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Exploration of a New Task-driven Model for Botany Field Practice
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作者 Ying ZHANG Shisheng LI +4 位作者 Jingcai LI Juan CHEN Yuanping FANG Fu XIANG Jun XIANG 《Asian Agricultural Research》 2019年第9期82-84,共3页
In the present context of increasing social demands for natural science education,increasing people s awareness of environmental biodiversity protection,and ecological civilization lifting to the state strategy,it is ... In the present context of increasing social demands for natural science education,increasing people s awareness of environmental biodiversity protection,and ecological civilization lifting to the state strategy,it is just the time to explore a new botany field practice model.The attempt of a new task-driven model for botany field practice will greatly enhance students thinking about plants and nature,plants and environment,and plant and ecological civilization,and will inevitably enhance students initiative awareness and practical ability to protect and rationally utilize plant resources. 展开更多
关键词 task-driven FIELD PRACTICE BOTANY
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Object-oriented Battlefield Environment Simulation Process Object Model Based on Task-driven 被引量:2
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作者 Jie ZHU Xiong YOU +1 位作者 Qing XIA Hongjun ZHANG 《Journal of Geodesy and Geoinformation Science》 2019年第3期31-43,共13页
Battlefield environment simulation process is an important part of battlefield environment information support, which needs to be built around the task process. At present, the interoperability between battlefield env... Battlefield environment simulation process is an important part of battlefield environment information support, which needs to be built around the task process. At present, the interoperability between battlefield environment simulation system and command and control system is still imperfect, and the traditional simulation data model cannot meet war fighters’ high-efficient and accurate understanding and analysis on battlefield environment’s information. Therefore, a kind of task-orientated battlefield environment simulation process model needs to be construed to effectively analyze the key information demands of the command and control system. The structured characteristics of tasks and simulation process are analyzed, and the simulation process concept model is constructed with the method of object-orientated. The data model and formal syntax of GeoBML are analyzed, and the logical model of simulation process is constructed with formal language. The object data structure of simulation process is defined and the object model of simulation process which maps tasks is constructed. In the end, the battlefield environment simulation platform modules are designed and applied based on this model, verifying that the model can effectively express the real-time dynamic correlation between battlefield environment simulation data and operational tasks. 展开更多
关键词 BATTLEFIELD environment simulation GeoBML object-orientated TASK driven process modeling
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Effect of power supply parameters on discharge characteristics and sterilization efficiency of magnetically driven rotating gliding arc
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作者 Shaohua QIN Meizhi WANG +2 位作者 Jun DU Lanlan NIE Jie PAN 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第9期61-68,共8页
