The spirit of the May 4th Movement has a profound influence on China’s self-confidence in its path,political system,guiding theories,and culture.This spirit,which conceived the choice of socialist path,has become the...The spirit of the May 4th Movement has a profound influence on China’s self-confidence in its path,political system,guiding theories,and culture.This spirit,which conceived the choice of socialist path,has become the foundation of confidence in the socialist path with Chinese characteristics.The Marxist theory contained in the spirit is the core of the theoretical self-confidence of socialism;the socialist system bred by the spirit has borne the fruit of confidence in the socialist system with Chinese characteristics;the new culture movement produced by the spirit is the thrust of cultural self-confidence of socialism with Chinese characteristics.Inheriting and developing the spirit of the May Fourth Movement in the new era is conducive to strengthen the Four Confidences.展开更多
Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.Ho...Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.However,the molecular mechanism underlying its efficacy remains unclear.In this study,a middle cerebral artery occlusion(MCAO)rat model was produced by the suture method.Rats received modified constraint-induced movement therapy 1 hour a day for 14 consecutive days,starting from the 7^th day after middle cerebral artery occlusion.Day 1 of treatment lasted for 10 minutes at 2r/min,day 2 for 20 minutes at 2 r/min,and from day 3 onward for 20 minutes at 4 r/min.CatWalk gait analysis,adhesive removal test,and Y-maze test were used to investigate motor function,sensory function as well as cognitive function in rodent animals from the 1st day before MCAO to the 21^st day after MCAO.On the 21^st day after MCAO,the neurotransmitter receptor-related genes from both contralateral and ipsilateral hippocampi were tested by micro-array and then verified by western blot assay.The glutamate related receptor was shown by transmission electron microscopy and the glutamate content was determined by high-performance liquid chromatography.The results of behavior tests showed that modified constraint-induced movement therapy promoted motor and sensory functional recovery in the middle cerebral artery-occluded rats,but had no effect on cognitive function.The modified constraint-induced movement therapy upregulated the expression of glutamate ionotropic receptor AMPA type subunit 3(Gria3)in the hippocampus and downregulated the expression of the beta3-adrenergic receptor gene Adrb3 and arginine vasopressin receptor 1 A,Avprla in the middle cerebral artery-occluded rats.In the ipsilateral hippocampus,only Adra2 a was downregulated,and there was no significant change in Gria3.Transmission electron microscopy revealed a denser distribution the more distribution of postsynaptic glutamate receptor 2/3,which is an a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor,within 240 nm of the postsynaptic density in the contralateral cornu ammonis 3 region.The size and distribution of the synaptic vesicles within 100 nm of the presynaptic active zone were unchanged.Western blot analysis showed that modified constraint-induced movement therapy also increased the expression of glutamate receptor 2/3 and brain-derived neurotrophic factor in the hippocampus of rats with middle cerebral artery occlusion,but had no effect on Synapsin I levels.Besides,we also found modified constraint-induced movement therapy effectively reduced glutamate content in the contralateral hippocampus.This study demonstrated that modified constraint-induced movement therapy is an effective rehabilitation therapy in middle cerebral artery-occluded rats,and suggests that these positive effects occur via the upregulation of the postsynaptic membrane a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor expression.This study was approved by the Institutional Animal Care and Use Committee of Fudan University,China(approval No.201802173 S)on March 3,2018.展开更多
The effects of two different nitrogen fertilizers （urea and NH4C1） with monocalcium phosphate （MCP） on the movement and transformation of fertilizer P in soil microsites along with soil pH changes at different dis...The effects of two different nitrogen fertilizers （urea and NH4C1） with monocalcium phosphate （MCP） on the movement and transformation of fertilizer P in soil microsites along with soil pH changes at different distances from the fertilizer application site were studied in an incubation experiment. A highly acidic red soil （Ultisol, pH 4.57） from south China with MCP fertilizer alone or in combination with NH4C1 or urea was added to the surface of soil cylinders and packed in wax blocks. After 7 and 28 days, the extraction and analysis of each 2 mm layer from the interface of the soil and fertilizer showed that added NH4C1 or urea did not change the movement distance of fertilizer P. However, P transformation was significantly affected （P 〈 0.05）. After 7 days, at 0-8 mm distance from the fertilizer site the addition of urea significantly decreased the water-extractable P concentration; however, after 28 days the effect of N addition had disappeared. Also,at limited distances close to the fertilizer site NH4Cl application with MCP significantly increased acid-extractable P and available P, while with the addition of urea they significantly decreased. Compared with application of MCP alone,addition of urea significantly increased soil pH in fertilizer microsites, whereas the addition of NH4Cl significantly decreased soil pH.展开更多
