Canonical Treatments for the Two Bodies Problem with Varying Mass Taking into Consideration the Periastron Effect

In this work, the Hamiltonian of the two body problem with varying mass was developed in the extended phase space taking into consideration the periastron effects. The short period solution was obtained through constructing a second order canonical transformation using “Hori’s” method developed by “Kamel”. The elements of the transformation as well as the inverse transformation were obtained too. The final solution of the problem was derived using “Delva-Hanslmeier” method.

A novel binary effective medium model to describe the prepeak stressstrain relationship of combined bodies of rock-like material and rock

Combined bodies of rock-like material and rock are widely encountered in geotechnical engineering,such as tunnels and mines.The existing theoretical models describing the stress-strain relationship of a combined body lack a binary feature.Based on effective medium theory,this paper presents the governing equation of the“elastic modulus”for combined and single bodies under triaxial compressive tests.A binary effective medium model is then established.Based on the compressive experiment of concretegranite combined bodies,the feasibility of determining the stress threshold based on crack axial strain is discussed,and the model is verified.The model is further extended to coal-rock combined bodies of more diverse types,and the variation laws of the compressive mechanical parameters are then discussed.The results show that the fitting accuracy of the model with the experimental curves of the concretegranite combined bodies and various types of coal-rock combined bodies are over 95%.The crack axial strain method can replace the crack volumetric strain method,which clarifies the physical meanings of the model parameters.The variation laws of matrix parameters and crack parameters are discussed in depth and are expected to be more widely used in geotechnical engineering.

On Reverses of the Blaschke-Santalo Inequality for Convex Bodies

Reisner proved a reverse of the Blaschke-Santal5 inequality for zonoid bodies, Bourgain and Milman showed another reverse of the Blaschke-Santal5 inequality for centered convex bodies. In this paper, two reverses of the Blaschke-Santal5 inequality for convex bodies are given by the Petty projection inequality and above two reverses. Further, using above methods, we also obtain two analogues of the Petty＇s conjecture for projection bodies, respectively.

The Research of the Flow of Bodies with Use of the Vector Form of the Newton’s Law for the Viscous Liquid

On the basis of the vector formula of the Newton’s law for a viscous liquid and the integrated vector form of the equation of an impulse for a viscous liquid for resistance and carrying power of a profile of any form and the big length dependences are found in a stream. Application of the found dependences at a circulating flow of the cylinder located across a stream is showed. The analysis of a tensor of viscosity for laminar and turbulent flow is carried out.

Asymptotic properties of two affine invariants for 1-unconditional convex bodies

Let K be a 1-unconditional convex bodies in Euclidean spaces.We study the asymptotic properties of two affine invariants m2（K） and S2（K） for a random simplex inside K.As an application,we discuss the asymptotic properties of two affine invariants m2（Bpn ） and S2（Bpn ）,where Bpn = {x ∈ Rn ： ‖x‖ p 1}.

Colliding Bodies Optimization with Machine Learning Based Parkinson’s Disease Diagnosis

Parkinson’s disease(PD)is one of the primary vital degenerative diseases that affect the Central Nervous System among elderly patients.It affect their quality of life drastically and millions of seniors are diagnosed with PD every year worldwide.Several models have been presented earlier to detect the PD using various types of measurement data like speech,gait patterns,etc.Early identification of PD is important owing to the fact that the patient can offer important details which helps in slowing down the progress of PD.The recently-emerging Deep Learning(DL)models can leverage the past data to detect and classify PD.With this motivation,the current study develops a novel Colliding Bodies Optimization Algorithm with Optimal Kernel Extreme Learning Machine(CBO-OKELM)for diagnosis and classification of PD.The goal of the proposed CBO-OKELM technique is to identify whether PD exists or not.CBO-OKELM technique involves the design of Colliding Bodies Optimization-based Feature Selection(CBO-FS)technique for optimal subset of features.In addition,Water Strider Algorithm(WSA)with Kernel Extreme Learning Machine(KELM)model is also developed for the classification of PD.CBO algorithm is used to elect the optimal set of fea-tures whereas WSA is utilized for parameter tuning of KELM model which alto-gether helps in accomplishing the maximum PD diagnostic performance.The experimental analysis was conducted for CBO-OKELM technique against four benchmark datasets and the model portrayed better performance such as 95.68%,96.34%,92.49%,and 92.36%on Speech PD,Voice PD,Hand PD Mean-der,and Hand PD Spiral datasets respectively.