Plasma sterilization is a new generation of high-tech sterilization method that is fast,safe,and pollution free.It is widely used in medical,food,and environmental protection fields.Home air sterilization is an emergi... Plasma sterilization is a new generation of high-tech sterilization method that is fast,safe,and pollution free.It is widely used in medical,food,and environmental protection fields.Home air sterilization is an emerging field of plasma application,which puts higher requirements on the miniaturization,operational stability,and operating cost of plasma device.In this study,a novel magnetically driven rotating gliding arc(MDRGA)discharge device was used to sterilize Lactobacillus fermentation.Compared with the traditional gas-driven gliding arc,this device has a simple structure and a more stable gliding arc.Simulation using COMSOL Multiphysics showed that adding permanent magnets can form a stable magnetic field,which is conducive to the formation of gliding arcs.Experiments on the discharge performance,ozone concentration,and sterilization effect were conducted using different power supply parameters.The results revealed that the MDRGA process can be divided into three stages:starting,gliding,and extinguishing.Appropriate voltage was the key factor for stable arc gliding,and both high and low voltages were not conducive to stable arc gliding and ozone production.In this experimental setup,the sterilization effect was the best at 6.6 kV.A high modulation duty ratio was beneficial for achieving stable arc gliding.However,when the duty ratio exceeded a certain value,the improvement in the sterilization effect was slow.Therefore,considering the sterilization effect and energy factors comprehensively,we chose 80%as the optimal modulation duty ratio for this experimental device. 展开更多
关键词 PLASMA magnetically driven rotating gliding arc STERILIZATION
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Data-driven modeling on anisotropic mechanical behavior of brain tissue with internal pressure
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作者 Zhiyuan Tang Yu Wang +3 位作者 Khalil I.Elkhodary Zefeng Yu Shan Tang Dan Peng 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期55-65,共11页
Brain tissue is one of the softest parts of the human body,composed of white matter and grey matter.The mechanical behavior of the brain tissue plays an essential role in regulating brain morphology and brain function... Brain tissue is one of the softest parts of the human body,composed of white matter and grey matter.The mechanical behavior of the brain tissue plays an essential role in regulating brain morphology and brain function.Besides,traumatic brain injury(TBI)and various brain diseases are also greatly influenced by the brain's mechanical properties.Whether white matter or grey matter,brain tissue contains multiscale structures composed of neurons,glial cells,fibers,blood vessels,etc.,each with different mechanical properties.As such,brain tissue exhibits complex mechanical behavior,usually with strong nonlinearity,heterogeneity,and directional dependence.Building a constitutive law for multiscale brain tissue using traditional function-based approaches can be very challenging.Instead,this paper proposes a data-driven approach to establish the desired mechanical model of brain tissue.We focus on blood vessels with internal pressure embedded in a white or grey matter matrix material to demonstrate our approach.The matrix