Cutaneous exposure to food allergens through a disrupted skin barrier is recognized as an important cause of food allergy,and the cutaneous sensitized mouse model has been established to investigate relevant allergic ...Cutaneous exposure to food allergens through a disrupted skin barrier is recognized as an important cause of food allergy,and the cutaneous sensitized mouse model has been established to investigate relevant allergic disorders.However,the role of different genetic backgrounds of mice on immune responses to food allergens upon epicutaneous sensitization is largely unknown.In this study,two strains of mice,i.e.,the BALB/c and C57BL/6 mice,were epicutaneously sensitized with ovalbumin on atopic dermatitis(AD)-like skin lesions,followed by intragastric challenge to induce IgE-mediated food allergy.Allergic outcomes were measured as clinical signs,specific antibodies and cytokines,and immune cell subpopulations,as well as changes in intestinal barrier function and gut microbiota.Results showed that both strains of mice exhibited typical food-allergic symptoms with a Th2-skewed response.The C57BL/6 mice,rather than the BALB/c mice,were fitter for establishing an epicutaneously sensitized model of food allergy since a stronger Th2-biased response and severer disruptions in the intestinal barrier and gut homeostasis were observed.This study provides knowledge for selecting an appropriate mouse model to study food-allergic responses associated with AD-like skin lesions and highlights the role of genetic variations in the immune mechanism underlying pathogenesis of food allergy.展开更多
This study focuses on a national regional coordinated development strategy and adopts China Multi-Regional Computable General Equilibrium model to analyze the economic and social development, energy demand, and carbon...This study focuses on a national regional coordinated development strategy and adopts China Multi-Regional Computable General Equilibrium model to analyze the economic and social development, energy demand, and carbon emissions of the provinces during the 14th Five-Year Plan (FYP, 2021 2025) period based on the economic development and energy demand since the New Normal. The main conclusions are the following: 1) Under the guidance of the regional coordinated development strategy, 13 provinces/municipalities are expected to have a per capita gross domestic product (GDP) of more than US$15,000, and 16 provinces/municipalities will have a per capita GDP of US$10,000 15,000. All provincial economies are expected to achieve steady and rapid development by the end of the 14th FYP. 2) The total energy consumption of the provinces is expected to reach 5.45 Gtce (excluding Tibet) in 2025, and the average annual growth rate is approximately 1.5%. The growth of energy demand will remain in low speed. The key point of energy demand will gradually shift from the eastern to the middle area, while the proportion of energy use in the western provinces will remain stable, which is consistent with the economic development stage and regional coordinated development strategy. 3) The annual average carbon intensity (mainly considering carbon emissions from energy use) of the provinces will approximately with most provinces dropping by over 4.0%. The trend of a considerable decline in carbon intensity, as observed in recent years, is expected to continue.展开更多
From 2 to 4 November, 2016, the 4th Symposium on Animal Models of Non-Human Primates （NHP） was held in Kunming, Yunnan, China. This meeting was organized by the Key Laboratory of Animal Models and Human Disease Mech...From 2 to 4 November, 2016, the 4th Symposium on Animal Models of Non-Human Primates （NHP） was held in Kunming, Yunnan, China. This meeting was organized by the Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences （CAS） ＆ Yunnan Province Kunming Primate Research Center （KPRC）, Zoological Research, and Kunming Institute of Zoology （KIZ）, CAS.展开更多
Bangladesh is a densely populated country than many other countries of the world. The population growth is termed as alarming, however, knowledge of growth in the years to come would be useful in planning for the deve...Bangladesh is a densely populated country than many other countries of the world. The population growth is termed as alarming, however, knowledge of growth in the years to come would be useful in planning for the development of the country. This article is based on the projection of future population growth of the country. The available actual population census data during 1991-2011 of Bangladesh was applied to the application of a non-linear, non-autonomous ordinary differential equation familiar as Verhulst logistic population model with the maximum environmental capability of Bangladesh. Bangladesh will reach its carrying capacity of 245.09 million population in the next 56 years i.e. the year 2067 and then it decreases as S-shaped curve. The article has provided a focus on the changing trends of the growth of the population of Bangladesh.展开更多