Bacterial Biofilm in Water Bodies of Cherrapunjee: The Rainiest Place on Planet Earth

Bacterial attachment is influenced by the cell surface, attachment media and other environmental factors. Bacterial community composition involved in biofilm formation in extremely high rainfall areas like Cherrapunjee has not been reported. The present study was undertaken to characterize bacteria involved in biofilm formation on different substrata in water bodies of Cherrapunjee, the highest rainfall receiving place on planet earth and to assess if the continuous rainfall has an effect on nature and colonization of biofilm bacteria. We developed the biofilm bacteria on stainless steel and glass surfaces immersed in water bodies of the study sites. Isolation of biofilm bacteria were performed on different culture media followed by estimation of protein and carbohydrate content of bacterial exopolysaccharides. 16S rRNA gene sequences were amplified for molecular characterization. The results showed that the biofilm bacterial diversity in water bodies of Cherrapunjee was influenced by substratum and was observed more in stainless steel than glass surface. Scanning electron microscopy images revealed that biofilm microstructure may represent a key determinant of biofilm growth and physiology of associated bacteria. The overall protein content of the extracted EPS of all the isolates were relatively higher than the carbohydrate content. Diverse bacteria proliferated on the substrata regardless of each other's presence, with more diverse bacteria colonizing the substrata on 7th day compared to 15th day of incubation. The biofilm bacteria compositions in the highest rainfall receiving habitat were not distinctly different from reports available, hence not unique from other water bodies.

Protein Bodies in Cotyledon Cells Exhibit Differential Patterns of Legumin-Like Proteins Mobilization during Seedling Germinating States

Olive (Olea europaea L.) tree is one of the most extensive and important agricultural crop in Mediterranean countries due to its beneficial health and nutritional properties and its high economic value. Currently, olive tree constitutes the sixth most important cultivated plant in the world, spreading from the Mediterranean region of origin to new production areas such as Australia, South and North America and South Africa. However, the mobilization processes of storage materials i.e. reserve proteins during seed germination, which are largely involved in essential physiological process including plant growth and development, remain poorly understood. Morphometric and immunohistochemistry analyses of protein bodies contained in olive seed storage tissues, cotyledon and endosperm, were performed by using different microscopy techniques, including light (bright-field and fluorescence) microscopy and transmission electron microscopy. Furthermore, we used legumin-like proteins (11S-type globulins) as a molecular marker to study the mobilization of reserve proteins from PBs of cotyledons at germinating seedling stages by using immunofluorescence assays. Results demonstrated that cotyledon and endosperm are characterized by distinct PBs populations containing legumin-like proteins, distinctly discriminated by the number of PBs per cell and tissue, size, immunofluorescence and histochemical staining. These features reflect differential PBs biogenesis during development and maturation processes in olive seed tissues endosperm and cotyledon, in relation to proteins (polypeptides) final composition, SSPs processing and/or packaging during seed maturation. Three different mobilization patterns of legumin-like proteins were identified for the first time in cotyledon PBs during seedling germinating process. Mature proteins composition and/or processing, cell types and enzyme composition and/or differential activation have been discussed as key features determining how proteins mobilize from PBs for further degradation in the cotyledon.

Recent progress and concerns in dementia: Distinguishing Alzheimer's disease and dementia with Lewy bodies via biochemical markers in the cerebrospinal fluid

Dementia is mainly a neurodegenerative disorder involved in several systems, including central nervous system, endocrinology/metabolism system and circulatory system. Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) are the most common forms of the dementia, accounting for 60% - 80% and 10% - 20% of all cases, respectively. DLB is defined by widespread neocortical, limbic and brainstem Lewy bodies but frequently accompanied by variable levels of AD pathology. This pathological and clinical overlap makes their differential diagnosis complicated. Recent advances in the identification of disease bio-markers now make it possible to detect and distinguish their pathology in the early or preclinical stage of the diseases, even in cognitively normal individuals. In addition to the key biomarkers (amyloid β or Aβ, tau and α-synuclein), neurotrophins such as cocaine- and amphetamine-regulated transcript (CART) have also drawn attention due to their expressions and functions. This article summarizes the progress in the definition, pathology and diagnosis of dementia, with a focus on potential biochemical markers in the cere-brospinal fluid (CSF) in the differential diagnosis of the main forms of dementia. To prediction or early diagnosis of dementia, the role of specific and sensitive CSF biomarkers seems to be crucial in a routine clinical setting. The concerns and challenges in the biomarker field are also discussed.

