During the three decades after the adoption of the Declaration on the Right to Development, the right to development has received wider acknowledgement throughout the international community, and has become a typical ...During the three decades after the adoption of the Declaration on the Right to Development, the right to development has received wider acknowledgement throughout the international community, and has become a typical example of 'third-generation rights.' The 2030 Agenda for Sustainable Development, which puts forward 17 goals of sustainable development, was adopted at the UN Sustainable Development Summit on September 25, 2015. From the contents of the agenda, we can see that the 2030 Agenda for Sustainable Development highly conforms to the right to development. Both match, not only in purpose and content, but also in object and subject, as well as in demands for countries and the foundations needed. We may regard the 2030 Agenda for Sustainable Development as setting action targets for the realization of the right to development in the new era. Meanwhile, to realize the right to development in the new situation is to accomplish the aim of the 2030 Agenda for Sustainable Development. The two adopt different approaches that lead to the same destination.展开更多
In April 2009, after receiving ap- proval from the State Council, the Information Office of the State Council published the NationalHuman Rights Action Plan of China （2009-2010）. It is China＇s first national plan o...In April 2009, after receiving ap- proval from the State Council, the Information Office of the State Council published the NationalHuman Rights Action Plan of China （2009-2010）. It is China＇s first national plan on the theme of human rights, and serves as a policy document of the current stage for advancing China＇s human rights in a comprehensive way. It is an important move to implement the constitutional principle of respect- ing and safeguarding human rights, and to promote sustainable development and social harmony. It is also a solemn commitment to the world made by the Chinese government on human rights.展开更多
针对人体动作识别任务中特征值选取不当导致识别率低、使用多模态数据导致训练成本高等问题,提出一种轻量级人体动作识别方法。首先使用OpenPose、PoseNet提取出人体骨架信息,使用BWT69CL传感器提取姿势信息;其次对数据进行预处理、特...针对人体动作识别任务中特征值选取不当导致识别率低、使用多模态数据导致训练成本高等问题,提出一种轻量级人体动作识别方法。首先使用OpenPose、PoseNet提取出人体骨架信息,使用BWT69CL传感器提取姿势信息;其次对数据进行预处理、特征融合,对人体动作进行深度学习分类识别;最后,为验证此方法的有效性,在公开数据集WISDM、UCIHAR、HASC和自建的人体动作数据集上进行实验验证,并使用改进的目标引导注意力机制(target-guided attention,TGA)–长短期记忆(long short term memory,LSTM)网络输出最终的分类结果。实验结果表明,在自建数据集下融合姿势和骨架特征达到99.87%准确率,相比于只使用姿势信息特征,识别准确率提高了约5.31个百分点;相比于只使用人体骨架特征,识别准确率提高了约1.87个百分点;在识别时间上相比于只使用姿势信息,识别时间降低了约29.73 s;相比于只使用人体骨架数据,识别时间降低了约9 s。使用该方法能及时有效地反映人体的运动意图,有助于提高人体动作和行为的识别准确率和训练效率。展开更多
胃癌是最常见的恶性肿瘤之一,患者多采用手术、放化疗及免疫治疗,但临床疗效及预后欠佳。去整合素⁃金属蛋白酶(a disintegrin and metalloproteinase,ADAM)17作为ADAMs家族的重要成员,在胃癌组织中的表达显著高于癌旁组织,并通过介导EGF...胃癌是最常见的恶性肿瘤之一,患者多采用手术、放化疗及免疫治疗,但临床疗效及预后欠佳。去整合素⁃金属蛋白酶(a disintegrin and metalloproteinase,ADAM)17作为ADAMs家族的重要成员,在胃癌组织中的表达显著高于癌旁组织,并通过介导EGFR和TNF⁃α、TGF⁃β/Smad、Notch和Wnt、FoxM1⁃ADAM17以及EGFR/ERK/SP1等信号通路参与胃癌的发生发展,其高表达与预后不良密切相关,提示ADAM17可作为胃癌的生物学指标,预测胃癌发展,有望成为胃癌新的治疗靶点。本文就ADAM17在胃癌发展中的作用机制、治疗及预测研究进展作一综述,以期为胃癌临床诊疗提供新思路。展开更多
