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Tendon injuries of the hand 被引量:3
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作者 Volker Schffl Andreas Heid Thomas Küpper 《World Journal of Orthopedics》 2012年第6期62-69,共8页
Tendon injuries are the second most common injuries of the hand and therefore an important topic in trauma and orthopedic patients.Most injuries are open injuries to the flexor or extensor tendons,but less frequent in... Tendon injuries are the second most common injuries of the hand and therefore an important topic in trauma and orthopedic patients.Most injuries are open injuries to the flexor or extensor tendons,but less frequent injuries,e.g.,damage to the functional system tendon sheath and pulley or dull avulsions,also need to be considered.After clinical examination,ultrasound and magnetic resonance imaging have proved to be important diagnostic tools.Tendon injuries mostly require surgical repair,dull avulsions of the distal phalanges extensor tendon can receive conservative therapy.Injuries of the flexor tendon sheath or single pulley injuries are treated conservatively and multiple pulley injuries receive surgical repair.In the postoperative course offlexor tendon injuries,the principle of early passive movement is important to trigger an"intrinsic"tendon healing to guarantee a good outcome.Many substances were evaluated to see if they improved tendon healing;however,little evidence was found.Nevertheless,hyaluronic acid may improve intrinsic tendon healing. 展开更多
关键词 FLEXOR tendon EXTENSOR tendon tendon SHEAth PULLEY injury tendon LESION
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Why forefoot striking in minimal shoes might positively change the course of running injuries 被引量:9
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作者 Irene S.Davis Hannah M.Rice Scott C.Wearing 《Journal of Sport and Health Science》 SCIE 2017年第2期154-161,共8页
It is believed that human ancestors evolved the ability to run bipedally approximately 2 million years ago. This form of locomotion may have been important to our survival and likely has influenced the evolution of ou... It is believed that human ancestors evolved the ability to run bipedally approximately 2 million years ago. This form of locomotion may have been important to our survival and likely has influenced the evolution of our body form. As our bodies have adapted to run, it seems unusual that up to 79% of modern day runners are injured annually. The etiology of these injuries is clearly multifactorial. However, 1 aspect of running that has significantly changed over the past 50 years is the footwear we use. Modern running shoes have become increasingly cushioned and supportive, and have changed the way we run. In particular, they have altered our footstrike pattern from a predominantly forefoot strike(FFS) landing to a predominantly rearfoot strike(RFS) landing. This change alters the way in which the body is loaded and may be contributing to the high rate of injuries runners experience while engaged in an activity for which they were adapted. In this paper, we will examine the benefits of barefoot running(typically an FFS pattern),and compare the lower