Assessment of tear film parameters post-treatment with commercial eyelid cleaning wipes:a pilot study

AIM:To investigate the short-term effects of commercially available eyelid-cleaning wipes on film parameters.METHODS:This study enrolled 48 healthy participants aged 20-35y(both males and females).Clinical assessment included the Ocular Surface Disease Index(OSDI)questionnaire,non-invasive tear break-up time(NITBUT),tear meniscus height(TMH),and lipid layer pattern(LLP).Based on these initial results,participants were categorized as either non-dry eye or dry eye.Participants in each group were randomly allocated to either Blephaclean■or Systane■treatments.Changes in NITBUT,TMH,and LLP levels before and after lid wipe treatment were assessed.RESULTS:The dry eye group exhibited significantly higher OSDI scores and lower NITBUT and TMH levels than in the non-dry eye group(P<0.001).Following the application of eyelid wipes(Systane■wipes),dry eye subjects experienced a significant improvement in NITBUT levels(P=0.0014)compared to the non-dry eye individuals.Although the remaining participants showed a marginal increase in TMH and NITBUT levels,these changes did not achieve statistical significance(P>0.05).Similarly,the LLP levels were significantly improved with Systane■(P<0.001)post-treatment compared to individuals in the non-dry eye group.However,the dry eye subjects showed higher posttreatment LLP levels than the untreated group(P<0.02).CONCLUSION:The short-term effects of Systane®eyelid wipes on tear film parameters suggest their effectiveness in dry eye disease.Nonetheless,further exploration of their long-term impact is essential to justify their cost effectiveness and efficacy in treating both aqueous deficiency and evaporative dryness.

Association between tear film break up time and blink interval in visual display terminal users

AIM：To investigate the association between tear film break up time（TBUT）and blinking interval in visual display terminal（VDT）users.METHODS：Nine hundred and thirty VDT users underwent dry eye testing,and functional visual acuity（FVA）test.The blinking interval during FVA was compared with TBUT.Subjects with longer blinking interval than TBUT were considered as unstable tear film.Logistic regression analysis revealed the risk factors for unstable tear group.RESULTS：Among 930 workers,858 subjects（92.3%）participated in this study.Almost 80% of the subjects were categorized into the unstable tear group.Unstable tear group has significantly lower Schirmer values and TBUT（17.5±11.6 vs 21.1±11.5 mm,3.7±2.6 vs 5.7±2.7s,both P〈0.001）.There were no significant differences in epithelial staining or severity of symptoms.Logistic regression showed that over 40y was a risk for being unstable tear group[odds ratio（OR）=1.53;95%confidence interval（CI）=1.06-2.20].Contact lens use was protective factor for being in the unstable tear group（OR=0.37;95%CI=0.26-0.53）.CONCLUSION：Subjects with shorter TBUT than blinking interval are prevalent among VDT users.Subjects over the age of 40 shows an increased risk for unstable tear film.

Ocular surface microbiota in patients with varying degrees of dry eye severity

AIM:To elucidate the profiles of commensal bacteria on the ocular surfaces of patients with varying severity of dry eye(DE).METHODS:The single-center,prospective,case-control,observational study categorized all participants into three distinct groups:1)control group(n=61),2)mild DE group(n=56),and 3)moderate-to-severe DE group(n=82).Schirmer’s tear secretion strips were used,and the bacterial microbiota was analyzed using 16S ribosomal ribonucleic acid gene sequencing.RESULTS:The three groups had significant differences in alpha diversity:the control group had the highest richness(Chao1,Faith’s phylogenetic diversity),the mild DE group showed the highest diversity(Shannon,Simpson),and the moderate-to-severe DE group had the lowest of the above-mentioned indices.DE severity was positively correlated with a reduction in beta diversity of the microbial community,with the moderate-to-severe DE group exhibiting the lowest beta diversity.Linear discriminant analysis effect size presented distinct dominant taxa that significantly differed between each.Furthermore,the exacerbation of DE corresponded with the enrichment of certain pathogenic bacteria,as determined by random forest analysis.CONCLUSION:As DE severity worsens,microbial community diversity tends to decrease.DE development corresponds with changes in microbial constituents,primarily characterized by reduced microbial diversity and a more homogenous species composition.

