A prognostic four-gene signature and a therapeutic strategy for hepatocellular carcinoma:Construction and analysis of a circRNA-mediated competing endogenous RNA network

Background:Hepatocellular carcinoma(HCC)has a poor long-term prognosis.The competition of circular RNAs(circRNAs)with endogenous RNA is a novel tool for predicting HCC prognosis.Based on the alterations of circRNA regulatory networks,the analysis of gene modules related to HCC is feasible.Methods:Multiple expression datasets and RNA element targeting prediction tools were used to construct a circRNA-microRNA-mRNA network in HCC.Gene function,pathway,and protein interaction analyses were performed for the differentially expressed genes(DEGs)in this regulatory network.In the proteinprotein interaction network,hub genes were identified and subjected to regression analysis,producing an optimized four-gene signature for prognostic risk stratification in HCC patients.Anti-HCC drugs were excavated by assessing the DEGs between the low-and high-risk groups.A circRNA-microRNA-hub gene subnetwork was constructed,in which three hallmark genes,KIF4A,CCNA2,and PBK,were subjected to functional enrichment analysis.Results:A four-gene signature(KIF4A,CCNA2,PBK,and ZWINT)that effectively estimated the overall survival and aided in prognostic risk assessment in the The Cancer Genome Atlas(TCGA)cohort and International Cancer Genome Consortium(ICGC)cohort was developed.CDK inhibitors,PI3K inhibitors,HDAC inhibitors,and EGFR inhibitors were predicted as four potential mechanisms of drug action(MOA)in high-risk HCC patients.Subsequent analysis has revealed that PBK,CCNA2,and KIF4A play a crucial role in regulating the tumor microenvironment by promoting immune cell invasion,regulating microsatellite instability(MSI),and exerting an impact on HCC progression.Conclusions:The present study highlights the role of the circRNA-related regulatory network,identifies a four-gene prognostic signature and biomarkers,and further identifies novel therapy for HCC.

Design of an Interconnection Architecture and Sizing of Two (2) EPC Core Networks: The Case of Orange-Guinea

With the arrival of the 4G and 5G,the telecommunications networks have experienced a large expansion of these networks.That enabled the integration of many services and adequate flow,thus enabling the operators to respond to the growing demand of users.This rapid evolution has given the operators to adapt,their methods to the new technologies that increase.This complexity becomes more important,when these networks include several technologies to access different from the heterogeneous network like in the 4G network.The dimensional new challenges tell the application and the considerable increase in demand for services and the compatibility with existing networks,the management of mobility intercellular of users and it offers a better quality of services.Thus,the proposed solution to meet these new requirements is the sizing of the EPC(Evolved Packet Core)core network to support the 5G access network.For the case of Orange Guinea,this involves setting up an architecture for interconnecting the core networks of Sonfonia and Camayenne.The objectives of our work are of two orders:(1)to propose these solutions and recommendations for the heart network EPC sizing and the deployment to be adopted;(2)supply and architectural interconnection in the heart network EPC and an existing heart network.In our work,the model of traffic in communication that we use to calculate the traffic generated with each technology has link in the network of the heart.

Research on the Development Trend of Electronic Communication Technology Based on Intelligent Network

With the rapid development of electronic communication technology,various new technical elements are constantly added to it,bringing many changes to people’s lives and work.The traditional data diversion mode can no longer truly meet the needs of actual work,and the electronic communication mode plays a huge role and occupies an important position in the communication market.Regarding how to develop and apply intelligent electronic communication technology more perfectly,there will be an overview of the specific principle of intelligent electronic communication technology,from the multi-faceted impact of electronic communication technology on human society.The article put forward the future development trend of electronic communication technology based on intelligent networks,emphasized expanding the scale of technology coverage,improved the comprehensive quality of technical products,optimized the structure of the communication industry,and formed a perfect industrial chain,so as to improve the intelligent level of electronic communication technology.