is described by an isotropic or anisotropic nonlinear elastic model.A representative unit cell(RUC)with blood vessels is built,which is used to generate the stress-strain data under different internal blood pressure and various proportional displacement loading paths.The generated stress-strain data is then used to train a mechanical law using artificial neural networks to predict the macroscopic mechanical response of brain tissue under different internal pressures.Finally,the trained material model is implemented into finite element software to predict the mechanical behavior of a whole brain under intracranial pressure and distributed body forces.Compared with a direct numerical simulation that employs a reference material model,our proposed approach greatly reduces the computational cost and improves modeling efficiency.The predictions made by our trained model demonstrate sufficient accuracy.Specifically,we find that the level of internal blood pressure can greatly influence stress distribution and determine the possible related damage behaviors. 展开更多
关键词 Data driven Constitutive law ANISOTROPY Brain tissue Internal pressure
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Effects of counter-current driven by electron cyclotron waves on neoclassical tearing mode suppression
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作者 高钦 郑平卫 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期501-509,共9页
Through theoretical analysis,we construct a physical model that includes the influence of counter-external driven current opposite to the plasma current direction in the neoclassical tearing mode(NTM).The equation is ... Through theoretical analysis,we construct a physical model that includes the influence of counter-external driven current opposite to the plasma current direction in the neoclassical tearing mode(NTM).The equation is used with this model to obtain the modified Rutherford equation with co-current and counter-current contributions.Consistent with the reported experimental results,numerical simulations have shown that the localized counter external current can only partially suppress NTM when it is far from the resonant magnetic surface.Under some circumstances,the Ohkawa mechanism dominated current drive(OKCD)by electron cyclotron waves can concurrently create both co-current and counter-current.In this instance,the minimal electron cyclotron wave power that suppresses a particular NTM was calculated by the Rutherford equation.The result is marginally less than when taking co-current alone into consideration.As a result,to suppress NTM using OKCD,one only needs to align the co-current with a greater OKCD peak well with the resonant magnetic surface.The effect of its lower counter-current does not need to be considered because the location of the counter-current deviates greatly from the resonant magnetic surface. 展开更多
关键词 driven current neoclassical tearing mode modified Rutherford equation electron cyclotron waves
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Research on the Microstructure Construction Technology of Fully Degraded Polymer Vascular Stent Based on Electric Field Driven 3D Printing
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作者 Yanpu Chao Fulai Cao +3 位作者 Hao Yi Shuai Lu Yaohui Li Hui Cen 《Fluid Dynamics & Materials Processing》 EI 2024年第11期2489-2508,共20页
