Ferroptosis is a cell death modality triggered by excessive lipid peroxidation.Two recent studies(Zou et al.,2020;Cui et al.,2021)not only reveal critical roles of ether-linked phospholipids as an additional source fo...Ferroptosis is a cell death modality triggered by excessive lipid peroxidation.Two recent studies(Zou et al.,2020;Cui et al.,2021)not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid(plasmalogen)synthesis in ferroptosis.展开更多
基金supported by The University of Texas MD Anderson Cancer CenterNational Institutes of Health grants(R01CA181196,R01CA244144,R01CA247992 to B.Gan)by Cancer Center Support(Core)Grant P30(CA016672 from the National Cancer Institute to The University of Texas MD Anderson Cancer Center)。
文摘Ferroptosis is a cell death modality triggered by excessive lipid peroxidation.Two recent studies(Zou et al.,2020;Cui et al.,2021)not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid(plasmalogen)synthesis in ferroptosis.
