The potential of stem cell-based therapy for retinal repair

Like injured neurons in the brain or spinal cord, neurons in the retina are incapable to regenerate following injury and ultimately would lead to irreversible neuronal loss and vision impairment. Over decades, extensive effort has been made to develop strategies to protect retinal neurons from death; however, the outcome is limited （Pettmann and Henderson, 1998; Bahr, 2000; Lagali and Picketts, 2011）. Replacing the degenerated retinal neurons by newly generated and functional neurons would be an ideal scenario. The rapid development of stem cell biology has recently demonstrated that stem cells could be a potential source of cells for cell replace- ment therapy because these cells have the self-renewal capacity and could be differentiated into many cell types. This review will dis- cuss the therapeutic potential of stem cell-based therapy to retinal degenerative diseases.

Differential Proteomics Reveals the Potential Injury Mechanism Induced by Heavy Ion Radiation in Mice Ovaries

In the present study, we used a proteomics approach based on a two-dimensional electrophoresis （2-DE） reference map to investigate protein expression in the ovarian tissues of pubertal Swiss-Webster mice subjected to carbon ion radiation （CIR）. Among the identified proteins, ubiquitin carboxy-terminal hydrolase L1 （UCH-L1） is associated with the cell cycle[1] and that it influences proliferation in ovarian tissues. We analyzed the expression of UCH-L1 and the proliferation marker proliferation cell nuclear antigen （PCNA） following CIR using immunoblotting and immunofluorescence. The proteomics and biochemical results provide insight into the underlying mechanisms of CIR toxicity in ovarian tissues.

A 420nm Blue Diode Laser for the Potential Rubidium Optical Frequency Standard

We report a 42Ohm external cavity diode laser with an interference filter （IF） of 0.5am narrow-bandwidth and 79% high transmission, which is first used for Rb optical frequency standard. The IF and the cat-eye reflector are used for selecting wavelength and light feedback, respectively. The measured laser linewidth is 24 kHz when the diode laser is free running. Using this narrow-linewidth IF blue diode laser, we realize a compact Rb optical frequency standard without a complicated PDH system. The preliminary stability of the Rb optical frequency standard is 2 × 10^-13 at I s and decreases to 1.9 ×10^-14 at 1000s. The narrow-linewidth characteristic makes the IF blue diode laser a well suited candidate for the compact Rb optical frequency standard.

Genetic polymorphism of CYP2A6 is one of the potential factors determining tobacco-related cancer risk

While we studied pharmacokinetics of SM-12502 which was under development as an anti-PAF agent, we found three subjects showing a slow metabolic phenotype in its pharmacokinetics. Analyzing the genes for CYP2A6 from the three subjects, we discovered that the three subjects possessed the whole CYP2A6 gene deletion (CYP2A6*4C), a novel genetic polymorphism of the CYP2A6 gene. Genetically engineered Salmonella YG7108 cells expressing human CYP2A6 or CYP2E1 together with the NADPH-CYP reductase were established in our laboratory to compare the mutagen-producing capacity of these enzymes for various N-nitrosamines. We found that CYP2E1 was responsible for the metabolic activation of N-nitrosamines with relatively short alkyl chains, whereas CYP2A6 was involved in the metabolic activation of N-nitrosamines possessing relatively bulky alkyl chains such as a tobacco-specific nitrosamine, NNK, which has been known to cause lung tumor in rodents. Thus, to examine a hypothesis that individuals possessing the CYP2A6*4C have the reduced risk of lung cancer due to the lack of the capacity of the metabolic activation of certain carcinogens in tobacco smoke, a case-control study was performed.

