目的系统评价携带细胞色素P450家族3亚家族A成员5(CYP3A5)*1对移植患儿他克莫司给药剂量、血药浓度和血药浓度/给药剂量(C/D)值的影响。方法计算机检索PubMed、Scopus、ISI Web of Science、ProQuest、中国知网、维普资讯中文期刊服务...目的系统评价携带细胞色素P450家族3亚家族A成员5(CYP3A5)*1对移植患儿他克莫司给药剂量、血药浓度和血药浓度/给药剂量(C/D)值的影响。方法计算机检索PubMed、Scopus、ISI Web of Science、ProQuest、中国知网、维普资讯中文期刊服务平台、万方数据知识服务平台,纳入携带CYP3A5*1(CYP3A5*1/*1或CYP3A5*1/*3)对移植患儿他克莫司给药剂量、血药浓度、C/D值影响的文献。评价文献质量及提取资料后,采用RevMan 5.3软件进行Meta分析。结果共纳入13篇文献进行Meta分析。Meta分析结果显示,在移植后第1、2、3、6、12个月时,CYP3A5*1携带者和非携带者的他克莫司给药剂量差异有统计学意义(P<0.05),其中携带者的他克莫司给药剂量更大;在移植后第1、2周和第1、2、6个月,CYP3A5*1携带者的他克莫司血药浓度低于CYP3A5*1非携带者(P<0.05);在移植后第1、2周和第1、2、3、4、5、6、7、8、9、10、11、12个月,CYP3A5*1携带者的他克莫司C/D值低于CYP3A5*1非携带者(P<0.05)。结论在移植患儿中,CYP3A5*1携带者和非携带者移植后的他克莫司给药剂量、血药浓度和C/D值存在明显差异,其中CYP3A5*1携带者所需的他克莫司剂量更大。在给药前进行CYP3A基因多态性检测有助于预测个体所需剂量。展开更多
Effects of antimicrobial peptides(AMP)added to diets on aquatic animal health and body function are influenced by multiple factors such as animal species,initial body weight,the dosage of AMP and feeding duration.Howe...Effects of antimicrobial peptides(AMP)added to diets on aquatic animal health and body function are influenced by multiple factors such as animal species,initial body weight,the dosage of AMP and feeding duration.However,there is limited knowledge on the relationship between these factors and the body function of aquatic animals.Here,we aimed to perform multiple meta-analyses to investigate the effects of dietary AMP on growth performance(feed conversion ratio[FCR],specific growth rate[SGR]),enzyme activity(superoxide dismutase activity[SOD],lysozyme activity[LSA]),disease resistance(cumulative survival rate[CSR],the expression of immune-related genes[GENE])and the abundance of gut microbiota(MICRO)from a pool of empirical studies.Additionally,the dose-effect model was applied to determine the optimal AMP dose,initial body weight and feeding duration to maximize body function.To conduct the meta-analyses,we included 34 publications that estimated 705 effect sizes across 21 fish,2 shrimp and 2 shellfish species.The results confirmed that the inclusion of AMP in the diet can significantly improve SGR,SOD,LSA,CSR and GENE and decrease FCR for aquatic animals.Interestingly,our findings implied a slight positive effect of AMP on MICRO albeit with a limited number of studies available on fish gut microbial communities.Although no significant linear or quadratic relationship was predicted by meta-regression,the dose-effect indicated that the optimal AMP doses for FCR,SGR,SOD and LSA were 707.5,750.0,1,050.0 and 937.5 mg/kg,respectively.Taken together,fish with an initial body weight of 30 g could be fed with a dose of 600 to 800 mg/kg for 2 mo when AMP-supplemented diets were applied in aquaculture,which can effectively improve body function and health while lowering aquafeed costs.In addition,more studies should address fish gut microbiota to delimitate the influence of dietary AMP on MICRO in the future.展开更多
文摘目的系统评价携带细胞色素P450家族3亚家族A成员5(CYP3A5)*1对移植患儿他克莫司给药剂量、血药浓度和血药浓度/给药剂量(C/D)值的影响。方法计算机检索PubMed、Scopus、ISI Web of Science、ProQuest、中国知网、维普资讯中文期刊服务平台、万方数据知识服务平台,纳入携带CYP3A5*1(CYP3A5*1/*1或CYP3A5*1/*3)对移植患儿他克莫司给药剂量、血药浓度、C/D值影响的文献。评价文献质量及提取资料后,采用RevMan 5.3软件进行Meta分析。结果共纳入13篇文献进行Meta分析。Meta分析结果显示,在移植后第1、2、3、6、12个月时,CYP3A5*1携带者和非携带者的他克莫司给药剂量差异有统计学意义(P<0.05),其中携带者的他克莫司给药剂量更大;在移植后第1、2周和第1、2、6个月,CYP3A5*1携带者的他克莫司血药浓度低于CYP3A5*1非携带者(P<0.05);在移植后第1、2周和第1、2、3、4、5、6、7、8、9、10、11、12个月,CYP3A5*1携带者的他克莫司C/D值低于CYP3A5*1非携带者(P<0.05)。结论在移植患儿中,CYP3A5*1携带者和非携带者移植后的他克莫司给药剂量、血药浓度和C/D值存在明显差异,其中CYP3A5*1携带者所需的他克莫司剂量更大。在给药前进行CYP3A基因多态性检测有助于预测个体所需剂量。
文摘Effects of antimicrobial peptides(AMP)added to diets on aquatic animal health and body function are influenced by multiple factors such as animal species,initial body weight,the dosage of AMP and feeding duration.However,there is limited knowledge on the relationship between these factors and the body function of aquatic animals.Here,we aimed to perform multiple meta-analyses to investigate the effects of dietary AMP on growth performance(feed conversion ratio[FCR],specific growth rate[SGR]),enzyme activity(superoxide dismutase activity[SOD],lysozyme activity[LSA]),disease resistance(cumulative survival rate[CSR],the expression of immune-related genes[GENE])and the abundance of gut microbiota(MICRO)from a pool of empirical studies.Additionally,the dose-effect model was applied to determine the optimal AMP dose,initial body weight and feeding duration to maximize body function.To conduct the meta-analyses,we included 34 publications that estimated 705 effect sizes across 21 fish,2 shrimp and 2 shellfish species.The results confirmed that the inclusion of AMP in the diet can significantly improve SGR,SOD,LSA,CSR and GENE and decrease FCR for aquatic animals.Interestingly,our findings implied a slight positive effect of AMP on MICRO albeit with a limited number of studies available on fish gut microbial communities.Although no significant linear or quadratic relationship was predicted by meta-regression,the dose-effect indicated that the optimal AMP doses for FCR,SGR,SOD and LSA were 707.5,750.0,1,050.0 and 937.5 mg/kg,respectively.Taken together,fish with an initial body weight of 30 g could be fed with a dose of 600 to 800 mg/kg for 2 mo when AMP-supplemented diets were applied in aquaculture,which can effectively improve body function and health while lowering aquafeed costs.In addition,more studies should address fish gut microbiota to delimitate the influence of dietary AMP on MICRO in the future.
