(Z)-7-Aryl-5-acyldibenzo[e,g][1,4]diazocin-6(5H)-one,a unique saddle-shaped bridged biaryl containing synchronized aryl–aryl and N-aryl stereogenic axes,was constructed for the first time in good yields with up to 96...(Z)-7-Aryl-5-acyldibenzo[e,g][1,4]diazocin-6(5H)-one,a unique saddle-shaped bridged biaryl containing synchronized aryl–aryl and N-aryl stereogenic axes,was constructed for the first time in good yields with up to 96%enantiomeric excess(ee).The threecomponent coupling reaction,involving aryl iodide,2,2′-diisocyano-1,1′-biphenyl,and carboxylate,constructs the eight-membered ring in an atroposelective manner through palladium-catalyzed double isocyanide insertion followed by C–Obond formation during reductive elimination and amide formation after acyl transfer.展开更多
The practical synthesis procedure of substituted tetraphenylene derivatives involving the synthesis of a precursor for 4,7-dimethoxyisobenzofuran and Diels-Alder addition of 4,7-dimethoxyisobenzofuran generated in sit...The practical synthesis procedure of substituted tetraphenylene derivatives involving the synthesis of a precursor for 4,7-dimethoxyisobenzofuran and Diels-Alder addition of 4,7-dimethoxyisobenzofuran generated in situ to 5,6,11,12-tetradehydrodibenzo[a,e]cyclooctene, followed by a low valent titanium mediated deoxygenation to give 1,4,11,14-tetra-methoxy-dibenzo[b, n]tetraphenylene, which can be further demethylated to the corresponding phenolic compound, which was acetylated to afford 1,4,11,14-tetraacetoxy-dibenzo[b,n] tetraphenylene.展开更多
基金the National Natural Science Foundation of China(nos.21772198,21871268,and 22071250)the Frontier Research Program of Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)(no.2018GRZ110105017)+2 种基金the Natural Science Foundation of Guangdong Province of China(no.2020A1515011428)the“BAGUI Scholar”Program of Guangxi Province of China,and SKLRD Open Project(no.SKLRD-Z-202014)for financial supportthe Guangzhou Branch of the Supercomputing Center of CAS for support.
文摘(Z)-7-Aryl-5-acyldibenzo[e,g][1,4]diazocin-6(5H)-one,a unique saddle-shaped bridged biaryl containing synchronized aryl–aryl and N-aryl stereogenic axes,was constructed for the first time in good yields with up to 96%enantiomeric excess(ee).The threecomponent coupling reaction,involving aryl iodide,2,2′-diisocyano-1,1′-biphenyl,and carboxylate,constructs the eight-membered ring in an atroposelective manner through palladium-catalyzed double isocyanide insertion followed by C–Obond formation during reductive elimination and amide formation after acyl transfer.
基金Project supported by the National Natural Science Foundation of China (No. 29872023) and the Ministry of Education of China (Research Funds for Chinese Scholars returning from abroad).
文摘The practical synthesis procedure of substituted tetraphenylene derivatives involving the synthesis of a precursor for 4,7-dimethoxyisobenzofuran and Diels-Alder addition of 4,7-dimethoxyisobenzofuran generated in situ to 5,6,11,12-tetradehydrodibenzo[a,e]cyclooctene, followed by a low valent titanium mediated deoxygenation to give 1,4,11,14-tetra-methoxy-dibenzo[b, n]tetraphenylene, which can be further demethylated to the corresponding phenolic compound, which was acetylated to afford 1,4,11,14-tetraacetoxy-dibenzo[b,n] tetraphenylene.