extremity mechanics between FFS and RFS. The implications of these mechanical differences, in terms of injury, will be discussed. We will then provide evidence to support our contention that FFS provides an optimal mechanical environment for specific foot and ankle structures, such as the heel pad, the plantar fascia, and the Achilles tendon. The importance of footwear will then be addressed, highlighting its interaction with strike pattern on mechanics. This analysis will underscore why footwear matters when assessing mechanics. Finally, proper preparation and safe transition to an FFS pattern in minimal shoes will be emphasized. Through the discussion of the current literature, we will develop a justification for returning to running in the way for which we were adapted to reduce running-related injuries. 展开更多
关键词 跑步 鞋子 受伤 身体形态 力学环境 FFS 可能影响 加载方式
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Epidemiology of insertional and midportion Achilles tendinopathy in runners:A prospective cohort study
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作者 Wenbo Chen Kyra L.A.Cloosterman +2 位作者 Sita M.A.Bierma-Zeinstra Marienke van Middelkoop Robert-Jan de Vos 《Journal of Sport and Health Science》 SCIE CAS CSCD 2024年第2期256-263,共8页
Background:Achilles tendinopathy(AT)is a common problem among runners.There is only limited evidence for risk factors for AT,and most studies have not defined the AT subcategories.No study has compared the incidence a... Background:Achilles tendinopathy(AT)is a common problem among runners.There is only limited evidence for risk factors for AT,and most studies have not defined the AT subcategories.No study has compared the incidence and risk factors between insertional AT and midportion AT,though they are considered distinct.This study aimed to assess incidence and risk factors of AT based on data from a large prospective cohort.The secondary aim was to explore differences in risk factors between insertional and midportion AT.Methods:Participants were recruited from among registered runners at registration for running events.Questionnaires were completed at baseline,1 month before the event,1 week before the event,and 1 month after the event.Information concerning demographics,training load,registered events,and running-related injuries were collected at baseline.The follow-up questionnaires collected information about new injuries.A pain map was used to diagnose midportion and insertional AT.The primary outcome was the incidence of AT.Multivariable logistic regression analysis was applied to identify risk factors for the onset.Results:We included 3379 participants with a mean follow-up of 20.4 weeks.The incidence of AT was 4.2%.The proportion of insertional AT was 27.7%and of midportion AT was 63.8%;the remaining proportion was a combined type of insertional and midportion AT.Men had a significantly higher incidence(5%,95%confidence interval(95%CI):4.1%-6.0%)than women(2.8%,95%CI:2.0%-3.8%).AT in the past12 months was the most predominant risk factor for new-onset AT(odds ratio(OR)=6.47,95%CI:4.27-9.81).This was similar for both subcategories of AT(insertional:OR=5.45,95%CI:2.51-11.81;midportion:OR=6.96,95%CI:4.24-11.40).Participants