Transportation consumes for about 27% of total energy. Almost 100% of the energy used for propelling transport vehicles is derived from petroleum resources. In Gaza Strip and West Bank, transportation consumes about 6...Transportation consumes for about 27% of total energy. Almost 100% of the energy used for propelling transport vehicles is derived from petroleum resources. In Gaza Strip and West Bank, transportation consumes about 60% of the total amount of imported fuel. The traffic congestion has a negative impact significantly on the environment because of the increased amount of fuel consumption and thus emissions of pollutants from vehicles. Serious traffic congestion is concentrated in the middle part of Gaza City, especially in major arterial roads such as Eljalaa Road. The congestion comes into view clearly in the segment of the street which consists of 5 consecutive signalized intersections. What makes the congestion even worse is the non-efficient traffic signal control;where each intersection is treated in isolation. The key solution to reduce the congestion and to save energy is to use signal coordination. Therefore, this study aims to redesign and coordinate the traffic signals along Eljalaa road using TRANSYT-7F Model. It aims also to compare between the traffic performance and the fuel consumption of the coordinated signals and the existing uncoordinated ones. The analysis and design are based on geometric data and manual traffic count. The results of comparison show a remarkable improvement of the traffic performance and energy saving of the studied area. There was a reduction of travel time, delay, stops and fuel consumption by 44%, 56%, 25% and 31% respectively. The level of service has been improved from F to D. Thus, it is recommended that signal coordination should be carried out at all arterial roads in Gaza city.展开更多
This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic inflammation.Arteriosclerosis model ApoE^(-/-)mice were orally administered with B.animalis F1-7 for 12 wee...This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic inflammation.Arteriosclerosis model ApoE^(-/-)mice were orally administered with B.animalis F1-7 for 12 weeks.The probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages,and downregulated the expression of toll-like receptor 4(TLR4)/nuclear factorκB(NF-κB)pathway to reduce the levels of inflammatory factors.The widely-targeted metabolomics analysis showed that acetyl-L-carnitine(ALC)in the intestine of atherosclerotic mice was significantly increased after B.animalis F1-7 intervention.Correlation analysis proved that ALC was associated with atherosclerotic inflammatory response.By using oxidized low density lipoprotein induced macrophage foam cells,we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NF-κB pathway.Finally,our results revealed that B.animalis F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses,leading to the reduction of plaque accumulation of atherosclerosis.展开更多
文摘Transportation consumes for about 27% of total energy. Almost 100% of the energy used for propelling transport vehicles is derived from petroleum resources. In Gaza Strip and West Bank, transportation consumes about 60% of the total amount of imported fuel. The traffic congestion has a negative impact significantly on the environment because of the increased amount of fuel consumption and thus emissions of pollutants from vehicles. Serious traffic congestion is concentrated in the middle part of Gaza City, especially in major arterial roads such as Eljalaa Road. The congestion comes into view clearly in the segment of the street which consists of 5 consecutive signalized intersections. What makes the congestion even worse is the non-efficient traffic signal control;where each intersection is treated in isolation. The key solution to reduce the congestion and to save energy is to use signal coordination. Therefore, this study aims to redesign and coordinate the traffic signals along Eljalaa road using TRANSYT-7F Model. It aims also to compare between the traffic performance and the fuel consumption of the coordinated signals and the existing uncoordinated ones. The analysis and design are based on geometric data and manual traffic count. The results of comparison show a remarkable improvement of the traffic performance and energy saving of the studied area. There was a reduction of travel time, delay, stops and fuel consumption by 44%, 56%, 25% and 31% respectively. The level of service has been improved from F to D. Thus, it is recommended that signal coordination should be carried out at all arterial roads in Gaza city.
基金supported by Shandong Taishan industry leading talent project(LJNY202101)the National Key R&D of China(2018YFC0311201)。
文摘This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic inflammation.Arteriosclerosis model ApoE^(-/-)mice were orally administered with B.animalis F1-7 for 12 weeks.The probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages,and downregulated the expression of toll-like receptor 4(TLR4)/nuclear factorκB(NF-κB)pathway to reduce the levels of inflammatory factors.The widely-targeted metabolomics analysis showed that acetyl-L-carnitine(ALC)in the intestine of atherosclerotic mice was significantly increased after B.animalis F1-7 intervention.Correlation analysis proved that ALC was associated with atherosclerotic inflammatory response.By using oxidized low density lipoprotein induced macrophage foam cells,we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NF-κB pathway.Finally,our results revealed that B.animalis F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses,leading to the reduction of plaque accumulation of atherosclerosis.
