AIM：To investigate the association between tear film break up time（TBUT）and blinking interval in visual display terminal（VDT）users.METHODS：Nine hundred and thirty VDT users underwent dry eye testing,and function...AIM：To investigate the association between tear film break up time（TBUT）and blinking interval in visual display terminal（VDT）users.METHODS：Nine hundred and thirty VDT users underwent dry eye testing,and functional visual acuity（FVA）test.The blinking interval during FVA was compared with TBUT.Subjects with longer blinking interval than TBUT were considered as unstable tear film.Logistic regression analysis revealed the risk factors for unstable tear group.RESULTS：Among 930 workers,858 subjects（92.3%）participated in this study.Almost 80% of the subjects were categorized into the unstable tear group.Unstable tear group has significantly lower Schirmer values and TBUT（17.5±11.6 vs 21.1±11.5 mm,3.7±2.6 vs 5.7±2.7s,both P〈0.001）.There were no significant differences in epithelial staining or severity of symptoms.Logistic regression showed that over 40y was a risk for being unstable tear group[odds ratio（OR）=1.53;95%confidence interval（CI）=1.06-2.20].Contact lens use was protective factor for being in the unstable tear group（OR=0.37;95%CI=0.26-0.53）.CONCLUSION：Subjects with shorter TBUT than blinking interval are prevalent among VDT users.Subjects over the age of 40 shows an increased risk for unstable tear film.展开更多
<strong>Background:</strong> Dry eye is characterized by tear film instability, decreased tear volume and a high Ocular Surface Disease Index (OSDI) score. Face masks have been linked to dry eye complaints...<strong>Background:</strong> Dry eye is characterized by tear film instability, decreased tear volume and a high Ocular Surface Disease Index (OSDI) score. Face masks have been linked to dry eye complaints in recent studies. <strong>Purpose:</strong> To evaluate the changes in tear-film status and Ocular Surface Disease Index (OSDI) score following prolonged use of face mask. <strong>Design:</strong> Cross-sectional study. <strong>Method:</strong> Patients between 18 to 70 years using masks regularly for at least 2 hours/day for at least 5 days/week from different eye-care centres in Dhaka were included. All subjects were divided into 4 groups. Mask use lasted approximately 2 hours/day in Group 1, 4 hours/day in Group 2, 6 hours/day in Group 3 and 8 hours or more/day in Group 4. Evaluation of symptoms, tear- film stability and tear volume was done by Ocular Surface Disease Index (OSDI) scores, Tear-film Break-Up Time (TBUT) and Schirmer-1 test. Average of right & left eye’s Tear-film Break Up time (TBUT) and Schirmer-1 value were noted. <strong>Results:</strong> Total 100 patients were enrolled (n = 100). The TBUT (p < 0.001) and Schirmer-1 measurement (p = 0.01) were significantly lesser and Ocular Surface Disease Index (OSDI) score were significantly higher in patients using face-masks for longer time (p < 0.001). <strong>Conclusion:</strong> Patients who wore masks for prolonged time had tear film instability, reduced tear volume and higher Ocular Surface Disease Index (OSDI) score.展开更多