registering for an event with a distance of 10/10.55 km were less likely to develop a new-onset AT(OR=0.59,95%CI:0.36-0.97)or midportion AT(OR=0.47,95%CI:0.23-0.93).Higher age had a significant negative association with insertional AT(OR=0.97,95%CI:0.94-1.00).Conclusion:The incidence of new-onset AT among recreational runners was 4.2%.The proportion of insertional and midportion AT was 27.7%and 63.8%,respectively.AT in the past 12 months was the predominant risk factor for the onset of AT.Risk factors varied between insertional and midportion AT,but we could not identify clinically relevant differences between the 2 subtypes. 展开更多
关键词 Achilles tendon injury INCIDENCE Risk factor Running-related injury
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Footfall patterns of a runner with an Achilles tendon rupture
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作者 Daniel Jandacka David Zahradnik +2 位作者 Roman Farana Jaroslav Uchytil Joseph Hamill 《Journal of Sport and Health Science》 SCIE 2017年第4期498-502,共5页
Purpose: This study aims to compare the load and the length of previously ruptured and healthy Achilles tendon(AT) of a recreational runner who used different footfall patterns on each limb during running.Methods: A 4... Purpose: This study aims to compare the load and the length of previously ruptured and healthy Achilles tendon(AT) of a recreational runner who used different footfall patterns on each limb during running.Methods: A 41-year-old recreational athlete with a ruptured AT participated in this report. Two force plates and a high-speed motion capture system were used to collect ground reaction force and kinematic data in shod and barefoot running conditions. AT length was measured using ultrasonography and an infrared camera system. AT force was estimated as the active plantar flexion moment divided by AT moment arm during stance phase.Results: The participant used a rearfoot pattern on the affected limb and a forefoot/midfoot pattern on the unaffected limb during shod running,and a forefoot/midfoot pattern during barefoot running. There was no difference between the length of the affected and the unaffected AT. During shod running, the maximal AT force and loading rate were lower in the affected AT versus the unaffected AT. During barefoot running, the affected maximal AT force and loading rate were greater than the unaffected AT.Conclusion: Footfall patterns can be an adaptation to reduce the loading on a previously injured AT. It appears that runners may consider using a rearfoot footfall pattern during running to reduce the stress on the AT. 展开更多
关键词 Achilles tendon CALCANEUS Footfall patterns INJURY Running tendon length
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Mesenchymal stem cells for the treatment of tendon disorders
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作者 Lucia Machová Urdzíková Petr Lesny +1 位作者 Eva Syková Pavla Jendelová 《Journal of Biomedical Science and Engineering》 2013年第8期14-23,共10页
