Thalassemia syndrome is a genetic blood disorder induced by the reduction of normal hemoglobin production,resulting in a drop in the size of red blood cells.In severe forms,it can lead to death.This genetic disorder h...Thalassemia syndrome is a genetic blood disorder induced by the reduction of normal hemoglobin production,resulting in a drop in the size of red blood cells.In severe forms,it can lead to death.This genetic disorder has posed a major burden on public health wherein patients with severe thalassemia need periodic therapy of iron chelation and blood transfusion for survival.Therefore,controlling thalassemia is extremely important and is made by promoting screening to the general population,particularly among thalassemia carriers.Today Twitter is one of the most influential social media platforms for sharing opinions and discussing different topics like people’s health conditions and major public health affairs.Exploring individuals’sentiments in these tweets helps the research centers to formulate strategies to promote thalassemia screening to the public.An effective Lexiconbased approach has been introduced in this study by highlighting a classifier called valence aware dictionary for sentiment reasoning(VADER).In this study applied twitter intelligence tool(TWINT),Natural Language Toolkit(NLTK),and VADER constitute the three main tools.VADER represents a gold-standard sentiment lexicon,which is basically tailored to attitudes that are communicated by using social media.The contribution of this study is to introduce an effective Lexicon-based approach by highlighting a classifier calledVADERto analyze the sentiment of the general population,particularly among thalassemia carriers on the social media platform Twitter.In this study,the results showed that the proposed approach achieved 0.829,0.816,and 0.818 regarding precision,recall,together with F-score,respectively.The tweets were crawled using the search keywords,“thalassemia screening,”thalassemia test,“and thalassemia diagnosis”.Finally,results showed that India and Pakistan ranked the highest in mentions in tweets by the public’s conversations on thalassemia screening with 181 and 164 tweets,respectively.展开更多
探究基于“-TT”结构经监护仪腹内压监测法降低重症患者喂养不耐受发生率的效果。选取2022年8月—2023年8月四川省自贡市第四人民医院抢救监护室(emergency intensive care unit,EICU)60例重症需行肠内营养(enteral nutrition,EN)支持...探究基于“-TT”结构经监护仪腹内压监测法降低重症患者喂养不耐受发生率的效果。选取2022年8月—2023年8月四川省自贡市第四人民医院抢救监护室(emergency intensive care unit,EICU)60例重症需行肠内营养(enteral nutrition,EN)支持的患者作为研究对象,采用随机数字表法将患者分为参照组和试验组,每组各30例。参照组实施常规EN管理,试验组在参照组基础上实施基于“-TT”结构经监护仪腹内压监测法,对比两组患者的喂养不耐受发生率。结果显示,与参照组相比,试验组喂养不耐受发生率较低(P<0.05);试验组达到目标喂养量时间较短(P<0.05);试验组EICU停留时间较短(P<0.05)。研究发现,于EICU重症需行EN支持患者的管理中,基于“-TT”结构经监护仪腹内压监测法具有一定的临床应用价值,通过对患者腹压变化的实时监测,可以及时调整喂养方案,降低其喂养不耐受发生率,缩短患者达到目标喂养量的时间,改善患者预后,值得借鉴。展开更多
In this Editorial,we highlight the possible role that metabolism dysfunction-associated steatotic liver disease(MASLD)may play in the future,regarding liver disease in patients with transfusion-dependent β-thalassemi...In this Editorial,we highlight the possible role that metabolism dysfunction-associated steatotic liver disease(MASLD)may play in the future,regarding liver disease in patients with transfusion-dependent β-thalassemia(TDBT).MASLD is characterized by excessive accumulation of fat in the liver(hepatic steatosis),in the presence of cardiometabolic factors.There is a strong correlation between the occurrence of MASLD and insulin resistance,while its increased prevalence parallels the global epidemic of diabetes mellitus(DM)and obesity.Patients with TDBT need regular transfusions for life to ensure their survival.Through these transfusions,a large amount of iron is accumulated,which causes saturation of transferrin and leads to the circulation of free iron molecules,which cause damage to vital organs(primarily the liver and myocardium).Over the past,the main mechanisms for the development of liver disease in these patients have been the toxic effect of iron on the liver and chronic hepatitis C,for which modern and effective treatments have been found,resulting in successful treatment.Additional advances in the treatment and monitoring of these patients have led to a reduction in deaths,and an increase in their life expectancy.This increased survival makes them vulnerable to the onset of diseases,which until recently were mainly related to the non-thalassemic general population,such as obesity and DM.There is insufficient data in the literature regarding the prevalence of MASLD in this population or on the risk factors for its occurrence.However,it was recently shown by a study of 45 heavily transfused patients with beta-thalassemia(Padeniya et al,BJH),that the presence of steatosis is a factor influencing the value of liver elastography and thus liver fibrosis.These findings suggest that future research in the field of liver disease in patients with TDBT should be focused on the occurrence,the risk factors,and the effect of MASLD on these patients.展开更多
