Synthesis, Structure and Fluorescence of a Copper(II) Complex [Cu_2(bipy)_2(Hpht)_2Cl](Hpht)(bipy=2,2'-Bipyridine,H_2pht=o-Phthalic Acid)

The title complex [Cu2(bipy)2(Hpht)2Cl](Hpht) (bipy = 2,2?-bipyridine, H2pht = o-phthalic acid) has been synthesized in the NaOH aqueous solution of CuCl2, Gd(NO3)3, bipy and H2pht, and its crystal structure was determined by single-crystal X-ray diffraction method. It crys- tallizes in triclinic, space group P1, C44H31ClCu2N4O12, Mr = 970.26, a = 8.175(2), b = 16.254(4), c = 16.946(4) ?, α = 62.966(6), β = 84.833(8), γ = 84.348(8)°, V = 1993.4(8) ?3, Z = 2, Dc = 1.616 g/cm3, F(000) = 988 and μ = 1.207 mm-1. The final R = 0.0429 and wR = 0.0843 for 5682 observed reflections with I > 2σ(I). Each copper(II) atom displays a distorted square-pyramidal geometry with two nitrogen atoms of one chelate 2,2?-bipy molecule, two oxygen atoms from two different bridging carboxylate groups of Hpht- and one bridging chloride atom occupying the apical position. The two copper(II) atoms are connected by a μ2-Cl atom and two bridging Hpht- ligands in a syn-syn coordination mode to form an isolated dinuclear unit. The molecular structure is extended to a one-dimensional wavy chain through hydrogen bonds. The title complex exhibits blue fluorescent emission at 443 nm (λex = 372 nm) in the solid state at room temperature.

Synthesis,Crystal Structure and Antibacterial Activity of a New Ternary Copper(Ⅱ) Complex with 2,6-Pyridinedicarboxylic Acid and 1,10-Phenanthroline

A new ternary copper（Ⅱ） complex, [C43H27Cu2N7O5][C14H6CuN2O8]＇6.5H2O, has been synthesized by the reaction of copper sulfate, 2,6-pyridinedicarboxylic acid and 1,10- phenanthroline （phen）, and characterized by elemental analysis, IR, UV and X-ray single-crystal diffraction. It crystallizes in triclinic, space group P1, with a = 14.379（5）, b = 15.510（5）, c = 15.835（6） A, a = 78.567（6）, β = 63.594（6）, y = 81.287（6）°, V= 3092.1（19） A3, C57H46Cn3N9O19.5, Mr = 1359.54, Z = 2, Dc = 1.446 Mg/m3, λ（MoKa） = 0.71073 A,μ = 1.101 mm^-1, F（000） = 1362, S = 1.071, the final R = 0.0718 and wR = 0.11960 for 10705 observer reflections （I 〉 2σ（I））. The structure unit of the title complex consisfs of a mononuclear part and a di-nuclear part, and the three copper ions show three coordination modes. Each 6-coordinated geometry of the Cu atom is a distorted octahedral coordination geometry. The 3D supramolecular system is formed by the hydrogen bond O-H-O and π-π stacking interaction between neighboring single cells. The antibacterial activity of the title complex is also studied.

Synthesis,Crystal Structure and Antimicrobial Activity of a New Ternary Copper(Ⅱ) Complex with p-Chlorophenoxyacetic Acid and 2-Amino Benzothiazole

