Objective:To evaluate the analgesic,anti-inflammatory and antipyretic activity of methanolic Tecomaria capensis(T.capensis) leaves extract using different models in rats.Methods: Methanolic T.capenssis leaves extract(...Objective:To evaluate the analgesic,anti-inflammatory and antipyretic activity of methanolic Tecomaria capensis(T.capensis) leaves extract using different models in rats.Methods: Methanolic T.capenssis leaves extract(100,300,1000 and 2000 mg/kg body weight) was given to rats orally to observe acute toxicity,and observed for 14 days.Analgesic activity was evaluated using tail immersion and formalin induced paw licking models in rats.Anti-inflammatory activity was evaluated using carrageenan induced paw edema model in rats.Antipyretic activity was evaluated using brewer's yeast induced pyrexia model in rats.Methanolic T.capensis leaves extract were given at dose of 100,200 and 500 mg/kg p.o.Results:Results demonstrated that the no mortality was reported even after 14 days.This indicated that the methanol extract was safe up to a single dose of 2000 mg/kg body weight Methanolic 71 capensis leaves extract(100,200 and 500 mg/kg p.o.) significantly increased the latency period in the tail immersion test,reduced the licking time in both the neurogenic and inflammatory phases in the formalin test.Methanolic T.capensis leaves extract(100,200 and 500 mg/kg p.o.) significantly prevented increase in volume of paw edema. Methanolic 7.capensis leaves extract at the doses of(100,200 and 500 mg/kg p.o.) significantly decreased the rectal temperature of the rats.Conclusions:This study exhibites that methanolic T. capensis leaves extract possesses analgesic,anti-inflammatory and antipyretic activity which may be mediated by the central and peripheral mechanisms.展开更多
The aim of the present study was to evaluate the potential wound healing activity of Tecomaria capensis leaves extract (TCLE) using different models in rats. (a) Excision wound model, (b) Incision wound model and (c) ...The aim of the present study was to evaluate the potential wound healing activity of Tecomaria capensis leaves extract (TCLE) using different models in rats. (a) Excision wound model, (b) Incision wound model and (c) Dead space wound model. TCLE (100, 300, 1 000 and 2 000 mg·kg-1) was given to rats to observe acute toxicity. No toxicity was found in animals till 14 days. TCLE 5% and 10% ointment were applied topically in excision wound model and incision wound model. TCLE 200 and 400 mg·kg-1 were given orally in dead space wound model. It improved healing in excision wound model, increased breaking strength of tissue in incision wound model, and increased granuloma breaking strength and hydroxyproline content in dead space wound model. These results showed that TCLE presents significant wound healing activity.展开更多
基金supported by management ofJaipur National University,Jaipur,India
文摘Objective:To evaluate the analgesic,anti-inflammatory and antipyretic activity of methanolic Tecomaria capensis(T.capensis) leaves extract using different models in rats.Methods: Methanolic T.capenssis leaves extract(100,300,1000 and 2000 mg/kg body weight) was given to rats orally to observe acute toxicity,and observed for 14 days.Analgesic activity was evaluated using tail immersion and formalin induced paw licking models in rats.Anti-inflammatory activity was evaluated using carrageenan induced paw edema model in rats.Antipyretic activity was evaluated using brewer's yeast induced pyrexia model in rats.Methanolic T.capensis leaves extract were given at dose of 100,200 and 500 mg/kg p.o.Results:Results demonstrated that the no mortality was reported even after 14 days.This indicated that the methanol extract was safe up to a single dose of 2000 mg/kg body weight Methanolic 71 capensis leaves extract(100,200 and 500 mg/kg p.o.) significantly increased the latency period in the tail immersion test,reduced the licking time in both the neurogenic and inflammatory phases in the formalin test.Methanolic T.capensis leaves extract(100,200 and 500 mg/kg p.o.) significantly prevented increase in volume of paw edema. Methanolic 7.capensis leaves extract at the doses of(100,200 and 500 mg/kg p.o.) significantly decreased the rectal temperature of the rats.Conclusions:This study exhibites that methanolic T. capensis leaves extract possesses analgesic,anti-inflammatory and antipyretic activity which may be mediated by the central and peripheral mechanisms.
文摘The aim of the present study was to evaluate the potential wound healing activity of Tecomaria capensis leaves extract (TCLE) using different models in rats. (a) Excision wound model, (b) Incision wound model and (c) Dead space wound model. TCLE (100, 300, 1 000 and 2 000 mg·kg-1) was given to rats to observe acute toxicity. No toxicity was found in animals till 14 days. TCLE 5% and 10% ointment were applied topically in excision wound model and incision wound model. TCLE 200 and 400 mg·kg-1 were given orally in dead space wound model. It improved healing in excision wound model, increased breaking strength of tissue in incision wound model, and increased granuloma breaking strength and hydroxyproline content in dead space wound model. These results showed that TCLE presents significant wound healing activity.
