Objective The study sought to investigate the clinical predictive value of quantitative flow ratio(QFR)for the long-term target vessel failure(TVF)outcome in patients with in-stent restenosis(ISR)by using drug-coated ...Objective The study sought to investigate the clinical predictive value of quantitative flow ratio(QFR)for the long-term target vessel failure(TVF)outcome in patients with in-stent restenosis(ISR)by using drug-coated balloon(DCB)treatment after a long-term follow-up.Methods This was a retrospective study.A total of 186 patients who underwent DCB angioplasty for ISR in two hospitals from March 2014 to September 2019 were enrolled.The QFR of the entire target vessel was measured offline.The primary endpoint was TVF,including target vessel-cardiac death(TV-CD),target vessel-myocardial infarction(TV-MI),and clinically driven-target vessel revascularization(CD-TVR).Results The follow-up time was 3.09±1.53 years,and 50 patients had TVF.The QFR immediately after percutaneous coronary intervention(PCI)was significantly lower in the TVF group than in the no-TVF group.Multivariable Cox regression analysis indicated that the QFR immediately after PCI was an excellent predictor for TVF after the long-term follow-up[hazard ratio(HR):5.15×10−5(6.13×10−8−0.043);P<0.01].Receiver-operating characteristic(ROC)curve analysis demonstrated that the optimal cut-off value of the QFR immediately after PCI for predicting the long-term TVF was 0.925(area under the curve:0.886,95%confidence interval:0.834–0.938;sensitivity:83.40%,specificity:88.00;P<0.01).In addition,QFR≤0.925 post-PCI was strongly correlated with the TVF,including TV-MI and CD-TVR(P<0.01).Conclusion The QFR immediately after PCI showed a high predictive value of TVF after a long-term follow-up in ISR patients who underwent DCB angioplasty.A lower QFR immediately after PCI was associated with a worse TVF outcome.展开更多
A topographic target light scattering-differential optical absorption spectroscopy ('IbTaL-DOA~) system is de- veloped for measuring average concentrations along a known optical path and studying surface-near distr...A topographic target light scattering-differential optical absorption spectroscopy ('IbTaL-DOA~) system is de- veloped for measuring average concentrations along a known optical path and studying surface-near distributions of atmospheric trace gases. The telescope of the ToTaL-DOAS system points to targets which are located at known dis- tances from the measurement device and illuminated by sunlight. Average concentrations with high spatial resolution can be retrieved by receiving sunlight reflected from the targets, A filed measurement of NO2 concentration is performed with the ToTaL-DOAS system in Shijiazhuang in the autumn of 2011. The measurement data are compared with con- centrations measured by the point monitoring technique at the same site. The results show that the ToTaL-DOAS system is sensitive to the variation of NO2 concentrations along the optical path.展开更多
Global Navigation Satellite System(GNSS)-based passive radar(GBPR)has been widely used in remote sensing applications.However,for moving target detection(MTD),the quadratic phase error(QPE)introduced by the non-cooper...Global Navigation Satellite System(GNSS)-based passive radar(GBPR)has been widely used in remote sensing applications.However,for moving target detection(MTD),the quadratic phase error(QPE)introduced by the non-cooperative target motion is usually difficult to be compensated,as the low power level of the GBPR echo signal renders the estimation of the Doppler rate less effective.Consequently,the moving target in GBPR image is usually defocused,which aggravates the difficulty of target detection even further.In this paper,a spawning particle filter(SPF)is proposed for defocused MTD.Firstly,the measurement model and the likelihood ratio function(LRF)of the defocused point-like target image are deduced.Then,a spawning particle set is generated for subsequent target detection,with reference to traditional particles in particle filter(PF)as their parent.After that,based on the PF estimator,the SPF algorithm and its sequential Monte Carlo(SMC)implementation are proposed with a novel amplitude estimation method to decrease the target state dimension.Finally,the effectiveness of the proposed SPF is demonstrated by numerical simulations and pre-liminary experimental results,showing that the target range and Doppler can be estimated accurately.展开更多