Prevalence of Dry Eye and Its Association with Various Risk Factors in Rural Setup of Western Uttar Pradesh in a Tertiary Care Hospital

Purpose: To study the prevalence of dry eye in a hospital based population of rural setup and to evaluate its association with various risk factors. Material and Methods: In this cross sectional study, patients above 20 years of age were screened randomly for dry eye. An 8 points questionnaires, slit lamp examination of meibomian glands, tear film breakup time, fluorescein staining of cornea, schirmer test were used to diagnose dry eye. The diagnosis was made when three of the five parameters were positive. The role of various occupations as well as role of different exposure factors like sunlight, excessive wind, smoking, drugs, and air pollution as dry eye risk factors was accessed. Result: Out of 445, 45.39% patients had dry eye. Dry eye prevalence was higher in those above 70 years of age (74%). It was higher in male population (51.82%) compare to female population (37.37%), nearly equal in rural (46.04%) and urban population (44.31%) and highest among factory workers (90%). Correlation of dry eye with drugs (P = 0.0002), sunlight/high temperature (P = 0.0003) and smoking (P = 0.03) were significant. Conclusion: This is a hospital based study which provides prevalence of dry eye in rural region of western Uttar Pradesh. It is more common in old age male population and significantly higher in factory workers. Out of different modifiable risk factors most important are drugs, sunlight/high temperature and smoking.

Validity of subjective assessment as screening tool for dry eye disease and its association with clinical tests

AIM: To determine the role of subjective assessment using Mc Monnies dry eye questionnaire in diagnosing dry eye disease and its association with clinical tests.METHODS: There were 500 patients screened for dry eye using Mc Monnies dry eye questionnaire between May to October 2013 at the outpatient Department of Ophthalmology of a medical college hospital. All 500 patients were subjected to clinical tests. Dry eye was defined as having one or more symptoms often or all the time. Positive signs were if one or both eyes revealed tear film breakup time(TBUT) of ≤10s, a Schirmer test score of ≤10 mm, a Rose Bengal staining score of ≥1, a Lissamine green staining score of ≥1 or existence of meibomian gland disease(≥grade 1). Statistical analysis was performed to describe the distribution of symptoms and signs, to assess the correlations between Mc Monnies score(MS) and variable clinical signs of dry eye, and to explore the association between dry eye symptoms and variable clinical signs. Analysis was performed using software package Epi info. A Probability(P) value using Chi-square test of 【0.005 was taken as significant.· RESULTS: Dry eye prevalence with symptoms(questionnaire), Schirmer test, TBUT, Rose Bengal staining and Lissamine green staining was 25.6%,15.20%, 20.80%, 23.60%, and 22.60% respectively. Among those with severe symptoms(MS】20), 75.86% had a low TBUT(【10s), 58.62% had a low Schirmer’s I test(≤10 mm),86.20% had Rose Bengal staining score of ≥1, 79.31%had Lissamine green staining score of ≥1. We found statistically significant associations between positive Schirmer test and arthritis(P 【0.002), dryness elsewhere(P 【0.001), contact lens use(P 【 0.002), systemic medication(P 【0.0001), sleeping with eyes partly open(P 【0.002), history of dry eyes treatment(P 【0.0001),environmental factors(P 【0.001), swimming(P 【0.001).· CONCLUSION: Subjective assessment plays an important role in diagnosing dry eye disease. There is strong correlation between MS and Schirmer test, TBUT,Rose Bengal staining and Lissamine green staining in normal as well as marginal and pathological dry eye.

Comparison of the Clinical Efficacy of Four Different Liposomal Sprays for the Treatment of Dry Eye

Purpose: To compare the clinical efficacy of four different liposomal sprays for dry eye treatment. Methods: Prospective randomized consecutive intraindividual comparison enrolling 166 patients (age, 18 - 93 years). Patients were randomly assigned to one of 4 groups, receiving one spray in their right eye and another one in their left eye: Ocuvers Hyaluron (OH) (87 eyes) and Ocuvers Lipostamin (OL) (80 eyes) (Innomedis AG), and Tears Again (TA) (80 eyes) and Tears Again Sensitive (TAS) (85 eyes) (Optima Pharmaceutical). Symptomatology was evaluated with the OSDI (Ocular Surface Disease Index) questionnaire. Subjective comfort, tear break up time (TBUT), redness, tear meniscus, application comfort and smell were evaluated during a 30-minute follow-up. Results: Smell for TA and TAS was significantly fattier compared to OH and OL (p Conclusions: The four evaluated liposome sprays may be useful for dry eye treatment, with higher subjective comfort and less dry eye signs using the Ocuvers sprays. The use of OL may be a better treatment option for severe dry eye.