A novel ternary complex of Cu（pcpa）2（aben）2 （pcpa=p-chlorophenoxyacetic acid anion,aben=2-amino benzothiazole） was synthesized by the reaction of copper acetate,2-amino benzothiazole and p-chlorophenoxyacetic acid.Elemental analysis,IR,UV and X-ray single-crystal diffraction were carried out to determine the composition and crystal structure.The crystal crystalli-zes in the monoclinic system,space group C2/c with a=25.795（4）,b=7.384（3）,c =17.741（6）,β=107.47（2）°,C30H24Cl2CuN4O6S2,Mr=735.09,V=3223.2（18） 3,Z=4,Dc=1.515 Mg/m3,λ（MoKα）=0.71073 ,μ=1.022 mm-1,F（000）=1500,the final R=0.0464 and wR=0.1244.A total of 3218 unique reflections were collected,of which 2228 with I 〉 2σ（I） were observed.The Cu（II） atom is four-coordinated with two carboxylate oxygen atoms of the two pcpa ligands and two nitrogen atoms in thiazole rings of two aben ligands.The analysis of crystal structure shows intermolecular and intramolecular hydrogen bonds between amino-nitrogen atoms of the two aben ligands and carboxylate oxygen atoms of the two pcpa ligands.The antimicrobial properties of the title complex and its two free ligands were tested against representative bacterial and fungal strains.Results show that the antibacterial activity of the complex is less than or equal to that of 2-amino benzothiazole,but for yeasts and moulds,it exhibits excellent inhibitory effect better than that of its two free ligands.

Synthesis, Structure and Spectral Characterization of a Discrete Binuclear Copper (II) Complex

A discrete binuclear copper (II) complex containing Cu 2O 2 unit has been synthesized by the reaction of Cu (ClO 4) 2·6H 2O with 2 aminopyridine in the CH 3OH solution and characterized by X ray diffraction study and IR spectroscopy. The crystal is monoclinic, space group: P2 1/n, with unit cell parameters: a=8.2952(2), b=18.4633(3), c=10.5049(2) . β=108.965(1)°, V=1521.56(5) 3, Z=2, C 22 H 30 N 8O 10 Cl 2Cu 2, M r =764.52, D c =1.669 Mg/m 3, F(000)=780, μ (Mo Kα )=8.60, T =293(2)K, final R=0.0623, wR =0.1536 for 2660 observed reflections with I>2.0σ(I ). The centrosymmetric complex Cu 2(CH 3O) 2(C 5H 6N 2) 4(ClO 4) 2 comprises a pair of Cu(II) atoms bridged by two methanoxo and N coordination 2 aminopyridine. The Cu(II)…Cu(II) distance is 3\^002(1).

Efficient Cleavage of DNA by the Novel Copper (II) Complex Derived From 2,2'-Pyridil Ligand

Copper (II) complex derived from 2, 2'-pyridil ligand has been, demonstrated to cleave efficiently DNA at micromolar concentrations at room temperature and pH 7.25.

Synthesis and Crystal Structure of Copper(II) Complex with N-Acetoxyl-picolinamide

Using Cu(II) as the template, a complex {[Cu2L2(H2O)2]·4H2O}n (L = N-acetoxyl- picolinamide) has been successfully synthesized and characterized by single-crystal X-ray diffrac- tion. The crystal is of monoclinic, space group C2/c, with a = 24.144(5), b = 7.1622(14), c = 17.283(4) ?, C16H24Cu2N4O12, Mr = 591.47, β = 131.73(3)o, V = 2230.3(8) ?3, Z = 4, Dc = 1.761 g/cm3, F(000) = 1208, μ = 1.978 mm?1, R = 0.0400 and wR = 0.1099. The copper (II) ion is five- coordinated with a distorted square pyramidal geometry. The complex can be viewed as a one- dimensional chain structure by carboxylic bridges among copper atoms. In the complex there exist hydrogen bonding interactions to stabilize the structure.

Synthesis and Characterization of Nickel(II) and Copper(II) Complexes with Schiff Base (1R,2R)-(-)-Diaminocyclohexane-N,N'-bis(3-tert-butyl-5-(4'-benzoic acid)-salicylidene)