The Potential Scenarios of the Impacts of Climate Change on Egyptian Resources and Agricultural Plant Production

The emissions of greenhouse gasses in Egypt are about 0.58% of the total emissions of the world in the year 2015, although Egypt is one of the countries most affected by the impacts of climate change. By assessment and analysis of the expected economic impacts of climate change by the year 2030, the Egyptian cultivated area will be reduced to about 0.949 million acres, equal to about 8.22% of the Egyptian cultivated area compared with the case of no sinking part of the Delta land, thus reducing crop area in Egypt to about 1.406 million acres, approximately to about 6.25% of crop area compared with the case of no sinking part of the Delta land, in addition to surplus in the Egyptian balance water to about 2.48 billion m3. In this case value of the Egyptian agriculture production will decrease by about 6.19 billion dollars, equal to about 6.19% compared with presumably no sinking of the Delta land. In the case of sinking 15% of Delta lands, with the change of the productivity and water consumption of most crops, the result will be a reduction in the cultivated area to about 0.94 million acres. In addition to decreasing the Egyptian crop area to about 1.39 million acres, with a deficit in the Egyptian balance water to about 4.74 billion m3 compared to the case of no sinking part of the Delta land, the cultivated area will decrease to about 8.17%, and the crop area will decrease 6.18%. Also, the value of the Egyptian agriculture production will decrease by about 12.51%. While compared to sinking part of the Delta land to about 15% of the total Delta area without the other impacts of climate change, the cultivated area will increase by about 0.06%;the crop area will increase by about 0.08%;also, the value of the Egyptian agriculture production will decrease by about 5.57%.

Unambiguously Resolving the Potential Neutrino Magnetic Moment Signal at Large Liquid Scintillator Detectors

Non-vanishing electromagnetic properties of neutrinos have been predicted by many theories beyond the Standard Model, and an enhanced neutrino magnetic moment can have profound implications for fundamental physics. The XENON1T experiment recently detected an excess of electron recoil events in the 1–7 keV energy range, which can be compatible with solar neutrino magnetic moment interaction at a most probable value of μ_(v) = 2.1 × 10^(-11)μ_(B).However, tritium backgrounds or solar axion interaction in this energy window are equally plausible causes.Upcoming multi-tonne noble liquid detectors will test these scenarios more in depth, but will continue to face similar ambiguity. We report a unique capability of future large liquid scintillator detectors to help resolve the potential neutrino magnetic moment scenario. With O(100) kton·year exposure of liquid scintillator to solar neutrinos, a sensitivity of μ_(v) < 10^(-11)μ_(B) can be reached at an energy threshold greater than 40 keV, where no tritium or solar axion events but only neutrino magnetic moment signal is still present.

Developing the Potential of Children's Brains

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The Potential for Technological Advances to Promote the Human Rights Cause

Discussion and study of the relationship between technological advance and human rights development can be achieved through both their interaction and interplay. In other words, we need to research and expound on the influences of technological advances on human rights development, and vice versa. However, despite the complexity of current human rights developments, this article, given length constraints, will only generally focus on whether technological advances have a potential role in promoting human rights improvements.

The Potential Effectiveness of Communicative Approach in Xinjiang

Teaching English as a foreign language has been carried out in our

A UNIFORMLY VALID ASYMPTOTIC SOLUTION OF THE NAVIER-STOKES EQUATIONS

In this paper, problems of the flow over a fat plate in the large Reynolds numbercase are studied by using the method of multiple scales￣[1,2].We have obtained N-orderuniformly valid asymptotic solutions of the Naver-Stodes equations.