Exploration of the mechanism of action of Xiayuxue Tang against hepatic fibrosis based on GEO data mining,network pharmacology and molecular docking technology

Objective:To study the mechanism of action of Xiayuxue Tang in treating hepatic fibrosis by combining GEO data mining,network pharmacology,and molecular docking technology,and provide new research directions for the treatment of hepatic fibrosis.Method:Utilizing multiple databases,we aim to identify the relevant targets of various components in Xiayuxue Tang and their associations with hepatic fibrosis.After pinpointing the key targets through interaction analysis,we will construct both the compound-target network and the protein interaction network for Xiayuxue Tang.Conclusively,we will conduct GO and KEGG enrichment analyses on these key targets,followed by molecular docking verification.Result:Through mining the GEO database,171 related targets were identified.When combined with other databases,a total of 2,343 hepatic fibrosis-related targets were obtained.Xiayuxue Tang comprises 82 related components,which include 26 active components from rhubarb,1 from ground beetle worm,46 from peach kernels,with a total of 314 predicted targets.The GO enrichment analysis revealed 748 biological processes,32 cellular components,and 73 molecular functions,while the KEGG enrichment analysis identified 222 pathways.Molecular docking verification confirmed that effective compounds can bind stably to key proteins,exhibiting strong binding activity.This underscores the potential efficacy of Xiayuxue Tang in addressing hepatic fibrosis.Conclusion:Xiayuxue Tang exerts regulatory effects on hepatic fibrosis through different targets and pathways,suggesting that the herbal compound has the characteristics of multiple pathways and targets.

Study on Cognitive Optical Network Structure and Self-optimization with the Application of Artificial Intelligence Technology

Cognitive optical network is the intermediate to combine artificial intelligence technology with network,and also the important network technology to promote network intelligence level constantly.In the paper,it analyzes the cognitive optical network structure with the application of artificial intelligence technology by starting from the basic conditions of cognitive network and cognitive optional network on the basis of fully understanding the connotation of cognitive network and cognitive optical network,and explores its self-governance functions,so as to better realize the self-optimization and self-configuration of network.

Porous-DeepONet:Learning the Solution Operators of Parametric Reactive Transport Equations in Porous Media

Reactive transport equations in porous media are critical in various scientific and engineering disciplines,but solving these equations can be computationally expensive when exploring different scenarios,such as varying porous structures and initial or boundary conditions.The deep operator network(DeepONet)has emerged as a popular deep learning framework for solving parametric partial differential equations.However,applying the DeepONet to porous media presents significant challenges due to its limited capability to extract representative features from intricate structures.To address this issue,we propose the Porous-DeepONet,a simple yet highly effective extension of the DeepONet framework that leverages convolutional neural networks(CNNs)to learn the solution operators of parametric reactive transport equations in porous media.By incorporating CNNs,we can effectively capture the intricate features of porous media,enabling accurate and efficient learning of the solution operators.We demonstrate the effectiveness of the Porous-DeepONet in accurately and rapidly learning the solution operators of parametric reactive transport equations with various boundary conditions,multiple phases,and multiphysical fields through five examples.This approach offers significant computational savings,potentially reducing the computation time by 50–1000 times compared with the finite-element method.Our work may provide a robust alternative for solving parametric reactive transport equations in porous media,paving the way for exploring complex phenomena in porous media.

Tracking direct and indirect impact on technology and policy of transformative research via ego citation network

Purpose:The disseminating of academic knowledge to nonacademic audiences partly relies on the transition of subsequent citing papers.This study aims to investigate direct and indirect impact on technology and policy originating from transformative research based on ego citation network.Design/methodology/approach:Key Nobel Prize-winning publications(NPs)in fields of gene engineering and astrophysics are regarded as a proxy for transformative research.In this contribution,we introduce a network-structural indicator of citing patents to measure technological impact of a target article and use policy citations as a preliminary tool for policy impact.Findings:The results show that the impact on technology and policy of NPs are higher than that of their subsequent citation generations in gene engineering but not in astrophysics.Research limitations:The selection of Nobel Prizes is not balanced and the database used in this study,Dimensions,suffers from incompleteness and inaccuracy of citation links.Practical implications:Our findings provide useful clues to better understand the characteristics of transformative research in technological and policy impact.Originality/value:This study proposes a new framework to explore the direct and indirect impact on technology and policy originating from transformative research.