The Anatomical Dry Eye <br/>—A Different Form of Ocular Surface Disease Deserves Focus

Introduction: Dry eye disease is currently considered mainly tear film related ocular surface condition. This concept does, however, not respect ocular surface topography. The micro-anatomy of the corneal changes may lead to enhanced demands on the tear film and lead to significant complaints. However, they often remain undetected and hence untreated. It is suggested that the pathophysiology for an entire subgroup of dry eye disease patients is primarily of surface morphological nature. Methods: The tear film break up was observed and used to identify anatomical alterations in eyes of patients with dry eye complaints. The localization and pattern of TFBUT using fluorescein was compared between eye with normal surfaces and surface alterations. Results: Premature tear film rupture was localized at constantly same areas and did match changes on the ocular epitheliopathy in patients with diseases such as microcystic epithliopathy, MFD, and after excimer laser treatment. Disusssion: Whereas in normal surfaces TFBUT does occur within the floating tear film, the anatomical dry eye identifies itself with constant location of tear film break up and a constant spreading pattern. In contrast to the classic, tear film caused dry eye, the anatomical dry eye is accessible to treatment. This should catch our attention and intent to identify it. It is the ease of possible treatment that should make these ocular surface alterations prime target of dry eye disease diagnostic. It is hence suggested to introduce the anatomical dry eye as a subgroup in the large group of dry eye and ocular surface disease.

润眼明目方熏蒸联合玻璃酸钠滴眼液治疗睑板腺功能障碍致干眼症临床研究

目的:观察润眼明目方熏蒸联合玻璃酸钠滴眼液(HYCOSAN)治疗睑板腺功能障碍(MGD)致干眼症患者的临床疗效。方法:选取MGD致干眼症患者112例,随机分为对照组和治疗组各56例。对照组采用HYCOSAN治疗,治疗组在对照组基础上联合润眼明目方熏蒸治疗。治疗4周后,比较2组临床疗效,以及2组治疗前后泪膜破裂时间(BUT)、角膜荧光素染色评分(FLS)、中医证候评分。结果:治疗后,治疗组总有效率为89.29%,对照组为75.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组BUT均较治疗前增加(P<0.05),FLS均较治疗前降低(P<0.05);且治疗组BUT长于对照组(P<0.05),FLS低于对照组(P<0.05)。治疗后,2组眼干涩、畏光、腰膝酸软、头晕耳鸣、夜寐多梦等中医证候评分均较治疗前降低(P<0.05),且治疗组各项评分均低于对照组(P<0.05)。结论:润眼明目方熏蒸联合HYCOSAN治疗睑板腺功能障碍致干眼症,能够有效缓解患者中医证候,提高临床总有效率,改善患者睑板腺功能。

针刺治疗肝经郁热型干眼症的疗效及对焦虑情绪的影响

【目的】观察针刺治疗肝经郁热型干眼症的疗效及其对焦虑情绪的影响。【方法】将78例肝经郁热型干眼症患者随机分为观察组和对照组,每组各39例。对照组给予聚乙烯醇滴眼液滴眼治疗,观察组在对照组的基础上加用针刺治疗,疗程为1个月。观察2组患者治疗前后主观症状评分、泪膜破裂时间(break-up time,BUT)、泪液分泌试验(Schirmer I test,SIT)、角膜荧光染色结果(fluorescein,FL)评分以及焦虑自评量表(SAS)评分的变化情况,并评价2组患者的临床疗效和焦虑改善疗效。【结果】(1)治疗1个月后,观察组的总有效率为89.74%(35/39),对照组为71.79%(28/39),组间比较,观察组的总有效率(χ^(2)检验)和总体疗效(秩和检验)均优于对照组(P<0.05)。(2)治疗后,2组患者的眼睛干燥感、异物感、疲劳感、烧灼感、不适感、视力波动等各项主观症状评分及总积分均较治疗前明显降低(P<0.05),且观察组的降低作用均明显优于对照组(P<0.05或P<0.01)。(3)治疗后,2组患者的BUT、SIT、FL评分均较治疗前明显改善(P<0.05),且观察组的改善作用均明显优于对照组(P<0.01)。(4)治疗后,2组患者的SAS评分均较治疗前明显降低(P<0.05),且观察组的降低作用明显优于对照组(P<0.01)。(5)治疗后,观察组的焦虑恢复正常率为89.29%(25/28),对照组为48.15%(13/27),组间比较(χ^(2)检验),观察组的焦虑改善疗效明显优于对照组(P<0.05)。【结论】在人工泪液治疗基础上加用针刺治疗肝经郁热型干眼症患者疗效确切,可有效改善患者临床症状和焦虑情绪,其疗效优于单纯人工泪液治疗。

