BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induce...BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.展开更多
目的:观察活血化瘀法对髋部骨折患者围手术期D-二聚体的影响,探讨活血化瘀法对髋部骨折并发下肢深静脉栓塞的防治作用。方法:选我院治疗的髋部骨折患者46例,随机分为两组,每组各23例。治疗组术前1天、术后1周连续静滴0.9%NS250 m L+复...目的:观察活血化瘀法对髋部骨折患者围手术期D-二聚体的影响,探讨活血化瘀法对髋部骨折并发下肢深静脉栓塞的防治作用。方法:选我院治疗的髋部骨折患者46例,随机分为两组,每组各23例。治疗组术前1天、术后1周连续静滴0.9%NS250 m L+复方丹参注射液20 m L,每天1次。术后第1天开始服用桃红四物汤,每日1剂,连续服用1周;对照组术前1天、术后连续1周腹壁皮下注射低分子肝素(速碧林)0.4 m L,每天1次。两组均于术前1天、术后1、3、7天,清晨空腹抽血测定静脉血D-二聚体含量。结果:术前1天、术后1天、术后3天2组D-二聚体含量比较,差异无统计学意义(P>0.05),术后7天2组D-二聚体差异有统计学意义(P<0.05)。结论:活血化瘀法对髋部骨折患者围手术期血浆D-二聚体含量有降低作用,可有效降低髋部骨折术后下肢深静脉栓塞形成的风险,是一种安全、可行和有效的治疗方案。展开更多
基金Supported by Liaoning Province“Xingliao Talent Program”Project,No.XLYC2007019.
文摘BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.
文摘目的:观察活血化瘀法对髋部骨折患者围手术期D-二聚体的影响,探讨活血化瘀法对髋部骨折并发下肢深静脉栓塞的防治作用。方法:选我院治疗的髋部骨折患者46例,随机分为两组,每组各23例。治疗组术前1天、术后1周连续静滴0.9%NS250 m L+复方丹参注射液20 m L,每天1次。术后第1天开始服用桃红四物汤,每日1剂,连续服用1周;对照组术前1天、术后连续1周腹壁皮下注射低分子肝素(速碧林)0.4 m L,每天1次。两组均于术前1天、术后1、3、7天,清晨空腹抽血测定静脉血D-二聚体含量。结果:术前1天、术后1天、术后3天2组D-二聚体含量比较,差异无统计学意义(P>0.05),术后7天2组D-二聚体差异有统计学意义(P<0.05)。结论:活血化瘀法对髋部骨折患者围手术期血浆D-二聚体含量有降低作用,可有效降低髋部骨折术后下肢深静脉栓塞形成的风险,是一种安全、可行和有效的治疗方案。