Two homochiral metallosalen complexes, Ni（salen） （salen = （1R,2R）-（-）-diamino- cyclohexane-N,N′-bis（3-tert-butyl-5-（4′-benzoic acid）-salicylidene） 1 and Cu（salen） 2, have been synthesized and characterized by IR, microanalysis, TGA, powder and single-crystal X-ray crystallography. Both 1 and 2 crystallize in orthorhombic space group P21212 with Z = 4. For 1, a = 12.082（2）, b = 15.447（3）, c = 18.784（4）A^°, V= 3505.7（12）A^°3, Mr = 731.50, Dc = 1.386 g/cm^3, μ = 0.606 mm^-1, F（000） = 1544, the final GOOF = 1.043, R = 0.0496 and wR = 0.1248 for 4791 observed reflections with I 〉 2σ（I）. For 2, a = 12.181（2）, b = 15.501（3）, c = 18.877（4） A^°, V = 3564.3（12）A^°3, Mr = 736.33, Dc = 1.372 g/cm^3, μ = 0.665 mm^-1, F（000） = 1548, the final GOOF = 1.062, R = 0.0575 and wR = 0.1508 for 4562 observed reflections with I 〉 2σ（I）. The crystal structures of 1 and 2 are isostructural with very similar supramolecular structures. An infinite two-dimensional network is generated by hydrogen bonding interactions and intermolecular π…π interactions.

SYNTHESIS AND STRUCTURE OF A 2D SHEET－LIKE COPPER（II） COMPLEX WITH BRIDGING PYRIDINE－4－CARBOXYLATE AND TRANS－OXAMIDATE LIGANDS

A complex polymer [Cu2(oxen)(pic)(H20)]n(Clo4)·2nHH2O, there oxen and pic are N.N' -bis(2aminoethyt )oxamide and Pyridine-4-carboxytate, respectivety, was synthesized. It crystallizes in the monoctinic space group P21/c, with a=10.420(2) A. b=13. 118(2) A, c=14 .863(5) A. β=93.05(2)°, and z=4. The structure of this complex consists of 2D network of copper(II) ions bridged by bis-tridentate oxen in transconformation, and by pyridine-4-carboxylate in which the pyridine ring acts as a monodentate group whereas the carboxylate as a tridentate group and bonds to three different copper centres in a novel fashion. The repeating asymmetric unit is a binuclear copper(II) fragment with one of the copper centre locating in a lengthening octahedrat environment, whereas the other in a distorted tetragonal pyramid geometry.

CRYSTAL STRUCTURE OF THE COPPER（II） COMPLEX OF NEW MACROCYCLIC DIOXOTETRAAMINE LIGAND FUNCTIONALIZED WITH 8－METHYL QUINOLINE PENDANT

The copper (II) complex (1) of a new Iigand 4- (quinolin-8-ylmethyl)- 1, 4, 7. 10-tetraazacycoltridecane-11. 13-dione (L) has been syntehsized and its crystal structure determined. It is of orthorhomic crystal system and Pcad space group with a=16.260 (3), b=7. 739 (2). c=27. 530 (9) A, Mr=416. 97, Z=8. Dx=1. 595 g/cm3,μ=12. 876 cm-1, and F(000)=1736. The final R factor is 0. 061 for 2594 observed reflections with I>3σ(I). The Cu .atom is five coordinated to form a distorted square pyramid geometry in which N(11) of the pendant is at apical site.

Crystal Structure and Inhibitory Activity against Xanthine Oxidase of Bis(μ_2-chloro)-chloro-(μ-N,N'-(2-pyridylmethylene) Furanmethanoamine Copper(II) Complex

A chloro-bridged dinuclear copper（H） complex with ligand 2-pyridylme-thylene- furfurylamine has been synthesized and characterized by single-crystal X-ray diffraction, and its inhibitory activity on xanthine oxidase （XO） was also evaluated. It crystallizes in the triclinic system, space group P 1 with a = 8.0441（16）, b = 8.5663（17）, c = 10.060（2）A, α = 77.52（3）, β = 72.04（3）, γ = 70.12（3）°, V = 615.3（2）A^3, Z = 1, Dc = 1.731 g/cm^3, F（000） = 322, the final R = 0.0401 and wR = 0.0934 for 1971 observed reflections with I 〉 2σ（I）. X-ray analysis reveals that the Cu（II） cation is five-coordinated by two N atoms of Schiff base and three Cl anions. The C-H…Cl intermolecular and intramolecular hydrogen bonds connect the molecules to form a three-dimensional network. This copper（II） complex shows more potent inhibitory activity against XO with IC50 = 3.48μM than the standard inhibitor allopurinol.