Beyond the traditional focus on improvements in mechanical, electronic and absorption properties, controllability, actuation, and dynamic response of monoliths have received increasing attentions for practical applica...Beyond the traditional focus on improvements in mechanical, electronic and absorption properties, controllability, actuation, and dynamic response of monoliths have received increasing attentions for practical applications. However, most of them could only realize simple response to constant conditions(e.g. a stationary magnetic field) while carrying out humdrum motions. By controlling distribution of metal organic framework obtained carbon-enriched Fe304 nanoparticles in self-assembly reduced graphene oxide(RGO) monoliths, we could achieve two distinctive RGO-Fe_3 O_4 stirrers that could dynamically respond to the rapidly changing magnetic field while executing designed movements precisely: rotating with lying down posture or standing straight posture. These stirrers can not only be applied in environmental remediation(e.g.suction skimmer), but also be recycled as electrode active materials for supercapacitors after fulfilling their destiny, realizing transformation of trash to treasure, which will inspire other dynamically responsive monoliths for various applications.展开更多
The core sample from well QZ-4 is an important climate archive for the central Tibetan Plateau in the middle-late Pleistocene. In this work, a detailed pollen analysis of it is carried out to provide a preliminary ins...The core sample from well QZ-4 is an important climate archive for the central Tibetan Plateau in the middle-late Pleistocene. In this work, a detailed pollen analysis of it is carried out to provide a preliminary insight into the paleo-climate and paleo-altimetry change in the central Tibetan Plateau. It can be concluded that the pollen assemblage can be obviously divided into two pollen zones, Pollen zone I (251.1 - 314 m in depth, 120.0 - 345.8 ka BP.) and Pollen zone II (200 - 251.1 m in depth, 105.4 - 120 ka BP.). The paleo-climate during pollen zone I deposition period was comparatively colder and wetter than it during the pollen zone II deposition period. After Gonghe Movement, the center of Tibetan Plateau was uplifted about 300 m (from 3500 - 3700 m to 3800 - 4000 m in elevation). The wind was changed from horizontal or downward direction to upward direction, in the study area. In the central of Tibetan Plateau, the climate change seems to be mainly driven by global climate change, and that tectonic uplift may have been a subordinate influence at the middle-late Pleistocene.展开更多
The initiation of the communism group and the founding of the Communist Party of China are deeply rooted in China’s political,economic,and social environments,which are not simply the result of Soviet Russia’forced ...The initiation of the communism group and the founding of the Communist Party of China are deeply rooted in China’s political,economic,and social environments,which are not simply the result of Soviet Russia’forced export of revolution.Out of the complete disappointment in China’s political reality and the profound reflection on its economic oppression,Chinese progressive intellectuals have yearned for one ideal society since the Republic of China,which is represented by socialism.The practical successful road provided by October Revolution caters to China’s trend.Therefore,the early Chinese communists begin to change their clothes and enter the labor masses.They look forward to establishing a revolutionary proletarian regime and carrying on economic career based on communist principle so as to promote national construction.Under the long-term promotion of the early communists,the former poor and undisciplined working class would bring the concept of socialism into their own life.展开更多
基金The key project of Humanities and Social Sciences of Chongqing Municipal Commission of Education“Research on the Construction of China’s National Cohesion in the New Era based on Cultural Soft Power”(19SKGH140)and the special theoretical key project of Chongqing Social Sciences Planning:“Research on‘Four Comprehensives’and National Cohesion in the Philosophical Context”(17ZDZT29).