The so-called fourth-generation biodegradable vascular stent has become a research hotspot in thefield of bioengineering because of its good degradation ability and drug-loading characteristics.However,the preparation... The so-called fourth-generation biodegradable vascular stent has become a research hotspot in thefield of bioengineering because of its good degradation ability and drug-loading characteristics.However,the preparationof polymer-degraded vascular stents is affected by known problem such as poor processflexibility,low formingaccuracy,large diameter wall thickness,limited complex pore structure,weak mechanical properties of radial support and high process cost.In this study,a deposition technique based on a high-voltage electric-field-driven continuous rotating jet is proposed to fabricate fully degraded polymer vascular stents.The experimental results showthat,due to the rotation of the deposition axis,the deposition direction of PCL(polycaprolactone)micro-jet isalways tangent to the surface of the deposition axis.The direction of the viscous drag force is also consistent withthe deposition direction of the jet.It is shown that by setting different rotation speeds of deposition axisωandlinear motion speeds of the nozzle V,the direction of rotation,pitch and angle of the individual printed spiralcurve can be precisely tuned.In the process of multiple spiral curves matching the deposition forming thin walltube mesh,the mesh shape and size of the thin wall tube can be accurately controlled by changing the number ofmatching spiral curves and the size of the matching position bias distance.Finally,the characteristics of a PCLtubular stent sample(with uniform-size microfibers and mesh shape),fabricated under the appropriate processparameters are described in detail. 展开更多
关键词 Electricfield driven micro-jet spiral curve polymer vascular stent
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Data-model coupling driven stress field measurements
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作者 Guangbo Wang Jian Zhao +1 位作者 Jiahui Liu Dong Zhao 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2024年第4期280-290,共11页
This paper presents a method for measuring stress fields within the framework of coupled data models,aimed at determining stress fields in isotropic material structures exhibiting localized deterioration behavior with... This paper presents a method for measuring stress fields within the framework of coupled data models,aimed at determining stress fields in isotropic material structures exhibiting localized deterioration behavior without relying on constitutive equations in the deteriorated region.This approach contributes to advancing the field of intrinsic equation-free mechanics.The methodology combines measured strain fields with data-model coupling driven algorithms.The gradient and Canny operators are utilized to process the strain field data,enabling the determination of the deterioration region's location.Meanwhile,an adaptive model building method is proposed for constructing coupling driven models.To address the issue of unknown datasets during computation,a dataset updating strategy based on a differential evolutionary algorithm is introduced.The resulting optimal dataset is then used to generate stress field results.Validation against finite element method calculations demonstrates the accuracy of the proposed method in obtaining full-field stresses in specimens with local degradation behavior. 展开更多
关键词 Stress field measurements Data-model coupling driven Differential evolutionary algorithm Material dataset
