[Objectives] To systemically review the efficacy and safety of Panax Notoginseng Saponins( PNS) in the treatment of traumatic spinal-cord injury( TSCI) in rat models. [Methods] Randomized controlled trials( RCT) about...[Objectives] To systemically review the efficacy and safety of Panax Notoginseng Saponins( PNS) in the treatment of traumatic spinal-cord injury( TSCI) in rat models. [Methods] Randomized controlled trials( RCT) about the effects of PNS for TSCI in rats were searched in Pub Med,EMbase,The Cochrane Library,CBM,CNKI,Wan Fang Data from inception to November 2016. Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data,and assessed the risk of bias of included studies.Then Meta-analysis was performed using Rev Man 5. 3 software. [Results] A total of 6 RCTs involving 264 rats were included. The results of Meta-analysis showed that: compared with the control group,the Basso,Beattie and Bresnahan( BBB) scores in the PNS group were superior in 7 days( SMD = 1. 81,95% CI( 1. 18,2. 43),P < 0. 00001),14 days( SMD = 1. 92,95% CI( 1. 51,2. 33),P < 0. 00001),21 days( SMD =2. 33,95% CI( 0. 98,3. 68),P <0. 0007) and 28 days( SMD =2. 72,95% CI( 1. 78,3. 67),P <0. 00001) after surgery. The results of Meta-analysis showed that: compared with the control group,ramp test in the PNS group were superior in 7 days [SMD = 1. 55,95% CI( 0. 78,2. 31),P <0. 0001]and 14 days[SMD =1. 83,95% CI( 1. 46,2. 20),P < 0. 00001]. [Conclusions] Current evidence indicates that PNS can promote the recovery of motor function in the rats with TSCI. Due to limited quality of the included studies,the above conclusion should be verified by conducting more large-scale,high quality RCTs.展开更多
文摘[Objectives] To systemically review the efficacy and safety of Panax Notoginseng Saponins( PNS) in the treatment of traumatic spinal-cord injury( TSCI) in rat models. [Methods] Randomized controlled trials( RCT) about the effects of PNS for TSCI in rats were searched in Pub Med,EMbase,The Cochrane Library,CBM,CNKI,Wan Fang Data from inception to November 2016. Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data,and assessed the risk of bias of included studies.Then Meta-analysis was performed using Rev Man 5. 3 software. [Results] A total of 6 RCTs involving 264 rats were included. The results of Meta-analysis showed that: compared with the control group,the Basso,Beattie and Bresnahan( BBB) scores in the PNS group were superior in 7 days( SMD = 1. 81,95% CI( 1. 18,2. 43),P < 0. 00001),14 days( SMD = 1. 92,95% CI( 1. 51,2. 33),P < 0. 00001),21 days( SMD =2. 33,95% CI( 0. 98,3. 68),P <0. 0007) and 28 days( SMD =2. 72,95% CI( 1. 78,3. 67),P <0. 00001) after surgery. The results of Meta-analysis showed that: compared with the control group,ramp test in the PNS group were superior in 7 days [SMD = 1. 55,95% CI( 0. 78,2. 31),P <0. 0001]and 14 days[SMD =1. 83,95% CI( 1. 46,2. 20),P < 0. 00001]. [Conclusions] Current evidence indicates that PNS can promote the recovery of motor function in the rats with TSCI. Due to limited quality of the included studies,the above conclusion should be verified by conducting more large-scale,high quality RCTs.