Tendon disorders are associated with increased morbidity and a reduction in the quality of life, especially in people of working age. Recently, a new approach, cell-based therapy, offers promising potential to treat t... Tendon disorders are associated with increased morbidity and a reduction in the quality of life, especially in people of working age. Recently, a new approach, cell-based therapy, offers promising potential to treat tendon injuries. Mesenchymal stem cells are the most suitable candidates for such therapies due to their capacity to differentiate into cells of mesodermal origin, their paracrine properties and their potential use in autologous transplantation. This review summarizes experimental as well as clinical data focusing on the use of mesenchymal stem cells to treat tendinophaties. 展开更多
关键词 Tendinophaty TENDINOSIS tendonITIS Models of tendon injuries Mesenchymal Stem Cells ROTATOR CUFF ACHILLES tendon tendon Rupture
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MANUAL TREATMENT FOR TRAUMATIC INJURIES
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《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 1998年第3期204-204,共1页
People in daily life may sometimes suffer from soft tissue injury or, even worse, dislocation of joints or fractures with muscle and tendon injuries. Such injuries often cause great pain and inconvenience and need pro... People in daily life may sometimes suffer from soft tissue injury or, even worse, dislocation of joints or fractures with muscle and tendon injuries. Such injuries often cause great pain and inconvenience and need prompt treatment, otherwise, they may cause complications resulting in lifelong infirmity. Fortunately, traditional Chinese maneuver therapy has proved especially effective in curing bodily injuries. Doctor Xu Mengzhong, as 展开更多
关键词 injuries tendon otherwise PROMPT worse suffer SOMETIMES DOCTOR MANEUVER joints
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Novel insights into the pathogenesis of tendon injury:mechanotransduction and neuroplasticity
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作者 Suellen Alessandra Soares de Moraes 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第10期2223-2224,共2页
Tendon pathology is characterized by damage to the tendon structural integrity with disruption of collagen fibers(Nourissat et al.,2015).Acute tendon injuries show a macroscopic discontinuity,ranging from partial to c... Tendon pathology is characterized by damage to the tendon structural integrity with disruption of collagen fibers(Nourissat et al.,2015).Acute tendon injuries show a macroscopic discontinuity,ranging from partial to complete tendon rupture.They involve inflammation and lead to loss of motion.In chronic conditions(or tendinopathy),symptoms include changes in both locomotor and sensorial functions of the tendon(Nourissat et al.,2015;Scott et al.,2020).Inconsistency in terminology for cases of painful tendon disorders is found,but recently the term tendinopathy was established in consensus as preferable for cases with persistent tendon pain and loss of function related to mechanical loading.This term excludes a problem in clinical practice-i.e.,specification of the presence of a particular pathological or biochemical process(Scott et al.,2020). 展开更多
关键词 tendon injuries Acute