文摘The spirit of the May 4th Movement has a profound influence on China’s self-confidence in its path,political system,guiding theories,and culture.This spirit,which conceived the choice of socialist path,has become the foundation of confidence in the socialist path with Chinese characteristics.The Marxist theory contained in the spirit is the core of the theoretical self-confidence of socialism;the socialist system bred by the spirit has borne the fruit of confidence in the socialist system with Chinese characteristics;the new culture movement produced by the spirit is the thrust of cultural self-confidence of socialism with Chinese characteristics.Inheriting and developing the spirit of the May Fourth Movement in the new era is conducive to strengthen the Four Confidences.
基金supported by the National Natural Science Foundation of China,No.81871841(to YLB) and No.81772453(to DSX)
文摘Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.However,the molecular mechanism underlying its efficacy remains unclear.In this study,a middle cerebral artery occlusion(MCAO)rat model was produced by the suture method.Rats received modified constraint-induced movement therapy 1 hour a day for 14 consecutive days,starting from the 7^th day after middle cerebral artery occlusion.Day 1 of treatment lasted for 10 minutes at 2r/min,day 2 for 20 minutes at 2 r/min,and from day 3 onward for 20 minutes at 4 r/min.CatWalk gait analysis,adhesive removal test,and Y-maze test were used to investigate motor function,sensory function as well as cognitive function in rodent animals from the 1st day before MCAO to the 21^st day after MCAO.On the 21^st day after MCAO,the neurotransmitter receptor-related genes from both contralateral and ipsilateral hippocampi were tested by micro-array and then verified by western blot assay.The glutamate related receptor was shown by transmission electron microscopy and the glutamate content was determined by high-performance liquid chromatography.The results of behavior tests showed that modified constraint-induced movement therapy promoted motor and sensory functional recovery in the middle cerebral artery-occluded rats,but had no effect on cognitive function.The modified constraint-induced movement therapy upregulated the expression of glutamate ionotropic receptor AMPA type subunit 3(Gria3)in the hippocampus and downregulated the expression of the beta3-adrenergic receptor gene Adrb3 and arginine vasopressin receptor 1 A,Avprla in the middle cerebral artery-occluded rats.In the ipsilateral hippocampus,only Adra2 a was downregulated,and there was no significant change in Gria3.Transmission electron microscopy revealed a denser distribution the more distribution of postsynaptic glutamate receptor 2/3,which is an a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor,within 240 nm of the postsynaptic density in the contralateral cornu ammonis 3 region.The size and distribution of the synaptic vesicles within 100 nm of the presynaptic active zone were unchanged.Western blot analysis showed that modified constraint-induced movement therapy also increased the expression of glutamate receptor 2/3 and brain-derived neurotrophic factor in the hippocampus of rats with middle cerebral artery occlusion,but had no effect on Synapsin I levels.Besides,we also found modified constraint-induced movement therapy effectively reduced glutamate content in the contralateral hippocampus.This study demonstrated that modified constraint-induced movement therapy is an effective rehabilitation therapy in middle cerebral artery-occluded rats,and suggests that these positive effects occur via the upregulation of the postsynaptic membrane a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor expression.This study was approved by the Institutional Animal Care and Use Committee of Fudan University,China(approval No.201802173 S)on March 3,2018.
基金Project supported by the National Natural Science Foundation of China (No. 40071051) and the National Key BasicResearch Support Foundation of China (No. G1999011802).