Efficacy observation of acupuncture for dry eye syndrome of lung-yin deficiency pattern

Objective:To observe the clinical efficacy of combining two needling manipulations,Er Long Xi Zhu(two dragons playing with a pearl)and Guo Yan Re(heat produced to reach the eyes),in treating dry eye syndrome(DES)of lung-yin deficiency pattern.Methods:Fifty-six eligible DES patients of lung-yin deficiency were randomized into an observation group and a control group,with 28 cases in each group.Same acupoints were selected in the two groups:Cuanzhu(BL 2),Sizhukong(TE 23),Taiyang(EX-HN 5)and Fengchi(GB 20)were chosen as the major points and Feishu(BL 13)and Chize(LU 5)as the adjuvant.Er Long Xi Zhu and Guo Yan Re needling manipulations were applied in the observation group while twirling reinforcing manipulation was used in the control group.Treatment was conducted once per day in both groups,for two sets of 15 consecutive days at a 2-day interval.Changes in the symptom score,tear break-up time(BUT)and tear production were observed afterwards,and the clinical efficacy was also compared between the two groups.Results:The total effective rate was 92.8%in the observation group,higher than 71.4%in the control group,and the between-group difference was statistically significant(P<0.05).After treatment,the symptom score,tear BUT and tear production showed significant improvements in both groups(all P<0.05);the symptom score,BUT and tear production in the observation group were significantly different from those in the control group(all P<0.05).Conclusion:Given the same acupoint selection,combining Er Long Xi Zhu and Guo Yan Re needling manipulations can produce more significant clinical efficacy than twirling reinforcing manipulation in treating DES of lung-yin deficiency pattern.

Keratograph眼表综合分析仪与传统方法对泪膜功能评价的一致性分析

目的:探讨一种最新的眼表综合分析仪Keratograph对于泪膜稳定性评估的重复性和准确性,将其测量值与传统的检查方法进行比较。方法:采用Keratograph测量包括首次泪膜破裂时间(the first tear film break-up time,BUT-f)和平均泪膜破裂时间(the average tear film break-up time,BUT-ave)在内的非侵入式泪膜破裂时间(noninvasive tear film break-up time,NI_BUT)结果。测量结果的重复性使用变异系数(coefficient of variation,CV)和组内相关系数(intraclass correlation coefficient,ICC)进行评价,NI-BUT与传统的荧光素泪膜破裂时间(fluorescein tear film break-up time,FBUT)的比较采用Wilcoxon符号秩和检验,确定NI-BUT与FBUT,SchirmerⅠ试验结果的相关关系,采用BlandAltman分析进行一致性评价。结果:本研究纳入了48个受检者(48眼),平均年龄38.7±15.2岁。BUT-f的CV和ICC分别为12.6%和0.95,BUT-ave的为9.8%和0.96。BUT-f值低于FBUT值,差异有统计学意义(6.16±2.46s vs 7.46±1.92s,P<0.01)。NI-BUT与FBUT,SchirmerⅠ试验结果之间存在显著的正相关关系(P<0.01)。BUT-f与FBUT的95%一致性界限(limits of agreement,Lo A)范围为4.46s,BUT-ave与FBUT的Lo A范围为3.64s。结论:Keratograph能够提供具有较好重复性和可靠性的NI-BUT数据,在干眼诊治和角膜屈光性手术等领域有很好的应用前景。