Improving Supply Chain Strategies towards Mitigating the Effect of Crude Oil Theft and Pipeline Vandalism in the Nigerian Oil and Gas Industry: A Case Study of the Nigerian National Petroleum Corporation (NNPC)

Generically, SCM may be said to include all activities carried out to ensure proper functioning of the supply chain. The activities included in proper management of a supply chain broadly include logistics activities, planning and control of the flow of information and materials in a firm, management of relationships with other organizations and government intervention, However, crude oil theft and pipeline vandalism are established products supply chain disruptors in Nigeria which are rendering the task of running an efficient petroleum supply chain onerous. This paper aims to establish the importance of effective supply chain strategies for companies in the oil and gas industry with special focus on the Nigerian oil and gas sector and the strategies by which the state oil and gas corporation in this sector may mitigate disruptions to its supply chain. This study investigates the enhancement of supply chain strategies towards meeting the challenge of crude oil theft and pipeline vandalism, using the Nigerian National Corporation (NNPC) as a case study. Based on this study, data were collected from two sources: A summary of incident reports obtained from NNPC and an interview with personnel in the PPMC Department. Incident report refers to a report produced when accidents such as equipment failure, injury, loss of life, or fire occur at the work site. Content analysis is utilized to evaluate data obtained from interview responses, CBN financial stability reports, NDIC annual reports, circulars, banking supervision reports and implementation guidelines. The study found out that NNPC should endeavor to sustain its value chain and ward of pipeline vandals and crude oil thieves by engaging in community partnership, detailing security outfits to ensure its pipelines’ right of way and bridging. Concluded that the oil supply chain of the Nigerian National Petroleum Corporation has been plagued by disruptions in the form of crude oil theft and pipeline vandalism which has had debilitating effects on its value.

An Intelligent Control Method for the Low-Carbon Operation of Energy-Intensive Equipment

Based on an analysis of the operational control behavior of operation experts on energy-intensive equipment,this paper proposes an intelligent control method for low-carbon operation by combining mechanism analysis with deep learning,linking control and optimization with prediction,and integrating decision-making with control.This method,which consists of setpoint control,self-optimized tuning,and tracking control,ensures that the energy consumption per tonne is as low as possible,while remaining within the target range.An intelligent control system for low-carbon operation is developed by adopting the end-edge-cloud collaboration technology of the Industrial Internet.The system is successfully applied to a fused magnesium furnace and achieves remarkable results in reducing carbon emissions.

A Survey on the Role of Complex Networks in IoT and Brain Communication

Complex networks on the Internet of Things(IoT)and brain communication are the main focus of this paper.The benefits of complex networks may be applicable in the future research directions of 6G,photonic,IoT,brain,etc.,communication technologies.Heavy data traffic,huge capacity,minimal level of dynamic latency,etc.are some of the future requirements in 5G+and 6G communication systems.In emerging communication,technologies such as 5G+/6G-based photonic sensor communication and complex networks play an important role in improving future requirements of IoT and brain communication.In this paper,the state of the complex system considered as a complex network(the connection between the brain cells,neurons,etc.)needs measurement for analyzing the functions of the neurons during brain communication.Here,we measure the state of the complex system through observability.Using 5G+/6G-based photonic sensor nodes,finding observability influenced by the concept of contraction provides the stability of neurons.When IoT or any sensors fail to measure the state of the connectivity in the 5G+or 6G communication due to external noise and attacks,some information about the sensor nodes during the communication will be lost.Similarly,neurons considered sing the complex networks concept neuron sensors in the brain lose communication and connections.Therefore,affected sensor nodes in a contraction are equivalent to compensate for maintaining stability conditions.In this compensation,loss of observability depends on the contraction size which is a key factor for employing a complex network.To analyze the observability recovery,we can use a contraction detection algorithm with complex network properties.Our survey paper shows that contraction size will allow us to improve the performance of brain communication,stability of neurons,etc.,through the clustering coefficient considered in the contraction detection algorithm.In addition,we discuss the scalability of IoT communication using 5G+/6G-based photonic technology.

Neural Network Based Thermal Analysis of Ultradeep Submicron Digital Circuit Design

With a reduction in transistor dimensions to the nanoscale regime of 45 nm or less, quantum mechanical effects begin to reveal themselves and have an impact on key device performance parameters. As a result, in order to develop simulation tools that can be used for the design of nanoscale transistors in the future, new theories and modelling methodologies must be developed that properly and effectively capture the physics of quantum transport. An artificial neural network(ANN) is used in this paper to examine nanoscale CMOS circuits and predict the performance parameters of CMOS-based digital inverters for a temperature range of 300 K to 400 K. The training algorithm included three hidden layers with sizes of 20, 10, and 8, as well as a function fitting ANN with Bayesian Backpropagation Regularization. Further, simulation through HSPICE using Predictive Technology Model(PTM) nominal parameters has been done to compare with ANN(trained using an analytical model) results. The obtained results lie within the acceptable range of 1%-10%. Moreover, it has also been demonstrated that the ANN simulation provides a speed improvement of around 85 % over the HSPICE simulation, and that it can be easily integrated into software tools for designing and simulating complicated CMOS logic circuits.