背景:鸢尾素在机体生理调节中发挥着至关重要的作用,能够促进白色脂肪组织细胞的棕色化进程,并且在能量代谢调节、产热活动、氧化应激削减及体质量减轻等方面具有显著作用。目的:梳理鸢尾素与相关疾病的最新研究进展。方法:应用计算机检...背景:鸢尾素在机体生理调节中发挥着至关重要的作用,能够促进白色脂肪组织细胞的棕色化进程,并且在能量代谢调节、产热活动、氧化应激削减及体质量减轻等方面具有显著作用。目的:梳理鸢尾素与相关疾病的最新研究进展。方法:应用计算机检索PubMed、MedReading、Web of Science、中国知网、万方、维普数据库,文献检索时限为2011-01-01/2024-04-13,搜集相关运动产生鸢尾素对疾病影响的研究,中文检索词为“鸢尾素,运动,疾病”等,英文检索词为“irisin,physical exercise,FNDC5,disease”等。通过纳入与排除标准,最终纳入71篇文献进行综述。结果与结论:鸢尾素在抗炎、脂肪代谢、骨代谢、大脑健康、癌症、糖尿病、心血管疾病及肾脏病等方面均有重要作用。运动可以促进鸢尾素的表达,并且不同运动形式对鸢尾素水平的影响不同,急性运动、长期运动、阻力及高强度运动均可提升鸢尾素水平。鸢尾素的发现为运动疗法提供了新的潜在基础,因鸢尾素多种生物学功能成为很有前途的治疗靶点,在治疗人类代谢性疾病及其并发症、肥胖、癌症等疾病中展现出潜在治疗价值。在临床应用方面,鸢尾素作为治疗肥胖、认知功能、心血管、癌症等疾病的潜在靶点,有一定应用前景。但鸢尾素的具体作用机制尚不明确,并且可能存在不良反应,未来需深入了解其作用机制,为鸢尾素治疗肥胖、认知功能障碍、心血管疾病、癌症等提供更充分的依据。展开更多
[目的]采用数据挖掘和网络药理学初步探讨大血藤治疗高脂血症的可能作用机制。[方法]借助PubMed和CNKI检索“大血藤化学成分”或“红藤成分”进行资料收集和化合物筛选,用Origin Pro 2021软件对涉及中药的功效类别等进行频数分析,用SPSS...[目的]采用数据挖掘和网络药理学初步探讨大血藤治疗高脂血症的可能作用机制。[方法]借助PubMed和CNKI检索“大血藤化学成分”或“红藤成分”进行资料收集和化合物筛选,用Origin Pro 2021软件对涉及中药的功效类别等进行频数分析,用SPSS Modeler 18.0软件进行关联规则分析和聚类分析。利用Swiss ADME平台来预测候选化合物的吸收度和类药性的相关参数。采用Swiss Target Prediction平台来收集预测到的所有靶点,以“hyperlipidemia”“dyslipidemia”等为关键词检索Genegards、Drug Bank Database等数据库中高脂血症的潜在靶点,通过Uniprot数据库去重和校正靶点名称,取活性成分和高脂血症靶点交集,进而运用Cytoscape 3.8.0软件来进行网络可视化并筛选核心靶点基因。通过DAVID 6.8数据库进行基因本体(GO)功能富集分析和京都基因和基因组百科全书(KEGG)通路富集分析,预测交集靶点作用机制,并绘制气泡图等进行可视化。[结果]通过数据挖掘对大血藤的用药配伍规律进行分析,结果显示性味以温性、寒性和苦味、辛味为主,归经方面以肝、脾为主,配伍以当归、甘草、红花等关联密切,研究结果与中药治疗高脂血症用药规律一致。中药-化合物-靶点网络包含了43个活性成分和相应靶点133个,关键靶点涉及类视黄酸受体α(RXRA)、信号转导及转录激活蛋白3(STAT3)、90 kDa热休克蛋白αA1(HSP90AA1)、蛋白激酶Bα(AKT1)、磷酸肌醇3-激酶调节亚基1(PIK3R1)、雌激素受体1(ESR1)、过氧化物酶体增殖物激活受体(PPAR)A、核受体亚家族3C组成员1(NR3C1)等。GO功能富集分析得到条目437个(P<0.01),KEGG通路富集分析筛选得到57条信号通路(P<0.05)。[结论]大血藤可以通过多个活性成分干预血脂异常中的多个靶点、多个环节,从多维、系统的层面参与调控血脂代谢和高脂血症的发生发展过程,为大血藤的进一步开发利用提供理论基础。展开更多
文摘During the three decades after the adoption of the Declaration on the Right to Development, the right to development has received wider acknowledgement throughout the international community, and has become a typical example of 'third-generation rights.' The 2030 Agenda for Sustainable Development, which puts forward 17 goals of sustainable development, was adopted at the UN Sustainable Development Summit on September 25, 2015. From the contents of the agenda, we can see that the 2030 Agenda for Sustainable Development highly conforms to the right to development. Both match, not only in purpose and content, but also in object and subject, as well as in demands for countries and the foundations needed. We may regard the 2030 Agenda for Sustainable Development as setting action targets for the realization of the right to development in the new era. Meanwhile, to realize the right to development in the new situation is to accomplish the aim of the 2030 Agenda for Sustainable Development. The two adopt different approaches that lead to the same destination.
