目的探讨甘精胰岛素U300联合口服降糖药治疗2型糖尿病的临床效果。方法选择2021年10月—2023年1月广东省吴川市人民医院收治的79例2型糖尿病患者,随机分为非甘精组(39例)和U300组(40例)。非甘精组口服降糖药物治疗,在此之上,U300组增加...目的探讨甘精胰岛素U300联合口服降糖药治疗2型糖尿病的临床效果。方法选择2021年10月—2023年1月广东省吴川市人民医院收治的79例2型糖尿病患者,随机分为非甘精组(39例)和U300组(40例)。非甘精组口服降糖药物治疗,在此之上,U300组增加甘精胰岛素U300治疗,持续治疗3个月,对比2组血糖及相关指标变化,并监测患者胰岛素功能相关指标改善情况,评估低血糖反应等不良反应情况。结果治疗后,U300组血糖指标、血糖波动指标均显著低于非甘精组,差异有统计学意义(P<0.05)。U300组治疗后胰岛素功能指标均显著优于非甘精组,空腹及餐后2 h C肽均显著高于非甘精组,差异有统计学意义(P<0.05)。U300组低血糖反应发生率(2.50%,1/40)和不良反应总发生率(20.00%,8/40)与非甘精组(2.56,1/39;17.95%,7/39)比较,差异无统计学意义(P>0.05)。结论增加甘精胰岛素U300治疗,可更好地提升患者血糖管理效果,并可改善胰岛功能,有利于稳定控制血糖,有助于提高患者病情控制效果,应用效果安全可靠。展开更多
攻击行为正逐渐上升为一个突出的公共卫生问题,是否能够寻找到攻击性行为的神经标志物,成为了心理学家和神经科学家的共同关注目标。P300被认为可作为独立指标有效预测攻击性行为。本文分别介绍了P300在临床群体、犯罪群体和非临床暴力...攻击行为正逐渐上升为一个突出的公共卫生问题,是否能够寻找到攻击性行为的神经标志物,成为了心理学家和神经科学家的共同关注目标。P300被认为可作为独立指标有效预测攻击性行为。本文分别介绍了P300在临床群体、犯罪群体和非临床暴力风险群体的攻击性行为测量中的应用,评估了研究结果的一致性,并从P300指标的多角度分析及与其他ERP成分的结合、对犯罪群体进行进一步的类型细分、P300的应用场景拓展(如监内暴力预测、暴力行为干预效果评估和正常人攻击风险测量)等三个方面对未来的研究方向进行了展望。Aggressive behavior is gradually emerging as a prominent public health problem. Finding neural markers for aggressive behavior has become a common focus for psychologists and neuroscientists. The P300 is considered to be an independent indicator that can effectively predict aggressive behavior. This article introduces the application of P300 in the measurement of aggressive behavior in clinical, criminal and non-clinical violence risk groups, evaluates the consistency of research results, and looks forward to future research directions from three perspectives: multi-dimensional analysis of P300 predictors and combination with other ERP components, further subdivision of criminal groups, and expansion of the application scenarios of P300 (such as the prediction of violence in prison, the evaluation of the effectiveness of violence intervention and the measurement of the risk of aggression in normal people).展开更多
Objective: The human cluster of differentiation(CD)300A, a type-I transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential immune checkpoint for human natural killer(...Objective: The human cluster of differentiation(CD)300A, a type-I transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential immune checkpoint for human natural killer(NK) cells targeting hematologic malignancies(HMs).Methods: We implemented a stimulation system involving the CD300A ligand, phosphatidylserine(PS), exposed to the outer surface of malignant cells. Additionally, we utilized CD300A overexpression, a CD300A blocking system, and a xenotransplantation model to evaluate the impact of CD300A on NK cell efficacy against HMs in in vitro and in vivo settings. Furthermore, we explored the association between CD300A and HM progression in patients.Results: Our findings indicated that PS hampers the function of NK cells. Increased CD300A expression inhibited HM lysis by NK cells. CD300A overexpression shortened the survival of HM-xenografted mice by impairing transplanted NK cells. Blocking PS–CD300A signals with antibodies significantly amplified the expression of lysis function-related proteins and effector cytokines in NK cells, thereby augmenting the ability to lyse HMs. Clinically, heightened CD300A expression correlated with shorter survival and an “exhausted” phenotype of intratumoral NK cells in patients with HMs or solid tumors.Conclusions: These results propose CD300A as a potential target for invigorating NK cell-based treatments against HMs.展开更多