Operation Control Method of Relay Protection in Flexible DC Distribution Network Compatible with Distributed Power Supply

A novel operation control method for relay protection in flexible DC distribution networks with distributed power supply is proposed to address the issue of inaccurate fault location during relay protection,leading to poor performance.The method combines a fault-tolerant fault location method based on long-term and short-term memory networks to accurately locate the fault section.Then,an operation control method for relay protection based on adaptive weight and whale optimization algorithm(WOA)is used to construct an objective function considering the shortest relay protection action time and the smallest impulse current.The adaptive weight and WOA are employed to obtain the optimal strategy for relay protection operation control,reducing the action time and impulse current.Experimental results demonstrate the effectiveness of the proposed method in accurately locating faults and improving relay protection performance.The longest operation time is reduced by 4.7023 s,and the maximum impulse current is limited to 0.3 A,effectively controlling the impact of large impulse currents and enhancing control efficiency.

Technical operation specification for cupping therapy

Cupping,as one of the characteristic therapies of traditional Chinese medicine,has been applied for more than 2000 years and has a unique curative effect in clinic.With the evolution of the times,the types and operation techniques of cupping method are also iterating.In the process of its inheritance and development,cupping technology is also known by more and more people.Starting from the development and efficacy of cupping method,this paper introduces the clinical operation steps and precautions of cupping method in detail,and lists the representative diseases such as lumbar muscle strain,herpes zoster,and ankylosing spondylitis,to provide reference for clinical application.

Technical operation specification for pricking-cupping therapy

Pricking-cupping therapy is a Traditional Chinese Medicine(TCM)nursing technology that can adjust the viscera of the human body,make the meridians smooth,and Yin and Yang balanced mainly by means of relieving heat and detoxification,harmonizing Qi and blood,promoting blood circulation and removing blood stasis,dredging meridians and activating collaterals,reducing swelling and pain,purging heat and calming shock,clearing heat,and opening orifices.Pricking-cupping therapy has a long history and wide application.After thousands of years of development,it has made great progress.They are widely used to treat lumbar disc herniation,herpes zoster,acute arthritis,migraine,and other diseases in China.Through the clinical practice and theoretical exploration of physicians of past dynasties,the therapeutic mechanism and application scope of pricking-cupping therapy have been greatly enriched.Modern TCM practitioners have conducted in-depth researches on the operation norms of the therapy on the basis of the ancients,hoping to grasp the essence of the disease more accurately and make the rational use of the operation technology of the therapy.

基于Prometheus的信息化软件监控系统的设计与实现

通过引入软件监控系统,实现软件实例的并行监控和告警,可以有效地提高软件运行和维护的效率,减少软件运行和维护的成本。以Prometheus时序数据库为核心设计了一套软件监控系统,阐述了软件监控系统的技术架构设计与功能结构设计,总结了系统实施过程中的主要工作。

The Comparative Research on the Location Technology of Wireless Sensor Networks

Wireless Sensor Network (WSN) which is composed of lots of self-organizational intelligence nodes has become new technology of information acquisition and processing. Location technology is one of the key technologies in WSN. There are many kinds of location algorithms currently and the research to performance evaluation and applicability analysis of algorithms has fundamental significance. For this reason, the paper firstly elaborated the performance evaluation indexes of location algorithms, and analyzed the location prin-ciples, characteristics and current fundamental problems to typical and some new location algorithms, and then analyzed and compared some typical location algorithms according to the location accuracy, node den-sity and hardware requirement, obtaining the sphere of application of these algorithms and pointing out the problems which need to be solved in WSN currently.