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Investigation of system parameters towards safer impact based shock-to-detonation transition in a novel laser driven flyer plate prototype
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作者 Gonca Saglam Ozkasapoglu Selis Onel 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第9期103-113,共11页
Laser driven flyer plate technology offers improved safety and reliability for detonation of explosives in industrial applications ranging from mining and stone quarrying to the aerospace and defense industries.This s... Laser driven flyer plate technology offers improved safety and reliability for detonation of explosives in industrial applications ranging from mining and stone quarrying to the aerospace and defense industries.This study is based on developing a safer laser driven flyer plate prototype comprised of a laser initiator and a flyer plate subsystem that can be used with secondary explosives.System parameters were optimized to initiate the shock-to-detonation transition(SDT)of a secondary explosive based on the impact created by the flyer plate on the explosive surface.Rupture of the flyer was investigated at the mechanically weakened region located on the interface of these subsystems,where the product gases from the deflagration of the explosive provide the required energy.A bilayer energetic material was used,where the first layer consisted of a pyrotechnic component,zirconium potassium perchlorate(ZPP),for sustaining the ignition by the laser beam and the second layer consisted of an insensitive explosive,cyclotetramethylene-tetranitramine(HMX),for deflagration.A plexiglass interface was used to enfold the energetic material.The focal length of the laser beam from the diode was optimized to provide a homogeneous beam profile with maximum power at the surface of the ZPP.Closed bomb experiments were conducted in an internal volume of 10 cm^(3) for evaluation of performance.Dependency of the laser driven flyer plate system output on confinement,explosive density,and laser beam power were analyzed.Measurements using a high-speed camera resulted in a flyer velocity of 670±20 m/s that renders the prototype suitable as a laser detonator in applications,where controlled employment of explosives is critical. 展开更多
关键词 Laser driven flyer plate Shock to detonation transition DETONATION Secondary explosives Pyrotechnic materials CONFINEMENT
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Data Driven Vibration Control:A Review
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作者 Weiyi Yang Shuai Li Xin Luo 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第9期1898-1917,共20页
With the ongoing advancements in sensor networks and data acquisition technologies across various systems like manufacturing,aviation,and healthcare,the data driven vibration control(DDVC)has attracted broad interests... With the ongoing advancements in sensor networks and data acquisition technologies across various systems like manufacturing,aviation,and healthcare,the data driven vibration control(DDVC)has attracted broad interests from both the industrial and academic communities.Input shaping(IS),as a simple and effective feedforward method,is greatly demanded in DDVC methods.It convolves the desired input command with impulse sequence without requiring parametric dynamics and the closed-loop system structure,thereby suppressing the residual vibration separately.Based on a thorough investigation into the state-of-the-art DDVC methods,this survey has made the following efforts:1)Introducing the IS theory and typical input shapers;2)Categorizing recent progress of DDVC methods;3)Summarizing commonly adopted metrics for DDVC;and 4)Discussing the engineering applications and future trends of DDVC.By doing so,this study provides a systematic and comprehensive overview of existing DDVC methods from designing to optimizing perspectives,aiming at promoting future research regarding this emerging and vital issue. 展开更多
