Background:This study will be aimed at investigating the effects of Baihu Renshen decoction(BHRS)on type 2 diabetes rats and on macromolecular enzyme 1(PINK1)/E3 ubiquitin protein ligase(Parkin)pathway.Methods:The exp...Background:This study will be aimed at investigating the effects of Baihu Renshen decoction(BHRS)on type 2 diabetes rats and on macromolecular enzyme 1(PINK1)/E3 ubiquitin protein ligase(Parkin)pathway.Methods:The experiment was divided into four groups:control group,model group,metformin group and BHRS low-dose group and high-dose group.Forty male rats were selected as samples and randomly assigned to at least one test group.Finally,there are 18 rats in each group.Except for the control group,the rats within the different teams got a high-fat diet associate in nursing an intraperitoneal injection of streptozotocin to make a type 2 diabetes mellitus(T2DM)rat model.The organic chemistry and inflammatory indexes of rats in every cluster were analyzed and compared once four weeks of intragastric administration of comparable reagents to review the therapeutic impact of BHRS on T2DM.In addition,we determined the pathological changes of ductal gland tissue of T2DM rats after treatment,and compared the expression of mitochondrial phagocytosis related proteins in ductal gland tissue of rats in each group.Results:FBG,LDL-C,TC,TG,MDA,IL-1,IL-6,TNF-,and mitophagy-related proteins COXIV,P62,VDAC1,and TOM20 were elevated in the model group compared to the control group,while HDL-C,SOD,GSH-Px,and mitophagy-related proteins PINK1,Parkin,and LC3II/I were decreased(P<0.05 or P<0.01).The expressions of FBG,TC,TG,LDL-C,MDA,IL-1,IL-6,TNF-,and mitophagy-related proteins COXIV,P62,VDAC1,and TOM20 were lowered in the BHRS group,while the expressions of HOMA-,HDL-C,SOD,GSH-Px,and mitophagy-related proteins PINK1,Parkin,and LC3II/I were(P<0.05 or P<0.01).After therapy with BHRS,hematoxylin-eosin staining showed that the intensity of pancreatic acinar staining increased,and islet cells became clear boundaries that were,regularly arranged,and with reduced vacuoles reduced.Conclusion:BHRS has a clear therapeutic effect on T2DM,which may be achieved by regulating mitochondrial autophagy through the PINK1/Parkin pathway.展开更多
In this paper we investigated the mechanisms of Baihu Decoction （白虎汤, BH） and Baihu with Radix Ginseng （BHG） in treating systemic inflammatory response syndrome （SIRS） and sepsis in humans and animals. By rev...In this paper we investigated the mechanisms of Baihu Decoction （白虎汤, BH） and Baihu with Radix Ginseng （BHG） in treating systemic inflammatory response syndrome （SIRS） and sepsis in humans and animals. By reviewing published data on the effects of BH and BHG and the control of blood glucose in treating SIRS and sepsis, we found that （1） BH and BHG were beneficial in the treatment of SIRS and sepsis in humans and animals; （2） BH and BHG also had great effect in lowering blood glucose level; and （3） the tight control of blood glucose during critical illness substantially improved the outcome. Considering these data together, we hypothesize that one of the major mechanisms of BH and BHG in treating SIRS and sepsis is to lower the blood glucose level. The findings also suggest that the application of BH and BHG can extend to many acute illnesses and injuries, which commonly cause hyperglycemia.展开更多
目的 观察白虎二至汤对热盛阴虚型糖尿病肾病(DKD)Ⅲ期患者的临床疗效。方法 将66例DKD患者随机分为对照组和治疗组,各33例。对照组采用缬沙坦胶囊治疗,治疗组在对照组治疗上加用白虎二至汤,观察2组患者空腹血糖(FBG)、餐后2 h血糖(2 h ...目的 观察白虎二至汤对热盛阴虚型糖尿病肾病(DKD)Ⅲ期患者的临床疗效。方法 将66例DKD患者随机分为对照组和治疗组,各33例。对照组采用缬沙坦胶囊治疗,治疗组在对照组治疗上加用白虎二至汤,观察2组患者空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、尿蛋白/肌酐比(UACR)、尿素氮(BUN)、血肌酐(Scr)以及中医证候积分水平。结果 治疗组有效率显著优于对照组(P<0.05)。治疗后2组患者的2 h PG、HbA1c、UACR、BUN、Scr及中医证候积分水平均低于治疗前(P<0.05),且治疗组均低于对照组(P<0.05)。结论 白虎二至汤可显著改善早期糖尿病肾病患者的临床症状及中医证候,控制血糖水平,改善肾功能,延缓患者疾病进展,提高患者生活质量。展开更多
