The Relationship Between Relative Hydration Free Energies of ^(99m)TcON_2S_2 Complexes and Their Brain Uptakes

A thermodynamic integration dual-transform method was firstly applied to calculating the relative hydration free energies of 99m TcO-N 2S 2 complexes. The relationship between the brain uptakes(B.U.) of 99m TcO-N 2S 2 complexes with different substituted functional groups and their relative hydration free energies was investigated. The simulation results show that the experiment brain uptake(B.U.) data are strongly influenced by the relative hydration free energies of 99m TcO-N 2S 2 complexes, thus the simulations can provide the useful information for the medicine design of 99m Tc brain imaging agents.

面向MRPⅡ的TCO策略研究

从降低ＭＲＰⅡ系统的综合拥有成本（Ｔｏｔａｌ Ｃｏｓｔ ｏｆ Ｏｗｎｅｒ， ＴＣＯ）的目标出发，经过对ＭＲＰⅡ系统软硬件特点的分析，结合当前网络与计算机的新趋势，提出和讨论了针对ＭＲＰⅡ系统的ＴＣＯ策略（包括软件、硬件、综合策略）。在介绍了国外著名厂商的解决方案的同时，从实际开发的角度简介了利用现有开发工具与硬件产品的开发实现方法。