Synthesis and Crystal Structure of the Copper(II)Complex with N,N'-Cyclohexanebis(3- formyl- 5-tert-butyl-salicylaldimine)

A mononuclear copper(II) complex CuL with a Schiff-base L (H2L = N,N(- cyclohexanebis(3-formyl-5-tert-butyl-salicylaldimine)) has been synthesized and characterized. X-ray diffraction analysis at room temperature indicates that the complex (Cu C30H36N2O4, Mr = 552.15) crystallizes in tetrahedral system, space group P41 with a = 13.4685(6), c = 31.326(2) ?, V = 5682.5(5) ?3, Z = 8, Dc = 1.291 g/cm3, F(000) = 4656, μ(MoK() = 0.805 mm-1. The final R and Rw factors are 0.0421 and 0.0815, respectively with 4435 observed reflections. The title complex is a neutral molecule in which the ligand is doubly deprotonated, forming a four-coordinated Cu(II) complex by nitrogen and oxygen donors of the ligand and the coordination geometry of Cu(II) could be considered as an approximately planar configuration. There are two independent molecules, having a transoid arrangement in this structure.

SYNTHESIS AND CARACTERIZATION OF TERNARY COMPLEXES CONTAINING Cu(II),L-HISTIDINE AND NUCLEOTIDE

The ternary complexes containing Cu(II),L-His and nucleotide (5'-GMP and 5'-IMP)were synthesized and characterized.IR and ~1H NMR spectra show that Cu(II)binds to carboxylate oxygen and imidazole nitrogen of L-His and purine N_7 of 5'-GMP and 5'-IMP.The interaction of Cu(II)with Po_3^(2-)of 5'-GMP is present,but that for 5'-IMP is not present.

SPECTROPHOTOMETRIC STUDY OF BIMETALLIC TERNARY COMPLEX OF LANTHANUM——COPPER WITH ALIZARIN FLUORINE BLUE

The bimetallic ternary complex formation in the aqueous solution of La and Cu with alizarin fluorine blue (AFB) was studied by spectrophotometry.The ternary complex LaCu3(AFB)3 has maximum light absorption at 550nm.The colour reaction selectivity is fairly good and the method can be applied to the direct photometric determination of copper in lanthanum or some pure metals.A new mathematical approach to the treatment of spectrophotometric data for differentiation between mononuclear and polynuclear in solution is presented.The improvable fixed logarithm method is for complexes of the type MmBn(m=n) or MmBn(m=n).We report that La(Ⅲ) combines with AFB at pH 4.5 to form a single complex,withm=n=2,La2(AFB)2.

Synthesis and Crystal Structure of the Copper(II) Complex with Tris-(1,10-phenanthroline-5,6-dione)

The title complex [CuL3]（ClO4）2·2H2O·2CH3CN （L = 1,10-phenanthroline-5,6-dione） has been synthesized and characterized by elemental analysis, conductivity, infrared and UV-Vis spectra. X-ray diffraction analysis at room temperature indicates that the complex （C40H28Cl2CuN8O16, Mr = 1011.14） crystallizes in orthorhombic system, space group P212121 with a=13.983（1）, b=14.310（1）, c= 20\^890（2） , V = 4179.7（6） 3, Z = 4, Dc = 1.607 g/cm3, F（000） = 2026,μ（MoKα） = 0.736 mm-1. The final R and wR factors are 0.0446 and 0.1212 respectively with 8545 independent reflections. The title complex is composed of a discrete [CuL3]2+ cation, uncoordinated ClO4- anions, H2O and CH3CN molecules. The central Cu（II） atom is six-coordinated by six nitrogen donors of three ligands. The coordination geometry of Cu（II） could be considered as an approximately ideal octahedral configuration with little static Jahn-Teller distortion （the longest and shortest Cu-N bonds are 2.102 vs 2.139 with the mean length of 2.122 ）, which is very rare for a six-coordinated Cu（II） complex.