目的系统评价常用的5种中药汤剂治疗类风湿关节炎(RA)的疗效及安全性。方法计算机检索PubMed、Embase、Cochrane Library、Web of Science、CNKI、WanFang Data和VIP数据库,搜集蠲痹汤、乌头汤、白虎加桂枝汤、桂枝芍药知母汤和独活寄...目的系统评价常用的5种中药汤剂治疗类风湿关节炎(RA)的疗效及安全性。方法计算机检索PubMed、Embase、Cochrane Library、Web of Science、CNKI、WanFang Data和VIP数据库,搜集蠲痹汤、乌头汤、白虎加桂枝汤、桂枝芍药知母汤和独活寄生汤等5种中药汤剂联合甲氨蝶呤、美洛昔康等常规疗法治疗RA的随机对照试验(RCT),检索时限均从建库至2024年1月1日,由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 17软件进行网状Meta分析。结果共纳入35个RCT,包括3316例患者。网状Meta分析结果显示,与单纯常规疗法相比,5种中药汤剂+常规疗法均显著提高临床总有效率(P<0.05),蠲痹汤+常规疗法、桂枝芍药知母汤+常规疗法、独活寄生汤+常规疗法均显著降低类风湿因子(RF)水平(P<0.05),蠲痹汤+常规疗法、乌头汤+常规疗法、桂枝芍药知母汤+常规疗法、独活寄生汤+常规疗法均显著降低C-反应蛋白(CRP)水平和血清红细胞沉降率(ESR)(P<0.05),桂枝芍药知母汤+常规疗法、独活寄生汤+常规疗法均显著降低不良反应发生率(P<0.05)。累积概率排序结果显示,桂枝芍药知母汤+常规疗法对提高临床总有效率、降低RF水平、降低不良反应发生率的效果均最佳,乌头汤+常规疗法对降低CRP水平的效果最佳,蠲痹汤+常规疗法对降低血清ESR效果最佳。结论中药汤剂与常规疗法联合应用治疗RA的效果显著优于单纯常规疗法,在改善指标方面,可选择桂枝芍药知母汤或蠲痹汤联合常规疗法;在提高安全性方面,可选择桂枝芍药知母汤或独活寄生汤联合常规疗法。受纳入研究数量和质量限制,上述结论尚需开展更多高质量研究予以验证。展开更多
基金the Construction Project of Workshop of Prestigious Chinese Physician Xiu-Hai Su(2022-75).
文摘Background:This study will be aimed at investigating the effects of Baihu Renshen decoction(BHRS)on type 2 diabetes rats and on macromolecular enzyme 1(PINK1)/E3 ubiquitin protein ligase(Parkin)pathway.Methods:The experiment was divided into four groups:control group,model group,metformin group and BHRS low-dose group and high-dose group.Forty male rats were selected as samples and randomly assigned to at least one test group.Finally,there are 18 rats in each group.Except for the control group,the rats within the different teams got a high-fat diet associate in nursing an intraperitoneal injection of streptozotocin to make a type 2 diabetes mellitus(T2DM)rat model.The organic chemistry and inflammatory indexes of rats in every cluster were analyzed and compared once four weeks of intragastric administration of comparable reagents to review the therapeutic impact of BHRS on T2DM.In addition,we determined the pathological changes of ductal gland tissue of T2DM rats after treatment,and compared the expression of mitochondrial phagocytosis related proteins in ductal gland tissue of rats in each group.Results:FBG,LDL-C,TC,TG,MDA,IL-1,IL-6,TNF-,and mitophagy-related proteins COXIV,P62,VDAC1,and TOM20 were elevated in the model group compared to the control group,while HDL-C,SOD,GSH-Px,and mitophagy-related proteins PINK1,Parkin,and LC3II/I were decreased(P<0.05 or P<0.01).The expressions of FBG,TC,TG,LDL-C,MDA,IL-1,IL-6,TNF-,and mitophagy-related proteins COXIV,P62,VDAC1,and TOM20 were lowered in the BHRS group,while the expressions of HOMA-,HDL-C,SOD,GSH-Px,and mitophagy-related proteins PINK1,Parkin,and LC3II/I were(P<0.05 or P<0.01).After therapy with BHRS,hematoxylin-eosin staining showed that the intensity of pancreatic acinar staining increased,and islet cells became clear boundaries that were,regularly arranged,and with reduced vacuoles reduced.Conclusion:BHRS has a clear therapeutic effect on T2DM,which may be achieved by regulating mitochondrial autophagy through the PINK1/Parkin pathway.
文摘In this paper we investigated the mechanisms of Baihu Decoction （白虎汤, BH） and Baihu with Radix Ginseng （BHG） in treating systemic inflammatory response syndrome （SIRS） and sepsis in humans and animals. By reviewing published data on the effects of BH and BHG and the control of blood glucose in treating SIRS and sepsis, we found that （1） BH and BHG were beneficial in the treatment of SIRS and sepsis in humans and animals; （2） BH and BHG also had great effect in lowering blood glucose level; and （3） the tight control of blood glucose during critical illness substantially improved the outcome. Considering these data together, we hypothesize that one of the major mechanisms of BH and BHG in treating SIRS and sepsis is to lower the blood glucose level. The findings also suggest that the application of BH and BHG can extend to many acute illnesses and injuries, which commonly cause hyperglycemia.
文摘目的 观察白虎二至汤对热盛阴虚型糖尿病肾病(DKD)Ⅲ期患者的临床疗效。方法 将66例DKD患者随机分为对照组和治疗组,各33例。对照组采用缬沙坦胶囊治疗,治疗组在对照组治疗上加用白虎二至汤,观察2组患者空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、尿蛋白/肌酐比(UACR)、尿素氮(BUN)、血肌酐(Scr)以及中医证候积分水平。结果 治疗组有效率显著优于对照组(P<0.05)。治疗后2组患者的2 h PG、HbA1c、UACR、BUN、Scr及中医证候积分水平均低于治疗前(P<0.05),且治疗组均低于对照组(P<0.05)。结论 白虎二至汤可显著改善早期糖尿病肾病患者的临床症状及中医证候,控制血糖水平,改善肾功能,延缓患者疾病进展,提高患者生活质量。