扩展目标检测通常采用距离像能量积累检测的方法,由于距离像信息掌握不完备,陷落损失会降低检测性能。本文提出一种距离像先验引导的扩展目标检测方法,通过利用距离像包络模先验,对信号进行积累以提升检测性能。该方法考虑了复距离像与...扩展目标检测通常采用距离像能量积累检测的方法,由于距离像信息掌握不完备,陷落损失会降低检测性能。本文提出一种距离像先验引导的扩展目标检测方法,通过利用距离像包络模先验,对信号进行积累以提升检测性能。该方法考虑了复距离像与复高斯白噪声的相干叠加与相位预测不准的因素,采用将观测数据取模的检测模型,基于似然比检测(Likelihood Ratio Test,LRT)理论推导了低信噪比下的特征平方匹配检测器。该检测器将目标复距离像的包络模与观测数据的包络模进行平方匹配,并通过门限判决来判断目标是否存在。包络模先验的获取是通过从ISAR图像提取二维散射中心,向对应姿态角下的雷达视线方向进行投影,来获得目标近似的一维散射中心模型,再由该模型进一步生成目标距离像的包络模先验。同时,本文从理论与实验两方面分析了能量检测器和特征平方匹配检测器之间的关系,通过散射中心模型重构与暗室测量的方法获取数据进行了实验验证。实验结果表明:在低信噪比下,距离像先验引导的特征平方匹配检测器能有效提升目标的检测性能,并且对先验模型失配的情况具有良好的适应性。展开更多
文章研究了背景为子空间干扰加高斯杂波的距离扩展目标方向检测问题。杂波是均值为零协方差矩阵未知但具有斜对称特性的高斯杂波,目标与干扰分别通过具备斜对称特性的目标子空间和干扰子空间描述。针对方向检测问题,利用上述斜对称性,...文章研究了背景为子空间干扰加高斯杂波的距离扩展目标方向检测问题。杂波是均值为零协方差矩阵未知但具有斜对称特性的高斯杂波,目标与干扰分别通过具备斜对称特性的目标子空间和干扰子空间描述。针对方向检测问题,利用上述斜对称性,根据广义似然比检验(Generalized Likeli-hood Ratio Test,GLRT)准则的一步与两步设计方法,设计了基于GLRT的一步法与两步法的距离扩展目标方向检测器。通过理论推导证明了这2种检测器相对于未知杂波协方差矩阵都具有恒虚警率。对比相同背景下已有检测器,特别是在辅助数据有限的场景下,文章提出的2个检测器表现出了优越的检测性能。展开更多
To the problem of the unknown underwater target detection, according to the feature that the underwater target radiated noise contains the stable line spectrum, a weighted method based on the main-to-side lobe ratio ...To the problem of the unknown underwater target detection, according to the feature that the underwater target radiated noise contains the stable line spectrum, a weighted method based on the main-to-side lobe ratio (MSLR) is proposed for broadband beam-forming. This weighted method can be implemented by using the following steps. Firstly, optimize the spatial spectrum of each frequency unit by the second-order cone programming (SOCP), and obtain the optimized spatial spectrum with lower side lobe. Secondly, construct weighting factors based on the MSLR of the optimized spatial spectrums to from weight factors. Lastly, cumulate the spatial spectrum of each frequency unit via the weight statistical method of this paper. This method can restrain the disturbance of background noise, enhance the output signal-to-noise ratio (SNR), and overcome the difficulty of traditional four-dimensional display. The theoretical analysis and simulation results both verify that this method can well enhance the spatial spectrum of line spectrum units, restrain the spatial spectrum of background noise units, and improve the performance of the broadband beam-forming.展开更多
In this paper, a flexible high-precision calibration method suitable for industrial field was proposed. The complexity of the coordinate transformation was simplified by choosing the camera coordinate system as the un...In this paper, a flexible high-precision calibration method suitable for industrial field was proposed. The complexity of the coordinate transformation was simplified by choosing the camera coordinate system as the unified reference coordinate system. A flexible planar calibration pattern was introduced to the calibration process, which can be arbitrarily placed and from which the known feature points can be extracted to construct other unknown feature points. With the known intrinsic parameters, the laser projector plane equation was fitted by the multi-noncollinear points, which were acquired through the principle of triangulation and the projective invariance of cross ratio. With this method, the strict alignment and multiple times of coordinate transformation can be avoided. Experimental results showed that the arithmetic mean of the root mean square(RMS) error of distance was 0.000 7 mm.展开更多
Irradiated by femtosecond laser pulses with different energies, opened cone targets behave very differently in the transmission of incident laser pulses. The targets, each with an opening angle of 71° and an open...Irradiated by femtosecond laser pulses with different energies, opened cone targets behave very differently in the transmission of incident laser pulses. The targets, each with an opening angle of 71° and an opening of 5 μm, are fabricated using standard semiconductor technology. When the incident laser energy is low and no pre-plasma is generated on the side walls of the cones, the cone target acts like an optical device to reflect the laser pulse, and 15% of the laser energy can be transmitted through the cones. In contrast, when the incident laser energy is high enough to generate pre-plasmas by the pre-pulse of the main pulse that fills the inner cone, the cone with the plasmas will block the transmission of the laser, which leads to a decrease in laser transmission compared with the low-energy case with no plasma. Simulation results using optical software in the low-energy case, and using the particle-in-cell code in the high-energy case, are primarily in agreement with the experimental results.展开更多
基金supported by the Nanjing Municipal Science and Technology Bureau(No.201803008)the Cardiocare Sponsored Optimized Antithrombotic Research Fund(No.BJUHFCSOARF201801-13).