Synthesis,Crystal Structure and Biological Activity of a Planar Copper Complex Derived from S-benzyldithiocarbazate

A planar transition metal complex Cu（L）2 （L = （E）-benzyl-2-（4-nitrobenzylidene）-hydrazinecarbodithioate） has been prepared and determined by X-ray single-crystal diffraction. The crystal belongs to the monoclinic system,space group P21/c with a = 6.7101（11）,b = 16.952（3）,c = 13.962（3） ,β = 92.458（4）°,V = 1586.7（5） 3,Z = 4,Mr = 724.33,Dc = 1.516 g·m-3,μ = 0.998 mm-1,F（000） = 742,S = 1.021,R = 0.0634 and wR = 0.1077 for 813 observed reflections with Ⅰ〉 2σ（Ⅰ） and 205 parameters. In the molecular structure of the title complex,the copper atom exhibits a slightly distorted square-planar geometry in which the basal plane is defined by two N and two S atoms from two bidentate ligands. The complex was evaluated for its antitumor activity against two kinds of cell lines （MKN45 and HepG2） by MTT method. The preliminary bioassay indicates that the complex exhibits weak antitumor activity.

Synthesis, Crystal Structure and Properties of a Copper Complex with the Bicycle[2.2.1]-2-heptene-5,6-dicarboxylic Acid

A new copper complex 2{Cu（C10H8N2）[C8H11O2（COO）]（H2O）3}·（H2O）5 with bicycle[2.2.1]hept-2-en-5,6-dicarboxylic acid（H2L） [C7H8（COOH）2], basic copper carbonate and 2,2＇-bipyridine has been synthesized in the mixed solvents of methanol and water. It crystallizes in the triclinic system, space group P1, with a = 7.4626（5）, b = 11.9779（8）, c = 12.9841（8）A, α = 109.7040（10）, β = 98.7550（10）, γ = 90.6240（10）°, V = 1077.50（12）A3, Dc = 1.538 g/cm^3, Z = 1, F（000） = 520, GOOF = 1.065, R = 0.0360 and wR = 0.0950. The copper ion is coordinated with four oxygen atoms from one H2 L molecule and three water molecules together with two nitrogen atoms from the 2,2＇-bipyridine molecule, forming a distorted octahedral coordination geometry. The thermal stability and electrochemical properties were also studied.

Crystal Structure and Magnetic and Fluorescent Properties of a New Copper(Ⅱ) Complex Cu_2(L)_4(2,2'-bipy)_2(H_2O)_2

A new copper（II） complex Cu2（L）a（2,2＇-bipy）2（H2O）2 （1） has been synthesized with 2-benzoylbenzoic acid （HL） and 2,2＇-bipyridin as ligands. The crystal belongs to a monoclinic system with space group Cc, a = 13.9979（II）, b = 15.9888（13）, c = 30.306（3） A, β = 100.8700（10）°, V= 6661.1（10） A3, Dc= 1.372 g/cm3, Z = 8, F（000） = 2840, the final GOOF = 1.018, R= 0.0685, and wR= 0.1731. There are two mononuclear Cu（L）2（2,2＇-bipy）（H20） units in the crystal of 1. Each Cu（II） cation is coordinated by five atoms. The magnetic and fluorescent properties of 1 were studied. The results show that 1 exhibits weak paramagnetism, and when the excitation wavelength is at 616 nm, it has an intense fluorescent emission band around 482 nm.