基金the financial support received from the Natural Science Foundation of China(32202202 and 31871735)the Zhejiang Provincial Natural Science Foundation of China(LGN22C200027)the Open Fund of the Key Laboratory of Biosafety Detection for Zhejiang Market Regulation(2022BS004)。
文摘Cutaneous exposure to food allergens through a disrupted skin barrier is recognized as an important cause of food allergy,and the cutaneous sensitized mouse model has been established to investigate relevant allergic disorders.However,the role of different genetic backgrounds of mice on immune responses to food allergens upon epicutaneous sensitization is largely unknown.In this study,two strains of mice,i.e.,the BALB/c and C57BL/6 mice,were epicutaneously sensitized with ovalbumin on atopic dermatitis(AD)-like skin lesions,followed by intragastric challenge to induce IgE-mediated food allergy.Allergic outcomes were measured as clinical signs,specific antibodies and cytokines,and immune cell subpopulations,as well as changes in intestinal barrier function and gut microbiota.Results showed that both strains of mice exhibited typical food-allergic symptoms with a Th2-skewed response.The C57BL/6 mice,rather than the BALB/c mice,were fitter for establishing an epicutaneously sensitized model of food allergy since a stronger Th2-biased response and severer disruptions in the intestinal barrier and gut homeostasis were observed.This study provides knowledge for selecting an appropriate mouse model to study food-allergic responses associated with AD-like skin lesions and highlights the role of genetic variations in the immune mechanism underlying pathogenesis of food allergy.
基金s This work was supported by the National Key Technology Research and Development Program of the Ministry of Science and Technology (2016YFA0602601), Science and Technology Project of the State Grid Corporation of China Headquarters ''Research and Development of China Multi-regional Compre hensive Analysis and Forecast Mcxlel System for Energy Sup ply and Demand Fourth National Climate Assessment Report: Mitigation of Climate Change’’, and National Natural Science Foundation of China Program (71573145, 71573062).
文摘This study focuses on a national regional coordinated development strategy and adopts China Multi-Regional Computable General Equilibrium model to analyze the economic and social development, energy demand, and carbon emissions of the provinces during the 14th Five-Year Plan (FYP, 2021 2025) period based on the economic development and energy demand since the New Normal. The main conclusions are the following: 1) Under the guidance of the regional coordinated development strategy, 13 provinces/municipalities are expected to have a per capita gross domestic product (GDP) of more than US$15,000, and 16 provinces/municipalities will have a per capita GDP of US$10,000 15,000. All provincial economies are expected to achieve steady and rapid development by the end of the 14th FYP. 2) The total energy consumption of the provinces is expected to reach 5.45 Gtce (excluding Tibet) in 2025, and the average annual growth rate is approximately 1.5%. The growth of energy demand will remain in low speed. The key point of energy demand will gradually shift from the eastern to the middle area, while the proportion of energy use in the western provinces will remain stable, which is consistent with the economic development stage and regional coordinated development strategy. 3) The annual average carbon intensity (mainly considering carbon emissions from energy use) of the provinces will approximately with most provinces dropping by over 4.0%. The trend of a considerable decline in carbon intensity, as observed in recent years, is expected to continue.
基金supported by the Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province,KPRC,KIZ,CAS,and Zoology Research
文摘From 2 to 4 November, 2016, the 4th Symposium on Animal Models of Non-Human Primates （NHP） was held in Kunming, Yunnan, China. This meeting was organized by the Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences （CAS） ＆ Yunnan Province Kunming Primate Research Center （KPRC）, Zoological Research, and Kunming Institute of Zoology （KIZ）, CAS.
文摘Bangladesh is a densely populated country than many other countries of the world. The population growth is termed as alarming, however, knowledge of growth in the years to come would be useful in planning for the development of the country. This article is based on the projection of future population growth of the country. The available actual population census data during 1991-2011 of Bangladesh was applied to the application of a non-linear, non-autonomous ordinary differential equation familiar as Verhulst logistic population model with the maximum environmental capability of Bangladesh. Bangladesh will reach its carrying capacity of 245.09 million population in the next 56 years i.e. the year 2067 and then it decreases as S-shaped curve. The article has provided a focus on the changing trends of the growth of the population of Bangladesh.
