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Propofol sedation in routine endoscopy:A case series comparing target controlled infusion vs manually controlled bolus concept
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作者 Riad Sarraj Lorenz Theiler +2 位作者 Nima Vakilzadeh Niklas Krupka Reiner Wiest 《World Journal of Gastrointestinal Endoscopy》 2024年第1期11-17,共7页
BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedatio... BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedation regimen by avoiding under-or oversedation.AIM To assess safety and performance of propofol TCI sedation in comparison with nurse-administered bolus-sedation.METHODS Fouty-five patients undergoing endoscopy under TCI propofol sedation were prospectively included from November 2016 to May 2017 and compared to 87 patients retrospectively included that underwent endoscopy with NAPS.Patients were matched for age and endoscopic procedure.We recorded time of sedation and endoscopy,dosage of medication and adverse events.RESULTS There was a significant reduction in dose per time of propofol administered in the TCI group,compared to the NAPS group(8.2±2.7 mg/min vs 9.3±3.4 mg/min;P=0.046).The time needed to provide adequate sedation levels was slightly but significantly lower in the control group(5.3±2.7 min vs 7.7±3.3 min;P<0.001),nonetheless the total endoscopy time was similar in both groups.No differences between TCI and bolus-sedation was observed for mean total-dosage of propofol rate as well as adverse events.CONCLUSION This study indicates that sedation using TCI for GI endoscopy reduces the dose of propofol necessary per minute of endoscopy.This may translate into less adverse events.However,further and randomized trials need to confirm this trend. 展开更多
关键词 SEDATION ENDOSCOPY PROPOFOL target controlled infusion Non-anaesthesiologist propofol sedation Adverse event
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丙泊酚-舒芬太尼TCI全凭静脉麻醉用于非停跳冠脉搭桥手术的可行性和剂量探讨 被引量:2
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作者 吴延 岳云 《国际麻醉学与复苏杂志》 CAS 2006年第3期129-133,共5页
关键词 PROPOFOL SUFENTANIL target controlled infusion coronary artery bypass graft
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