文摘The effects of two different nitrogen fertilizers （urea and NH4C1） with monocalcium phosphate （MCP） on the movement and transformation of fertilizer P in soil microsites along with soil pH changes at different distances from the fertilizer application site were studied in an incubation experiment. A highly acidic red soil （Ultisol, pH 4.57） from south China with MCP fertilizer alone or in combination with NH4C1 or urea was added to the surface of soil cylinders and packed in wax blocks. After 7 and 28 days, the extraction and analysis of each 2 mm layer from the interface of the soil and fertilizer showed that added NH4C1 or urea did not change the movement distance of fertilizer P. However, P transformation was significantly affected （P 〈 0.05）. After 7 days, at 0-8 mm distance from the fertilizer site the addition of urea significantly decreased the water-extractable P concentration; however, after 28 days the effect of N addition had disappeared. Also,at limited distances close to the fertilizer site NH4Cl application with MCP significantly increased acid-extractable P and available P, while with the addition of urea they significantly decreased. Compared with application of MCP alone,addition of urea significantly increased soil pH in fertilizer microsites, whereas the addition of NH4Cl significantly decreased soil pH.
基金supported by Natural Science Foundation of SZU (Grant No. 2017004)Early Career Scheme of the Research Grants Council of Hong Kong SAR, China, under the Project No. CityU 109213a Grant from the City University of Hong Kong (9610372)
文摘Beyond the traditional focus on improvements in mechanical, electronic and absorption properties, controllability, actuation, and dynamic response of monoliths have received increasing attentions for practical applications. However, most of them could only realize simple response to constant conditions(e.g. a stationary magnetic field) while carrying out humdrum motions. By controlling distribution of metal organic framework obtained carbon-enriched Fe304 nanoparticles in self-assembly reduced graphene oxide(RGO) monoliths, we could achieve two distinctive RGO-Fe_3 O_4 stirrers that could dynamically respond to the rapidly changing magnetic field while executing designed movements precisely: rotating with lying down posture or standing straight posture. These stirrers can not only be applied in environmental remediation(e.g.suction skimmer), but also be recycled as electrode active materials for supercapacitors after fulfilling their destiny, realizing transformation of trash to treasure, which will inspire other dynamically responsive monoliths for various applications.
文摘The core sample from well QZ-4 is an important climate archive for the central Tibetan Plateau in the middle-late Pleistocene. In this work, a detailed pollen analysis of it is carried out to provide a preliminary insight into the paleo-climate and paleo-altimetry change in the central Tibetan Plateau. It can be concluded that the pollen assemblage can be obviously divided into two pollen zones, Pollen zone I (251.1 - 314 m in depth, 120.0 - 345.8 ka BP.) and Pollen zone II (200 - 251.1 m in depth, 105.4 - 120 ka BP.). The paleo-climate during pollen zone I deposition period was comparatively colder and wetter than it during the pollen zone II deposition period. After Gonghe Movement, the center of Tibetan Plateau was uplifted about 300 m (from 3500 - 3700 m to 3800 - 4000 m in elevation). The wind was changed from horizontal or downward direction to upward direction, in the study area. In the central of Tibetan Plateau, the climate change seems to be mainly driven by global climate change, and that tectonic uplift may have been a subordinate influence at the middle-late Pleistocene.
文摘The initiation of the communism group and the founding of the Communist Party of China are deeply rooted in China’s political,economic,and social environments,which are not simply the result of Soviet Russia’forced export of revolution.Out of the complete disappointment in China’s political reality and the profound reflection on its economic oppression,Chinese progressive intellectuals have yearned for one ideal society since the Republic of China,which is represented by socialism.The practical successful road provided by October Revolution caters to China’s trend.Therefore,the early Chinese communists begin to change their clothes and enter the labor masses.They look forward to establishing a revolutionary proletarian regime and carrying on economic career based on communist principle so as to promote national construction.Under the long-term promotion of the early communists,the former poor and undisciplined working class would bring the concept of socialism into their own life.
