为提高静止无功补偿器(static var compensator,SVC)应对直流电弧炉等冲击性负载的闪变抑制性能,文中在改进Takagi-Sugeno(TS)模糊算法的基础上,提出一种SVC滚动预测控制方法。首先,建立直流电弧炉电气模型并仿真分析其无功特性;然后,...为提高静止无功补偿器(static var compensator,SVC)应对直流电弧炉等冲击性负载的闪变抑制性能,文中在改进Takagi-Sugeno(TS)模糊算法的基础上,提出一种SVC滚动预测控制方法。首先,建立直流电弧炉电气模型并仿真分析其无功特性;然后,针对经典TS模糊预测算法应用于波动负荷时出现的输出异常置0情况,提出一种范围自适应修正的改进方法,该方法能消除一类算法应用机理导致的异常值,从而提高TS模糊算法对波动负荷无功功率预测的可靠性和准确性;最后,基于模型训练时间约束,建立无功功率半周期滚动预测控制模型,提前10 ms预测无功功率,改善了SVC传统控制系统响应的滞后特性。仿真结果表明,相比于SVC传统控制方法,所提方法的平均闪变改善率提高了54.17%,验证了所提方法对闪变现象的抑制效果提升显著。展开更多
Transfer RNA-derived small RNAs(tsRNAs)have been shown to be involved in early embryo development and repression of endogenous retroelements in embryos and stem cells.However,it is unknown whether tsRNAs also regulate...Transfer RNA-derived small RNAs(tsRNAs)have been shown to be involved in early embryo development and repression of endogenous retroelements in embryos and stem cells.However,it is unknown whether tsRNAs also regulate embryo hatching.In this study,we mined the sequencing data of a previous experiment in which we demonstrated that the microRNA(miRNA)cargo of preimplantation embryonic extracellular vesicles(EVs)influences embryo development.We thus profiled the tsRNA cargo of EVs secreted by blastocysts and non-blastocysts.The majority of tsRNAs was identified as tRNA halves originating from the 5'ends of tRNAs.Among the 148 differentially expressed tsRNAs,the 19 nt tRNA fragment(tRF)tDR-14:32-Glu-CTC-1 was found to be significantly up-regulated in EVs derived from non-blastocysts.RT-qPCR assays confirmed its significant up-regulation in non-blastocyst embryos and their conditioned medium compared to the blastocyst group(P<0.05).Inhibition of tDR-14:32-Glu-CTC-1 by supplementing antagomirs to the conditioned medium improved embryo hatching(P<0.05).Transcriptomic analysis of embryos treated with tDR-14:32-Glu-CTC-1 antagomirs further showed differential expression of genes that are associated with embryo hatching and implantation.In summary,tDR-14:32-Glu-CTC-1 is up-regulated in non-blastocyst embryos and their secretions,and inhibition of tDR-14:32-Glu-CTC-1 promotes embryo hatching,while influencing embryo implantation-related genes and pathways.These results indicate that embryonic EVs containing specific tRFs may regulate preimplantation embryo development.展开更多
UNIVANTS卓越医疗奖(UNIVANTS of healthcare excellence)是一项享有盛名的全球性奖项,UNIVANTS卓越医疗奖是由雅培(Abbott)发起,联合全球领先的医疗保健组织[国际临床化学与检验医学联合会(International Federation of Clinical Chemi...UNIVANTS卓越医疗奖(UNIVANTS of healthcare excellence)是一项享有盛名的全球性奖项,UNIVANTS卓越医疗奖是由雅培(Abbott)发起,联合全球领先的医疗保健组织[国际临床化学与检验医学联合会(International Federation of Clinical Chemistry and Laboratory Medicine,IFCC)、美国临床化学协会(American Association for Clinical Chemistry,AACC,现称ADLM)、欧洲健康管理学会(European Health Management Association,EHMA)。展开更多
6月19日—22日,第四届“设计上海TALENTS”在上海世博展览馆再启新篇章。本届设计TALENTS展区依旧采用严格的准入机制,最终共有24组/位Talents参展,其中包括3组国际Talents和6组往届参与者。在设计的世界里,问题与答案总是相互纠缠,互...6月19日—22日,第四届“设计上海TALENTS”在上海世博展览馆再启新篇章。本届设计TALENTS展区依旧采用严格的准入机制,最终共有24组/位Talents参展,其中包括3组国际Talents和6组往届参与者。在设计的世界里,问题与答案总是相互纠缠,互为因果。本次TALENTS展将这种复杂的关系提炼为本届的主题——“The Quest for the Question问是亟的问题”。设计不仅仅是一种表达,更是一种探索和提问的过程。在这个过程中,每个设计师都是探险家,每次尝试都可能开启新的可能性(图01)。展开更多