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Rupture of the long head of the biceps brachii tendon near the musculotendinous junction in a young patient: A case report
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作者 Xuan Liu Andrew Hwee Chye Tan 《World Journal of Orthopedics》 2020年第2期123-128,共6页
We report an unusual case of the long head of the biceps brachii tendon rupture near the musculotendinous junction in a young patient.The injury occurred in a young athlete during sports competition.The clinical prese... We report an unusual case of the long head of the biceps brachii tendon rupture near the musculotendinous junction in a young patient.The injury occurred in a young athlete during sports competition.The clinical presentation,surgical treatment,and technique with tenodesis using a unicortical button of the ruptured tendon were presented.The post-surgical recovery was uneventful,and the patient returned to sports in 6 mo.The treatment approach and surgical technique of the long head of biceps brachii rupture was reviewed and discussed.In conclusion,surgical treatment of the long head of the biceps brachii tendon rupture with unicortical button tenodesis resulted in a favorable outcome in a young athlete. 展开更多
关键词 AthLETE Sport injury SHOULDER Biceps tendon TENODESIS
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Achilles Tendon Rupture with Isolated Medial Malleolar Fracture in Ipsilateral Ankle:A Case Report
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作者 Fatih Turkmensoy Ismail Turkmen +2 位作者 Yalcin Turhan Korhan Ozkan Mehmet Akif Akcal 《Open Journal of Orthopedics》 2013年第5期224-226,共3页
Achilles tendon ruptures and malleol fractures are commonly seen injuries in orthopaedic and traumatology practice, but what is rare is their concomitant. In this report, we aimed to present a rare case of a patient w... Achilles tendon ruptures and malleol fractures are commonly seen injuries in orthopaedic and traumatology practice, but what is rare is their concomitant. In this report, we aimed to present a rare case of a patient who has isolated medial malleolar fracture and achilles tendon rupture in ipsilateral ankle after an ankle sprain due to a fall from stairs and mechanism of injury. 展开更多
关键词 Achilles tendon Rupture and Malleol Fracture Injury Mechanism
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基于组织及病理变化探讨筋针疗法对慢性骨骼肌损伤的效应机制
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作者 邓小玲 林星镇 +2 位作者 袁娟 侯新聚 彭天忠 《中国中医药现代远程教育》 2024年第2期131-133,共3页
目的基于组织及病理变化探讨筋针疗法对慢性骨骼肌损伤的效应机制。方法选取健康雄性SD大鼠12只,采用随机数字表法分为对照组6只,造模成功后不处理;实验组6只,造模成功后给予筋针疗法治疗。比较2组雌激素相关受体α(ERRα)、乙酰化酶3(S... 目的基于组织及病理变化探讨筋针疗法对慢性骨骼肌损伤的效应机制。方法选取健康雄性SD大鼠12只,采用随机数字表法分为对照组6只,造模成功后不处理;实验组6只,造模成功后给予筋针疗法治疗。比较2组雌激素相关受体α(ERRα)、乙酰化酶3(SIRT3)、锰超氧化物歧化酶(SOD2)蛋白表达,肌酸激酶(CK)、乳酸脱氢酶(LDH)活性。结果实验组ERRα、SIRT3、SOD2蛋白表达均高于对照组(P<0.05);实验组CK、LDH表达均低于对照组(P<0.05)。结论筋针治疗慢性骨骼肌损伤通过调控线粒体生物合成,降低氧化应激反应,有利于慢性骨骼肌的修复。 展开更多
关键词 筋伤 慢性骨骼肌损伤 病理变化 筋针
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MRI诊断肩袖损伤及撕裂程度的临床应用观察
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作者 潘小文 高艳 +2 位作者 但倩 董晚亭 万趸 《河北医学》 CAS 2024年第6期951-955,共5页
