver tissue of the macrophages’specific SHP-2-deficient mice(SHP-2MACKO)+planted tumor mice.Compared with the SHP-2 wild type mice(SHP-2WT)+planted tumor group,the SHP-2MAC-KO+planted tumor group experienced increased expression of p-Tie2,p-PI3K,p-Akt,p-mTOR,vascular endothelial growth factor(VEGF),cyclooxygenase-2(COX-2),matrix metalloproteinase 2(MMP2),and MMP9 in the liver tissue.TEMs selected by in vitro experiments were co-cultured with remodeling endothelial cells and tumor cells as carriers.It was found that when Angpt1/2 was used for stimulation,the SHP-2MAC-KO+Angpt1/2 group displayed evident increases in the expression of the Ang/Tie2-PI3K/Akt/mTOR pathway.The number of cells passing through the lower chamber and the basement membrane and the number of blood vessels formed by cells compared with the SHP-2WT+Angpt1/2 group,while these indexes were subjected to no changes under the simultaneous stimulation of Angpt1/2+Neamine.To sum up,the conditional knockout of SHP-2 can activate the Ang/Tie2-PI3K/Akt/mTOR pathway in TEMs,thereby strengthening tumor micro angiogenesis in the microenvironment and facilitating CRC liver metastasis.
基金supported by the National Natural Science Foundation of China(grant no.8187080758).
文摘Cutaneomucosal venous malformations(VMCMs)can manifest as sporadic or familial forms,following an autosomal dominant inheritance pattern.This report highlights the case of a 5-year-old girl presenting with a substantial congenital VMCM attributed to a TIE2 mutation,who underwent percutaneous sclerotherapy followed by surgery.The clinical,three-dimensional computed tomographic angiography(3D-CTA),as well as pathological and genetic findings concerning a patient with an extensive VMCM in the left pro-axillary region,are elucidated.The genetic analysis in this patient verified a missense mutation(c.2545T>C)in TIE2,confirming familial VMCMs.The combined strategy integrating percutaneous sclerotherapy and surgical excision is the most efficacious approach for managing large VMCMs and can successfully attain therapeutic goals.
文摘“The Jakarta-Bandung High-Speed Railway(HSR)is a crucial achievement in practical cooperation between China and Indonesia,”said Paulus Rudolf Yuniarto,a researcher at the Indonesia National Research and Innovation Agency.