文摘Objective The study sought to investigate the clinical predictive value of quantitative flow ratio(QFR)for the long-term target vessel failure(TVF)outcome in patients with in-stent restenosis(ISR)by using drug-coated balloon(DCB)treatment after a long-term follow-up.Methods This was a retrospective study.A total of 186 patients who underwent DCB angioplasty for ISR in two hospitals from March 2014 to September 2019 were enrolled.The QFR of the entire target vessel was measured offline.The primary endpoint was TVF,including target vessel-cardiac death(TV-CD),target vessel-myocardial infarction(TV-MI),and clinically driven-target vessel revascularization(CD-TVR).Results The follow-up time was 3.09±1.53 years,and 50 patients had TVF.The QFR immediately after percutaneous coronary intervention(PCI)was significantly lower in the TVF group than in the no-TVF group.Multivariable Cox regression analysis indicated that the QFR immediately after PCI was an excellent predictor for TVF after the long-term follow-up[hazard ratio(HR):5.15×10−5(6.13×10−8−0.043);P<0.01].Receiver-operating characteristic(ROC)curve analysis demonstrated that the optimal cut-off value of the QFR immediately after PCI for predicting the long-term TVF was 0.925(area under the curve:0.886,95%confidence interval:0.834–0.938;sensitivity:83.40%,specificity:88.00;P<0.01).In addition,QFR≤0.925 post-PCI was strongly correlated with the TVF,including TV-MI and CD-TVR(P<0.01).Conclusion The QFR immediately after PCI showed a high predictive value of TVF after a long-term follow-up in ISR patients who underwent DCB angioplasty.A lower QFR immediately after PCI was associated with a worse TVF outcome.
基金Project supported by the National High Technology Research and Development of China (Grant No.2009AA063006)the National Natural Science Foundation of China (Grant No. 40905010)the Special Project of Environmental Nonprofit Industry Research,China (Grant No. 201109007)
文摘A topographic target light scattering-differential optical absorption spectroscopy ('IbTaL-DOA~) system is de- veloped for measuring average concentrations along a known optical path and studying surface-near distributions of atmospheric trace gases. The telescope of the ToTaL-DOAS system points to targets which are located at known dis- tances from the measurement device and illuminated by sunlight. Average concentrations with high spatial resolution can be retrieved by receiving sunlight reflected from the targets, A filed measurement of NO2 concentration is performed with the ToTaL-DOAS system in Shijiazhuang in the autumn of 2011. The measurement data are compared with con- centrations measured by the point monitoring technique at the same site. The results show that the ToTaL-DOAS system is sensitive to the variation of NO2 concentrations along the optical path.
基金supported by the National Natural Science Foundation of China(62101014)the National Key Laboratory of Science and Technology on Space Microwave(6142411203307).
文摘Global Navigation Satellite System(GNSS)-based passive radar(GBPR)has been widely used in remote sensing applications.However,for moving target detection(MTD),the quadratic phase error(QPE)introduced by the non-cooperative target motion is usually difficult to be compensated,as the low power level of the GBPR echo signal renders the estimation of the Doppler rate less effective.Consequently,the moving target in GBPR image is usually defocused,which aggravates the difficulty of target detection even further.In this paper,a spawning particle filter(SPF)is proposed for defocused MTD.Firstly,the measurement model and the likelihood ratio function(LRF)of the defocused point-like target image are deduced.Then,a spawning particle set is generated for subsequent target detection,with reference to traditional particles in particle filter(PF)as their parent.After that,based on the PF estimator,the SPF algorithm and its sequential Monte Carlo(SMC)implementation are proposed with a novel amplitude estimation method to decrease the target state dimension.Finally,the effectiveness of the proposed SPF is demonstrated by numerical simulations and pre-liminary experimental results,showing that the target range and Doppler can be estimated accurately.
