Epilepsy is one of the most common neurological diseases worldwide with a high prevalence and unknown pathogenesis.Further,its control is challenging.It is generally accepted that an imbalance between the excitatory a...Epilepsy is one of the most common neurological diseases worldwide with a high prevalence and unknown pathogenesis.Further,its control is challenging.It is generally accepted that an imbalance between the excitatory and inhibitory properties of the central nervous system(CNS)leads to a large number of abnormally synchronized neuronal discharges in the brain.Transient receptor potential vanilloid protein type 1(TRPV1)is a non-selective cation channel that contributes to the regulation of the nervous system and influences the excitability of the nervous system.This includes the release of neurotransmitters,action potential generation due to alterations in ion channels,synaptic transmission,and the changes in glial cells.There is abundant evidence that TRPV1 is widely expressed in the central nervous system(including microglia)and is involved in the development of epilepsy through neuroinflammation.In conclusion,microglial TRPV1 participates in neuroinflammatory reactions and functions as a potential proinflammatory mediator.This presents a novel treatment approach to regulate seizures brought on by neuroinflammation.展开更多
文摘Epilepsy is one of the most common neurological diseases worldwide with a high prevalence and unknown pathogenesis.Further,its control is challenging.It is generally accepted that an imbalance between the excitatory and inhibitory properties of the central nervous system(CNS)leads to a large number of abnormally synchronized neuronal discharges in the brain.Transient receptor potential vanilloid protein type 1(TRPV1)is a non-selective cation channel that contributes to the regulation of the nervous system and influences the excitability of the nervous system.This includes the release of neurotransmitters,action potential generation due to alterations in ion channels,synaptic transmission,and the changes in glial cells.There is abundant evidence that TRPV1 is widely expressed in the central nervous system(including microglia)and is involved in the development of epilepsy through neuroinflammation.In conclusion,microglial TRPV1 participates in neuroinflammatory reactions and functions as a potential proinflammatory mediator.This presents a novel treatment approach to regulate seizures brought on by neuroinflammation.