Women Bodies at Trial by Ordeal since Christianity to Trier Movies

In his Antichrist and Nymphomaniac, Lars von Trier seems to defy norms on sex and women＇s desires. However he actually reproduces Christianity＇s perspective that women are sinful by their dispositions. According to the classical creation story, Eve falls into temptation and then, convinces Adam to commit the same crime. All Abrahamic religions but especially Christianity identifies women with the body and bodily desires, rather than the mind which comes from nonmaterial and divine substance. Accordingly, women can easily be deceived by Satan since they contain a lesser amount of mental substance compared to men. In Antichrist, Trier reiterates the story of Adam and Eve in a different context. The woman writes her dissertation on women who are burnt with the accusation of being a witch. But she realizes that her body is sinful and deserving of punishment, too. She finds her salvation when she cuts her clitoris. In Nymphomaniac, the main character gets her clitoris whipped. While she resists traditional and bourgeois morality, she defines herself as morally evil because of her unmanageable sexual desires. Thus, reputed as critical of all social structures and morality, Trier in fact simply rehashes the classical sexist and misogynist perspective.

Correlation between Alzheimer’s Disease and Dementia with Lewy Bodies Scores Using VSRAD Advance

The objective of the study was to explore the relationship between the indicators of Alzheimer’s disease and dementia with Lewy bodies using the voxel-based specific regional analysis system for Alzheimer’s Disease (VSRAD) advance. Among 36 patients with suspected dementia, patients with Alzheimer’s disease and dementia with Lewy bodies were identified using VSRAD advance from March 1 to October 30, 2019. All patients underwent brain Magnetic Resonance Imaging (MRI). We diagnosed Alzheimer’s disease using Volume of Interest (VOI) in the Medial Temporal Lobe (MTL) atrophy ratio > 2 and dementia with Lewy bodies using both VOI in the MTL atrophy ratio ≤ 2 and gray/white matter atrophy ratio ≥ 0.2. The correlation between the indicators of Alzheimer’s disease and dementia with Lewy bodies was calculated. The number of patients classified as having Alzheimer’s disease and dementia with Lewy bodies was 25 and 11, respectively. In the Alzheimer’s disease group, the correlation coefficient between the extent of gray matter atrophy and the severity of atrophy in the dorsal brainstem gray matter was r = -0.40 (p = 0.045). In dementia with Lewy bodies group, the correlation coefficient between the extent of gray matter atrophy and the severity of atrophy in the dorsal brainstem white matter was r = -0.78 (p < 0.01). Using VSRAD advance, gray matter atrophy and dorsal brainstem grey/white matter atrophy were found to be negatively correlated in Alzheimer’s disease and dementia with Lewy bodies.

Some Methods of Solution of Problems of Sound Diffraction on Bodies of Non-Analytical Form

This review analyzes following numerical methods of a solution of problems of a sound diffraction on ideal and elastic scatterers of a non-analytical form: a method of integral equations, a method of Green’s functions, a method of finite elements, a boundary elements method, a method of Kupradze, a T-matrix method and a method of a geometrical theory of a diffraction.

An Analysis of Interpersonal Function of the Dialogues in the Film The King's Speech

Based on the framework of Halliday's theory of interpersonal function, this study intends to analyze the dialogues in the film The King's Speech from the three aspects of mood type, modal operator and vocative address by adopting both quantitative and qualitative methods. The significances of successful realizations of interpersonal function to the role characterization, plot development and thematic construction in the film are also demonstrated, thus deepening the understanding and appreciation of the film.