The Estimates L_(1)-L_(∞) for the Reduced Radial Equation of Schrodinger

Estimates of the type L1-L∞ for the Schr&#246;dinger Equation on the Line and on Half-Line with a regular potential V(x), express the dispersive nature of the Schr&#246;dinger Equation and are the essential elements in the study of the problems of initial values, the asymptotic times for large solutions and Scattering Theory for the Schr&#246;dinger equation and non-linear in general;for other equations of Non-linear Evolution. In general, the estimates Lp-Lp' express the dispersive nature of this equation. And its study plays an important role in problems of non-linear initial values;likewise, in the study of problems nonlinear initial values;see [1] [2] [3]. On the other hand, following a series of problems proposed by V. Marchenko [4], that we will name Marchenko’s formulation, and relate it to a generalized version of Theorem 1 given in [1], the main theorem (Theorem 1) of this article provides a transformation operator W?that transforms the Reduced Radial Schr&#246;dinger Equation (RRSE) (whose main characteristic is the addition a singular term of quadratic order to a regular potential V(x)) in the Schr&#246;dinger Equation on Half-Line (RSEHL) under W. That is to say;W?eliminates the singular term of quadratic order of potential V(x) in the asymptotic development towards zero and adds to the potential V(x) a bounded term and a term exponentially decrease fast enough in the asymptotic development towards infinity, which continues guaranteeing the uniqueness of the potential V(x) in the condition of the infinity boundary. Then the L1-L∞ estimates for the (RRSE) are preserved under the transformation operator , as in the case of (RSEHL) where they were established in [3]. Finally, as an open question, the possibility of extending the L1-L∞ estimates for the case (RSEHL), where added to the potential V(x) an analytical perturbation is mentioned.

Accuracy Analysis of Gravity Model Based on Fictitious Compress Recovery Approach

The potential field determined based on the fictitious compress recovery approach is influenced by the errors contained in the boundary （the Earth＇s surface or the surface corresponding to the satellite altitude） values. Given the boundary value with definite accuracy, the accuracy of the field determined based on the fictitious compress recovery approach is estimated, and it is theoretically shown that the determined field has the same accuracy level as the given boundary value.

Concentrated Standing Tailwater： A Mechanism for Nutrient Delivery to Downstream Aquatic Ecosystems

Contribution of first flush runoff events from intense rainfall to downstream aquatic ecosystems are often reported in terms of sediment and nutrient delivery, with hardly any consideration to the contribution that standing, concentrated tailwater in primary aquatic systems makes to downstream nutrient loads. Two geographically distinct studies （Jonesboro Arkansas, and Stoneville Mississippi; 4 studies, n = 30） evaluated the effectiveness of drainage ditch systems to mitigate nutrient concentrations and loads. Within each independent study all experimental ditches had elevated background nutrient concentrations as a result of standing water, prior to the start of each simulated runoff experiment. These concentrations remained elevated 15-30 minutes post the start of each simulation as the concentrated, impounded water was pushed out through each system. In both these systems, it was hypothesized that water had accumulated in the respective drainage ditches and had been concentrated though evaporation and aquatic macrophyte transpiration. It is theorized that additional controlled drainage with improved dilution and hydraulic residence management.

Simulating and modeling the breakdown voltage in a semi-insulating GaAs P^+N junction diode

This work aims to determine the characteristic PN junction diode, subject to a reverse polarization, while I （breakdown voltage） of the inverse current in a GaAs specifying the parameters that influence the breakdown voltage of the diode. In this work, we simulated the behavior of the ionization phenomenon by impact breakdown by avalanche of the PN junctions, subject to an inverse polarization. We will take into account both the trapping model in a stationary regime in the P＋N structure using like material of basis the Ⅲ-Ⅴ compounds and mainly the GaAs semi-insulating in which the deep centers have in important densities. We are talking about the model of trapping in the space charge region （SCR） and that is the trap density donor and acceptor states. The carrier crossing the space charge region （SCR） of W thickness creates N electron-hole pairs： for every created pair, the electron and the hole are swept quickly by the electric field, each in an opposite direction, which comes back, according to an already accepted reasoning, to the crossing of the space charge region （SCR） by an electron or a hole. So the even N pair created by the initial particle provoke N2 ionizations and so forth. The study of the physical and electrical behaviour of semiconductors is based on the influence of the presence of deep centers on the characteristic I（V） current-tension, which requires the calculation of the electrostatic potential, the electric field, the integral of ionization, the density of the states traps, the diffusion current of minority in the regions （1） and （3）, the current thermal generation in the region （2）, the leakage current in the surface, and the breakdown voltage.