THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to pos...THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real environments.In this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].展开更多
BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induce...BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.展开更多
WE are in an exciting new intelligent era where various Web 3.0 systems emerge and flourish.[1]–[3].In this new epoch,the collaboration of data and knowledge,humans and machines,actual and virtual worlds is undergoin...WE are in an exciting new intelligent era where various Web 3.0 systems emerge and flourish.[1]–[3].In this new epoch,the collaboration of data and knowledge,humans and machines,actual and virtual worlds is undergoing an unprecedented diversification and community-driven transformation,unveiling an open future full of boundless possibilities.However,the value of dispersed data extends far beyond passive storage and application.展开更多
It is universally accepted that the philosophy of the Tao is the essence that animates the Chinese Cosmogony. Therefore, in last decades I have tried to consolidate its scientific background, looking for solid explana...It is universally accepted that the philosophy of the Tao is the essence that animates the Chinese Cosmogony. Therefore, in last decades I have tried to consolidate its scientific background, looking for solid explanations through Exact Sciences (“Between Heaven and Earth” Scientific Basis of the Action of Shao Yin: Lightning’s Physical-Mathematical Analysis”;“Is Traditional Chinese Medicine Definitely an Exact Science?”;“Euclidean Geometry and Traditional Chinese Medicine: Diving into the Real Origin of the Five Elements”;“Solitons: A Cutting-Edge Scientific Proposal Explaining the Mechanisms of Acupuntural Action”) Currently, research on Chinese medicine leads us—with Dr. Erica Arakaki, collaborator and assistant—to verify through a profound bibliographic review the application of Fibonacci’s Golden Ratio in the constitution of T’ai Ji Tu, adding yet more substance to the hypothesis of Acupuncture and demonstrating how said Chinese Ancient Science is not only an empirical knowledge but a wisdom derived from the most ancient exact science: Geometry.展开更多
In the evolution of modern railway thought,it includes not only the discussion of railway planning,sovereignty,debt,and construction,but also the discussion of spiritual guiding ideology such as“Tao,body and utility...In the evolution of modern railway thought,it includes not only the discussion of railway planning,sovereignty,debt,and construction,but also the discussion of spiritual guiding ideology such as“Tao,body and utility”and“material and spirit”.From the perspective of the relationship between road and equipment,the development of modern railway thought in China has experienced three stages.During the Westernization Movement,Li Hongzhang and other people expounded the benefits brought by railway construction from the angle of“utility”,and believed that there was still a unity of“Tao and style”.After the Sino-Japanese Naval Battle,with the emergence of the theory of railway sovereignty and the theory of dividing China,Kang Youwei and others questioned the thought of Westernization school.The unified Tao body was divided into two parts:China and the West.After the May Fourth Movement,railway,as a product of western material civilization,was compared with Eastern spiritual civilization by Liang Shuming,Li Dazhao,and others.The conflict between material and spirit made the Western“Tao style”evolve into the Europe-American way of pursuing“scientific spirit”and the Soviet-Russian way of exploring the ideas of revolution and transformation.The railway has thus become an important carrier of the“scientific spirit”and socialism.展开更多
基金supported by the National Natural Science Foundation of China(62302047,62203250)the Science and Technology Development Fund of Macao SAR(0093/2023/RIA2,0050/2020/A1).
文摘THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real environments.In this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].
基金Supported by Liaoning Province“Xingliao Talent Program”Project,No.XLYC2007019.
文摘BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.
基金partially supported by the National Natural Science Foundation of China (62103411)the Science and Technology Development Fund of Macao SAR (0050/2020/A1)。
文摘WE are in an exciting new intelligent era where various Web 3.0 systems emerge and flourish.[1]–[3].In this new epoch,the collaboration of data and knowledge,humans and machines,actual and virtual worlds is undergoing an unprecedented diversification and community-driven transformation,unveiling an open future full of boundless possibilities.However,the value of dispersed data extends far beyond passive storage and application.
文摘It is universally accepted that the philosophy of the Tao is the essence that animates the Chinese Cosmogony. Therefore, in last decades I have tried to consolidate its scientific background, looking for solid explanations through Exact Sciences (“Between Heaven and Earth” Scientific Basis of the Action of Shao Yin: Lightning’s Physical-Mathematical Analysis”;“Is Traditional Chinese Medicine Definitely an Exact Science?”;“Euclidean Geometry and Traditional Chinese Medicine: Diving into the Real Origin of the Five Elements”;“Solitons: A Cutting-Edge Scientific Proposal Explaining the Mechanisms of Acupuntural Action”) Currently, research on Chinese medicine leads us—with Dr. Erica Arakaki, collaborator and assistant—to verify through a profound bibliographic review the application of Fibonacci’s Golden Ratio in the constitution of T’ai Ji Tu, adding yet more substance to the hypothesis of Acupuncture and demonstrating how said Chinese Ancient Science is not only an empirical knowledge but a wisdom derived from the most ancient exact science: Geometry.
文摘In the evolution of modern railway thought,it includes not only the discussion of railway planning,sovereignty,debt,and construction,but also the discussion of spiritual guiding ideology such as“Tao,body and utility”and“material and spirit”.From the perspective of the relationship between road and equipment,the development of modern railway thought in China has experienced three stages.During the Westernization Movement,Li Hongzhang and other people expounded the benefits brought by railway construction from the angle of“utility”,and believed that there was still a unity of“Tao and style”.After the Sino-Japanese Naval Battle,with the emergence of the theory of railway sovereignty and the theory of dividing China,Kang Youwei and others questioned the thought of Westernization school.The unified Tao body was divided into two parts:China and the West.After the May Fourth Movement,railway,as a product of western material civilization,was compared with Eastern spiritual civilization by Liang Shuming,Li Dazhao,and others.The conflict between material and spirit made the Western“Tao style”evolve into the Europe-American way of pursuing“scientific spirit”and the Soviet-Russian way of exploring the ideas of revolution and transformation.The railway has thus become an important carrier of the“scientific spirit”and socialism.