目的:观察微型角膜刀准分子激光上皮瓣下角膜磨镶术(epipolis laser in situ keratomileusis,Epi-LASIK)术后角膜中央知觉和泪膜稳定性的变化。方法:选择92例184眼近视患者行Epi-LASIK手术,其中低中度近视组48例96眼,高度近视组44例88...目的:观察微型角膜刀准分子激光上皮瓣下角膜磨镶术(epipolis laser in situ keratomileusis,Epi-LASIK)术后角膜中央知觉和泪膜稳定性的变化。方法:选择92例184眼近视患者行Epi-LASIK手术,其中低中度近视组48例96眼,高度近视组44例88眼。观察术眼术前及术后1,3,6mo的角膜中央知觉、泪膜破裂时间(break-up time,BUT)、泪液分泌量(SchirmerⅠ实验),并对结果进行统计学分析。结果:两组术后角膜中央知觉及泪膜稳定性均有不同程度的下降。低中度近视组术后1mo角膜中央知觉及BUT与术前比有显著性差异(P<0.05),术后3mo时角膜中央知觉及BUT已恢复。高度近视组术后1,3mo角膜中央知觉及BUT与术前比有显著性差异(P<0.05),术后6mo时角膜中央知觉及BUT已基本恢复。高度近视组角膜中央知觉和泪膜稳定性减退更明显,恢复时间更长。两组术后泪液分泌量(SchirmerⅠ实验)分别与术前相比无显著性差异。结论:Epi-LASIK术影响角膜中央知觉和泪膜的稳定性。高度近视对角膜中央知觉和泪膜稳定性的影响比中低度近视大而且持续时间长,但最终可随着角膜的愈合而恢复。展开更多
Background:To investigate the effect of eye rubbing on keratometry(K),aberrometry,tear film break-up-time(TFBUT)and anterior chamber depth(ACD).Methods:Volunteers without any corneal pathology or dry eyes were randomi...Background:To investigate the effect of eye rubbing on keratometry(K),aberrometry,tear film break-up-time(TFBUT)and anterior chamber depth(ACD).Methods:Volunteers without any corneal pathology or dry eyes were randomised to rubbing in one eye and the fellow-eye was control.Eye rubbing was performed for 2 min.Primary outcomes studied were anterior and posterior K changes.Secondary outcomes were changes in TFBUT,axial length(AL)&ACD,K changes in various zones,asphericity and aberrometry.Pre and post rubbing K,aberrometry,ACD and TFBUT were assessed in a predetermined sequence.The relationship of the above parameters to axial length(AL)was also assessed.Astigmatism was analysed using vector analysis.Results:Pre versus post rubbing,anterior flatter K further flattened(42.51±1.52 D vs.42.36±1.53 D,p=0.003)and the changes to J0 vector in central cornea(−0.16±0.26 D vs.-0.27±0.33 D,p=0.038)suggested change to against-the-rule(ATR)astigmatism.There was significant change in Z^(+2)_(2) polynomial following rubbing.We found a positive correlation between axial length and change in posterior K(r=0.335,p=0.020).The TFBUT reduced following eye rubbing(15.3 s vs.13.9 s,p=0.0001).There was a positive correlation between AL and increase in ACD post rubbing(r=0.300,p=0.038).There was a positive correlation between ACD and change in mean posterior K(r=0.305,p=0.035).Conclusions:In healthy eyes,following eye rubbing,there is a significant change in TFBUT and central anterior K changes towards ATR astigmatism.Longer eyes had more changes in posterior K and ACD.Whereas,eyes with deeper ACD showed more steepness of posterior K.展开更多
目的:探讨一种最新的眼表综合分析仪Keratograph对于泪膜稳定性评估的重复性和准确性,将其测量值与传统的检查方法进行比较。方法:采用Keratograph测量包括首次泪膜破裂时间(the first tear film break-up time,BUT-f)和平均泪膜破裂时...目的:探讨一种最新的眼表综合分析仪Keratograph对于泪膜稳定性评估的重复性和准确性,将其测量值与传统的检查方法进行比较。方法:采用Keratograph测量包括首次泪膜破裂时间(the first tear film break-up time,BUT-f)和平均泪膜破裂时间(the average tear film break-up time,BUT-ave)在内的非侵入式泪膜破裂时间(noninvasive tear film break-up time,NI_BUT)结果。测量结果的重复性使用变异系数(coefficient of variation,CV)和组内相关系数(intraclass correlation coefficient,ICC)进行评价,NI-BUT与传统的荧光素泪膜破裂时间(fluorescein tear film break-up time,FBUT)的比较采用Wilcoxon符号秩和检验,确定NI-BUT与FBUT,SchirmerⅠ试验结果的相关关系,采用BlandAltman分析进行一致性评价。结果:本研究纳入了48个受检者(48眼),平均年龄38.7±15.2岁。BUT-f的CV和ICC分别为12.6%和0.95,BUT-ave的为9.8%和0.96。BUT-f值低于FBUT值,差异有统计学意义(6.16±2.46s vs 7.46±1.92s,P<0.01)。NI-BUT与FBUT,SchirmerⅠ试验结果之间存在显著的正相关关系(P<0.01)。BUT-f与FBUT的95%一致性界限(limits of agreement,Lo A)范围为4.46s,BUT-ave与FBUT的Lo A范围为3.64s。结论:Keratograph能够提供具有较好重复性和可靠性的NI-BUT数据,在干眼诊治和角膜屈光性手术等领域有很好的应用前景。展开更多