传统检查方法与OCT在狼疮性肾炎所致干眼症诊断的应用

目的:应用传统干眼症检查方法与光学相干断层扫描(OCT)对狼疮性肾炎患者进行干眼症检查,分析狼疮性肾炎与干眼症患病关系,并探讨传统检查方法与OCT在干眼症诊断方面的作用。方法:选取2014-01/2015-01在我院肾脏病科住院的狼疮性肾炎患者组和患者家属(无免疫系统疾病史)作为正常对照组各27例54眼,分别进行干眼症症状询问、行泪液分泌试验(SchirmerⅠtest,SⅠt)、泪膜破裂时间(break-up time,BUT)、角膜荧光素染色(fluorescein staining,FL)、光学相干断层扫描(OCT)测量泪河高度(tear meniscus height,TMH)及面积(tear meniscus area,TMA)检查。结果:狼疮性肾炎组干眼症主观症状发生率(59%)高于对照组(35%),SⅠt低于对照组,差异有统计学意义(P<0.01),BUT短于对照组,差异有统计学意义(P<0.01),角膜荧光素染色阳性率(63%)高于对照组(30%),光学相干断层扫描测TMH低于对照组,差异有统计学意义(P=0.002),TMA小于对照组,差异有统计学意义(P=0.028)。OCT测量TMH与SⅠt(P=0.012)、BUT(P=0.002)检查呈正相关;OCT测量TMA与SⅠt(P=0.023)、BUT(P=0.004)检查呈正相关。结论:狼疮性肾炎患者干眼症患病率高,OCT作为一种操作简便、高效、准确的干眼症检查方法,在干眼症的诊断中具有价值。

小牛血去蛋白提取物凝胶和羟糖苷眼液对LASIK术后角膜上皮损伤的修复作用

目的对比小牛血去蛋白提取物凝胶(兴齐制药)和羟糖苷眼液(爱尔康)在准分子激光原位角膜磨镶术(laser in situkeratomileusis,LASIK)后对角膜上皮损伤修复作用的功能差异,为改善术后干眼的临床用药提供帮助。方法将2010年1月至4月在我院实施LASIK手术的76例(152眼)近视患者依据术后用药进行分组,Ⅰ组为小牛血去蛋白提取物凝胶组,Ⅱ组为羟糖苷眼液组,术前和术后1个月分别行角膜荧光素染色检查,记录泪膜破裂时间(break-up time,BUT)和角膜上皮染色评分,对比两种药物对LASIK术后角膜上皮损伤修复作用的差异。结果术前、术后的BUT[术后Ⅰ组:(5.61±2.72)s,Ⅱ组:(5.42±3.17)s]和角膜上皮染色评分,组内比较差异无统计学意义(P值分别为0.877和0.092),组间比较差异亦无统计学意义(P值分别为0.683和0.212)。进一步对术前轻度干眼对象进行比较,手术前后BUT变化量组间差异无统计学意义(P=0.107),角膜上皮染色评分变化量的组间差异亦无统计学意义(P=0.181)。结论对于实施了LASIK的患者,术后为防止干眼,使用两类药物具有等同疗效,在BUT的延长上,小牛去蛋白提取物凝胶具有优势;但对于术前轻度干眼的患者,羟糖苷眼液效果更佳。