目的:探究MRI在肩袖损伤诊断及撕裂程度的评估中的应用效果。方法:回顾性分析我院183例肩部损伤患者资料,所有患者均行核磁共振成像(MRI)检查,以关节镜检查为金标准,探究MRI对肩袖损伤的诊断价值,对肩袖不同肌腱损伤及撕裂程度的检出情... 目的:探究MRI在肩袖损伤诊断及撕裂程度的评估中的应用效果。方法:回顾性分析我院183例肩部损伤患者资料,所有患者均行核磁共振成像(MRI)检查,以关节镜检查为金标准,探究MRI对肩袖损伤的诊断价值,对肩袖不同肌腱损伤及撕裂程度的检出情况,分析MRI与关节镜测量肩袖全层撕裂肌腱撕裂尺寸偏差情况。结果:经关节镜检查,183例患者肩袖损伤阳性136例,阴性47例,MRI检查134例阳性,49例阴性,诊断敏感度95.59%(130/136),特异度91.49%(43/47),准确度为94.54%(173/183),阳性预测值为97.01%(130/134),阴性预测值87.76%(43/49),Kappa值为0.859。183例患者关节镜共诊断373处损伤,其中冈上肌腱136处,冈下肌腱122处,肩胛下肌腱115处。MRI对冈上肌腱、冈下肌腱、肩胛下肌腱的检出率显著低于关节镜检查(P<0.05);136例肩袖损伤患者中全层撕裂45例,部分撕裂91例,MRI诊断全层撕裂准确率为93.33%(42/45),部分撕裂为94.51%(86/91),总准确率为94.12%(128/136),显著低于关节镜检查(P<0.05);MRI测量全层撕裂肌腱断端回缩度、撕裂跨度的准确率分别为86.67%(39/45)、82.22%(37/45)。结论:MRI对肩袖损伤及肌腱撕裂程度均具有较高的诊断价值,可为肩袖损伤提供可靠的术前诊断依据,值得在临床推广应用。 展开更多
关键词 肩袖损伤 核磁共振成像 肩袖撕裂 肌腱
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MR检查在踝关节不同体位下对周围韧带和肌腱损伤的诊断价值研究
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作者 周祺源 杨俊霞 +1 位作者 詹浩辉 程鹏 《临床研究》 2024年第6期124-126,共3页
目的分析磁共振(MRI)检查在踝关节不同体位下对周围韧带和肌腱损伤的诊断价值。方法选择2021年1月至2023年7月河南科技大学第二附属医院收治的76例踝关节扭伤/骨折患者作为此次研究对象,纳入研究患者均接受MRI检查(分不同体位检查:自然... 目的分析磁共振(MRI)检查在踝关节不同体位下对周围韧带和肌腱损伤的诊断价值。方法选择2021年1月至2023年7月河南科技大学第二附属医院收治的76例踝关节扭伤/骨折患者作为此次研究对象,纳入研究患者均接受MRI检查(分不同体位检查:自然体位、完全跖屈、完全背屈)。对比不同体位下踝骨内侧、外侧MRI T_(2)值;另外将MRI检查与手术结果进行对照,对其诊断结果及阳性征象检出率进行分析比较。结果自然体位、完全跖屈、完全背屈踝骨内外侧负重区、非负重区MRI T_(2)指对比差异无统计学差异(P>0.05);经手术发现阳性70例,阴性6例,自然体位MRI检查诊断阳性68例,阴性8例,完全跖屈MRI检查诊断阳性67例,阴性9例,完全背屈MRI检查诊断阳性65例,阴性11例。自然体位MRI检查诊断准确度、灵敏度及特异度分别为94.74%、95.71%、83.33%,完全跖屈MRI检查诊断准确度、灵敏度及特异度分别为90.79%、92.86%、66.67%;完全背屈MRI检查诊断准确度、灵敏度及特异度分别为90.79%、91.43%、83.33%,三种体位MRI诊断效能对比差异无统计学意义(P>0.05)。结论MRI能较准确的评估踝扭伤/骨折患者的踝关节稳定性,在踝关节3种体位下(自然体位、完全跖屈、完全背屈)均能较敏感的反映周围韧带和肌腱损伤情况。 展开更多
关键词 MRI检查 踝关节 韧带损伤 肌腱损伤 诊断效能
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理筋手法调控兔骨骼肌损伤修复中瘢痕形成的作用机制
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作者 李开颖 魏晓歌 +5 位作者 宋斐 杨楠 赵振宁 王燕 穆静 马惠昇 《中国组织工程研究》 CAS 北大核心 2025年第8期1600-1608,共9页
背景:理筋手法能够促进骨骼肌修复,治疗骨骼肌损伤。但骨骼肌损伤在修复过程中的纤维化形成、瘢痕组织增生等与损伤修复质量密切相关。开展理筋手法对纤维化形成、瘢痕组织增生的调控作用研究,有利于阐述理筋手法提高骨骼肌损伤修复质... 背景:理筋手法能够促进骨骼肌修复,治疗骨骼肌损伤。但骨骼肌损伤在修复过程中的纤维化形成、瘢痕组织增生等与损伤修复质量密切相关。开展理筋手法对纤维化形成、瘢痕组织增生的调控作用研究,有利于阐述理筋手法提高骨骼肌损伤修复质量的相关机制。目的:探索理筋手法提高兔骨骼肌损伤后修复质量的作用机制,为临床治疗提供科学依据。方法:45只健康成年日本大耳白兔随机分为空白组、模型组、理筋组,每组15只。其中模型组和理筋组均进行腓肠肌打击造模;造模后理筋组于第3天开始进行理筋手法干预,1次/d,15 min/次。各组在造模后的第7,14,21天分别处死5只兔进行观察。苏木精-伊红染色法观察腓肠肌形态及炎性细胞量,Masson染色法观察腓肠肌胶原纤维量,ELISA法检测腓肠肌白细胞介素6和白细胞介素10的表达量,Western blot和RT-PCR检测配对盒基因7、成肌分化因子、肌细胞生成素、肌动蛋白α、转化生长因子β1、Ⅰ型胶原蛋白的蛋白及mRNA表达,免疫组织化学法检测Ⅰ型胶原蛋白的表达。结果与结论:①苏木精-伊红染色及Masson染色结果显示,与模型组比较,理筋组各观察点炎性细胞浸润减少,胶原纤维量减少(P<0.01),肌纤维逐渐愈合;②ELISA结果显示,与模型组比较,理筋组白细胞介素6表达持续降低(P<0.05),而白细胞介素10在造模后第7天时升高(P<0.05),随后呈下降趋势(P<0.05);③Western blot和RT-PCR结果显示,与模型组比较,理筋组造模后第14天配对盒基因7、成肌分化因子、肌细胞生成素的蛋白及mRNA表达量均显著升高(P<0.05),而第21天时却较之前下降(P<0.05);理筋组各观察点肌动蛋白α、转化生长因子β1、Ⅰ型胶原蛋白的蛋白及mRNA表达量相较于模型组均显著降低(P<0.05);④免疫组化结果显示,理筋组各观察点Ⅰ型胶原蛋白的表达量相较于模型组均显著降低(P<0.05);⑤结果表明,理筋手法能够通过抑制炎症、促进肌卫星细胞的增殖分化、减少纤维化的生成,从而提高兔骨骼肌损伤的修复质量。 展开更多
关键词 理筋手法 筋伤 骨骼肌损伤 炎症 肌卫星细胞 纤维化 瘢痕组织 修复质量
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第三趾趾深屈肌腱Ⅱ区损伤模型肌腱粘连的功能锻炼
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作者 程杰 王继宏 张沛 《中国组织工程研究》 CAS 北大核心 2024年第8期1161-1167,共7页