目的探讨Oculus眼表综合分析仪测量准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)术后干眼患者的非侵入性泪液功能指标与干眼症状、体征的相关性。方法选择鄂州市中心医院2014年9月至12月行LASIK且术后1个月被诊断为...目的探讨Oculus眼表综合分析仪测量准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)术后干眼患者的非侵入性泪液功能指标与干眼症状、体征的相关性。方法选择鄂州市中心医院2014年9月至12月行LASIK且术后1个月被诊断为干眼的患者40例(40眼),Oculus眼表综合分析仪测量非侵入性首次泪膜破裂时间(non-invasive first tear film break-up time,NIBUTf)、非侵入性平均泪膜破裂时间(non-invasive average tear film break-up time,NIBUTav)、Oculus自动干眼分级、下泪河高度(lower tear meniscus hight,LTMH);基础泪液分泌(SchirmerⅠTest,SⅠT)、角膜荧光素染色(corneal fluorescein staining,CFS)评分、患者干眼主观症状评分。采用Spearman秩相关分析NIBUTf、NIBUTav、Oculus自动干眼分级、LTMH与SⅠT、FS、干眼主观症状评分之间的关系。结果 NIBUTf、NIBUTav与Oculus自动干眼分级均呈负相关(r=-0.430,P=0.006;r=-0.747,P=0.000);SⅠT与NIBUTf、NIBUTav、LTMH均呈正相关(r=0.459,P=0.003;r=0.394,P=0.012;r=0.733,P=0.000),SⅠT与Oculus自动干眼分级无相关性(r=-0.259,P=0.107);CFS评分与NIBUTav、LTMH均呈负相关(r=-0.466,P=0.002;r=-0.687,P=0.000),CFS评分与NIBUTf、Oculus自动干眼分级均无相关性(r=-0.189,P=0.244;r=0.301,P=0.059);干眼主观症状评分与NIBUTf、NIBUTav均呈负相关(r=-0.530,P=0.000;r=-0.700,P=0.000),与Oculus自动干眼分级呈正相关(r=0.623,P=0.000)、与LTMH无明显相关性(r=-0.243,P=0.130)。结论 Oculus眼表综合分析仪能客观地测量非侵入性泪液功能指标,与干眼其他指标存在相关性,可作为辅助LASIK术后干眼诊断和随访的有效工具。展开更多
目的:探讨儿童与成人干眼临床表现的差异。方法:选取2018-06/2019-02在我院眼科门诊就诊的具有干眼主观症状的儿童患者52例52眼(儿童组)和成人患者55例55眼(成人组),进行主观症状问诊,并采用Keratograph 5M非侵入性眼表综合分析仪进行...目的:探讨儿童与成人干眼临床表现的差异。方法:选取2018-06/2019-02在我院眼科门诊就诊的具有干眼主观症状的儿童患者52例52眼(儿童组)和成人患者55例55眼(成人组),进行主观症状问诊,并采用Keratograph 5M非侵入性眼表综合分析仪进行下睑泪河高度(TMH)、首次泪膜破裂时间(BUTf)、平均泪膜破裂时间(BUTave)、泪膜脂质层厚度(LLT)、睑板腺缺失率测量。结果:儿童组患者TMH(0.15±0.04mm)、BUTf(3.22±1.24s)、BUTave(4.27±1.67s)、睑板腺缺失率[0.00%(0.00%,5.03%)]均明显低于成人组[0.20±0.05mm、4.36±1.93s、5.15±1.49s、9.90%(5.30%,18.40%),均P<0.01],但两组患者LLT无差异(72.31±22.20nm vs 68.58±21.05nm,P>0.05)。两组患者BUTf与BUTave均呈正相关,儿童组患者LLT和睑板腺缺失率无相关性(r_s=-0.23,P=0.10),而成人组患者LLT和睑板腺缺失率呈负相关(r_s=-0.28,P<0.05)。结论:儿童与成人干眼在症状、临床表现、检查方面均不同,症状主要为瞬目次数增加,检查主要表现为短BUT,伴随TMH降低,而睑板腺缺失率相对不明显。展开更多
文摘AIM：To investigate the association between tear film break up time（TBUT）and blinking interval in visual display terminal（VDT）users.METHODS：Nine hundred and thirty VDT users underwent dry eye testing,and functional visual acuity（FVA）test.The blinking interval during FVA was compared with TBUT.Subjects with longer blinking interval than TBUT were considered as unstable tear film.Logistic regression analysis revealed the risk factors for unstable tear group.RESULTS：Among 930 workers,858 subjects（92.3%）participated in this study.Almost 80% of the subjects were categorized into the unstable tear group.Unstable tear group has significantly lower Schirmer values and TBUT（17.5±11.6 vs 21.1±11.5 mm,3.7±2.6 vs 5.7±2.7s,both P〈0.001）.There were no significant differences in epithelial staining or severity of symptoms.Logistic regression showed that over 40y was a risk for being unstable tear group[odds ratio（OR）=1.53;95%confidence interval（CI）=1.06-2.20].Contact lens use was protective factor for being in the unstable tear group（OR=0.37;95%CI=0.26-0.53）.CONCLUSION：Subjects with shorter TBUT than blinking interval are prevalent among VDT users.Subjects over the age of 40 shows an increased risk for unstable tear film.
