Three dimensional （3D） printing technology was utilized to fabricate a new type of drug implant with complicated architectures, employing levofloxacin （LVFX） and rifampicine （RFP） as model drugs. The prepared dr...Three dimensional （3D） printing technology was utilized to fabricate a new type of drug implant with complicated architectures, employing levofloxacin （LVFX） and rifampicine （RFP） as model drugs. The prepared drug implant prototype consists of a doublelayer structure, of which the upper region is a reservoir system containing RFP and the lower region is a matrix one containing LVFX. The release test in vivo revealed that LVFX was released in the early stage; no RFP was detected until 8th day; both of them continuously released more than 6 weeks. Therefore, 3D printing technology provides a precise and feasible method to fabricate a controlled-releasing drug implant with complicated architectures and this drug implant may present a new strategy for the prophylaxis and treatment of bone diseases such as combined bone infections and bone tuberculosis in the near future.展开更多
This paper presents a modified half-sine-squared load model of the jumping impulses for a single person. The model is based on a database of 22,921 experimentally measured single jumping load cycles from 100 test subj...This paper presents a modified half-sine-squared load model of the jumping impulses for a single person. The model is based on a database of 22,921 experimentally measured single jumping load cycles from 100 test subjects. Threedimensional motion capture technology in conjunction with force plates was employed in the experiment to record jumping loads. The variation range and probability distribution of the controlling parameters for the load model such as the impact factor, jumping frequency and contact ratio, are discussed using the experimental data. Correlation relationships between the three parameters are investigated. The contact ratio and jumping frequency are identified as independent model parameters, and an empirical frequency-dependent function is derived for the impact factor. The feasibility of the proposed load model is established by comparing the simulated load curves with measured ones, and by comparing the acceleration responses of a single-degree-of-freedom system to the simulated and measured jumping loads. The results show that a realistic individual jumping load can be generated by the proposed method. This can then be used to assess the dynamic response of assembly structures.展开更多
基金Funded by the Graduate Innovation Fund of the Huazhong University of Science and Technology, the "863" Key Project of the National High Technology Research and Development Program of China (No.2006AA02A124)the Program for New Century Excellent Talents in University from the Ministry of Education of China( NCET-05-0647)
文摘Three dimensional （3D） printing technology was utilized to fabricate a new type of drug implant with complicated architectures, employing levofloxacin （LVFX） and rifampicine （RFP） as model drugs. The prepared drug implant prototype consists of a doublelayer structure, of which the upper region is a reservoir system containing RFP and the lower region is a matrix one containing LVFX. The release test in vivo revealed that LVFX was released in the early stage; no RFP was detected until 8th day; both of them continuously released more than 6 weeks. Therefore, 3D printing technology provides a precise and feasible method to fabricate a controlled-releasing drug implant with complicated architectures and this drug implant may present a new strategy for the prophylaxis and treatment of bone diseases such as combined bone infections and bone tuberculosis in the near future.
基金the National Natural Science Foundation of China under Grant Nos.51178338 and 51478346State Key Laboratory of Disaster Reduction in Civil Engineering under Grant No.SLDRCE14-B-16
文摘This paper presents a modified half-sine-squared load model of the jumping impulses for a single person. The model is based on a database of 22,921 experimentally measured single jumping load cycles from 100 test subjects. Threedimensional motion capture technology in conjunction with force plates was employed in the experiment to record jumping loads. The variation range and probability distribution of the controlling parameters for the load model such as the impact factor, jumping frequency and contact ratio, are discussed using the experimental data. Correlation relationships between the three parameters are investigated. The contact ratio and jumping frequency are identified as independent model parameters, and an empirical frequency-dependent function is derived for the impact factor. The feasibility of the proposed load model is established by comparing the simulated load curves with measured ones, and by comparing the acceleration responses of a single-degree-of-freedom system to the simulated and measured jumping loads. The results show that a realistic individual jumping load can be generated by the proposed method. This can then be used to assess the dynamic response of assembly structures.
