A previous study of European Caucasian patients with sporadic amyotrophic lateral sclerosis demonstrated that a polymorphism in the microtubule-associated protein Tau （MAPT） gene was significantly associated with sp...A previous study of European Caucasian patients with sporadic amyotrophic lateral sclerosis demonstrated that a polymorphism in the microtubule-associated protein Tau （MAPT） gene was significantly associated with sporadic amyotrophic lateral sclerosis pathogenesis. Here, we tested this association in 107 sporadic amyotrophic lateral sclerosis patients and 100 healthy controls from the Chinese Han population. We screened the mutation-susceptible regions of MAPT- the 3＇ and 5＇ untranslated regions as well as introns 9, 10, 11, and 12 - by direct sequencing, and identified 33 genetic variations. Two of these, 105788 A 〉 G in intron 9 and 123972 T 〉 A in intron 11, were not present in the control group. The age of onset in patients with the 105788 A 〉 G and/or the 123972 T 〉 A variant was younger than that in patients without either genetic variation. Moreover, the pa- tients with a genetic variation were more prone to bulbar palsy and breathing difficulties than those with the wild-type genotype. This led to a shorter survival period in patients with a MAPT genetic variant. Our study suggests that the MAPT gene is a potential risk gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population.展开更多
This article takes Fu Chang's Precedents of Ritual Protocol for Jin's Imperial Ministers and Xun Chuo's Annotations to the Report on Jin's Official Posts as a means to observe the interactions between ...This article takes Fu Chang's Precedents of Ritual Protocol for Jin's Imperial Ministers and Xun Chuo's Annotations to the Report on Jin's Official Posts as a means to observe the interactions between books and political processes during the Western and Eastern Jin dynasties. Both Fu Chang and Xun Chuo were employed as high-ranking officials, with a background of being from the Central Plain, by the regime of the Later Zhao founded by Shi Le. Their purpose for writing the two books was to provide guidance for the regime's institutional establishment. The collapse of Shi Le's regime led to the flow of people and their possessions to the south. During these movements, the two books along with other materials and records were brought to Jiankang and then contributed to the institutional and cultural development in the middle and late Eastern Jin Dynasty. As historical facts and references for political reformation, these books revealed the duality of institutional writings. The collection and dispersion of books after the Disaster of Yongjia, as well as the social and cultural changes, should be placed in a wider political process for further examination.展开更多
基金funded by the National Natural Science Foundation of China,No.30560042 and 81260194Jiangxi Provincial Health Bureau of Science and Technology Program,No.20111028
文摘A previous study of European Caucasian patients with sporadic amyotrophic lateral sclerosis demonstrated that a polymorphism in the microtubule-associated protein Tau （MAPT） gene was significantly associated with sporadic amyotrophic lateral sclerosis pathogenesis. Here, we tested this association in 107 sporadic amyotrophic lateral sclerosis patients and 100 healthy controls from the Chinese Han population. We screened the mutation-susceptible regions of MAPT- the 3＇ and 5＇ untranslated regions as well as introns 9, 10, 11, and 12 - by direct sequencing, and identified 33 genetic variations. Two of these, 105788 A 〉 G in intron 9 and 123972 T 〉 A in intron 11, were not present in the control group. The age of onset in patients with the 105788 A 〉 G and/or the 123972 T 〉 A variant was younger than that in patients without either genetic variation. Moreover, the pa- tients with a genetic variation were more prone to bulbar palsy and breathing difficulties than those with the wild-type genotype. This led to a shorter survival period in patients with a MAPT genetic variant. Our study suggests that the MAPT gene is a potential risk gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population.
文摘This article takes Fu Chang's Precedents of Ritual Protocol for Jin's Imperial Ministers and Xun Chuo's Annotations to the Report on Jin's Official Posts as a means to observe the interactions between books and political processes during the Western and Eastern Jin dynasties. Both Fu Chang and Xun Chuo were employed as high-ranking officials, with a background of being from the Central Plain, by the regime of the Later Zhao founded by Shi Le. Their purpose for writing the two books was to provide guidance for the regime's institutional establishment. The collapse of Shi Le's regime led to the flow of people and their possessions to the south. During these movements, the two books along with other materials and records were brought to Jiankang and then contributed to the institutional and cultural development in the middle and late Eastern Jin Dynasty. As historical facts and references for political reformation, these books revealed the duality of institutional writings. The collection and dispersion of books after the Disaster of Yongjia, as well as the social and cultural changes, should be placed in a wider political process for further examination.
