The tripartite motif(TRIMs)protein family has E3 ubiquitin ligase activity among most of its members.They participate in multiple cellular processes and signaling pathways in living organisms,including cell cycle,grow...The tripartite motif(TRIMs)protein family has E3 ubiquitin ligase activity among most of its members.They participate in multiple cellular processes and signaling pathways in living organisms,including cell cycle,growth,and metabolism,and mediate chromatin modification,transcriptional regulation,post-translational modification,and cellular autophagy.Previous studies have confirmed that the TRIMs protein family is involved in the development of various cancers and correlated with the prognosis of tumor patients.Here we summarize the biological roles of the TRIMs protein family in cancers.展开更多
基金supported by the National Natural Science Foundation of China(82060607,81860586)the Natural Science Foundation of Guangxi Province(2020GXNSFDA297010).
文摘The tripartite motif(TRIMs)protein family has E3 ubiquitin ligase activity among most of its members.They participate in multiple cellular processes and signaling pathways in living organisms,including cell cycle,growth,and metabolism,and mediate chromatin modification,transcriptional regulation,post-translational modification,and cellular autophagy.Previous studies have confirmed that the TRIMs protein family is involved in the development of various cancers and correlated with the prognosis of tumor patients.Here we summarize the biological roles of the TRIMs protein family in cancers.