基于King达标理论的培训方案对临床护士叙事能力及人文关怀能力的影响

目的:探讨基于King达标理论构建临床护士叙事护理培训方案对临床护士叙事护理能力、人文关怀能力及共情能力的影响。方法:2023年3月—5月选取淄博市某三级甲等医院138名护士,采用随机数字表法分为试验组和对照组。对照组实施常规叙事护理培训,试验组在对照组的基础上实施基于King达标理论指导下的叙事护理方案。采用医学叙事能力量表(NCS)、关怀能力评价量表(CAI)、杰弗逊共情量表(JSE-HP)进行效果评价。结果:干预后,试验组护士NCS、CAI及JSE-HP得分均高于对照组,差异均有统计学意义(P<0.05)。结论:基于King达标理论构建的临床护士叙事培训方案可有效提高临床护士叙事护理能力、促进人文关怀能力并提升护士共情能力。

基于King达标理论的心理干预结合亲情干预模式对BPH患者行PKEP术后恢复情况及GQOLI-74、IPSS评分的影响

目的研究基于King达标理论的心理干预结合亲情干预模式对前列腺增生(BPH)患者行经尿道双极等离子前列腺剜除术(PKEP)术后恢复情况及生活质量综合评定问卷(GQOLI-74)、国际前列腺症状评分(IPSS)的影响。方法选择2017年8月~2019年2月浙江省嘉兴市第二医院收治的BPH患者120例作为研究对象,采用随机数字表法将其分为对照组和观察组,每组60例.两组患者均采取PKEP治疗,手术治疗后,对照组患者采取常规护理措施,观察组患者采取基于King达标理论的心理干预结合亲情干预模式,两组患者的护理时间均为4周。比较两组患者的围术期指标、症状改善情况、并发症、生命质量以及依从性之间的差异。结果两组IPSS评分、最大尿流速(Qmax)、残余尿量(RUV)组内治疗前后比较,差异均有统计学意义(均P<0.05),治疗后两组手术时间、术中出血量、切除组织量、IPSS评分、Qmax、RUV之间比较,差异均无统计学意义(P>0.05);治疗后,两组患者的生命质量评分均升高,且观察组患者的生命质量评分均显著高于对照组,差异有统计学意义(P<0.05),两组患者的遵医嘱服药行为以及不良服药行为、日常生活管理行为、烟酒嗜好管理行为、依从性总分均高于治疗前,且观察组各项评分均高于对照组,差异均有统计学意义(P<0.05)。结论通过对BPH患者基于King达标理论的心理干预结合亲情干预模式护理,患者GQOLI-74、IPSS评分显著改善,患者的并发症显著下降,对患者的治疗具有积极的意义。

Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma

In recent decades there has been a dramatic rise in the incidence of esophageal adenocarcinoma(EAC) in the developed world. Over approximately the same period there has also been an increase in the prevalence of obesity. Obesity, especially visceral obesity, is an important independent risk factor for the development of gastro-esophageal reflux disease, Barrett's esophagus and EAC. Although the simplest explanation is that this mediated by the mechanical effects of abdominal obesity promoting gastro-esophageal reflux, the epidemiological data suggest that the EAC-promoting effects are independent of reflux. Several, not mutually exclusive, mechanisms have been implicated, which may have different effects at various points along the refluxBarrett's-cancer pathway. These mechanisms include a reduction in the prevalence of Helicobacter pylori infection enhancing gastric acidity and possibly appetite byincreasing gastric ghrelin secretion, induction of both low-grade systemic inflammation by factors secreted by adipose tissue and the metabolic syndrome with insulin-resistance. Obesity is associated with enhanced secretion of leptin and decreased secretion of adiponectin from adipose tissue and both increased leptin and decreased adiponectin have been shown to be independent risk factors for progression to EAC. Leptin and adiponectin have a set of mutually antagonistic actions on Barrett's cells which appear to influence the progression of malignant behaviour. At present no drugs are of proven benefit to prevent obesity associated EAC. Roux-en-Y reconstruction is the preferred bariatric surgical option for weight loss in patients with reflux. Statins and aspirin may have chemopreventative effects and are indicated for their circulatory benefits.