Synthesis and Crystal Structure of Tri(4-(3-hydroxy2-ethyl-4-pyridinone-1-yl)-aniline Condensation Salicylaldehydato) Monohydratotricopper(II)Dimethylformamide Monohydrate Solvate

The title complex [Cu3L3(H2O)]DMFH2O (H2L = 4-(3-hydroxy-2-ethyl-4- pyridinone-1-yl)-aniline condensation salicylaldehyde) was obtained. The single-crystal X-ray study shows that it is a trinuclear compound [Cu3(C20H15N2O3)3(H2O)]DMFH2O. The coordi- nation sphere about each copper ion in the complex consists of two oxygen atoms from hydroxylpyridinone moiety of one ligand and one oxygen and one nitrogen atoms from salicyladehyde Schiff-base moiety of another ligand arranged in a slightly distorted square planar geometry. Among the three copper ions, one (Cu(2)) is coordinated by the other oxygen atom of water molecule on the fifth coordinate position to form a distorted square pyramid geometry. The crystal is of monoclinic, space group P21/c with a = 12.9202(5), b = 27.197(1), c = 17.0116(7) ? b = 100.588(1), V = 5875.9(4) 3, Z = 4, C63H57N7O12Cu3, Mr = 1294.78, Dc = 1.464 g/cm3, m = 1.146 mm-1, F(000) = 2668, R = 0.0784 and wR = 0.1546 for 6926 observed reflections with I > 2s(I). The differences of coordinate bond lengths are observed between anhydrous and hydrous units: in the former unit, the average bond lengths are 1.978 ?for CuN (azomethine), 1.883 ?for CuO (phenolic) in Schiff-base moiety, 1.959 ?for CuO (keto), and 1.919 ?for CuO (hydroxy) in hydroxypyridinone moiety; while those in the latter are longer with the following corresponding values: 1.985(5), 1.908(5), 1.993(5) and 1.919(4) ? respectively. The Cu(2)O (water) bond length is 2.375(6) ?

Synthesis and Structure of bis(μ-2-aminopyridine N-oxide)-bis[dichlorocopper(II)]

The complex [Cu2（apo）4Cl4]·2H2O （apo=2-aminopyridine N-oxide） was obtained. A single- crystal X-ray study shows that the complex is a binuclear compound （Cu2C20H28Cl4N8O6）. The coordination geometry about each copper atom is best described as a distorted square pyramid. The compound [Cu2（apo）4Cl4]·2H2O belongs to the triclinic system with space group P, lattice constants: a = 7.8550（7）, b = 8.5378（7）, c = 12.082（1） ?, α = 72.807（1）, β = 77.641（1）, γ = 70.800（1）(, V =724.85（11） ?3, Z=1, Mr =745.38, Dc=1.708 g/cm3, μ =1.886mm-1, F（000） =378, R=0.0359, wR2=0.0884 for 2220 reflections with I >2σ（I）. The distances between Cu（II） and O atoms are in the range from 1.934（2） to 2.042（2）?. The distance between two copper atoms Cu-Cu（A） is 3.2978（8） ?. The distances of Cu-Cl（1） and Cu-Cl（2） are 2.2322（9）, 2.5095（10） ?, respectively. There is no evident hydrogen bond between N and Cl.

Synethesis and Crystal Structure of Bi(ethylenediamine)copper Tetracyanonickelate(II)

The crystal structure of the title compound C 8H 16 CuN 8Ni has been determined by single crystal X ray diffraction. The crystal is triclinic with space group P1, a=6.494(3), b=7.270(4), c=7.936(5) , α=106.67(3), β=91.33(4), γ=106.80(6)°, V=341.3(3) 3, Z=1, M r=346.54, F(000)=177, μ =2\^933mm -1 , D c =1.686 Mg/m 3. The final R factor is 0.0603 for 1214 unique observed reflections 〔 I≥2σ(I) 〕. The structure consists of 〔Cu(en) 2〕 2+ (en=ethylenediamine) cations and 〔Ni(CN) 4〕 2- anions linked together by two of the CN groups (the remaining two act as unidentate ligands) to form infinite chains, in the chain, the hydrogen bonds of N(4)…H-N(5) exist,with distance 3.148 , at the same time the hydrogen bonds of N(4)…H-N(7a) and N(5)-H…N(1a) (a: x-1,y-1,z-1 ) between the interchains also exist, with distances of 3.160 and 3.124 , so it forms a three\|dimensional structure of the title compound.