文摘<strong>Background:</strong> Dry eye is characterized by tear film instability, decreased tear volume and a high Ocular Surface Disease Index (OSDI) score. Face masks have been linked to dry eye complaints in recent studies. <strong>Purpose:</strong> To evaluate the changes in tear-film status and Ocular Surface Disease Index (OSDI) score following prolonged use of face mask. <strong>Design:</strong> Cross-sectional study. <strong>Method:</strong> Patients between 18 to 70 years using masks regularly for at least 2 hours/day for at least 5 days/week from different eye-care centres in Dhaka were included. All subjects were divided into 4 groups. Mask use lasted approximately 2 hours/day in Group 1, 4 hours/day in Group 2, 6 hours/day in Group 3 and 8 hours or more/day in Group 4. Evaluation of symptoms, tear- film stability and tear volume was done by Ocular Surface Disease Index (OSDI) scores, Tear-film Break-Up Time (TBUT) and Schirmer-1 test. Average of right & left eye’s Tear-film Break Up time (TBUT) and Schirmer-1 value were noted. <strong>Results:</strong> Total 100 patients were enrolled (n = 100). The TBUT (p < 0.001) and Schirmer-1 measurement (p = 0.01) were significantly lesser and Ocular Surface Disease Index (OSDI) score were significantly higher in patients using face-masks for longer time (p < 0.001). <strong>Conclusion:</strong> Patients who wore masks for prolonged time had tear film instability, reduced tear volume and higher Ocular Surface Disease Index (OSDI) score.
文摘Background:To investigate the effect of eye rubbing on keratometry(K),aberrometry,tear film break-up-time(TFBUT)and anterior chamber depth(ACD).Methods:Volunteers without any corneal pathology or dry eyes were randomised to rubbing in one eye and the fellow-eye was control.Eye rubbing was performed for 2 min.Primary outcomes studied were anterior and posterior K changes.Secondary outcomes were changes in TFBUT,axial length(AL)&ACD,K changes in various zones,asphericity and aberrometry.Pre and post rubbing K,aberrometry,ACD and TFBUT were assessed in a predetermined sequence.The relationship of the above parameters to axial length(AL)was also assessed.Astigmatism was analysed using vector analysis.Results:Pre versus post rubbing,anterior flatter K further flattened(42.51±1.52 D vs.42.36±1.53 D,p=0.003)and the changes to J0 vector in central cornea(−0.16±0.26 D vs.-0.27±0.33 D,p=0.038)suggested change to against-the-rule(ATR)astigmatism.There was significant change in Z^(+2)_(2) polynomial following rubbing.We found a positive correlation between axial length and change in posterior K(r=0.335,p=0.020).The TFBUT reduced following eye rubbing(15.3 s vs.13.9 s,p=0.0001).There was a positive correlation between AL and increase in ACD post rubbing(r=0.300,p=0.038).There was a positive correlation between ACD and change in mean posterior K(r=0.305,p=0.035).Conclusions:In healthy eyes,following eye rubbing,there is a significant change in TFBUT and central anterior K changes towards ATR astigmatism.Longer eyes had more changes in posterior K and ACD.Whereas,eyes with deeper ACD showed more steepness of posterior K.