不同润眼液对近视患者配戴角膜塑形镜后疗效和眼表的影响

目的评价舒润液、不含防腐剂的玻璃酸钠滴眼液和质量分数0.9%生理盐水对角膜塑形镜配戴患者眼表和近视疗效的影响。方法采用对检查者单独设盲的随机对照研究,纳入2017年6月至2018年4月在海南省眼科医院接受正规角膜塑形镜验配的近视患者90例90眼,均取右眼数据进行分析,按照随机数字表法随机分为玻璃酸钠组、舒润液组及生理盐水组,每组各30例,分别使用不含防腐剂的1 g/L玻璃酸钠滴眼液、舒润液和9 g/L不含防腐剂的生理盐水摘戴眼镜。分别于戴镜前和戴镜后1 d、1周、1个月、3个月进行裸眼视力、等效球镜、角膜地形图、非侵入首次泪膜破裂时间(NIKf-BUT)以及角膜上皮荧光素染色(FL)检测。结果玻璃酸钠组戴镜后1 d、1周、1个月、3个月的NIKf-BUT分别为(7.13±1.71)、(6.61±1.49)、(6.37±1.82)和(7.01±1.63)s,舒润液组分别为(6.32±1.71)、(5.53±1.42)、(5.57±1.50)和(6.17±1.63)s,生理盐水组分别为(6.36±1.58)、(5.81±1.49)、(5.74±1.77)和(6.28±1.53)s;戴镜后各时间点玻璃酸钠组NIKf-BUT均高于舒润液组和生理盐水组,差异均有统计学意义(均P<0.05),舒润液组和生理盐水组各时间点NIKf-BUT比较,差异均无统计学意义(均P>0.05)。玻璃酸钠组戴镜后各时间点FL评分均低于舒润液组和生理盐水组,差异均有统计学意义(均P<0.05),生理盐水组和舒润液组戴镜后各时间点FL评分比较,差异均无统计学意义(均P>0.05)。3个组间戴镜后各时间点的裸眼视力、等效球镜度和平均角膜前表面曲率K值比较,差异均无统计学意义(均P>0.05)。结论相较于舒润液和生理盐水,不含防腐剂的1 g/L玻璃酸钠滴眼液在角膜塑形镜配戴早期可以更好地稳定泪膜,对角膜上皮的影响更小,但在视力提高和角膜塑形的速度上无明显差别。

干眼症发病相关因素的多因素非条件Logistic回归分析

目的探讨干眼症发生的主要相关因素。方法选择2006年5月至2007年11月间眼科门诊就诊的屈光不正、眼底病患者及行常规体检的健康者133人为研究对象,主要包括问卷调查和干眼病检测两个部分。问卷调查内容有人口学特征、工作环境、生活习惯与全身疾病等。先进行单因素分析,找出与干眼症发病相关联的因素,然后再对有意义的因素进行多因素综合分析,找出干眼病发生的主要危险因素。结果单因素分析结果表明:与干眼症发病相关的因素有年龄、荧光屏接触时间、野外工作时间、工作环境、吸烟和糖尿病。行Logistic回归分析,最终有统计学意义的因素为:年龄、野外工作时间和工作环境。结论就纳入本研究的因素而言,影响干眼症发病的主要因素是年龄、野外工作时间和工作环境,而荧光屏接触时间、吸烟及罹患糖尿病在一定程度上影响着干眼病的发生。

重组牛bFGF对超声乳化联合IOL植入术后干眼的疗效

目的:评价重组牛碱性成纤维细胞生长因子(basic fibroblast growth factor,b FGF)在白内障超声乳化联合人工晶状体(intraocular lens,IOL)植入术后干眼症状治疗中的应用价值。方法:选取140例140眼白内障超声乳化联合IOL植入术后干眼患者,随机分为对照组和观察组,分别使用聚乙二醇滴眼液和聚乙二醇滴眼液联合重组牛b FGF眼用凝胶治疗。在治疗前和治疗后1mo进行干眼症状评分和基础泪液分泌试验Ⅰ(SchirmerⅠtest,SⅠt)、泪膜破裂时间(tear break-up time,BUT)、角膜荧光素染色检测,统计分析两组疗效差异。结果:治疗前两组患者干眼症状评分和SⅠt、BUT均无统计学差异(P>0.05)。治疗后经配对t检验发现以上三个测量值在两组内比较,差异有统计学意义(P<0.05),均有明显改善。但治疗后组间比较仅发现观察组的干眼症状评分和BUT明显优于对照组,差异有统计学意义(P<0.05),观察组的角膜荧光素染色评分下降率显著高于对照组,差异有统计学意义(P<0.05)。结论:针对白内障超声乳化联合IOL植入术后干眼的治疗,联合应用传统人工泪液聚乙二醇和重组牛b FGF较单独应用聚乙二醇可显著改善患者眼部不适,明显延长BUT,有效降低角膜荧光素染色评分,疗效更为理想。