关键词 Data driven vibration control(DDVC) data science designing method feedforward control industrial robot input shaping optimizing method residual vibration
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磁驱动固体套筒实验模拟中的电流系数
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作者 阚明先 陈涵 +4 位作者 吴凤超 贾月松 张南川 傅贞 段书超 《高压物理学报》 CAS 北大核心 2025年第1期79-85,共7页
采用不可压缩理论模型,对FP-2装置上开展的磁驱动固体套筒实验进行了模拟分析。模拟结果表明,无论是二维磁流体力学理论模型,还是其他不可压缩理论模型,回流罩结构磁驱动固体套筒的边界磁感应强度公式中都包含一个小于1的套筒电流系数... 采用不可压缩理论模型,对FP-2装置上开展的磁驱动固体套筒实验进行了模拟分析。模拟结果表明,无论是二维磁流体力学理论模型,还是其他不可压缩理论模型,回流罩结构磁驱动固体套筒的边界磁感应强度公式中都包含一个小于1的套筒电流系数。对不同套筒厚度、不同套筒半径条件下磁驱动固体套筒实验的电流系数进行了模拟,发现电流系数不仅与套筒内半径有关,还与套筒厚度有关;套筒内半径越大,套筒电流系数越小;套筒厚度越大,套筒电流系数越小。准确掌握磁驱动固体套筒电流系数的变化规律,可使磁流体程序从磁驱动固体套筒实验的后验模拟发展为精确预测,使磁流体力学模型真正具备正确设计和指导磁驱动固体套筒相关实验的理论能力。 展开更多
关键词 磁驱动固体套筒实验 二维磁驱动数值模拟程序 磁流体力学 电流系数 回流罩结构
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基于简易冲击分解模型的爆轰驱动硅橡胶数值模拟及实验解读
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作者 刘军 殷建伟 张凤国 《爆炸与冲击》 EI CAS 北大核心 2025年第1期123-132,共10页
为了反映爆轰驱动下硅橡胶发生冲击分解反应的物理过程,提出了一种简易的硅橡胶冲击分解模型。基于该模型,对爆轰驱动含硅橡胶夹层钢板实验进行了模拟,并分析解读了钢板的自由面速度。结果表明,实验中硅橡胶发生了冲击分解反应,导致钢... 为了反映爆轰驱动下硅橡胶发生冲击分解反应的物理过程,提出了一种简易的硅橡胶冲击分解模型。基于该模型,对爆轰驱动含硅橡胶夹层钢板实验进行了模拟,并分析解读了钢板的自由面速度。结果表明,实验中硅橡胶发生了冲击分解反应,导致钢板的自由面速度曲线出现了首次起跳中间速度平台及首次起跳速度峰值降低的现象。受硅橡胶冲击分解影响,首次入射波压力将在临界冲击分解压力附近弛豫一段时间,再继续升高至最高压力。该压力波作用于钢板的自由面后,出现了自由面速度在中间速度平台停留一段时间,之后继续升高至速度峰值的现象。硅橡胶冲击分解后的气相物质可压缩性较高,首次加载波内较多的能量被用于压缩气体做功,导致首次波传播至自由面时能量衰减,峰值压力降低,首次起跳速度峰值降低。 展开更多
关键词 硅橡胶 爆轰驱动 冲击分解 分解压力
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轮毂电动机驱动车辆并联式复合制动策略
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作者 付翔 肖帅 徐超 《江苏大学学报(自然科学版)》 CAS 北大核心 2025年第1期9-17,共9页
基于并联式轮毂电动机驱动实车构型,分析影响制动能量回收效率的主要因素,采用联邦卡尔曼滤波纵向车速估计算法,提出了三层式复合制动控制策略.该策略中的制动决策层根据踏板输入信号和行驶状态来识别制动工况,并进入相应的制动模式.制... 基于并联式轮毂电动机驱动实车构型,分析影响制动能量回收效率的主要因素,采用联邦卡尔曼滤波纵向车速估计算法,提出了三层式复合制动控制策略.该策略中的制动决策层根据踏板输入信号和行驶状态来识别制动工况,并进入相应的制动模式.制动控制层根据制动决策层的指令,在常规制动工况下通过粒子群优化(PSO)算法优化前、后轮电制动力矩分配,实现电池有效回收效率最大化;紧急制动工况下,通过模糊自整定PID算法实现车辆在不同附着路面上各轮滑移率的安全有效控制,优化了制动防抱死控制的鲁棒性,提高制动安全性.制动执行层响应制动控制层的指令,设计了电制动补偿机制,以迅速补偿调节各轮轮缸的压力误差,提高车辆制动稳定性.最后实车验证了该复合控制策略的有效性. 展开更多
关键词 轮毂电动机驱动车辆 并联式复合制动 粒子群优化 制动能量回收 模糊自整定PID
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自驱动双关节模组同步控制系统研究
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作者 杨洪涛 姜西祥 +3 位作者 沈梅 高荟荟 秦鹏飞 金磊 《煤矿机械》 2025年第1期190-195,共6页
针对自驱动关节臂测量机双关节模组的双电机同步控制问题,根据双关节模组的组成结构和工作原理设计了一种双关节模组同步控制系统。该系统采用LabVIEW软件搭建双电机的上位机控制界面,主控制器为FPGA,两者通过USB串口通信;STM32为双关... 针对自驱动关节臂测量机双关节模组的双电机同步控制问题,根据双关节模组的组成结构和工作原理设计了一种双关节模组同步控制系统。该系统采用LabVIEW软件搭建双电机的上位机控制界面,主控制器为FPGA,两者通过USB串口通信;STM32为双关节模组内部的核心处理器,通过CAN总线与主控制器通信。通过设定不同的负载和速度进行了正反转对比实验,得到双关节模组电机最大转速误差为4.26%,关节转角的最大误差为0.25°,两电机同步时间控制精度为2 ms,验证了双关节模组在负载状态下仍满足技术指标要求,为提高传动精度提供了依据。 展开更多
关键词 自驱动关节臂测量机 双关节模组 同步控制 FPGA
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活化的乙醛脱氢酶2通过调节双孔钾离子通道TASK-1减轻糖尿病大鼠心肌损伤 被引量:5
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作者 张恒 陶敏 +5 位作者 康品方 郭建路 宣玲 唐碧 高琴 王洪巨 《中南大学学报(医学版)》 CAS CSCD 北大核心 2019年第1期14-21,共8页