Introduction: Sickle cell disease and thalassemia are the most frequent hemoglobinopathies. During their evolution, they present certain complications, among which are two neurosurgical emergencies, namely spontaneous...Introduction: Sickle cell disease and thalassemia are the most frequent hemoglobinopathies. During their evolution, they present certain complications, among which are two neurosurgical emergencies, namely spontaneous cranial epidural hematoma and non traumatic radiculo-medullary compression, with some particularities for each. Method: In order to highlight these particularities, we compared the characteristics of these two complications, from a number of publications reported between 2000 and 2021. Results: Sickle cell disease was complicated by spontaneous cranial epidural hematoma. Forty-two cases were reported, the mean age was 14.7 years (2 - 21 years) and the sex ratio was 6.4. The clinical presentation combined, in a non-traumatic context, signs of intracranial hypertension with those of neurological focalization. Neuroimaging showed epidural-type collection, often frontal and parietal in location. The incriminating mechanisms were ischemia, hemorrhage and extra medullary hematopoiesis. The treatment was surgical. Non traumatic radiculo-medullary was the complication of thalassemia. Of the 77 cases reported, the mean age was 27.5 years (9 - 66 years) and the sex ratio was 4.1. The lesions were epidural with a clear thoracic predominance and resulted from extra marrow hematopoiesis. Treatment included: hypertransfusion, radiotherapy, hydroxyurea and surgery. Vital and functional prognosis were globally satisfactory when the management was rapid. Conclusion: Cranial and spinal epidural lesions, respective complications of sickle cell disease and thalassemia, result from similar mechanisms. Their prognosis depends on the rapidity of management. .展开更多
A 49 years old Vietnamese male with a history of thalassemia,presented with gastrointestinal symptoms and signs of hemolysis.He was diagnosed with yersinia enterocolitis.Yersinia is a gram-negative rod that most frequ...A 49 years old Vietnamese male with a history of thalassemia,presented with gastrointestinal symptoms and signs of hemolysis.He was diagnosed with yersinia enterocolitis.Yersinia is a gram-negative rod that most frequently occurs in children especially during the winter months.In the current case,the bone marrow biopsy showed hemophagocytosis along with positive cultures for Yersinia.The microorganism likely triggered hemophagocytosis.This syndrome,also known as,hemophagocytic lymphohistiocytosis,is defined by fever for more than 7 d,cytopenia of two or more cell lines,hemophagocytosis,hepatitis,serum ferritin greater than500,jaundice,lymphadenopathy,and hepatosplenomegaly.This disorder can be either familial or secondary to a strong immunologic activation.Both have an overwhelming activation of T-cells and macrophages.展开更多
This study focused on the way that Adolescents with Transfusion- dependent thalassemia explained negative or positive events in their life （Attributional Styles）. It is defined by three dimensions describing the cog...This study focused on the way that Adolescents with Transfusion- dependent thalassemia explained negative or positive events in their life （Attributional Styles）. It is defined by three dimensions describing the cognitive appraisal of the events： internal-external, stable-unstable, and global-specific. With cross-sectional research design, the observations consist of 102 adolescents （48 males, 54 females） who diagnosed with Transfusion-dependent thalassemia （more than 50 times for blood transfusions） completed the measure of Attributional Styles and Anxiety Questionnaires. The correlations in the predicted directions among variables examine with Pearson product-moment correlation coefficients, t-test, and One-way ANOVA to ascertain a significant between the group differences on attributional factors and levels of anxiety symptoms. The results show that