文摘扩展目标检测通常采用距离像能量积累检测的方法,由于距离像信息掌握不完备,陷落损失会降低检测性能。本文提出一种距离像先验引导的扩展目标检测方法,通过利用距离像包络模先验,对信号进行积累以提升检测性能。该方法考虑了复距离像与复高斯白噪声的相干叠加与相位预测不准的因素,采用将观测数据取模的检测模型,基于似然比检测(Likelihood Ratio Test,LRT)理论推导了低信噪比下的特征平方匹配检测器。该检测器将目标复距离像的包络模与观测数据的包络模进行平方匹配,并通过门限判决来判断目标是否存在。包络模先验的获取是通过从ISAR图像提取二维散射中心,向对应姿态角下的雷达视线方向进行投影,来获得目标近似的一维散射中心模型,再由该模型进一步生成目标距离像的包络模先验。同时,本文从理论与实验两方面分析了能量检测器和特征平方匹配检测器之间的关系,通过散射中心模型重构与暗室测量的方法获取数据进行了实验验证。实验结果表明:在低信噪比下,距离像先验引导的特征平方匹配检测器能有效提升目标的检测性能,并且对先验模型失配的情况具有良好的适应性。
文摘文章研究了背景为子空间干扰加高斯杂波的距离扩展目标方向检测问题。杂波是均值为零协方差矩阵未知但具有斜对称特性的高斯杂波,目标与干扰分别通过具备斜对称特性的目标子空间和干扰子空间描述。针对方向检测问题,利用上述斜对称性,根据广义似然比检验(Generalized Likeli-hood Ratio Test,GLRT)准则的一步与两步设计方法,设计了基于GLRT的一步法与两步法的距离扩展目标方向检测器。通过理论推导证明了这2种检测器相对于未知杂波协方差矩阵都具有恒虚警率。对比相同背景下已有检测器,特别是在辅助数据有限的场景下,文章提出的2个检测器表现出了优越的检测性能。
基金supported by the National Natural Science Foundation of China(Grant No.61372180)the National Key Scientific Instrument Equipment Development Project of China(Grant No.2013YQ140431)
文摘To the problem of the unknown underwater target detection, according to the feature that the underwater target radiated noise contains the stable line spectrum, a weighted method based on the main-to-side lobe ratio (MSLR) is proposed for broadband beam-forming. This weighted method can be implemented by using the following steps. Firstly, optimize the spatial spectrum of each frequency unit by the second-order cone programming (SOCP), and obtain the optimized spatial spectrum with lower side lobe. Secondly, construct weighting factors based on the MSLR of the optimized spatial spectrums to from weight factors. Lastly, cumulate the spatial spectrum of each frequency unit via the weight statistical method of this paper. This method can restrain the disturbance of background noise, enhance the output signal-to-noise ratio (SNR), and overcome the difficulty of traditional four-dimensional display. The theoretical analysis and simulation results both verify that this method can well enhance the spatial spectrum of line spectrum units, restrain the spatial spectrum of background noise units, and improve the performance of the broadband beam-forming.
基金Supported by the National Natural Science Foundation of China(No.51105273)
文摘In this paper, a flexible high-precision calibration method suitable for industrial field was proposed. The complexity of the coordinate transformation was simplified by choosing the camera coordinate system as the unified reference coordinate system. A flexible planar calibration pattern was introduced to the calibration process, which can be arbitrarily placed and from which the known feature points can be extracted to construct other unknown feature points. With the known intrinsic parameters, the laser projector plane equation was fitted by the multi-noncollinear points, which were acquired through the principle of triangulation and the projective invariance of cross ratio. With this method, the strict alignment and multiple times of coordinate transformation can be avoided. Experimental results showed that the arithmetic mean of the root mean square(RMS) error of distance was 0.000 7 mm.
基金supported by National Natural Science Foundation of China(Nos.10925421,10735050,10974250,10935002)
文摘Irradiated by femtosecond laser pulses with different energies, opened cone targets behave very differently in the transmission of incident laser pulses. The targets, each with an opening angle of 71° and an opening of 5 μm, are fabricated using standard semiconductor technology. When the incident laser energy is low and no pre-plasma is generated on the side walls of the cones, the cone target acts like an optical device to reflect the laser pulse, and 15% of the laser energy can be transmitted through the cones. In contrast, when the incident laser energy is high enough to generate pre-plasmas by the pre-pulse of the main pulse that fills the inner cone, the cone with the plasmas will block the transmission of the laser, which leads to a decrease in laser transmission compared with the low-energy case with no plasma. Simulation results using optical software in the low-energy case, and using the particle-in-cell code in the high-energy case, are primarily in agreement with the experimental results.