COVID-19 disease is spreading exponentially due to the rapid transmission of the virus between humans.Different countries have tried different solutions to control the spread of the disease,including lockdowns of coun...COVID-19 disease is spreading exponentially due to the rapid transmission of the virus between humans.Different countries have tried different solutions to control the spread of the disease,including lockdowns of countries or cities,quarantines,isolation,sanitization,and masks.Patients with symptoms of COVID-19 are tested using medical testing kits;these tests must be conducted by healthcare professionals.However,the testing process is expensive and time-consuming.There is no surveillance system that can be used as surveillance framework to identify regions of infected individuals and determine the rate of spread so that precautions can be taken.This paper introduces a novel technique based on deep learning(DL)that can be used as a surveillance system to identify infected individuals by analyzing tweets related to COVID-19.The system is used only for surveillance purposes to identify regions where the spread of COVID-19 is high;clinical tests should then be used to test and identify infected individuals.The system proposed here uses recurrent neural networks(RNN)and word-embedding techniques to analyze tweets and determine whether a tweet provides information about COVID-19 or refers to individuals who have been infected with the virus.The results demonstrate that RNN can conduct this analysis more accurately than other machine learning(ML)algorithms.展开更多
目的以雌激素样作用中药为例,探究中药药性、功效、药理作用以及临床应用之间的关联关系。方法以中国知网、PubMed等数据库作为信息来源筛选雌激素样作用中药及复方,通过频数统计分析其药性、功效、来源、主治疾病的分布规律,筛选核心...目的以雌激素样作用中药为例,探究中药药性、功效、药理作用以及临床应用之间的关联关系。方法以中国知网、PubMed等数据库作为信息来源筛选雌激素样作用中药及复方,通过频数统计分析其药性、功效、来源、主治疾病的分布规律,筛选核心药性组合;从药性组合-功效-作用靶标-功能模块-病理变化-疾病的角度诠释雌激素样作用与中药药性、功效、主治的内在关联。结果共筛选得到82味雌激素样作用中药,主要分布在补虚药与活血化瘀药中,多具有活血、补肾的功效,其核心药性组合为温甘肾、温甘肝、平甘肾、寒苦肝和温辛肝。高频药性组合温甘肾包含了研究频次较高的淫羊藿与人参等中药,其活性成分淫羊藿苷、人参皂苷等可通过调控雌激素受体信号通路、丝裂原活化蛋白激酶(mitogen activated protein kinases,MAPK)级联激活与钙离子的转运从而发挥雌激素样作用。结论核心药性组合温甘肾通过参与细胞自噬与凋亡、腺体发育、免疫调节、糖代谢、骨代谢等生物过程发挥雌激素样作用,防治围绝经期综合征、卵巢早衰、2型糖尿病、肿瘤、神经退行性疾病、骨质疏松等疾病。从分子网络水平阐释了雌激素样作用中药的性-效-理-病关系,为药性理论指导中药临床应用提供科学依据。展开更多
基金support from Taif university through Researchers Supporting Project number(TURSP-2020/231),Taif University,Taif,Saudi Arabia.
文摘COVID-19 disease is spreading exponentially due to the rapid transmission of the virus between humans.Different countries have tried different solutions to control the spread of the disease,including lockdowns of countries or cities,quarantines,isolation,sanitization,and masks.Patients with symptoms of COVID-19 are tested using medical testing kits;these tests must be conducted by healthcare professionals.However,the testing process is expensive and time-consuming.There is no surveillance system that can be used as surveillance framework to identify regions of infected individuals and determine the rate of spread so that precautions can be taken.This paper introduces a novel technique based on deep learning(DL)that can be used as a surveillance system to identify infected individuals by analyzing tweets related to COVID-19.The system is used only for surveillance purposes to identify regions where the spread of COVID-19 is high;clinical tests should then be used to test and identify infected individuals.The system proposed here uses recurrent neural networks(RNN)and word-embedding techniques to analyze tweets and determine whether a tweet provides information about COVID-19 or refers to individuals who have been infected with the virus.The results demonstrate that RNN can conduct this analysis more accurately than other machine learning(ML)algorithms.
文摘目的以雌激素样作用中药为例,探究中药药性、功效、药理作用以及临床应用之间的关联关系。方法以中国知网、PubMed等数据库作为信息来源筛选雌激素样作用中药及复方,通过频数统计分析其药性、功效、来源、主治疾病的分布规律,筛选核心药性组合;从药性组合-功效-作用靶标-功能模块-病理变化-疾病的角度诠释雌激素样作用与中药药性、功效、主治的内在关联。结果共筛选得到82味雌激素样作用中药,主要分布在补虚药与活血化瘀药中,多具有活血、补肾的功效,其核心药性组合为温甘肾、温甘肝、平甘肾、寒苦肝和温辛肝。高频药性组合温甘肾包含了研究频次较高的淫羊藿与人参等中药,其活性成分淫羊藿苷、人参皂苷等可通过调控雌激素受体信号通路、丝裂原活化蛋白激酶(mitogen activated protein kinases,MAPK)级联激活与钙离子的转运从而发挥雌激素样作用。结论核心药性组合温甘肾通过参与细胞自噬与凋亡、腺体发育、免疫调节、糖代谢、骨代谢等生物过程发挥雌激素样作用,防治围绝经期综合征、卵巢早衰、2型糖尿病、肿瘤、神经退行性疾病、骨质疏松等疾病。从分子网络水平阐释了雌激素样作用中药的性-效-理-病关系,为药性理论指导中药临床应用提供科学依据。