Adolescent samples with higher levels of anxiety revealed statistically significant relationship among three negative attributional dimensions （overall composite F = 4.5, p 〈 0.05; negative composite F = 4.99, p 〈 0.01; negative-internality F = 4.99 p 〈 0.01; negative-stability F = 3.42, p 〈 0.05 and negative-globality F = 3.77, p 〈 0.05）. In addition, significant age- group differences were found for the total negative-globality （t = 2.05, p 〈 0.05） and negative- globality （t = -2.22, p 〈 0.05）. These data are consistent with the reformulated learned helplessness model of depression. In finding, the individuals who attribute negative life events to internal, stable, and global causes will be more vulnerable to anxiety than those who make external, unstable, and specific attributions. Most interestingly, those adolescents more than 17 years evidence more negative-globality attfibutional style than group less than 16 years, and female adolescents may influence this pattern. These results suggest that targeting Adolescents with Transfusion-dependent thalassemia may be important for improving aspect of coping on psychological adjustment to their chronic illness.展开更多
Introduction: Thalassemia disorder is a genetic disease that causes the blood to have less hemoglobin than normal, the main requirement to control thalassemia’s propagation is to educate the entire society. Methodolo...Introduction: Thalassemia disorder is a genetic disease that causes the blood to have less hemoglobin than normal, the main requirement to control thalassemia’s propagation is to educate the entire society. Methodology: A descriptive survey was taken to evaluate the awareness of thalassemia among Saudi Arabia’s society, with a sample size of 384. Results: The results were written in frequencies, and it shows that most of the participants were unaware and lacking information on thalassemia syndrome. Discussion: The results of this study provide valuable insights into the awareness of thalassemia in Saudi Arabia and highlight the need to raise awareness of this disease. Conclusion: This study is not comprehensive because the survey was not disrupted evenly, but it can give us an overview of the awareness of thalassemia in Saudi Arabia, and it shows that most of the participants were unaware and lacked information on thalassemia.展开更多
基金The authors are thankful to the Deanship of Scientific Research at Najran University for funding this work under the Research Collaboration Funding program grant coder NU/RC/SERC/11/5.
文摘Thalassemia syndrome is a genetic blood disorder induced by the reduction of normal hemoglobin production,resulting in a drop in the size of red blood cells.In severe forms,it can lead to death.This genetic disorder has posed a major burden on public health wherein patients with severe thalassemia need periodic therapy of iron chelation and blood transfusion for survival.Therefore,controlling thalassemia is extremely important and is made by promoting screening to the general population,particularly among thalassemia carriers.Today Twitter is one of the most influential social media platforms for sharing opinions and discussing different topics like people’s health conditions and major public health affairs.Exploring individuals’sentiments in these tweets helps the research centers to formulate strategies to promote thalassemia screening to the public.An effective Lexiconbased approach has been introduced in this study by highlighting a classifier called valence aware dictionary for sentiment reasoning(VADER).In this study applied twitter intelligence tool(TWINT),Natural Language Toolkit(NLTK),and VADER constitute the three main tools.VADER represents a gold-standard sentiment lexicon,which is basically tailored to attitudes that are communicated by using social media.The contribution of this study is to introduce an effective Lexicon-based approach by highlighting a classifier calledVADERto analyze the sentiment of the general population,particularly among thalassemia carriers on the social media platform Twitter.In this study,the results showed that the proposed approach achieved 0.829,0.816,and 0.818 regarding precision,recall,together with F-score,respectively.The tweets were crawled using the search keywords,“thalassemia screening,”thalassemia test,“and thalassemia diagnosis”.Finally,results showed that India and Pakistan ranked the highest in mentions in tweets by the public’s conversations on thalassemia screening with 181 and 164 tweets,respectively.