目的:观察激活乙醛脱氢酶2(aldehyde dehydrogenase 2,ALDH2)对糖尿病心肌损伤中双孔钾离子通道TASK-1的影响及其对糖尿病心肌损伤的保护作用。方法:将雄性SD大鼠随机分为正常组(N组)、糖尿病4周组(DM4W组)、糖尿病8周组(DM8W组),糖尿病... 目的:观察激活乙醛脱氢酶2(aldehyde dehydrogenase 2,ALDH2)对糖尿病心肌损伤中双孔钾离子通道TASK-1的影响及其对糖尿病心肌损伤的保护作用。方法:将雄性SD大鼠随机分为正常组(N组)、糖尿病4周组(DM4W组)、糖尿病8周组(DM8W组),糖尿病8周组+低浓度乙醇干预组(DM8W+Et OH组)。采用腹腔单次注射链脲佐菌素(55mg/kg)复制糖尿病大鼠模型。行心脏超声测定大鼠心功能,ELISA法检测心肌组织羟脯氨酸含量,HE染色观察心肌组织结构,PAS染色观察心肌组织阳性物质沉积情况,Western印迹检测心肌组织TASK-1蛋白表达情况,膜片钳记录心室肌细胞复极30%和90%时的动作电位时程(APD30,APD90)和双孔钾离子通道TASK-1电流,同时根据该钾通道对酸碱敏感的电生理特性判断是否为双孔钾离子通道TASK-1电流。结果:与N组相比,DM4W组和DM8W组大鼠左室舒张末期内径(end-diastole left ventricular diameter,LVIDd)及左室收缩末期内径(end-systolic left ventricular diameter,LVIDs)、羟脯氨酸含量、TASK-1蛋白表达增加,左室内径缩短率(leftventricular fractional shortening,LVFS)和射血分数(leftventricular ejection fraction,LVEF)均下降,APD30和APD90延长,TASK-1电流减少(P<0.01);HE染色结果显示DM4W组和DM8W组大鼠心肌细胞及纤维排列紊乱,心肌细胞肥大,心肌间隙增宽;PAS染色显示DM4W组和DM8W组大鼠心肌组织阳性物质沉积增加。与DM4W组相比,DM8W组大鼠上述指标的变化更加明显(P<0.05或P<0.01)。与DM8W相比,DM8W+Et OH组左室心功能指标LVIDd,LVIDs,LVFS,LVEF有所恢复,羟脯氨酸含量和TASK-1蛋白表达减少,TASK-1电流增加,APD30和APD90缩短(均P<0.01);HE染色显示心肌细胞损伤较前减轻,PAS染色显示大鼠心肌组织阳性物质沉积减少。结论:ALDH2被低浓度的乙醇激活后可减轻糖尿病所致的心肌损伤及纤维化,其机制可能与其调节双孔钾离子通道TASK-1蛋白表达和TASK-1电流有关。 展开更多
关键词 糖尿病 心肌损伤 双孔钾离子通道 task-1
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双孔钾通道TASK-1在糖尿病大鼠心肌损伤中的变化 被引量:1
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作者 张恒 陶敏 +5 位作者 康品方 郭建路 宣玲 唐碧 高琴 王洪巨 《南方医科大学学报》 CAS CSCD 北大核心 2018年第10期1228-1233,共6页
目的观察双孔钾通道TASK-1在糖尿病大鼠心肌损伤中的变化并分析其可能机制。方法 36只SD大鼠随机分为3组(n=12/组):正常对照组(N)、糖尿病4周组(DM 4W)和糖尿病8周组(DM 8W),造模成功后,小动物超声测定各组大鼠心功能;测定不同时期各组... 目的观察双孔钾通道TASK-1在糖尿病大鼠心肌损伤中的变化并分析其可能机制。方法 36只SD大鼠随机分为3组(n=12/组):正常对照组(N)、糖尿病4周组(DM 4W)和糖尿病8周组(DM 8W),造模成功后,小动物超声测定各组大鼠心功能;测定不同时期各组大鼠体质量及心脏重量,计算心系数(HW/BW),Masson染色观察心肌纤维化程度,Western blotting检测心肌组织TASK-1的蛋白表达;急性分离N和DM 8W组大鼠心室肌细胞,全细胞膜片钳技术记录其动作电位时程(APD)和TASK-1电流,同时应用TASK-1特异性抑制剂ML-365观察TASK-1电流抑制情况。结果与N组相比,DM组大鼠心系数增加(P<0.05),大鼠舒张末期左室内径及收缩末期左室内径增加(P<0.01),TASK-1的蛋白表达增加(P<0.01),左室内径缩短率及射血分数均下降(P<0.01),Masson染色显示DM组心肌胶原纤维粗大,交织成网状,排列不均匀,沉积增多;与DM 4W相比,DM 8W组大鼠舒张末期左室内径、收缩末期左室内径、心系数和TASK-1蛋白表达持续增加(P<0.01,P<0.05),左室内径缩短率及射血分数进一步下降(P<0.01),Masson染色显示心肌形态更加不规则,沉积增加明显。与N组相比,DM 8W糖尿病心肌病组TASK-1的电流明显减少(P<0.01),动作电位时程延长(P<0.05),TASK-1电流被ML-365成功抑制。结论糖尿病可诱发心肌纤维化,加重心肌损伤,其机制可能与双孔钾通道TASK-1的蛋白及电流变化有关。 展开更多
关键词 糖尿病 心肌损伤 双孔钾通道 task-1
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二十二碳六烯酸对心房颤动大鼠心房肌细胞双孔钾通道TASK-1表达的影响 被引量:2
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作者 唐碧 高大胜 +2 位作者 侯秀杰 王洪巨 单锋 《广东医学》 CAS CSCD 北大核心 2014年第23期3613-3616,共4页
目的探讨二十二碳六烯酸(DHA)在大鼠心房颤动(房颤)模型中的作用及其对双孔钾离子通道TASK-1表达的影响。方法 SD雄性大鼠分为4组:(1)对照组:每天注射等体积生理盐水;(2)DHA组:每天注射等体积DHA;(3)房颤组:每天给予乙酰胆碱+氯化钙混... 目的探讨二十二碳六烯酸(DHA)在大鼠心房颤动(房颤)模型中的作用及其对双孔钾离子通道TASK-1表达的影响。方法 SD雄性大鼠分为4组:(1)对照组:每天注射等体积生理盐水;(2)DHA组:每天注射等体积DHA;(3)房颤组:每天给予乙酰胆碱+氯化钙混合液建立房颤模型;(4)房颤DHA组:每天先给予DHA,半小时后建立房颤模型,方法同房颤组。分别观察各组大鼠房颤发生时间和检测心房有效不应期(ERP);应用Western blot测定大鼠心房肌中TASK-1蛋白表达及RT-PCR测定大鼠心房肌中TASK-1 mRNA表达。结果房颤DHA组较房颤组大鼠心房颤动出现时间明显推迟,稳定时间提前,分别为第3天和第1天出现,第8天[(22±5.0)s]比第10天[(35±5.3)s]稳定;每天房颤持续时间显著缩短,与对照组相比,房颤组ERP明显缩短[从(77.3±6.0)s到(60.4±4.3)s],与DHA组相比,房颤DHA组ERP显著缩短[从(90.8±3.4)s到(82.4±5.7)s];与对照组相比,DHA组TASK-1 mRNA和蛋白表达降低,房颤组及房颤DHA组TASK-1 mRNA和蛋白表达水平升高;与房颤组相比,DHA组及房颤DHA组TASK-1 mRNA和蛋白表达降低。结论 DHA具有抗房颤作用,其机制可能与下调双孔钾离子通道TASK-1蛋白表达有关。 展开更多
关键词 二十二碳六烯酸 大鼠心房肌细胞 心房颤动 task-1
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TASK-3钾离子通道的研究现状 被引量:7
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作者 瓮占平 王波 《国际病理科学与临床杂志》 CAS 2006年第3期225-227,共3页
双孔钾离子通道是一个膜蛋白家族,广泛分布于可兴奋和不可兴奋细胞中。TASK-3钾离子通道是新发现的一个双孔钾离子通道家族成员,编码374个氨基酸,对细胞凋亡和增殖有重要的作用。在多种肿瘤组织中TASK-3钾离子通道基因呈高表达,并表现... 双孔钾离子通道是一个膜蛋白家族,广泛分布于可兴奋和不可兴奋细胞中。TASK-3钾离子通道是新发现的一个双孔钾离子通道家族成员,编码374个氨基酸,对细胞凋亡和增殖有重要的作用。在多种肿瘤组织中TASK-3钾离子通道基因呈高表达,并表现出与钾离子通道功能相关的原癌基因特性。 展开更多