背景:前期研究显示,改良津下缝合法可用于修复鸡肌腱损伤,由于未进行修复后的功能锻炼,使得肌腱出现较明显的粘连,体现了肌腱修复术后进行功能锻炼的重要性。目的:探讨预防改良津下缝合法修复鸡屈趾肌腱断裂模型肌腱粘连被动功能锻炼的... 背景:前期研究显示,改良津下缝合法可用于修复鸡肌腱损伤,由于未进行修复后的功能锻炼,使得肌腱出现较明显的粘连,体现了肌腱修复术后进行功能锻炼的重要性。目的:探讨预防改良津下缝合法修复鸡屈趾肌腱断裂模型肌腱粘连被动功能锻炼的方案。方法:取10月龄三黄鸡100只,建立右足第三趾Ⅱ区趾深屈肌腱断裂模型后,采用随机数字表法分为5组,每组20只:A组术后石膏固定3周,并且每天给予1次的被动功能锻炼,连续3周;B组术后石膏固定3周,并且每天给予2次的被动功能锻炼,连续3周;C组术后石膏固定3周,并且每天给予3次的被动功能锻炼,连续3周;D组术后石膏固定3周;E组不进行石膏固定也不进行被动功能锻炼。3周后,观察鸡爪的大体形态、肌腱吻合端的形态及腱周粘连程度,检测第三趾屈趾深肌腱滑移距离和所有关节的屈曲角度、肌腱吻合端病理形态和羟脯氨酸含量。结果与结论:①E组肌腱在术后6 d左右完全断裂,从实验中剔除;B、C组鸡爪有较好的抓握形态,D组鸡爪几乎无抓握形态,A组鸡爪抓握形态差于B、C组;②B、C组肌腱吻合端膨大不明显,质地和正常腱性组织差别不大,相对于C组,B组肌腱粘连程度相对轻;D组肌腱吻合端膨大明显,质地较硬,腱周组织瘢痕明显,粘连程度重;A组的表现介于B、C组和D组之间;③B、C组鸡第三趾屈趾深肌腱滑移距离和所有关节的屈曲角度均优于A、D组(P<0.05),B组鸡肌腱中羟脯氨酸含量高于A、C、D组(P<0.05);④苏木精-伊红与天狼星红染色显示,A、C、B组肌腱胶原纤维排列逐渐有方向性,鲜红粗大的Ⅰ型胶原纤维逐渐增多,绿色细小的Ⅲ型胶原纤维逐渐减少;E组肌腱胶原纤维排列方向性差,Ⅰ型和Ⅲ型胶原纤维交叉分布;⑤结果表明,改良津下缝合法修复鸡屈趾肌腱断裂模型术后,每天2次充分的被动功能锻炼既能有效减轻肌腱粘连又能减少肌腱断裂的发生。 展开更多
关键词 腱损伤 动物实验 肌腱粘连 被动功能锻炼 趾深屈肌腱 石膏固定
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3种急性跟腱止点断裂修复方式的对比研究
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作者 冯杰 宋鹏 +1 位作者 刘德臣 曹玉净 《中医正骨》 2024年第5期13-18,共6页
目的:比较3种急性跟腱止点断裂修复方式的治疗效果。方法:选取56只5周龄SPF级雄性SD大鼠,随机分为4组,每组14只。适应性喂养1周后,将其中3组大鼠双侧后肢跟腱自止点处锐性离断,然后分别采用面缝合(面缝合组)、点缝合(点缝合组)及穿隧道... 目的:比较3种急性跟腱止点断裂修复方式的治疗效果。方法:选取56只5周龄SPF级雄性SD大鼠,随机分为4组,每组14只。适应性喂养1周后,将其中3组大鼠双侧后肢跟腱自止点处锐性离断,然后分别采用面缝合(面缝合组)、点缝合(点缝合组)及穿隧道缝合(穿隧道缝合组)的方式修复断裂的跟腱;另外1组(空白组)经相同入路暴露跟腱但不离断,然后缝合切口。术后1周和4周,分别从各组随机选取7只大鼠,测定踝关节疼痛评分、血清白细胞介素(interleukin,IL)-1β水平、跟腱最大破坏载荷,并于术后4周时进行跟腱组织病理学观察。结果:①踝关节疼痛评分。术后1周时,面缝合组、点缝合组及穿隧道缝合组的踝关节跖屈、背伸疼痛评分均高于空白组(跖屈:P=0.000,P=0.000,P=0.000;背伸:P=0.000,P=0.000,P=0.000);面缝合组和点缝合组的踝关节跖屈疼痛评分均高于穿隧道缝合组(P=0.000,P=0.019);面缝合组的踝关节背伸疼痛评分高于穿隧道缝合组(P=0.001);其余各组踝关节跖屈、背伸疼痛评分两两比较,组间差异均无统计学意义。术后4周时,面缝合组、点缝合组及穿隧道缝合组的踝关节跖屈、背伸疼痛评分均高于空白组(跖屈:P=0.000,P=0.000,P=0.000;背伸:P=0.000,P=0.000,P=0.000)。面缝合组的踝关节跖屈疼痛评分高于穿隧道缝合组(P=0.044);面缝合组和点缝合组的踝关节背伸疼痛评分均高于穿隧道缝合组(P=0.024,P=0.000);其余各组踝关节跖屈、背伸疼痛评分两两比较,组间差异均无统计学意义。②血清IL-1β水平。术后1周、4周时,面缝合组、点缝合组及穿隧道缝合组的血清IL-1β水平均高于空白组(术后1周:P=0.000,P=0.000,P=0.000;术后4周:P=0.000,P=0.000,P=0.000)。术后1周时,穿隧道缝合组的血清IL-1β水平高于面缝合组和点缝合组(P=0.003,P=0.001);面缝合组和点缝合组血清IL-1β水平的差异无统计学意义(P=0.542)。术后4周时,面缝合组、点缝合组及穿隧道缝合组血清IL-1β水平的组间差异均无统计学意义(P=0.864,P=0.622,P=0.748)。③跟腱最大破坏载荷。术后1周、4周时,面缝合组、点缝合组及穿隧道缝合组的跟腱最大破坏载荷均低于空白组(术后1周:P=0.000,P=0.000,P=0.000;术后4周:P=0.000,P=0.000,P=0.000)。术后1周时,穿隧道缝合组的跟腱最大破坏载荷高于面缝合组(P=0.023);点缝合组与面缝合组、穿隧道缝合组跟腱最大破坏载荷的差异均无统计学意义(P=0.779,P=0.053)。术后4周时,穿隧道缝合组的跟腱最大破坏载荷高于面缝合组(P=0.011);点缝合组与面缝合组、穿隧道缝合组跟腱最大破坏载荷比较,组间差异均无统计学意义(P=0.154,P=0.217)。④跟腱组织病理学观察结果。HE染色结果显示,术后4周时空白组大鼠跟腱组织结构正常,肌纤维排列紧密,未见明显变性,周围可见纤维结缔组织,未见炎症细胞浸润;面缝合组大鼠跟腱组织结构中度异常,结缔组织致密,可见少量炎症细胞浸润及少量新生血管;点缝合组大鼠跟腱组织结构中度异常,肌纤维数量增多,部分区域间隙增大,可见纤维组织及少量炎症细胞浸润,并可见少量新生血管;穿隧道缝合组大鼠跟腱组织结构轻度异常,结缔组织致密,可见大量炎症细胞浸润,新生血管数量较少。结论:与面缝合和点缝合相比,采用穿隧道缝合修复急性跟腱止点断裂,可获得更好的生物力学稳定性,但创伤较大。 展开更多
关键词 腱损伤 跟腱 重建 动物实验
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损伤前交叉韧带修复及促进移植物愈合的策略 被引量:1
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作者 白晨 杨文骞 +1 位作者 孟志超 王宇泽 《中国组织工程研究》 CAS 北大核心 2024年第9期1457-1463,共7页