文摘目的探讨甘精胰岛素U300联合口服降糖药治疗2型糖尿病的临床效果。方法选择2021年10月—2023年1月广东省吴川市人民医院收治的79例2型糖尿病患者,随机分为非甘精组(39例)和U300组(40例)。非甘精组口服降糖药物治疗,在此之上,U300组增加甘精胰岛素U300治疗,持续治疗3个月,对比2组血糖及相关指标变化,并监测患者胰岛素功能相关指标改善情况,评估低血糖反应等不良反应情况。结果治疗后,U300组血糖指标、血糖波动指标均显著低于非甘精组,差异有统计学意义(P<0.05)。U300组治疗后胰岛素功能指标均显著优于非甘精组,空腹及餐后2 h C肽均显著高于非甘精组,差异有统计学意义(P<0.05)。U300组低血糖反应发生率(2.50%,1/40)和不良反应总发生率(20.00%,8/40)与非甘精组(2.56,1/39;17.95%,7/39)比较,差异无统计学意义(P>0.05)。结论增加甘精胰岛素U300治疗,可更好地提升患者血糖管理效果,并可改善胰岛功能,有利于稳定控制血糖,有助于提高患者病情控制效果,应用效果安全可靠。
文摘攻击行为正逐渐上升为一个突出的公共卫生问题,是否能够寻找到攻击性行为的神经标志物,成为了心理学家和神经科学家的共同关注目标。P300被认为可作为独立指标有效预测攻击性行为。本文分别介绍了P300在临床群体、犯罪群体和非临床暴力风险群体的攻击性行为测量中的应用,评估了研究结果的一致性,并从P300指标的多角度分析及与其他ERP成分的结合、对犯罪群体进行进一步的类型细分、P300的应用场景拓展(如监内暴力预测、暴力行为干预效果评估和正常人攻击风险测量)等三个方面对未来的研究方向进行了展望。Aggressive behavior is gradually emerging as a prominent public health problem. Finding neural markers for aggressive behavior has become a common focus for psychologists and neuroscientists. The P300 is considered to be an independent indicator that can effectively predict aggressive behavior. This article introduces the application of P300 in the measurement of aggressive behavior in clinical, criminal and non-clinical violence risk groups, evaluates the consistency of research results, and looks forward to future research directions from three perspectives: multi-dimensional analysis of P300 predictors and combination with other ERP components, further subdivision of criminal groups, and expansion of the application scenarios of P300 (such as the prediction of violence in prison, the evaluation of the effectiveness of violence intervention and the measurement of the risk of aggression in normal people).
基金supported by the National Key R&D Program of China (2019YFA0508502/3 and 2021YFC2300604)the Natural Science Foundation of China (Reference numbers 82388201, 82241216, and 32270963)+1 种基金the Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM (QYZD20220008)the Anhui Key Research and Development Plan (Reference number 2023z04020011)。
文摘Objective: The human cluster of differentiation(CD)300A, a type-I transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential immune checkpoint for human natural killer(NK) cells targeting hematologic malignancies(HMs).Methods: We implemented a stimulation system involving the CD300A ligand, phosphatidylserine(PS), exposed to the outer surface of malignant cells. Additionally, we utilized CD300A overexpression, a CD300A blocking system, and a xenotransplantation model to evaluate the impact of CD300A on NK cell efficacy against HMs in in vitro and in vivo settings. Furthermore, we explored the association between CD300A and HM progression in patients.Results: Our findings indicated that PS hampers the function of NK cells. Increased CD300A expression inhibited HM lysis by NK cells. CD300A overexpression shortened the survival of HM-xenografted mice by impairing transplanted NK cells. Blocking PS–CD300A signals with antibodies significantly amplified the expression of lysis function-related proteins and effector cytokines in NK cells, thereby augmenting the ability to lyse HMs. Clinically, heightened CD300A expression correlated with shorter survival and an “exhausted” phenotype of intratumoral NK cells in patients with HMs or solid tumors.Conclusions: These results propose CD300A as a potential target for invigorating NK cell-based treatments against HMs.