关键词 task-3 钾离子通道 肿瘤
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Material driven workability simulation by FEM including 3D processing maps for magnesium alloy 被引量:2
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作者 刘娟 李居强 +2 位作者 崔振山 欧立安 阮立群 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2013年第10期3011-3019,共9页
The three-dimensional (3D) processing maps considering strain based on the two-dimensional (2D) processing maps proposed by PRASAD can describe the distribution of the efficiency of power dissipation and flow inst... The three-dimensional (3D) processing maps considering strain based on the two-dimensional (2D) processing maps proposed by PRASAD can describe the distribution of the efficiency of power dissipation and flow instability regions at various temperatures, strain rates and strains, which exhibit intrinsic workability related to material itself. Finite element (FE) simulation can obtain the distribution of strain, strain rate, temperature and die filling status, which indicates state-of-stress (SOS) workability decided by die shape and different processing conditions. On the basis of this, a new material driven analysis method for hot deformation was put forward by the combination of FE simulation with 3D processing maps, which can demonstrate material workability of the entire hot deformation process including SOS workability and intrinsic workability. The hot forging process for hard-to-work metal magnesium alloy was studied, and the 3D thermomechanical FE simulation including 3D processing maps of complex hot forging spur bevel gear was first conducted. The hot forging experiments were carried out. The results show that the new method is reasonable and suitable to determine the aoorooriate nrocess narameters. 展开更多
关键词 material driven workability simulation 3D processing maps magnesium alloy hot forging
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二十二碳六烯酸对心房颤动大鼠心房肌生理改变及双孔钾通道TASK-1蛋白表达的影响 被引量:1
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作者 葛敏 单锋 +1 位作者 唐碧 侯秀杰 《中国应用生理学杂志》 CAS CSCD 2016年第2期128-131,136,共5页
目的:探讨二十二碳六烯酸(DHA)对大鼠心房颤动(AF)模型心房肌生理特性的影响及相关机制研究。方法:80只乙酰胆碱-氯化钙混合液敏感的SD大鼠分为对照组(CTL组)、DHA处理组(DHA组)、房颤组(AF组)和房颤+DHA处理组(DHA+AF组),观察房颤持续... 目的:探讨二十二碳六烯酸(DHA)对大鼠心房颤动(AF)模型心房肌生理特性的影响及相关机制研究。方法:80只乙酰胆碱-氯化钙混合液敏感的SD大鼠分为对照组(CTL组)、DHA处理组(DHA组)、房颤组(AF组)和房颤+DHA处理组(DHA+AF组),观察房颤持续时间;采用全细胞膜片钳技术记录大鼠心房肌细胞动作电位时程(APD)和双孔钾通道TASK-1电流,Western blot测定大鼠心房组织TASK-1蛋白表达。结果:大鼠尾静脉注射乙酰胆碱-氯化钙混合液后,房颤持续时间随实验天数增加而逐渐延长,DHA干预缩短房颤持续时间。与CTL组相比,AF组大鼠心房肌细胞复极50%时的动作电位时程(APD50)和复极90%时的动作电位时程(APD90)明显缩短,心房肌细胞TASK-1电流密度升高,蛋白表达升高(P<0.05)。与AF组相比,DHA+AF组大鼠心房肌细胞APD50和APD90明显延长,TASK-1电流密度和蛋白表达降低(P<0.05)。结论:DHA具有延长房颤大鼠心房肌细胞APD的作用,可能与其下调心房肌TASK-1蛋白的表达从而降低心房肌细胞TASK-1电流密度有关。 展开更多
关键词 心房颤动 二十二碳六烯酸 心房电重构 task-1 大鼠
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基于北斗测速的电驱式小麦播种机监控系统设计与试验
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作者 李涛 刘江涛 +2 位作者 桑永英 胡敏英 周训 《农机化研究》 北大核心 2025年第4期116-121,共6页
针对当前小麦播种机智能化程度低、播种作业时种子漏播肥料堵塞导致缺苗断垄现象产生的问题,设计了一款基于北斗测速的电驱式小麦播种机监控系统。通过电容检测可以实时监测小麦种子漏播情况,通过光电检测可以实时监控排肥管内肥料堵塞... 针对当前小麦播种机智能化程度低、播种作业时种子漏播肥料堵塞导致缺苗断垄现象产生的问题,设计了一款基于北斗测速的电驱式小麦播种机监控系统。通过电容检测可以实时监测小麦种子漏播情况,通过光电检测可以实时监控排肥管内肥料堵塞情况;北斗卫星实时定位并计算出播种机的前进速度,控制器根据播种机前进速度实时调节播种施肥电机转速,实现种子漏播、肥料堵塞报警和精量播种施肥的目的。在田间试验中,装载监控系统的播种机各项性能表现良好,漏播检测准确率91%以上,肥料堵塞检测准确率95%以上,播种合格率平均值大于94.6%,漏播指数小于2.8%,重播指数小于3%,均匀度变异系数小于3.5%,能够满足小麦精量播种的要求。 展开更多
关键词 小麦播种机 监控系统 北斗测速 电驱式
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