In this work,TTHMP was synthesized and labelled with ^(117m)Sn.The preparation conditions,stability and lipophilicity of ^(117m)Sn(Ⅳ)-TTHMP were investigated.Biodistribution of the complex in rabbits and mice was stu...In this work,TTHMP was synthesized and labelled with ^(117m)Sn.The preparation conditions,stability and lipophilicity of ^(117m)Sn(Ⅳ)-TTHMP were investigated.Biodistribution of the complex in rabbits and mice was studied. It was found that the quantity of TTHMP and pH value of the preparation solution had vital effects on the labeling yield of ^(117m)Sn(Ⅳ)-TTHMP.It was also found that ^(117)Sn(Ⅳ)-TTHMP was hydrophilic and stable at room tempera- ture and 37℃in open air.^(117m)Sn(Ⅳ)-TTHMP showed unexpectedly high bone uptake and bone-to-blood ratio in the animals.This made it potentially useful as an reagent for skeletal scintigraphy and radiotherapy of bone tumors.展开更多
TTHMP (triethylenetetraaminehexamethylenephosphonic acid) was labeled with 153Sm. The labeling condition, stability, mole ratio of 153Sm to TTHMP, rabbit bone imaging and bio-distribution of 153Sm-TTHMP in mice were i...TTHMP (triethylenetetraaminehexamethylenephosphonic acid) was labeled with 153Sm. The labeling condition, stability, mole ratio of 153Sm to TTHMP, rabbit bone imaging and bio-distribution of 153Sm-TTHMP in mice were investigated. The results showed that weak basic media and high concentration ligands were favorable to form 153Sm-TTHMP; labeling compounds were stable at pH 7 in 7 days. The results also indicated that the chemical mole ratio of 153Sm-TTHMP is n(153Sm)﹕n(TTHMP) = 1﹕1 and skeleton uptake of 153Sm-TTHMP is high((13.96(3.51)%/g at 1h post injection and (13.54(2.98)%/g at 48h post injection), while the non-target tissue uptake is relatively low, so 153Sm-TTHMP is a promising bone tumor therapeutic agent.展开更多
基金Supported by Master Foundation of Institute of Nuclear Physics and Chemistry,CAEP(2005CX09)
文摘In this work,TTHMP was synthesized and labelled with ^(117m)Sn.The preparation conditions,stability and lipophilicity of ^(117m)Sn(Ⅳ)-TTHMP were investigated.Biodistribution of the complex in rabbits and mice was studied. It was found that the quantity of TTHMP and pH value of the preparation solution had vital effects on the labeling yield of ^(117m)Sn(Ⅳ)-TTHMP.It was also found that ^(117)Sn(Ⅳ)-TTHMP was hydrophilic and stable at room tempera- ture and 37℃in open air.^(117m)Sn(Ⅳ)-TTHMP showed unexpectedly high bone uptake and bone-to-blood ratio in the animals.This made it potentially useful as an reagent for skeletal scintigraphy and radiotherapy of bone tumors.
文摘TTHMP (triethylenetetraaminehexamethylenephosphonic acid) was labeled with 153Sm. The labeling condition, stability, mole ratio of 153Sm to TTHMP, rabbit bone imaging and bio-distribution of 153Sm-TTHMP in mice were investigated. The results showed that weak basic media and high concentration ligands were favorable to form 153Sm-TTHMP; labeling compounds were stable at pH 7 in 7 days. The results also indicated that the chemical mole ratio of 153Sm-TTHMP is n(153Sm)﹕n(TTHMP) = 1﹕1 and skeleton uptake of 153Sm-TTHMP is high((13.96(3.51)%/g at 1h post injection and (13.54(2.98)%/g at 48h post injection), while the non-target tissue uptake is relatively low, so 153Sm-TTHMP is a promising bone tumor therapeutic agent.