The Optimization Study about Fault Self-Healing Restoration of Power Distribution Network Based on Multi-Agent Technology

In order to quickly and accurately locate the fault location of the distribution network and increase the stability of the distribution network,a fault recovery method based on multi-objective optimization algorithm is proposed.The optimization of the power distribution network fault system based on multiagent technology realizes fast recovery of multi-objective fault,solve the problem of network learning and parameter adjustment in the later stage of particle swarm optimization algorithm falling into the local extreme value dilemma,and realize the multi-dimensional nonlinear optimization of the main grid and the auxiliary grid.The system proposed in this study takes power distribution network as the goal,applies fuzzy probability algorithm,simplifies the calculation process,avoids local extreme value,and finally realizes the energy balance between each power grid.Simulation results show that the Multi-Agent Technology enjoys priority in restoring important load,shortening the recovery time of power grid balance,and reducing the overall line loss rate of power grid.Therefore,the power grid fault self-healing system can improve the safety and stability of the important power grid,and reduce the economic loss rate of the whole power grid.

IMPACT OF OPERATING COSTS ON INVESTMENT STRATEGIES IN NEW TECHNOLOGY ADOPTION WITH A FURTHER NEW TECHNOLOGY ANTICIPATED

The adoption of new technologies often represents a crucial component of firms＇ investment decisions. This paper studies a dynamic duopoly model in which two firms compete in adoption of current technology with a further new technology anticipated. Here it is assumed that the operating costs are not zero which has more explanatory power of the real world. There exist three kinds of equilibria that may occur in adoption of current technology, which mainly depends on the level of operating costs and the first-move advantage. It shows that the faster technological substitution or innovation encourages the leader to invest earlier while induces the follower to invest later. Furthermore,like the investment costs,with the increase of operating costs the follower tends to invest later while the leader tends to invest earlier ,the investment thresholds are more sensitive to the change of operating costs than that of investment costs.

Experimental investigation on the invert stability of operating railway tunnels with different drainage systems using 3D printing technology

In recent years, the invert anomalies of operating railway tunnels in water-rich areas occur frequently,which greatly affect the transportation capacity of the railway lines. Tunnel drainage system is a crucial factor to ensure the invert stability by regulating the external water pressure(EWP). By means of a threedimensional(3D) printing model, this paper experimentally investigates the deformation behavior of the invert for the tunnels with the traditional drainage system(TDS) widely used in China and its optimized drainage system(ODS) with bottom drainage function. Six test groups with a total of 110 test conditions were designed to consider the design factors and environmental factors in engineering practice,including layout of the drainage system, blockage of the drainage system and groundwater level fluctuation. It was found that there are significant differences in the water discharge, EWP and invert stability for the tunnels with the two drainage systems. Even with a dense arrangement of the external blind tubes, TDS was still difficult to eliminate the excessive EWP below the invert, which is the main cause for the invert instability. Blockage of drainage system further increased the invert uplift and aggravated the track irregularity, especially when the blockage degree is more than 50%. However, ODS can prevent these invert anomalies by reasonably controlling the EWP at tunnel bottom. Even when the groundwater level reached 60 m and the blind tubes were fully blocked, the invert stability can still be maintained and the railway track experienced a settlement of only 1.8 mm. Meanwhile, the on-site monitoring under several rainstorms further showed that the average EWP of the invert was controlled within 84 k Pa, while the maximum settlement of the track slab was only 0.92 mm, which also was in good agreement with the results of model test.

The Fuzzy Neural Network Control Scheme With H∞ Tracking Characteristic of Space Robot System With Dual-arm After Capturing a Spin Spacecraft

In this paper,the dynamic evolution for a dualarm space robot capturing a spacecraft is studied,the impact effect and the coordinated stabilization control problem for postimpact closed chain system are discussed.At first,the pre-impact dynamic equations of open chain dual-arm space robot are established by Lagrangian approach,and the dynamic equations of a spacecraft are obtained by Newton-Euler method.Based on the results,with the process of integral and simplify,the response of the dual-arm space robot impacted by the spacecraft is analyzed by momentum conservation law and force transfer law.The closed chain system is formed in the post-impact phase.Closed chain constraint equations are obtained by the constraints of closed-loop geometry and kinematics.With the closed chain constraint equations,the composite system dynamic equations are derived.Secondly,the recurrent fuzzy neural network control scheme is designed for calm motion of unstable closed chain system with uncertain system parameter.In order to overcome the effects of uncertain system inertial parameters,the recurrent fuzzy neural network is used to approximate the unknown part,the control method with H∞tracking characteristic.According to the Lyapunov theory,the global stability is demonstrated.Meanwhile,the weighted minimum-norm theory is introduced to distribute torques guarantee that cooperative operation between manipulators.At last,numerical examples simulate the response of the collision,and the efficiency of the control scheme is verified by the simulation results.