Association between childhood obesity and gut microbiota:16S rRNA gene sequencing-based cohort study

BACKGROUND This study aimed to identify characteristic gut genera in obese and normal-weight children(8-12 years old)using 16S rDNA sequencing.The research aimed to provide insights for mechanistic studies and prevention strategies for childhood obesity.Thirty normal-weight and thirty age-and sex-matched obese children were included.Questionnaires and body measurements were collected,and fecal samples underwent 16S rDNA sequencing.Significant differences in body mass index(BMI)and body-fat percentage were observed between the groups.Analysis of gut microbiota diversity revealed lowerα-diversity in obese children.Differences in gut microbiota composition were found between the two groups.Prevotella and Firmicutes were more abundant in the obese group,while Bacteroides and Sanguibacteroides were more prevalent in the control group.AIM To identify the characteristic gut genera in obese and normal-weight children(8-12-year-old)using 16S rDNA sequencing,and provide a basis for subsequent mechanistic studies and prevention strategies for childhood obesity.METHODS Thirty each normal-weight,1:1 matched for age and sex,and obese children,with an obese status from 2020 to 2022,were included in the control and obese groups,respectively.Basic information was collected through questionnaires and body measurements were obtained from both obese and normal-weight children.Fecal samples were collected from both groups and subjected to 16S rDNA sequencing using an Illumina MiSeq sequencing platform for gut microbiota diversity analysis.RESULTS Significant differences in BMI and body-fat percentage were observed between the two groups.The Ace and Chao1 indices were significantly lower in the obese group than those in the control group,whereas differences were not significant in the Shannon and Simpson indices.Kruskal-Wallis tests indicated significant differences in unweighted and weighted UniFrac distances between the gut microbiota of normal-weight and obese children(P<0.01),suggesting substantial disparities in both the species and quantity of gut microbiota between the two groups.Prevotella,Firmicutes,Bacteroides,and Sanguibacteroides were more abundant in the obese and control groups,respectively.Heatmap results demonstrated significant differences in the gut microbiota composition between obese and normal-weight children.CONCLUSION Obese children exhibited lowerα-diversity in their gut microbiota than did the normal-weight children.Significant differences were observed in the composition of gut microbiota between obese and normal-weight children.

TRUE KINGLY HONOUR IN SHAKESPEARE′S HENRY IV PART I

Honour, one of the eternal themes in Shakespeare, is again in the spotlightin Henry IV Part I. In this play, the rivalry between Prince Hal and Hotspuremerges actually out of their cravings for the title of royal honour and valour.Hotspur appears to be formidable, courageous and energetic. He is exactly

α-Synuclein pathology from the body to the brain:so many seeds so close to the central soil

α-Synuclein is a protein that mainly exists in the presynaptic terminals.Abnormal folding and accumulation of α-synuclein are found in several neurodegenerative diseases,including Parkinson’s disease.Aggregated and highly phospho rylated a-synuclein constitutes the main component of Lewy bodies in the brain,the pathological hallmark of Parkinson s disease.For decades,much attention has been focused on the accumulation of α-synuclein in the brain parenchyma rather than considering Parkinson s disease as a systemic disease.Recent evidence demonstrates that,at least in some patients,the initial α-synuclein pathology originates in the peripheral organs and spreads to the brain.Injection of α-synuclein preformed fibrils into the gastrointestinal tra ct trigge rs the gutto-brain propagation of α-synuclein pathology.However,whether α-synuclein pathology can occur spontaneously in peripheral organs independent of exogenous α-synuclein preformed fibrils or pathological α-synuclein leakage from the central nervous system remains under investigation.In this review,we aimed to summarize the role of peripheral α-synuclein pathology in the pathogenesis of Parkinson’s disease.We also discuss the pathways by which α-synuclein pathology spreads from the body to the brain.

Jordan＇s King Hussein＇s Peace Initiative and the Treaty with Israel： Overcoming Domestic and Foreign Pressures

The Wadi ＇Araba peace treaty which Jordan＇s King Hussein signed with Israel on October 26, 1994 became a target of criticism ever since it became known to the Jordanian public. Intense pressure was exerted on the Jordanian government to revoke the treaty even before its signature. The opposition to it reached its peak in the following year, when the tension in the holy sites in Jerusalem mounted. Given the persistence of the Arab-Israeli conflict and the fact that the Palestinian issue remained unresolved, it was clear that the King was aware of the potential danger of signing a peace accord with Israel, and that he was prepared to face criticism not only from the Arab states but also from nationalists, Islamists and Leftists all of whom disapproved of his decision. Yet the King remained undeterred and boldly carried on the discussions that culminated in the peace treaty＇s signature. Bearing in mind the fact the Egypt was the first country to sign a peace treaty with Israel it seemed as if there was little risk involved in the normalization process, and that the opposition to the treaty would soon subside. As it turned out, however, the pressure to abrogate it continues to mount.