文摘In April 2009, after receiving ap- proval from the State Council, the Information Office of the State Council published the NationalHuman Rights Action Plan of China （2009-2010）. It is China＇s first national plan on the theme of human rights, and serves as a policy document of the current stage for advancing China＇s human rights in a comprehensive way. It is an important move to implement the constitutional principle of respect- ing and safeguarding human rights, and to promote sustainable development and social harmony. It is also a solemn commitment to the world made by the Chinese government on human rights.
文摘针对人体动作识别任务中特征值选取不当导致识别率低、使用多模态数据导致训练成本高等问题,提出一种轻量级人体动作识别方法。首先使用OpenPose、PoseNet提取出人体骨架信息,使用BWT69CL传感器提取姿势信息;其次对数据进行预处理、特征融合,对人体动作进行深度学习分类识别;最后,为验证此方法的有效性,在公开数据集WISDM、UCIHAR、HASC和自建的人体动作数据集上进行实验验证,并使用改进的目标引导注意力机制(target-guided attention,TGA)–长短期记忆(long short term memory,LSTM)网络输出最终的分类结果。实验结果表明,在自建数据集下融合姿势和骨架特征达到99.87%准确率,相比于只使用姿势信息特征,识别准确率提高了约5.31个百分点;相比于只使用人体骨架特征,识别准确率提高了约1.87个百分点;在识别时间上相比于只使用姿势信息,识别时间降低了约29.73 s;相比于只使用人体骨架数据,识别时间降低了约9 s。使用该方法能及时有效地反映人体的运动意图,有助于提高人体动作和行为的识别准确率和训练效率。
文摘胃癌是最常见的恶性肿瘤之一,患者多采用手术、放化疗及免疫治疗,但临床疗效及预后欠佳。去整合素⁃金属蛋白酶(a disintegrin and metalloproteinase,ADAM)17作为ADAMs家族的重要成员,在胃癌组织中的表达显著高于癌旁组织,并通过介导EGFR和TNF⁃α、TGF⁃β/Smad、Notch和Wnt、FoxM1⁃ADAM17以及EGFR/ERK/SP1等信号通路参与胃癌的发生发展,其高表达与预后不良密切相关,提示ADAM17可作为胃癌的生物学指标,预测胃癌发展,有望成为胃癌新的治疗靶点。本文就ADAM17在胃癌发展中的作用机制、治疗及预测研究进展作一综述,以期为胃癌临床诊疗提供新思路。
文摘背景:鸢尾素在机体生理调节中发挥着至关重要的作用,能够促进白色脂肪组织细胞的棕色化进程,并且在能量代谢调节、产热活动、氧化应激削减及体质量减轻等方面具有显著作用。目的:梳理鸢尾素与相关疾病的最新研究进展。方法:应用计算机检索PubMed、MedReading、Web of Science、中国知网、万方、维普数据库,文献检索时限为2011-01-01/2024-04-13,搜集相关运动产生鸢尾素对疾病影响的研究,中文检索词为“鸢尾素,运动,疾病”等,英文检索词为“irisin,physical exercise,FNDC5,disease”等。通过纳入与排除标准,最终纳入71篇文献进行综述。结果与结论:鸢尾素在抗炎、脂肪代谢、骨代谢、大脑健康、癌症、糖尿病、心血管疾病及肾脏病等方面均有重要作用。运动可以促进鸢尾素的表达,并且不同运动形式对鸢尾素水平的影响不同,急性运动、长期运动、阻力及高强度运动均可提升鸢尾素水平。鸢尾素的发现为运动疗法提供了新的潜在基础,因鸢尾素多种生物学功能成为很有前途的治疗靶点,在治疗人类代谢性疾病及其并发症、肥胖、癌症等疾病中展现出潜在治疗价值。在临床应用方面,鸢尾素作为治疗肥胖、认知功能、心血管、癌症等疾病的潜在靶点,有一定应用前景。但鸢尾素的具体作用机制尚不明确,并且可能存在不良反应,未来需深入了解其作用机制,为鸢尾素治疗肥胖、认知功能障碍、心血管疾病、癌症等提供更充分的依据。