文摘探究基于“-TT”结构经监护仪腹内压监测法降低重症患者喂养不耐受发生率的效果。选取2022年8月—2023年8月四川省自贡市第四人民医院抢救监护室(emergency intensive care unit,EICU)60例重症需行肠内营养(enteral nutrition,EN)支持的患者作为研究对象,采用随机数字表法将患者分为参照组和试验组,每组各30例。参照组实施常规EN管理,试验组在参照组基础上实施基于“-TT”结构经监护仪腹内压监测法,对比两组患者的喂养不耐受发生率。结果显示,与参照组相比,试验组喂养不耐受发生率较低(P<0.05);试验组达到目标喂养量时间较短(P<0.05);试验组EICU停留时间较短(P<0.05)。研究发现,于EICU重症需行EN支持患者的管理中,基于“-TT”结构经监护仪腹内压监测法具有一定的临床应用价值,通过对患者腹压变化的实时监测,可以及时调整喂养方案,降低其喂养不耐受发生率,缩短患者达到目标喂养量的时间,改善患者预后,值得借鉴。
文摘In this Editorial,we highlight the possible role that metabolism dysfunction-associated steatotic liver disease(MASLD)may play in the future,regarding liver disease in patients with transfusion-dependent β-thalassemia(TDBT).MASLD is characterized by excessive accumulation of fat in the liver(hepatic steatosis),in the presence of cardiometabolic factors.There is a strong correlation between the occurrence of MASLD and insulin resistance,while its increased prevalence parallels the global epidemic of diabetes mellitus(DM)and obesity.Patients with TDBT need regular transfusions for life to ensure their survival.Through these transfusions,a large amount of iron is accumulated,which causes saturation of transferrin and leads to the circulation of free iron molecules,which cause damage to vital organs(primarily the liver and myocardium).Over the past,the main mechanisms for the development of liver disease in these patients have been the toxic effect of iron on the liver and chronic hepatitis C,for which modern and effective treatments have been found,resulting in successful treatment.Additional advances in the treatment and monitoring of these patients have led to a reduction in deaths,and an increase in their life expectancy.This increased survival makes them vulnerable to the onset of diseases,which until recently were mainly related to the non-thalassemic general population,such as obesity and DM.There is insufficient data in the literature regarding the prevalence of MASLD in this population or on the risk factors for its occurrence.However,it was recently shown by a study of 45 heavily transfused patients with beta-thalassemia(Padeniya et al,BJH),that the presence of steatosis is a factor influencing the value of liver elastography and thus liver fibrosis.These findings suggest that future research in the field of liver disease in patients with TDBT should be focused on the occurrence,the risk factors,and the effect of MASLD on these patients.
文摘Introduction: Sickle cell disease and thalassemia are the most frequent hemoglobinopathies. During their evolution, they present certain complications, among which are two neurosurgical emergencies, namely spontaneous cranial epidural hematoma and non traumatic radiculo-medullary compression, with some particularities for each. Method: In order to highlight these particularities, we compared the characteristics of these two complications, from a number of publications reported between 2000 and 2021. Results: Sickle cell disease was complicated by spontaneous cranial epidural hematoma. Forty-two cases were reported, the mean age was 14.7 years (2 - 21 years) and the sex ratio was 6.4. The clinical presentation combined, in a non-traumatic context, signs of intracranial hypertension with those of neurological focalization. Neuroimaging showed epidural-type collection, often frontal and parietal in location. The incriminating mechanisms were ischemia, hemorrhage and extra medullary hematopoiesis. The treatment was surgical. Non traumatic radiculo-medullary was the complication of thalassemia. Of the 77 cases reported, the mean age was 27.5 years (9 - 66 years) and the sex ratio was 4.1. The lesions were epidural with a clear thoracic predominance and resulted from extra marrow hematopoiesis. Treatment included: hypertransfusion, radiotherapy, hydroxyurea and surgery. Vital and functional prognosis were globally satisfactory when the management was rapid. Conclusion: Cranial and spinal epidural lesions, respective complications of sickle cell disease and thalassemia, result from similar mechanisms. Their prognosis depends on the rapidity of management. .