针对高速龙门式包带机的驱动过程平行轴产生噪声、振动和卡滞等问题,造成其驱动过程不同步的影响,提出一种降阶扩张状态观测器(reduced-order extended state observer,RESO)的线性自抗扰控制(linear active disturbance rejection cont...针对高速龙门式包带机的驱动过程平行轴产生噪声、振动和卡滞等问题,造成其驱动过程不同步的影响,提出一种降阶扩张状态观测器(reduced-order extended state observer,RESO)的线性自抗扰控制(linear active disturbance rejection contro,LADRC)控制器和TS型模糊神经网络(TS fuzzy neural network,TS-FNN)同步补偿器相结合的控制方法。首先,针对高速龙门式包带机单轴的噪声、摩擦力和振动对伺服系统控制精度的影响,采用RESO的LADRC算法,以抑制控制系统的外部扰动和减少参数调节数量,从而提高位置跟踪精度;同时,针对平行轴中双直线电机因参数摄动和机械耦合等不确定扰动对位置同步精度的影响,采用交叉耦合的控制方法并结合TS-FNN同步补偿器来提高两平行轴的同步精度。通过实验对比验证,所采用的控制策略能有效减少高速龙门式包带机的单轴的跟踪误差,并提高平行轴的同步误差和抗扰性。展开更多
文摘为提高静止无功补偿器(static var compensator,SVC)应对直流电弧炉等冲击性负载的闪变抑制性能,文中在改进Takagi-Sugeno(TS)模糊算法的基础上,提出一种SVC滚动预测控制方法。首先,建立直流电弧炉电气模型并仿真分析其无功特性;然后,针对经典TS模糊预测算法应用于波动负荷时出现的输出异常置0情况,提出一种范围自适应修正的改进方法,该方法能消除一类算法应用机理导致的异常值,从而提高TS模糊算法对波动负荷无功功率预测的可靠性和准确性;最后,基于模型训练时间约束,建立无功功率半周期滚动预测控制模型,提前10 ms预测无功功率,改善了SVC传统控制系统响应的滞后特性。仿真结果表明,相比于SVC传统控制方法,所提方法的平均闪变改善率提高了54.17%,验证了所提方法对闪变现象的抑制效果提升显著。
基金supported by Ghent University(Grant:Bijzonder Onderzoeksfonds Geconcerteerde Onderzoeksactie 2018000504[GOA030-18 BOF])supported by Ghent University:BOF.STG.2022.02.0034.01+1 种基金supported by China Scholarship Council:Grant 202006910034supported by Fonds Wetenschappelijk Onderzoek:Grant 1228821N and 12A2H24N。
文摘Transfer RNA-derived small RNAs(tsRNAs)have been shown to be involved in early embryo development and repression of endogenous retroelements in embryos and stem cells.However,it is unknown whether tsRNAs also regulate embryo hatching.In this study,we mined the sequencing data of a previous experiment in which we demonstrated that the microRNA(miRNA)cargo of preimplantation embryonic extracellular vesicles(EVs)influences embryo development.We thus profiled the tsRNA cargo of EVs secreted by blastocysts and non-blastocysts.The majority of tsRNAs was identified as tRNA halves originating from the 5'ends of tRNAs.Among the 148 differentially expressed tsRNAs,the 19 nt tRNA fragment(tRF)tDR-14:32-Glu-CTC-1 was found to be significantly up-regulated in EVs derived from non-blastocysts.RT-qPCR assays confirmed its significant up-regulation in non-blastocyst embryos and their conditioned medium compared to the blastocyst group(P<0.05).Inhibition of tDR-14:32-Glu-CTC-1 by supplementing antagomirs to the conditioned medium improved embryo hatching(P<0.05).Transcriptomic analysis of embryos treated with tDR-14:32-Glu-CTC-1 antagomirs further showed differential expression of genes that are associated with embryo hatching and implantation.In summary,tDR-14:32-Glu-CTC-1 is up-regulated in non-blastocyst embryos and their secretions,and inhibition of tDR-14:32-Glu-CTC-1 promotes embryo hatching,while influencing embryo implantation-related genes and pathways.These results indicate that embryonic EVs containing specific tRFs may regulate preimplantation embryo development.
文摘UNIVANTS卓越医疗奖(UNIVANTS of healthcare excellence)是一项享有盛名的全球性奖项,UNIVANTS卓越医疗奖是由雅培(Abbott)发起,联合全球领先的医疗保健组织[国际临床化学与检验医学联合会(International Federation of Clinical Chemistry and Laboratory Medicine,IFCC)、美国临床化学协会(American Association for Clinical Chemistry,AACC,现称ADLM)、欧洲健康管理学会(European Health Management Association,EHMA)。
文摘6月19日—22日,第四届“设计上海TALENTS”在上海世博展览馆再启新篇章。本届设计TALENTS展区依旧采用严格的准入机制,最终共有24组/位Talents参展,其中包括3组国际Talents和6组往届参与者。在设计的世界里,问题与答案总是相互纠缠,互为因果。本次TALENTS展将这种复杂的关系提炼为本届的主题——“The Quest for the Question问是亟的问题”。设计不仅仅是一种表达,更是一种探索和提问的过程。在这个过程中,每个设计师都是探险家,每次尝试都可能开启新的可能性(图01)。