中药熏蒸治疗白内障手术相关性干眼的临床研究

目的探讨中药熏蒸治疗白内障手术后干眼的临床疗效,为术后干眼的治疗提供新的思路,丰富中医外治法在眼科中的应用。方法采用前瞻性随机对照方法。将白内障术后干眼患者60例随机分为2组,治疗组为中药熏蒸+玻璃酸钠滴眼液;对照组为单纯玻璃酸钠滴眼液。治疗14 d为1个疗程。对比两组在治疗前后的各项客观指标和主观症状评分,评价在改善白内障术后干眼方面的疗效。结果最终纳入并完成研究47例,治疗组24例,对照组23例。两组的泪液分泌量、泪膜破裂时间、角膜荧光素染色及主观症状评分在治疗前后进行对比,P<0.05,均有统计学意义。治疗组和对照组的疗效进行对比,在泪液分泌量(Schirmer)、角膜荧光素染色(FL)、主观症状评分方面,P>0.05,无统计学意义,在泪膜破裂时间(BUT)方面,P<0.05,具有统计学差异。结论中药熏蒸能改善白内障术后干眼患者的泪液分泌量、泪膜破裂时间、角膜荧光素染色及主观症状评分,且在改善患者泪膜破裂时间方面疗效优于对照组,提示中药熏蒸对白内障术后干眼的治疗具有良好的疗效。

上提眼睑对泪膜破裂时间的影响

目的：探讨上提眼睑引起的泪膜破裂时间的改变。方法：对五名学生分别检测上提眼睑（HTBUT）和未提眼睑（TBUT）时的泥股破裂时间，并进行比较，结果：HTBUT的均值为10．469±5381s，TBUT的均值为11.3312±5.468s，两者无明显的差异；男性的TB叶均值11.5838±5.915s，女性TBUT均值为11．0788±5.165s，无显著差异。结论：认为轻微上提眼睑对泪膜稳定性无明显的影响，

人工泪液凝胶联合双氯芬酸钠滴眼液对干眼症患者F S与BUT指标的影响

目的研究人工泪液凝胶联合双氯芬酸钠滴眼液对干眼症患者角膜荧光素染色(FS)与泪膜破裂时间(BUT)指标的影响。方法选择我院2017年3月至2018年3月收治的干眼症患者100例,随机分为对照组和观察组各50例。对照组单纯采用人工泪液凝胶治疗,观察组采用人工泪液凝胶联合双氯芬酸钠滴眼液治疗,对比分析两组患者的临床疗效、 FS、 BUT指标及眼部症状评分。结果观察组的治疗总有效率为96.00%,显著高于对照组的76.00%(P <0.05)。治疗前,两组的FS、 BUT水平比较差异无统计学意义(P>0.05);与对照组相比,观察组治疗后的FS水平明显降低, BUT水平明显升高(P均<0.05)。治疗后,两组的眼部症状评分均降低,且观察组的眼部症状评分优于对照组(P均<0.05)。结论采用人工泪液凝胶联合双氯芬酸钠滴眼液治疗可有效改善干眼症患者的眼部临床症状,调节FS、 BUT指标,值得临床推广。

养肝润目方联合玻璃酸钠滴眼液治疗肝肾阴虚型干眼症临床研究

目的:观察养肝润目方联合玻璃酸钠滴眼液治疗肝肾阴虚型干眼症(DE)的临床疗效。方法:选取96例肝肾阴虚型DE患者,按随机数字表法分为对照组和观察组各48例。对照组给予0.3%玻璃酸钠滴眼液治疗,观察组在对照组基础上加用养肝润目方治疗,7 d为1个疗程,2组均连续治疗4个疗程。观察2组治疗前后泪液分泌试验(SIt)滤纸湿长、泪膜破裂时间(BUT)、角膜荧光素染色(FL)及眼部症状积分的变化情况,评估2组临床疗效及安全性。结果:治疗后,2组SIt滤纸湿长、BUT均较治疗前增加(P<0.05),FL评分均较治疗前降低(P<0.05);观察组SIt滤纸湿长及BUT均长于对照组(P<0.05),FL评分低于对照组(P<0.05)。治疗后,2组眼干涩、畏光、眼疲劳、异物感积分均较治疗前降低(P<0.05),观察组上述4项眼部症状积分均低于对照组(P<0.05)。观察组总有效率为91.67%,高于对照组的75.00%(P<0.05)。2组均未发生不良反应。结论:养肝润目方联合玻璃酸钠滴眼液治疗肝肾阴虚型DE可以提高临床疗效,且用药安全性高。