文摘目的:探讨一种最新的眼表综合分析仪Keratograph对于泪膜稳定性评估的重复性和准确性,将其测量值与传统的检查方法进行比较。方法:采用Keratograph测量包括首次泪膜破裂时间(the first tear film break-up time,BUT-f)和平均泪膜破裂时间(the average tear film break-up time,BUT-ave)在内的非侵入式泪膜破裂时间(noninvasive tear film break-up time,NI_BUT)结果。测量结果的重复性使用变异系数(coefficient of variation,CV)和组内相关系数(intraclass correlation coefficient,ICC)进行评价,NI-BUT与传统的荧光素泪膜破裂时间(fluorescein tear film break-up time,FBUT)的比较采用Wilcoxon符号秩和检验,确定NI-BUT与FBUT,SchirmerⅠ试验结果的相关关系,采用BlandAltman分析进行一致性评价。结果:本研究纳入了48个受检者(48眼),平均年龄38.7±15.2岁。BUT-f的CV和ICC分别为12.6%和0.95,BUT-ave的为9.8%和0.96。BUT-f值低于FBUT值,差异有统计学意义(6.16±2.46s vs 7.46±1.92s,P<0.01)。NI-BUT与FBUT,SchirmerⅠ试验结果之间存在显著的正相关关系(P<0.01)。BUT-f与FBUT的95%一致性界限(limits of agreement,Lo A)范围为4.46s,BUT-ave与FBUT的Lo A范围为3.64s。结论:Keratograph能够提供具有较好重复性和可靠性的NI-BUT数据,在干眼诊治和角膜屈光性手术等领域有很好的应用前景。
文摘目的探讨Oculus眼表综合分析仪测量准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)术后干眼患者的非侵入性泪液功能指标与干眼症状、体征的相关性。方法选择鄂州市中心医院2014年9月至12月行LASIK且术后1个月被诊断为干眼的患者40例(40眼),Oculus眼表综合分析仪测量非侵入性首次泪膜破裂时间(non-invasive first tear film break-up time,NIBUTf)、非侵入性平均泪膜破裂时间(non-invasive average tear film break-up time,NIBUTav)、Oculus自动干眼分级、下泪河高度(lower tear meniscus hight,LTMH);基础泪液分泌(SchirmerⅠTest,SⅠT)、角膜荧光素染色(corneal fluorescein staining,CFS)评分、患者干眼主观症状评分。采用Spearman秩相关分析NIBUTf、NIBUTav、Oculus自动干眼分级、LTMH与SⅠT、FS、干眼主观症状评分之间的关系。结果 NIBUTf、NIBUTav与Oculus自动干眼分级均呈负相关(r=-0.430,P=0.006;r=-0.747,P=0.000);SⅠT与NIBUTf、NIBUTav、LTMH均呈正相关(r=0.459,P=0.003;r=0.394,P=0.012;r=0.733,P=0.000),SⅠT与Oculus自动干眼分级无相关性(r=-0.259,P=0.107);CFS评分与NIBUTav、LTMH均呈负相关(r=-0.466,P=0.002;r=-0.687,P=0.000),CFS评分与NIBUTf、Oculus自动干眼分级均无相关性(r=-0.189,P=0.244;r=0.301,P=0.059);干眼主观症状评分与NIBUTf、NIBUTav均呈负相关(r=-0.530,P=0.000;r=-0.700,P=0.000),与Oculus自动干眼分级呈正相关(r=0.623,P=0.000)、与LTMH无明显相关性(r=-0.243,P=0.130)。结论 Oculus眼表综合分析仪能客观地测量非侵入性泪液功能指标,与干眼其他指标存在相关性,可作为辅助LASIK术后干眼诊断和随访的有效工具。
文摘目的:探讨儿童与成人干眼临床表现的差异。方法:选取2018-06/2019-02在我院眼科门诊就诊的具有干眼主观症状的儿童患者52例52眼(儿童组)和成人患者55例55眼(成人组),进行主观症状问诊,并采用Keratograph 5M非侵入性眼表综合分析仪进行下睑泪河高度(TMH)、首次泪膜破裂时间(BUTf)、平均泪膜破裂时间(BUTave)、泪膜脂质层厚度(LLT)、睑板腺缺失率测量。结果:儿童组患者TMH(0.15±0.04mm)、BUTf(3.22±1.24s)、BUTave(4.27±1.67s)、睑板腺缺失率[0.00%(0.00%,5.03%)]均明显低于成人组[0.20±0.05mm、4.36±1.93s、5.15±1.49s、9.90%(5.30%,18.40%),均P<0.01],但两组患者LLT无差异(72.31±22.20nm vs 68.58±21.05nm,P>0.05)。两组患者BUTf与BUTave均呈正相关,儿童组患者LLT和睑板腺缺失率无相关性(r_s=-0.23,P=0.10),而成人组患者LLT和睑板腺缺失率呈负相关(r_s=-0.28,P<0.05)。结论:儿童与成人干眼在症状、临床表现、检查方面均不同,症状主要为瞬目次数增加,检查主要表现为短BUT,伴随TMH降低,而睑板腺缺失率相对不明显。