文摘A 49 years old Vietnamese male with a history of thalassemia,presented with gastrointestinal symptoms and signs of hemolysis.He was diagnosed with yersinia enterocolitis.Yersinia is a gram-negative rod that most frequently occurs in children especially during the winter months.In the current case,the bone marrow biopsy showed hemophagocytosis along with positive cultures for Yersinia.The microorganism likely triggered hemophagocytosis.This syndrome,also known as,hemophagocytic lymphohistiocytosis,is defined by fever for more than 7 d,cytopenia of two or more cell lines,hemophagocytosis,hepatitis,serum ferritin greater than500,jaundice,lymphadenopathy,and hepatosplenomegaly.This disorder can be either familial or secondary to a strong immunologic activation.Both have an overwhelming activation of T-cells and macrophages.
文摘This study focused on the way that Adolescents with Transfusion- dependent thalassemia explained negative or positive events in their life （Attributional Styles）. It is defined by three dimensions describing the cognitive appraisal of the events： internal-external, stable-unstable, and global-specific. With cross-sectional research design, the observations consist of 102 adolescents （48 males, 54 females） who diagnosed with Transfusion-dependent thalassemia （more than 50 times for blood transfusions） completed the measure of Attributional Styles and Anxiety Questionnaires. The correlations in the predicted directions among variables examine with Pearson product-moment correlation coefficients, t-test, and One-way ANOVA to ascertain a significant between the group differences on attributional factors and levels of anxiety symptoms. The results show that Adolescent samples with higher levels of anxiety revealed statistically significant relationship among three negative attributional dimensions （overall composite F = 4.5, p 〈 0.05; negative composite F = 4.99, p 〈 0.01; negative-internality F = 4.99 p 〈 0.01; negative-stability F = 3.42, p 〈 0.05 and negative-globality F = 3.77, p 〈 0.05）. In addition, significant age- group differences were found for the total negative-globality （t = 2.05, p 〈 0.05） and negative- globality （t = -2.22, p 〈 0.05）. These data are consistent with the reformulated learned helplessness model of depression. In finding, the individuals who attribute negative life events to internal, stable, and global causes will be more vulnerable to anxiety than those who make external, unstable, and specific attributions. Most interestingly, those adolescents more than 17 years evidence more negative-globality attfibutional style than group less than 16 years, and female adolescents may influence this pattern. These results suggest that targeting Adolescents with Transfusion-dependent thalassemia may be important for improving aspect of coping on psychological adjustment to their chronic illness.
文摘Introduction: Thalassemia disorder is a genetic disease that causes the blood to have less hemoglobin than normal, the main requirement to control thalassemia’s propagation is to educate the entire society. Methodology: A descriptive survey was taken to evaluate the awareness of thalassemia among Saudi Arabia’s society, with a sample size of 384. Results: The results were written in frequencies, and it shows that most of the participants were unaware and lacking information on thalassemia syndrome. Discussion: The results of this study provide valuable insights into the awareness of thalassemia in Saudi Arabia and highlight the need to raise awareness of this disease. Conclusion: This study is not comprehensive because the survey was not disrupted evenly, but it can give us an overview of the awareness of thalassemia in Saudi Arabia, and it shows that most of the participants were unaware and lacked information on thalassemia.