背景:近些年,对于前交叉韧带损伤的治疗日益成熟,但是,临床上对于前交叉韧带损伤的手术时机、手术方式的选择、移植物的选择及促进移植物愈合的方法等问题还存在争议。目的:总结前交叉韧带损伤的手术时机、手术方式、移植物选择和促进... 背景:近些年,对于前交叉韧带损伤的治疗日益成熟,但是,临床上对于前交叉韧带损伤的手术时机、手术方式的选择、移植物的选择及促进移植物愈合的方法等问题还存在争议。目的:总结前交叉韧带损伤的手术时机、手术方式、移植物选择和促进移植物愈合方法的最新研究进展,为前交叉韧带损伤寻找新的治疗方向。方法:从PubMed、中国知网、万方数据、维普、SinoMed、ScienceDirect、Springer和Cochrane图书馆数据库进行前交叉韧带损伤相关文献的检索,最终经过筛选纳入相关文献72篇进行综述分析。结果与结论:①在手术时机方面:前交叉韧带早期重建与延迟重建相比,早期重建可减缓半月板的损伤、提高生活质量、促进功能恢复,然而手术时机的不同是否会加速软骨损伤,目前还无定论。②在手术方式方面:关节镜下前交叉韧带重建术是前交叉韧带损伤的常用手术方式;前交叉韧带动态内稳定修复术在短期和长期疗效中,都可以带来和传统前交叉韧带重建术相似的结局。③在移植物的选择方面:自体腘绳肌肌腱是前交叉韧带移植物的首要选择;骨-髌腱-骨移植物和同种异体移植物作为次要选择。④在促进移植物愈合的策略方面:缝合带加强可以增加膝关节稳定性,保证移植物的愈合;干细胞通过抗炎作用、血管生成作用、抑制骨溶解和促进软骨细胞分化促进移植物的腱-骨愈合;保留前交叉韧带残端可以维持膝关节稳定、促进本体感觉恢复,为移植物的愈合提供先决条件;富血小板血浆促进移植物愈合的有效性有待商榷;而生物材料、基因治疗及干细胞治疗等促进肌腱愈合的方法还停留在分子和动物研究阶段,未来还需要进行临床转化。 展开更多
关键词 前交叉韧带损伤 前交叉韧带重建 移植物 移植物愈合 延迟重建 LARS 股四头肌肌腱 干细胞 基因 生物材料
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自体同侧腓骨长肌腱和腘绳肌腱重建后交叉韧带的效果分析
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作者 姜定君 李俊 +4 位作者 路晓 周铭剑 侯刚 何洲 徐杨俊 《外科研究与新技术(中英文)》 2024年第2期115-119,共5页
目的在后交叉韧带断裂患者中采用自体同侧腓骨长肌腱(PLT)重建,并与腘绳肌腱(HT)重建比较,分析其安全性与有效性。方法回顾性分析收治的后交叉韧带断裂行重建手术患者,根据取材不同分为PLT组(22例,采用自体同侧腓骨长肌腱重建)和HT组(20... 目的在后交叉韧带断裂患者中采用自体同侧腓骨长肌腱(PLT)重建,并与腘绳肌腱(HT)重建比较,分析其安全性与有效性。方法回顾性分析收治的后交叉韧带断裂行重建手术患者,根据取材不同分为PLT组(22例,采用自体同侧腓骨长肌腱重建)和HT组(20例,采用自体腘绳肌腱重建)。观察指标包括围手术期情况、随访期指标及影像学评估。结果两组患者的各项围手术期指标差异均无统计学意义;PLT组患者的不良反应发生率明显小于HT组。末次随访时,PLT组患者的膝关节评分和影像学指标明显优于HT组。结论在后交叉韧带损伤重建的患者中应用自体同侧腓骨长肌腱治疗可高效恢复膝关节功能、缓解疼痛症状和促进关节活动,并规避手术创伤对康复的影响。 展开更多
关键词 后交叉韧带损伤 自体肌腱 腓骨长肌腱 腘绳肌腱
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针刺筋会穴阳陵泉对帕金森模型小鼠黑质TH表达的影响研究 被引量:4
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作者 陈伶利 李杰 +2 位作者 李新华 陈北阳 莫莉 《中医药导报》 2010年第11期67-69,共3页
目的:观察比较1-甲基-4-苯基-1,2,3,6四氢吡啶(MPTP)诱导的帕金森小鼠模型及其接受针刺治疗后黑质酪氨酸羟化酶(TH)的表达变化。方法:以腹腔注射(30 mg/kg)MPTP诱导7 d形成帕金森小鼠模型,针刺双侧筋会穴"阳陵泉"及"舞... 目的:观察比较1-甲基-4-苯基-1,2,3,6四氢吡啶(MPTP)诱导的帕金森小鼠模型及其接受针刺治疗后黑质酪氨酸羟化酶(TH)的表达变化。方法:以腹腔注射(30 mg/kg)MPTP诱导7 d形成帕金森小鼠模型,针刺双侧筋会穴"阳陵泉"及"舞蹈震颤区",1次/d,共治疗21 d。针刺结束后,采用免疫荧光组化检测小鼠脑黑质TH的表达变化。结果:在7 d造模后,模型组和针刺组TH阳性细胞显著丢失;治疗结束后,与模型组比较,针刺组TH阳性细胞数量增加。结论:MPTP可促进帕金森模型小鼠表达;针刺筋会穴阳陵泉可对MPTP诱导小鼠黑质多巴胺能神经有保护作用,能明显地减弱MPTP伤害性刺激引起的行为反应。 展开更多
关键词 筋会穴阳陵泉 帕金森模型小鼠 th
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基于柔筋解结法综合防治慢性筋骨病损述要
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作者 任我行 丁立鹏 +3 位作者 杨宗睿 王媛媛 刘永铭 詹红生 《辽宁中医杂志》 CAS 北大核心 2024年第7期54-56,共3页
筋结是筋受伤的表现,是慢性筋骨病损的开端。筋作为人体的重要组成部分,受伤以后其形态结构发生改变,引起“筋出槽”,形成筋结,致其功能受损,表现出慢性疼痛。但随着科学技术发展,施术者在诊疗过程中往往忽视或不够重视筋的作用,从而误... 筋结是筋受伤的表现,是慢性筋骨病损的开端。筋作为人体的重要组成部分,受伤以后其形态结构发生改变,引起“筋出槽”,形成筋结,致其功能受损,表现出慢性疼痛。但随着科学技术发展,施术者在诊疗过程中往往忽视或不够重视筋的作用,从而误诊、失治,导致病情迁延难愈,形成慢性筋骨病损。文章基于詹红生教授“筋主骨从、筋为骨用”的学术思想,强调“筋结”这一关键病因病机,阐述以“柔筋解结”为核心,“四‘以’相合、医患合作”为总则,重视体格检查,顺应四时规律,注重医患合作,结合中医整体辨证施治思维综合论治慢性筋骨病损的科学性、合理性及重要性。 展开更多
关键词 筋结 柔筋解结 慢性筋骨病损 詹红生
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不同指法着力点的会阴保护技术对初产妇分娩结局的影响
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作者 平燕 樊雪梅 +5 位作者 周春秀 李六兰 叶宁 刘婧岩 支军 周文胜 《护理学杂志》 CSCD 北大核心 2024年第10期51-53,58,共4页
目的探讨2种指法保护着力点的会阴保护技术对初产妇分娩结局的影响。方法将329例经阴道分娩的初产妇随机分为观察组165例和对照组164例。对照组以距离会阴后联合2 cm处为指法着力点进行适度会阴保护,观察组以胎儿额骨最高点与会阴中心... 目的探讨2种指法保护着力点的会阴保护技术对初产妇分娩结局的影响。方法将329例经阴道分娩的初产妇随机分为观察组165例和对照组164例。对照组以距离会阴后联合2 cm处为指法着力点进行适度会阴保护,观察组以胎儿额骨最高点与会阴中心腱交汇点为指法着力点进行适度会阴保护。比较两组第二产程时间、会阴裂伤程度、伤口缝合时间、产后2 h出血量、产后24 h会阴水肿情况、产后48 h会阴疼痛程度及新生儿Apgar评分。结果观察组会阴裂伤程度、伤口缝合时间、产后2 h出血量、产后48 h会阴疼痛程度显著低于对照组(均P<0.05);两组产妇第二产程时间、产后24 h会阴水肿程度、1 min新生儿Apgar评分比较,差异无统计学意义(均P>0.05)。结论以胎儿额骨最高点与会阴中心肌腱交汇点为指法着力点的适度会阴保护技术能有效保护会阴,降低会阴损伤程度,提升产妇产后舒适度。 展开更多
关键词 初产妇 阴道分娩 胎儿额骨 会阴中心腱 会阴保护 指法保护 会阴损伤 产科护理
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