He and his colleagues[1]reported identification of the mobile resistance genes tet(X3)and tet(X4)on conjugative plasmids in Enterobacteriaceae and Acinetobacter isolated in China recently published in Nature Microbiol...He and his colleagues[1]reported identification of the mobile resistance genes tet(X3)and tet(X4)on conjugative plasmids in Enterobacteriaceae and Acinetobacter isolated in China recently published in Nature Microbiology.They noted that both tet(X3)and tet(X4)can confer resistance to tigecycline and the newly FDA-approved eravacycline and omadacyclin,which are last-resort antibiotics used to treat multi-drug-resistant(MDR)bacterial infections.Our previous report[2]revealed that live poultry market(LPM)is a huge antibiotic resistance gene(ARG)reservoir,including the mobile colistin resistance(mcr)genes,mcr-1,mcr-3,mcr-4 and mcr-5.Large-scale metagenomic data screening showed that tigecycline resistance gene tet(X3)was widespread in poultry faecal samples collected from China LPMs,whereas it has not been detected in human(n=2019)gut microbiomes[3],which suggested that tet(X3)is previously confined to animal guts or animal-derived bacteria.展开更多
The emergence of mobile Tigecycline-resistant tet(X3)and tet(X4)is believed to be a global threat to public health.Here,we investigated the prevalence of tet(X3)and tet(X4)in our metagenomic data of migratory birds.Wh...The emergence of mobile Tigecycline-resistant tet(X3)and tet(X4)is believed to be a global threat to public health.Here,we investigated the prevalence of tet(X3)and tet(X4)in our metagenomic data of migratory birds.While tet(X4)was not identified in our samples,tet(X3)was found in two gut microbiomes of bird fecal samples,with 100%amino acid identity of sites 150–387.These results suggest that tet(X3)has been spreading into the environment for a long period of time and that there is an urgent need to control its further transmission.展开更多
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29010000)the External Cooperation Program of CAS(153211KYSB20160001).
文摘He and his colleagues[1]reported identification of the mobile resistance genes tet(X3)and tet(X4)on conjugative plasmids in Enterobacteriaceae and Acinetobacter isolated in China recently published in Nature Microbiology.They noted that both tet(X3)and tet(X4)can confer resistance to tigecycline and the newly FDA-approved eravacycline and omadacyclin,which are last-resort antibiotics used to treat multi-drug-resistant(MDR)bacterial infections.Our previous report[2]revealed that live poultry market(LPM)is a huge antibiotic resistance gene(ARG)reservoir,including the mobile colistin resistance(mcr)genes,mcr-1,mcr-3,mcr-4 and mcr-5.Large-scale metagenomic data screening showed that tigecycline resistance gene tet(X3)was widespread in poultry faecal samples collected from China LPMs,whereas it has not been detected in human(n=2019)gut microbiomes[3],which suggested that tet(X3)is previously confined to animal guts or animal-derived bacteria.
基金This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS,XDB29010202)the External Cooperation Program of CAS(153211KYSB20160001).
文摘The emergence of mobile Tigecycline-resistant tet(X3)and tet(X4)is believed to be a global threat to public health.Here,we investigated the prevalence of tet(X3)and tet(X4)in our metagenomic data of migratory birds.While tet(X4)was not identified in our samples,tet(X3)was found in two gut microbiomes of bird fecal samples,with 100%amino acid identity of sites 150–387.These results suggest that tet(X3)has been spreading into the environment for a long period of time and that there is an urgent need to control its further transmission.
